PTM - CPLM Gene Name UniProt ID Type Position Code USP15; KIAA0529 Q9Y4E8 Ubiquitination 154 K USP15; KIAA0529 Q9Y4E8 Ubiquitination 228 K USP15; KIAA0529 Q9Y4E8 Ubiquitination 353 K USP15; KIAA0529 Q9Y4E8 Ubiquitination 605 K USP15; KIAA0529 Q9Y4E8 Ubiquitination 813 K USP15; KIAA0529 Q9Y4E8 Ubiquitination 259 K USP15; KIAA0529 Q9Y4E8 Ubiquitination 363 K USP15; KIAA0529 Q9Y4E8 Ubiquitination 193 K

PTM - dbPAF Gene Name UniProt ID Position Type Species USP15; KIAA0529 Q9Y4E8 102 S Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 104 Y Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 134 T Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 170 S Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 219 T Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 225 S Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 226 T Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 229 S Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 233 S Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 236 S Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 237 T Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 242 S Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 244 S Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 245 S Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 247 S Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 261 S Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 263 Y Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 268 Y Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 269 T Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 271 Y Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 274 Y Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 276 Y Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 602 T Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 607 Y Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 630 S Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 678 S Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 726 Y Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 78 S Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 826 S Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 881 S Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 89 Y Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 926 Y Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 952 S Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 955 T Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 961 S Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 965 S Homo sapiens(Human) USP15; KIAA0529 Q9Y4E8 980 T Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q9Y4E8 K758-ac Acetylation LDWDPDLkkRYFDEN Q9Y4E8 K759-ac Acetylation DWDPDLkkRYFDENA Q9Y4E8 K259-m1 Methylation NMNNRNVkNsNyCLP Q9Y4E8 K363-m1 Methylation YVTPRAFkTQVGRFA Q9Y4E8 S49-p Phosphorylation KKYVGFDsWDKYQMG Q9Y4E8 S78-p Phosphorylation LKDGDAQsLKEHLID Q9Y4E8 Y89-p Phosphorylation HLIDELDyILLPTEG Q9Y4E8 S102-p Phosphorylation EGWNKLVsWYTLMEG Q9Y4E8 S170-p Phosphorylation KEIRKIFsIPDEKET Q9Y4E8 T219-p Phosphorylation EQKNEDGtWPRGPst Q9Y4E8 S225-p Phosphorylation GtWPRGPstPksPGA Q9Y4E8 T226-p Phosphorylation tWPRGPstPksPGAs Q9Y4E8 S229-p Phosphorylation RGPstPksPGAsNFs Q9Y4E8 S233-p Phosphorylation tPksPGAsNFstLPK Q9Y4E8 S236-p Phosphorylation sPGAsNFstLPKIsP Q9Y4E8 T237-p Phosphorylation PGAsNFstLPKIsPs Q9Y4E8 S242-p Phosphorylation FstLPKIsPsSLSNN Q9Y4E8 S244-p Phosphorylation tLPKIsPsSLSNNYN Q9Y4E8 S261-p Phosphorylation NNRNVkNsNyCLPSy Q9Y4E8 Y263-p Phosphorylation RNVkNsNyCLPSytA Q9Y4E8 Y268-p Phosphorylation sNyCLPSytAyKNyD Q9Y4E8 T269-p Phosphorylation NyCLPSytAyKNyDy Q9Y4E8 Y271-p Phosphorylation CLPSytAyKNyDySE Q9Y4E8 Y274-p Phosphorylation SytAyKNyDySEPGR Q9Y4E8 Y276-p Phosphorylation tAyKNyDySEPGRNN Q9Y4E8 T602-p Phosphorylation MAVPRNNtEDkLyNL Q9Y4E8 Y607-p Phosphorylation NNtEDkLyNLLLLRM Q9Y4E8 S630-p Phosphorylation ETEETEGsLHCCKDQ Q9Y4E8 S678-p Phosphorylation LPSENENsQSEDSVG Q9Y4E8 Y726-p Phosphorylation LGNTDINyIkDDTRH Q9Y4E8 S826-p Phosphorylation TKKLDLWsLPPVLVV Q9Y4E8 S881-p Phosphorylation RYNLIAVsNHYGGMG Q9Y4E8 Y926-p Phosphorylation QIVSKAAyVLFYQRQ Q9Y4E8 S961-p Phosphorylation ATGIPLEsDEDsNDN Q9Y4E8 S965-p Phosphorylation PLEsDEDsNDNDNDI Q9Y4E8 K154-ub Ubiquitination VVTRRFSkADTIDTI Q9Y4E8 K228-ub Ubiquitination PRGPstPksPGAsNF Q9Y4E8 K259-ub Ubiquitination NMNNRNVkNsNyCLP Q9Y4E8 K353-ub Ubiquitination IKQMWSGkFSYVTPR Q9Y4E8 K605-ub Ubiquitination PRNNtEDkLyNLLLL Q9Y4E8 K728-ub Ubiquitination NTDINyIkDDTRHIR Q9Y4E8 K813-ub Ubiquitination PWYCPNCkEHQQATK

PTM - dbPTM UniProt ID Position Code Type Resources References Q9Y4E8 2 A Acetylation Swiss-Prot 1010711 19413330 Q9Y4E8 229 S Phosphorylation Swiss-Prot 1010711 16964243;18669648;19413330;19690332 Q9Y4E8 961 S Phosphorylation Swiss-Prot 1010711 18669648;19413330 Q9Y4E8 965 S Phosphorylation Swiss-Prot 1010711 18669648;19413330 Q9Y4E8 229 S Phosphorylation PhosphoELM.10011 18669648;16964243 Q9Y4E8 244 S Phosphorylation PhosphoELM.10011 18669648 Q9Y4E8 961 S Phosphorylation PhosphoELM.10011 18669648 Q9Y4E8 965 S Phosphorylation PhosphoELM.10011 18669648 Q9Y4E8 226 T Phosphorylation PhosphoELM.10011 18669648 Q9Y4E8 154 K Ubiquitylation Phosphositeplus.1010730 21890473 Q9Y4E8 228 K Ubiquitylation Phosphositeplus.1010730 21890473 Q9Y4E8 353 K Ubiquitylation Phosphositeplus.1010730 21890473 Q9Y4E8 605 K Ubiquitylation Phosphositeplus.1010730 21890473 Q9Y4E8 102 S Phosphorylation Phosphositeplus.1010730 20068231 Q9Y4E8 225 S Phosphorylation Phosphositeplus.1010730 19276368;19690332;20068231;20363803 Q9Y4E8 229 S Phosphorylation Phosphositeplus.1010730 16964243;18669648;19276368;19664994;19664995;19690332;20058876;20068231;20363803;20562096;20815410;21406692 Q9Y4E8 242 S Phosphorylation Phosphositeplus.1010730 19664995;20068231 Q9Y4E8 678 S Phosphorylation Phosphositeplus.1010730 17478428 Q9Y4E8 961 S Phosphorylation Phosphositeplus.1010730 18669648;20068231;20363803 Q9Y4E8 965 S Phosphorylation Phosphositeplus.1010730 18669648;19415658;20068231;20363803 Q9Y4E8 226 T Phosphorylation Phosphositeplus.1010730 16964243;18669648;19276368 Q9Y4E8 602 T Phosphorylation Phosphositeplus.1010730 20068231 Q9Y4E8 263 Y Phosphorylation Phosphositeplus.1010730 21403953;21447384 Q9Y4E8 268 Y Phosphorylation Phosphositeplus.1010730 20562096;21403953 Q9Y4E8 274 Y Phosphorylation Phosphositeplus.1010730 20007894;21403953 Q9Y4E8 607 Y Phosphorylation Phosphositeplus.1010730 20068231 Q9Y4E8 102 S Phosphorylation HPRD 9.0 20068231 Q9Y4E8 225 S Phosphorylation HPRD 9.0 20068231 Q9Y4E8 229 S Phosphorylation HPRD 9.0 17322306,18669648,19413330,19664995,19651622,19664994,18767875,16964243,20068231,20058876 Q9Y4E8 242 S Phosphorylation HPRD 9.0 19664995,20068231 Q9Y4E8 244 S Phosphorylation HPRD 9.0 18669648,19651622,20068231 Q9Y4E8 245 S Phosphorylation HPRD 9.0 20068231 Q9Y4E8 952 S Phosphorylation HPRD 9.0 20068231 Q9Y4E8 961 S Phosphorylation HPRD 9.0 18669648,19413330,20068231 Q9Y4E8 965 S Phosphorylation HPRD 9.0 18669648,19413330,19415658,20068231 Q9Y4E8 226 T Phosphorylation HPRD 9.0 18669648,16964243 Q9Y4E8 602 T Phosphorylation HPRD 9.0 20068231 Q9Y4E8 955 T Phosphorylation HPRD 9.0 20068231 Q9Y4E8 980 T Phosphorylation HPRD 9.0 20068231 Q9Y4E8 104 Y Phosphorylation HPRD 9.0 20068231 Q9Y4E8 607 Y Phosphorylation HPRD 9.0 20068231 Q9Y4E8 229 S Phosphorylation SysPTM 1.1 16964243;18669648 Q9Y4E8 961 S Phosphorylation SysPTM 1.1 18669648 Q9Y4E8 965 S Phosphorylation SysPTM 1.1 18669648 Q9Y4E8 226 T Phosphorylation SysPTM 1.1 16964243

PTM - HPRD Symbol Position Code Type References USP15 102 S Phosphorylation 20068231 USP15 104 Y Phosphorylation 20068231 USP15 225 S Phosphorylation 20068231 USP15 226 T Phosphorylation 18669648,16964243 USP15 229 S Phosphorylation 17322306,18669648,19413330,19664995,19651622,19664994,18767875,16964243,20068231,20058876 USP15 242 S Phosphorylation 19664995,20068231 USP15 244 S Phosphorylation 18669648,19651622,20068231 USP15 245 S Phosphorylation 20068231 USP15 573 T Phosphorylation 20068231 USP15 578 Y Phosphorylation 20068231 USP15 602 T Phosphorylation 20068231 USP15 607 Y Phosphorylation 20068231 USP15 923 S Phosphorylation 20068231 USP15 926 T Phosphorylation 20068231 USP15 932 S Phosphorylation 18669648,19413330,20068231 USP15 936 S Phosphorylation 18669648,19413330,19415658,20068231 USP15 951 T Phosphorylation 20068231 USP15 952 S Phosphorylation 20068231 USP15 955 T Phosphorylation 20068231 USP15 961 S Phosphorylation 18669648,19413330,20068231 USP15 965 S Phosphorylation 18669648,19413330,19415658,20068231 USP15 980 T Phosphorylation 20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q9Y4E8 229 S 18669648 HTP Phosphorylation Q9Y4E8 229 S 16964243 HTP Phosphorylation Q9Y4E8 965 S 18669648 HTP Phosphorylation Q9Y4E8 244 S 18669648 HTP Phosphorylation Q9Y4E8 226 T 18669648 HTP Phosphorylation Q9Y4E8 961 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q9Y4E8 2 N-acetylalanine 19413330;22223895;22814378 Q9Y4E8 226 Phosphothreonine 23186163 Q9Y4E8 229 Phosphoserine 16964243;18669648;19690332;20068231;21406692;23186163 Q9Y4E8 242 Phosphoserine 20068231;23186163 Q9Y4E8 961 Phosphoserine 18669648;20068231 Q9Y4E8 965 Phosphoserine 18669648;20068231

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type USP15 IPI00000728 S 102 GWNKLVpSWYTLME phosphorylation USP15 IPI00000728 S 225 TWPRGPpSTPKSPG phosphorylation USP15 IPI00000728 S 229 GPSTPKpSPGASNF phosphorylation USP15 IPI00000728 S 242 STLPKIpSPSSLSN phosphorylation USP15 IPI00000728 S 244 LPKISPpSSLSNNY phosphorylation USP15 IPI00000728 S 245 PKISPSpSLSNNYN phosphorylation USP15 IPI00000728 S 961 TGIPLEpSDEDSND phosphorylation USP15 IPI00000728 S 965 LESDEDpSNDNDND phosphorylation USP15 IPI00000728 T 226 WPRGPSpTPKSPGA phosphorylation

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID USP15 Homo sapiens (Human) 154 "154,VTRRFSKADTIDT" 154:21890473 USP15 Homo sapiens (Human) 576; 154; 324 "576,RNNTEDKLYNLLL; 154,VTRRFSKADTIDT; 324,KQMWSGKFSYVTP" 576:21890473; 154:21890473; 324:21890473 USP15 Homo sapiens (Human) 154 "154,VTRRFSKADTIDT" 154:21890473 USP15 Homo sapiens (Human) 154; 353; 228; 605 "154,VTRRFSKADTIDT; 353,KQMWSGKFSYVTP; 228,RGPSTPKSPGASN; 605,RNNTEDKLYNLLL" 154:21890473; 353:21890473; 228:21890473; 605:21890473 USP15 Homo sapiens (Human) 154; 353; 228; 605 "154,VTRRFSKADTIDT; 353,KQMWSGKFSYVTP; 228,RGPSTPKSPGASN; 605,RNNTEDKLYNLLL" 154:21890473; 353:21890473; 228:21890473; 605:21890473 USP15 Homo sapiens (Human) 576; 154; 324 "576,RNNTEDKLYNLLL; 154,VTRRFSKADTIDT; 324,KQMWSGKFSYVTP" 576:21890473; 154:21890473; 324:21890473 USP15 Homo sapiens (Human) 154; 581; 329 "154,VTRRFSKADTIDT; 581,RNNTEDKLYNLLL; 329,KQMWSGKFSYVTP" 154:21890473; 581:21890473; 329:21890473