PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus UBE2E1 RNF122 20553626 biogrid exp GP GP G G G GP G G GP G GP G G GP G GP GP GP G G GP G G GP GP G GP GP G UBA1 RNF122 25260751 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF122 RNF122 20553626 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2D1 RNF122 20553626 biogrid exp GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G UBE2N RNF122 20553626,25260751 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G UBE2V1 RNF122 25260751 intact exp ELAVL1 RNF122 19322201 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE2D2 RNF122 20553626 biogrid exp GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G UBE2L6 RNF122 19690564 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CAMLG RNF122 20553626 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G UBE2D3 RNF122 20553626, 23023127 biogrid exp, pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G PSG6 RNF122 25402006 pred G GP G G G GP G G GP G GP GP GP G G G GP G G G GP G G G G G GP GP G ACRV1 RNF122 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G GP G PGLYRP4 RNF122 25402006 pred GP G G G GP GP G G GP G GP G GP GP G GP GP G GP G G GP GP G GP GP GP GP G GPATCH4 RNF122 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G NTRK3 RNF122 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF122 CCDC9 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CER1 RNF122 25402006 pred G G G G G G G G G G G G G GP G G G G G G G G G G G G G G IFNA16 RNF122 25402006 pred P G G G P G G GP P G P GP G G G G P P P G GLYAT RNF122 25402006 pred G G G RNF122 HS3ST2 25402006 pred G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G G G GP G GP GP G RNF122 TNFRSF19 21836163 pred GP GP G G P G GP GP G GP P GP GP G GP GP GP GP G P GP GP GP GP GP GP GP G IFNA4 RNF122 25402006 pred P G G G G GP G G GP GP G G P GP G G G G P P GP G DRD5 RNF122 25402006 pred G G G G G GP G G G G G G GP G G G GP G G G GP G G G G G GP GP G KCNMB4 RNF122 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TAF4B RNF122 25402006 pred G GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G G GP GP GP G GP GP G UBE2B RNF122 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NKX3-1 RNF122 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G SEC14L5 RNF122 25402006 pred GP GP G G G GP G G GP G GP G GP G G GP GP G GP G G G GP G GP G GP GP G FASLG RNF122 25402006 pred P GP G G GP GP G G GP G GP G P G P GP GP GP G GP P GP GP P GP P GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A0A087WW00 Q9H9V4 pull down 20553626 direct interaction X 2 P0CG48 Q9H9V4 affinity chromatography technology 22505724 physical association X 2 P0CG48 Q9H9V4 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q9H9V4 affinity chromatography technology 25147182 physical association X 2 P0CG48 Q9H9V4 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q9H9V4 affinity chromatography technology 21906983 physical association X 2 Q9H9V4 O14933-2 two hybrid 19690564 direct interaction X 2 Q9H9V4 Q9H9V4 enzymatic study 20553626 direct interaction X 2 P61088 Q9H9V4 pull down 20553626 direct interaction X 2 P49069 Q9H9V4 two hybrid 20553626 direct interaction X 2 P49069 Q9H9V4 affinity chromatography technology 20553626 physical association X 2 Q9H9V4 A0A024R2K3 pull down 20553626 direct interaction X 2 Q9H9V4 P62837 pull down 20553626 direct interaction X 2 Q9H9V4 P61077-3 pull down 20553626 direct interaction X 2 O14933 Q9H9V4 two hybrid array 19690564 physical association X 2 Q9H9V4 ubiquitinase assay 25260751 ubiquitination reaction C 4 Q7CJF5 Q9H9V4 two hybrid pooling approach 20711500 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality UBE2L6 RNF122 19690564,19690564 0397,0018 HT UBA1 RNF122 25260751 0997 LC CAMLG RNF122 20553626,20553626 0018,0004 LC UBE2N RNF122 25260751 0997 LC UBE2V1 RNF122 25260751 0997 LC RNF122 RNF122 20553626 0415 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9H9V4 O14933 RNF122 UBE2L6 0.376 19690564 Q9H9V4 P22314 RNF122 UBA1 0.033 25260751 Q9H9V4 P61088 RNF122 UBE2N 0.033 25260751 Q9H9V4 Q13404 RNF122 UBE2V1 0.033 25260751 Q9H9V4 Q7CJF5 RNF122 CYSK 0.126 20711500 Q9H9V4 Q9H9V4 RNF122 RNF122 0.332 20553626 Q9H9V4 P49069 RNF122 CAMLG 0.454 20553626 Q9H9V4 Q15717 RNF122 ELAVL1 0.126 19322201