Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change BLCA 6 30131570 30131570 + Missense_Mutation SNP C C T TCGA-5N-A9KM-01A-11D-A42E-08 TCGA-5N-A9KM-10A-01D-A42H-08 g.chr6:30131570C>T c.109C>T c.(109-111)Cgg>Tgg p.R37W BLCA 6 30131831 30131831 + Nonsense_Mutation SNP C C T TCGA-DK-A2I4-01A-11D-A21A-08 TCGA-DK-A2I4-10A-01D-A21A-08 g.chr6:30131831C>T c.370C>T c.(370-372)Cag>Tag p.Q124* BLCA 6 30134998 30134998 + Missense_Mutation SNP G G A TCGA-FD-A43P-01A-31D-A23U-08 TCGA-FD-A43P-10A-01D-A23U-08 g.chr6:30134998G>A c.427G>A c.(427-429)Gag>Aag p.E143K BLCA 6 30138762 30138762 + Missense_Mutation SNP C C T TCGA-4Z-AA7M-01A-11D-A391-08 TCGA-4Z-AA7M-10A-01D-A394-08 g.chr6:30138762C>T c.857C>T c.(856-858)gCg>gTg p.A286V BLCA 6 30139765 30139765 + Missense_Mutation SNP C C G TCGA-BT-A0YX-01A-11D-A10S-08 TCGA-BT-A0YX-10A-01D-A10S-08 g.chr6:30139765C>G c.1037C>G c.(1036-1038)tCc>tGc p.S346C BRCA 6 30131731 30131731 + Silent SNP C C T TCGA-C8-A3M8-01A-11D-A20S-09 TCGA-C8-A3M8-10A-01D-A20S-09 g.chr6:30131731C>T c.270C>T c.(268-270)atC>atT p.I90I COAD 6 30131724 30131726 + In_Frame_Del DEL AGA AGA - TCGA-AZ-6598-01A-11D-1771-10 TCGA-AZ-6598-11A-01D-1771-10 g.chr6:30131724_30131726delAGA c.263_265delAGA c.(262-267)gagaag>gag p.K89del COAD 6 30136204 30136204 + Missense_Mutation SNP G G T TCGA-A6-6781-01A-22D-1924-10 TCGA-A6-6781-10A-01D-1924-10 g.chr6:30136204G>T c.605G>T c.(604-606)aGg>aTg p.R202M COAD 6 30138323 30138323 + Silent SNP C C T TCGA-CA-6716-01A-11D-1835-10 TCGA-CA-6716-10A-01D-1835-10 g.chr6:30138323C>T c.777C>T c.(775-777)gaC>gaT p.D259D COAD 6 30138339 30138339 + Missense_Mutation SNP C C T TCGA-AA-3966-01A-01W-1073-09 TCGA-AA-3966-10A-01W-1073-09 g.chr6:30138339C>T c.793C>T c.(793-795)Cgt>Tgt p.R265C COAD 6 30139635 30139635 + Missense_Mutation SNP G G A TCGA-AA-3663-01A-01D-1719-10 TCGA-AA-3663-11A-01D-1719-10 g.chr6:30139635G>A c.907G>A c.(907-909)Gcc>Acc p.A303T COAD 6 30139754 30139754 + Silent SNP G G A TCGA-AA-3877-01A-01W-0995-10 TCGA-AA-3877-10A-01W-0995-10 g.chr6:30139754G>A c.1026G>A c.(1024-1026)ccG>ccA p.P342P COAD 6 30139772 30139772 + Silent SNP C C A TCGA-AZ-6601-01A-11D-1771-10 TCGA-AZ-6601-11A-01D-1771-10 g.chr6:30139772C>A c.1044C>A c.(1042-1044)cgC>cgA p.R348R COAD 6 30139941 30139941 + Missense_Mutation SNP G G A TCGA-CM-4752-01A-01D-1408-10 TCGA-CM-4752-10A-01D-1408-10 g.chr6:30139941G>A c.1213G>A c.(1213-1215)Gac>Aac p.D405N COADREAD 6 30131724 30131726 + In_Frame_Del DEL AGA AGA - TCGA-AZ-6598-01A-11D-1771-10 TCGA-AZ-6598-11A-01D-1771-10 g.chr6:30131724_30131726delAGA c.263_265delAGA c.(262-267)gagaag>gag p.K89del COADREAD 6 30136204 30136204 + Missense_Mutation SNP G G T TCGA-A6-6781-01A-22D-1924-10 TCGA-A6-6781-10A-01D-1924-10 g.chr6:30136204G>T c.605G>T c.(604-606)aGg>aTg p.R202M COADREAD 6 30138323 30138323 + Silent SNP C C T TCGA-CA-6716-01A-11D-1835-10 TCGA-CA-6716-10A-01D-1835-10 g.chr6:30138323C>T c.777C>T c.(775-777)gaC>gaT p.D259D COADREAD 6 30138339 30138339 + Missense_Mutation SNP C C T TCGA-AA-3966-01A-01W-1073-09 TCGA-AA-3966-10A-01W-1073-09 g.chr6:30138339C>T c.793C>T c.(793-795)Cgt>Tgt p.R265C COADREAD 6 30139635 30139635 + Missense_Mutation SNP G G A TCGA-AA-3663-01A-01D-1719-10 TCGA-AA-3663-11A-01D-1719-10 g.chr6:30139635G>A c.907G>A c.(907-909)Gcc>Acc p.A303T COADREAD 6 30139754 30139754 + Silent SNP G G A TCGA-AA-3877-01A-01W-0995-10 TCGA-AA-3877-10A-01W-0995-10 g.chr6:30139754G>A c.1026G>A c.(1024-1026)ccG>ccA p.P342P COADREAD 6 30139772 30139772 + Silent SNP C C A TCGA-AZ-6601-01A-11D-1771-10 TCGA-AZ-6601-11A-01D-1771-10 g.chr6:30139772C>A c.1044C>A c.(1042-1044)cgC>cgA p.R348R COADREAD 6 30139941 30139941 + Missense_Mutation SNP G G A TCGA-CM-4752-01A-01D-1408-10 TCGA-CM-4752-10A-01D-1408-10 g.chr6:30139941G>A c.1213G>A c.(1213-1215)Gac>Aac p.D405N DLBC 6 30131527 30131527 + Silent SNP G G T TCGA-G8-6326-01A-11D-2210-10 TCGA-G8-6326-10A-01D-2210-10 g.chr6:30131527G>T c.66G>T c.(64-66)ccG>ccT p.P22P DLBC 6 30139971 30139971 + Missense_Mutation SNP G G C TCGA-G8-6324-01A-11D-2210-10 TCGA-G8-6324-10A-01D-2210-10 g.chr6:30139971G>C c.1243G>C c.(1243-1245)Gtg>Ctg p.V415L ESCA 6 30131704 30131705 + Frame_Shift_Del DEL TT TT - TCGA-R6-A6L6-01B-11D-A33E-09 TCGA-R6-A6L6-10A-01D-A33H-09 g.chr6:30131704_30131705delTT c.243_244delTT c.(241-246)acttacfs p.Y82fs ESCA 6 30136085 30136085 + Silent SNP C C A TCGA-XP-A8T6-01A-11D-A36J-09 TCGA-XP-A8T6-10A-01D-A36M-09 g.chr6:30136085C>A c.486C>A c.(484-486)atC>atA p.I162I GBMLGG 6 30131720 30131720 + Missense_Mutation SNP G G A TCGA-HT-7854-01A-11D-2253-08 TCGA-HT-7854-10A-01D-2253-08 g.chr6:30131720G>A c.259G>A c.(259-261)Ggc>Agc p.G87S GBMLGG 6 30134981 30134981 + Missense_Mutation SNP T T C TCGA-HW-8321-01A-11D-2395-08 TCGA-HW-8321-10A-01D-2396-08 g.chr6:30134981T>C c.410T>C c.(409-411)cTg>cCg p.L137P GBMLGG 6 30136149 30136149 + Nonsense_Mutation SNP C C T TCGA-DU-A7TJ-01A-11D-A34J-08 TCGA-DU-A7TJ-10A-01D-A34M-08 g.chr6:30136149C>T c.550C>T c.(550-552)Cga>Tga p.R184* GBMLGG 6 30138295 30138295 + Missense_Mutation SNP T T C TCGA-DU-8166-01A-11D-2253-08 TCGA-DU-8166-10A-01D-2253-08 g.chr6:30138295T>C c.749T>C c.(748-750)tTt>tCt p.F250S GBMLGG 6 30138337 30138337 + Missense_Mutation SNP T T C TCGA-HT-7688-01A-11D-2253-08 TCGA-HT-7688-10A-01D-2253-08 g.chr6:30138337T>C c.791T>C c.(790-792)aTc>aCc p.I264T HNSC 6 30131821 30131821 + Silent SNP C C T TCGA-CN-A642-01A-12D-A30E-08 TCGA-CN-A642-10A-01D-A30H-08 g.chr6:30131821C>T c.360C>T c.(358-360)gaC>gaT p.D120D HNSC 6 30131831 30131831 + Missense_Mutation SNP C C G TCGA-CR-6484-01A-11D-1870-08 TCGA-CR-6484-10A-01D-1870-08 g.chr6:30131831C>G c.370C>G c.(370-372)Cag>Gag p.Q124E HNSC 6 30138306 30138306 + Missense_Mutation SNP G G C TCGA-CN-A6V1-01A-12D-A34J-08 TCGA-CN-A6V1-10B-01D-A34M-08 g.chr6:30138306G>C c.760G>C c.(760-762)Gag>Cag p.E254Q HNSC 6 30140093 30140093 + Nonsense_Mutation SNP G G A TCGA-CR-7377-01A-11D-2012-08 TCGA-CR-7377-10A-01D-2013-08 g.chr6:30140093G>A c.1365G>A c.(1363-1365)tgG>tgA p.W455* KICH 6 30139748 30139748 + Silent SNP C C T TCGA-KL-8326-01A-11D-2310-10 TCGA-KL-8326-11A-01D-2310-10 g.chr6:30139748C>T c.1020C>T c.(1018-1020)ggC>ggT p.G340G KIPAN 6 30139748 30139748 + Silent SNP C C T TCGA-KL-8326-01A-11D-2310-10 TCGA-KL-8326-11A-01D-2310-10 g.chr6:30139748C>T c.1020C>T c.(1018-1020)ggC>ggT p.G340G KIPAN 6 30140094 30140094 + Frame_Shift_Del DEL A A - TCGA-AL-3472-01A-01D-1252-08 TCGA-AL-3472-10A-01D-1252-08 g.chr6:30140094delA c.1366delA c.(1366-1368)aaafs p.K457fs KIRP 6 30140094 30140094 + Frame_Shift_Del DEL A A - TCGA-AL-3472-01A-01D-1252-08 TCGA-AL-3472-10A-01D-1252-08 g.chr6:30140094delA c.1366delA c.(1366-1368)aaafs p.K457fs LGG 6 30131720 30131720 + Missense_Mutation SNP G G A TCGA-HT-7854-01A-11D-2253-08 TCGA-HT-7854-10A-01D-2253-08 g.chr6:30131720G>A c.259G>A c.(259-261)Ggc>Agc p.G87S LGG 6 30134981 30134981 + Missense_Mutation SNP T T C TCGA-HW-8321-01A-11D-2395-08 TCGA-HW-8321-10A-01D-2396-08 g.chr6:30134981T>C c.410T>C c.(409-411)cTg>cCg p.L137P LGG 6 30136149 30136149 + Nonsense_Mutation SNP C C T TCGA-DU-A7TJ-01A-11D-A34J-08 TCGA-DU-A7TJ-10A-01D-A34M-08 g.chr6:30136149C>T c.550C>T c.(550-552)Cga>Tga p.R184* LGG 6 30138295 30138295 + Missense_Mutation SNP T T C TCGA-DU-8166-01A-11D-2253-08 TCGA-DU-8166-10A-01D-2253-08 g.chr6:30138295T>C c.749T>C c.(748-750)tTt>tCt p.F250S LGG 6 30138337 30138337 + Missense_Mutation SNP T T C TCGA-HT-7688-01A-11D-2253-08 TCGA-HT-7688-10A-01D-2253-08 g.chr6:30138337T>C c.791T>C c.(790-792)aTc>aCc p.I264T LIHC 6 30138285 30138285 + Missense_Mutation SNP A A C TCGA-G3-A5SK-01A-11D-A27I-10 TCGA-G3-A5SK-10A-01D-A27I-10 g.chr6:30138285A>C c.739A>C c.(739-741)Atg>Ctg p.M247L LIHC 6 30139690 30139692 + In_Frame_Del DEL AGA AGA - TCGA-4R-AA8I-01A-11D-A382-10 TCGA-4R-AA8I-10B-01D-A385-10 g.chr6:30139690_30139692delAGA c.962_964delAGA c.(961-966)cagaag>cag p.K323del LUAD 6 30131581 30131582 + Frame_Shift_Del DEL CC CC - TCGA-44-6777-01A-11D-1855-08 TCGA-44-6777-10A-01D-1855-08 g.chr6:30131581_30131582delCC c.120_121delCC c.(118-123)ctccccfs p.P41fs LUAD 6 30131594 30131594 + Nonsense_Mutation SNP C C T TCGA-17-Z021-01A-01W-0746-08 TCGA-17-Z021-11A-01W-0746-08 g.chr6:30131594C>T c.133C>T c.(133-135)Cag>Tag p.Q45* LUAD 6 30131749 30131749 + Missense_Mutation SNP C C G TCGA-05-4382-01A-01D-1931-08 TCGA-05-4382-10A-01D-1265-08 g.chr6:30131749C>G c.288C>G c.(286-288)aaC>aaG p.N96K LUAD 6 30131761 30131761 + Silent SNP C C T TCGA-17-Z026-01A-01W-0746-08 TCGA-17-Z026-11A-01W-0746-08 g.chr6:30131761C>T c.300C>T c.(298-300)ttC>ttT p.F100F LUAD 6 30138348 30138348 + Missense_Mutation SNP C C T TCGA-05-4382-01A-01D-1931-08 TCGA-05-4382-10A-01D-1265-08 g.chr6:30138348C>T c.802C>T c.(802-804)Cac>Tac p.H268Y LUAD 6 30138770 30138770 + Missense_Mutation SNP C C A TCGA-17-Z016-01A-01W-0746-08 TCGA-17-Z016-11A-01W-0746-08 g.chr6:30138770C>A c.865C>A c.(865-867)Ctg>Atg p.L289M LUAD 6 30139640 30139640 + Missense_Mutation SNP C C A TCGA-44-7662-01A-11D-2063-08 TCGA-44-7662-10A-01D-2063-08 g.chr6:30139640C>A c.912C>A c.(910-912)agC>agA p.S304R LUAD 6 30139658 30139658 + Silent SNP G G A TCGA-55-8506-01A-11D-2393-08 TCGA-55-8506-10A-01D-2393-08 g.chr6:30139658G>A c.930G>A c.(928-930)tcG>tcA p.S310S LUSC 6 30131465 30131465 + Missense_Mutation SNP C C T TCGA-43-3394-01A-01D-0983-08 TCGA-43-3394-10A-01D-0983-08 g.chr6:30131465C>T c.4C>T c.(4-6)Ccc>Tcc p.P2S LUSC 6 30131596 30131596 + Missense_Mutation SNP G G C TCGA-39-5028-01A-01D-1441-08 TCGA-39-5028-11A-01D-1441-08 g.chr6:30131596G>C c.135G>C c.(133-135)caG>caC p.Q45H LUSC 6 30131694 30131695 + Missense_Mutation DNP TG TG CT TCGA-22-5473-01A-01D-1632-08 TCGA-22-5473-11A-11D-1632-08 g.chr6:30131694_30131695TG>CT c.233_234TG>CT c.(232-234)cTG>cCT p.L78P OV 6 30131602 30131602 + Silent SNP G G T TCGA-23-2645-01A-01W-1091-09 TCGA-23-2645-10A-01W-1091-09 g.chr6:30131602G>T c.141G>T c.(139-141)ggG>ggT p.G47G PRAD 6 30131521 30131521 + Silent SNP G G A TCGA-XK-AAIW-01A-11D-A41K-08 TCGA-XK-AAIW-10A-01D-A41N-08 g.chr6:30131521G>A c.60G>A c.(58-60)gcG>gcA p.A20A PRAD 6 30138773 30138773 + Missense_Mutation SNP G G A TCGA-HC-A8D1-01A-11D-A364-08 TCGA-HC-A8D1-10A-01D-A362-08 g.chr6:30138773G>A c.868G>A c.(868-870)Gaa>Aaa p.E290K SKCM 6 30131573 30131573 + Missense_Mutation SNP C C T TCGA-EE-A2A5-06A-11D-A197-08 TCGA-EE-A2A5-10A-01D-A199-08 g.chr6:30131573C>T c.112C>T c.(112-114)Ctc>Ttc p.L38F SKCM 6 30131599 30131599 + Missense_Mutation SNP G G A TCGA-GN-A265-06A-21D-A197-08 TCGA-GN-A265-10A-01D-A199-08 g.chr6:30131599G>A c.138G>A c.(136-138)atG>atA p.M46I SKCM 6 30131648 30131648 + Missense_Mutation SNP G G A TCGA-FS-A1Z3-06A-11D-A197-08 TCGA-FS-A1Z3-10A-01D-A199-08 g.chr6:30131648G>A c.187G>A c.(187-189)Gag>Aag p.E63K SKCM 6 30131762 30131762 + Missense_Mutation SNP C C T TCGA-EE-A3AA-06A-11D-A196-08 TCGA-EE-A3AA-10A-01D-A198-08 g.chr6:30131762C>T c.301C>T c.(301-303)Ctc>Ttc p.L101F SKCM 6 30131816 30131816 + Silent SNP C C T TCGA-ER-A19H-06A-12D-A196-08 TCGA-ER-A19H-10A-01D-A198-08 g.chr6:30131816C>T c.355C>T c.(355-357)Ctg>Ttg p.L119L SKCM 6 30134956 30134956 + Missense_Mutation SNP C C T TCGA-EE-A2MD-06A-11D-A197-08 TCGA-EE-A2MD-10A-01D-A199-08 g.chr6:30134956C>T c.385C>T c.(385-387)Cgt>Tgt p.R129C SKCM 6 30134964 30134964 + Silent SNP G G A TCGA-EE-A181-06A-11D-A196-08 TCGA-EE-A181-10A-01D-A198-08 g.chr6:30134964G>A c.393G>A c.(391-393)agG>agA p.R131R SKCM 6 30134964 30134964 + Silent SNP G G A TCGA-FW-A3R5-06A-11D-A23B-08 TCGA-FW-A3R5-10A-01D-A23B-08 g.chr6:30134964G>A c.393G>A c.(391-393)agG>agA p.R131R SKCM 6 30134986 30134986 + Missense_Mutation SNP A A C TCGA-D9-A6EC-06A-11D-A30X-08 TCGA-D9-A6EC-10A-01D-A30X-08 g.chr6:30134986A>C c.415A>C c.(415-417)Acg>Ccg p.T139P SKCM 6 30135034 30135034 + Missense_Mutation SNP C C T TCGA-EE-A2M6-06A-12D-A197-08 TCGA-EE-A2M6-10A-01D-A199-08 g.chr6:30135034C>T c.463C>T c.(463-465)Ctt>Ttt p.L155F SKCM 6 30136161 30136161 + Silent SNP C C T TCGA-DA-A1HV-06A-21D-A196-08 TCGA-DA-A1HV-10A-01D-A198-08 g.chr6:30136161C>T c.562C>T c.(562-564)Ctg>Ttg p.L188L SKCM 6 30136170 30136170 + Silent SNP C C T TCGA-EE-A29R-06A-11D-A197-08 TCGA-EE-A29R-10A-01D-A199-08 g.chr6:30136170C>T c.571C>T c.(571-573)Ctg>Ttg p.L191L SKCM 6 30136175 30136175 + Silent SNP G G A TCGA-EE-A3J5-06A-11D-A20D-08 TCGA-EE-A3J5-10A-01D-A20D-08 g.chr6:30136175G>A c.576G>A c.(574-576)agG>agA p.R192R SKCM 6 30136262 30136262 + Silent SNP G G A TCGA-EE-A3J7-06A-11D-A20D-08 TCGA-EE-A3J7-10A-01D-A20D-08 g.chr6:30136262G>A c.663G>A c.(661-663)aaG>aaA p.K221K SKCM 6 30137018 30137018 + Splice_Site SNP G G A TCGA-D3-A3CB-06A-11D-A196-08 TCGA-D3-A3CB-10A-01D-A198-08 g.chr6:30137018G>A c.709G>A c.(709-711)Gat>Aat p.D237N SKCM 6 30137031 30137031 + Missense_Mutation SNP A A G TCGA-FS-A4F5-06A-11D-A25O-08 TCGA-FS-A4F5-10B-01D-A25O-08 g.chr6:30137031A>G c.722A>G c.(721-723)aAc>aGc p.N241S SKCM 6 30138389 30138389 + Silent SNP C C T TCGA-GN-A262-06A-11D-A196-08 TCGA-GN-A262-10A-01D-A198-08 g.chr6:30138389C>T c.843C>T c.(841-843)ttC>ttT p.F281F SKCM 6 30138773 30138773 + Missense_Mutation SNP G G A TCGA-GF-A6C9-06A-11D-A30X-08 TCGA-GF-A6C9-10A-01D-A30X-08 g.chr6:30138773G>A c.868G>A c.(868-870)Gaa>Aaa p.E290K SKCM 6 30138786 30138786 + Splice_Site SNP G G A TCGA-GF-A6C9-06A-11D-A30X-08 TCGA-GF-A6C9-10A-01D-A30X-08 g.chr6:30138786G>A c.e6+1 SKCM 6 30139662 30139662 + Missense_Mutation SNP G G A TCGA-FW-A3R5-06A-11D-A23B-08 TCGA-FW-A3R5-10A-01D-A23B-08 g.chr6:30139662G>A c.934G>A c.(934-936)Gac>Aac p.D312N SKCM 6 30139833 30139833 + Frame_Shift_Del DEL G G - TCGA-DA-A1I2-06A-21D-A19A-08 TCGA-DA-A1I2-10A-01D-A19A-08 g.chr6:30139833delG c.1105delG c.(1105-1107)gggfs p.G369fs SKCM 6 30140006 30140006 + Silent SNP G G A TCGA-EE-A29E-06A-11D-A197-08 TCGA-EE-A29E-10A-01D-A199-08 g.chr6:30140006G>A c.1278G>A c.(1276-1278)gtG>gtA p.V426V

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand CSCC-30-T COSM4462608 c.1253C>T p.A418V Substitution - Missense 6:30172204-30172204 + TCGA-D9-A6EC-06 COSM4404630 c.415A>C p.T139P Substitution - Missense 6:30167209-30167209 + TCGA-AA-3966-01 COSM273380 c.793C>T p.R265C Substitution - Missense 6:30170562-30170562 + Pat_24_A COSM5870026 c.13C>T p.P5S Substitution - Missense 6:30163697-30163697 + TCGA-AP-A051-01 COSM1077317 c.288C>T p.N96N Substitution - coding silent 6:30163972-30163972 + TCGA-43-3394-01 COSM741489 c.4C>T p.P2S Substitution - Missense 6:30163688-30163688 + LUAD-NYU739 COSM376305 c.451G>A p.E151K Substitution - Missense 6:30167245-30167245 + Pat_54_A COSM5870031 c.1105G>A p.G369R Substitution - Missense 6:30172056-30172056 + TCGA-DU-8166-01 COSM3928299 c.749T>C p.F250S Substitution - Missense 6:30170518-30170518 + HCC19T COSM1621378 c.128T>G p.L43R Substitution - Missense 6:30163812-30163812 + TCGA-AX-A05Z-01 COSM1077319 c.487G>A p.E163K Substitution - Missense 6:30168309-30168309 + CHC1734T COSM4800887 c.12C>T p.T4T Substitution - coding silent 6:30163696-30163696 + LUAD-NYU1219 COSM370187 c.805A>C p.R269R Substitution - coding silent 6:30170574-30170574 + TCGA-AZ-4615-01 COSM3761794 c.85A>G p.I29V Substitution - Missense 6:30163769-30163769 + TCGA-EE-A2A5-06 COSM3624184 c.112C>T p.L38F Substitution - Missense 6:30163796-30163796 + P04-594 COSM247976 c.289G>A p.D97N Substitution - Missense 6:30163973-30163973 + T3090 COSM4735930 c.273_275delCTT p.F93delF Deletion - In frame 6:30163957-30163959 + TCGA-AA-3663-01 COSM1442981 c.907G>A p.A303T Substitution - Missense 6:30171858-30171858 + 2218458 COSM4421204 c.118C>T p.L40F Substitution - Missense 6:30163802-30163802 + Pat_41_B COSM5870030 c.361G>A p.E121K Substitution - Missense 6:30164045-30164045 + TCGA-EE-A3J5-06 COSM3624203 c.576G>A p.R192R Substitution - coding silent 6:30168398-30168398 + CSCC-1-T COSM4511141 c.859C>T p.H287Y Substitution - Missense 6:30170987-30170987 + TCGA-CM-4752-01 COSM1442983 c.1213G>A p.D405N Substitution - Missense 6:30172164-30172164 + TCGA-FS-A4F5-06 COSM3624205 c.722A>G p.N241S Substitution - Missense 6:30169254-30169254 + TCGA-A3-3316-01 COSM1496311 c.854T>C p.L285S Substitution - Missense 6:30170982-30170982 + TCGA-C8-A3M8-01 COSM3829984 c.270C>T p.I90I Substitution - coding silent 6:30163954-30163954 + TCGA-ER-A19H-06 COSM3624197 c.355C>T p.L119L Substitution - coding silent 6:30164039-30164039 + ESO-859 COSM1240512 c.1079G>A p.G360D Substitution - Missense 6:30172030-30172030 + TCGA-EE-A3J7-06 COSM3921307 c.663G>A p.K221K Substitution - coding silent 6:30168485-30168485 + 8044079 COSM3394044 c.420G>A p.E140E Substitution - coding silent 6:30167214-30167214 + CHC197T COSM3669578 c.1336G>T p.G446C Substitution - Missense 6:30172287-30172287 + TCGA-FW-A3R5-06 COSM3921306 c.393G>A p.R131R Substitution - coding silent 6:30167187-30167187 + TCGA-FW-A3R5-06 COSM3921308 c.934G>A p.D312N Substitution - Missense 6:30171885-30171885 + CSCC-27-T COSM4526323 c.1389G>A p.L463L Substitution - coding silent 6:30172340-30172340 + TCGA-AM-5821-01 COSM3761796 c.971G>A p.S324N Substitution - Missense 6:30171922-30171922 + ME009T COSM223068 c.785A>G p.K262R Substitution - Missense 6:30170554-30170554 + Pat_40_A COSM5870028 c.220C>T p.P74S Substitution - Missense 6:30163904-30163904 + TP_2060 COSM5549388 c.858G>A p.A286A Substitution - coding silent 6:30170986-30170986 + PT35 COSM5912533 c.673G>A p.E225K Substitution - Missense 6:30168495-30168495 + CN-AML-CR-29-Dx COSM3761794 c.85A>G p.I29V Substitution - Missense 6:30163769-30163769 + TCGA-HT-7854-01 COSM3928296 c.259G>A p.G87S Substitution - Missense 6:30163943-30163943 + TCGA-HT-7688-01 COSM3928300 c.791T>C p.I264T Substitution - Missense 6:30170560-30170560 + TCGA-22-5473-01 COSM741487 c.233T>C p.L78P Substitution - Missense 6:30163917-30163917 + CHC433T COSM3669577 c.1202C>A p.S401Y Substitution - Missense 6:30172153-30172153 + 61 COSM5737524 c.601G>A p.E201K Substitution - Missense 6:30168423-30168423 + ESO-0133 COSM1268511 c.751G>A p.V251M Substitution - Missense 6:30170520-30170520 + SW48 COSM3251174 c.913C>T p.R305W Substitution - Missense 6:30171864-30171864 + TCGA-GN-A265-06 COSM3624186 c.138G>A p.M46I Substitution - Missense 6:30163822-30163822 + 1_RESISTANT COSM1720764 c.436G>A p.D146N Substitution - Missense 6:30167230-30167230 + TCGA-GF-A6C9-06 COSM4900122 c.868G>A p.E290K Substitution - Missense 6:30170996-30170996 + CSCC-20-T COSM4568285 c.106T>C p.C36R Substitution - Missense 6:30163790-30163790 + BCM723T COSM5347477 c.968_970delAGA p.K323delK Deletion - In frame 6:30171919-30171921 + TCGA-G3-A5SK-01 COSM4927439 c.739A>C p.M247L Substitution - Missense 6:30170508-30170508 + Pat_24_B COSM5870026 c.13C>T p.P5S Substitution - Missense 6:30163697-30163697 + CHC197T COSM3669578 c.1336G>T p.G446C Substitution - Missense 6:30172287-30172287 + TCGA-B5-A0JY-01 COSM1077320 c.770C>A p.S257Y Substitution - Missense 6:30170539-30170539 + TCGA-BR-4201-01 COSM3861380 c.1263C>T p.Y421Y Substitution - coding silent 6:30172214-30172214 + HCC19 COSM1621378 c.128T>G p.L43R Substitution - Missense 6:30163812-30163812 + TCGA-AZ-6601-01 COSM1442982 c.1044C>A p.R348R Substitution - coding silent 6:30171995-30171995 + TCGA-GN-A269-01 COSM1722841 c.149C>T p.S50F Substitution - Missense 6:30163833-30163833 + CSCC-29-T COSM4461517 c.120C>T p.L40L Substitution - coding silent 6:30163804-30163804 + SM-4AX87 COSM4412594 c.859C>A p.H287N Substitution - Missense 6:30170987-30170987 + C086 COSM5540791 c.184G>A p.E62K Substitution - Missense 6:30163868-30163868 + 3402_T COSM3948963 c.294C>A p.A98A Substitution - coding silent 6:30163978-30163978 + 3T COSM3733951 c.1360G>C p.V454L Substitution - Missense 6:30172311-30172311 + PD13310a COSM5797533 c.351G>T p.G117G Substitution - coding silent 6:30164035-30164035 + TCGA-ER-A194-01 COSM3624200 c.535G>A p.E179K Substitution - Missense 6:30168357-30168357 + 3P3 COSM3733951 c.1360G>C p.V454L Substitution - Missense 6:30172311-30172311 + 8013222 COSM3394045 c.1156G>A p.V386I Substitution - Missense 6:30172107-30172107 + TCGA-DK-A2I4-01 COSM3777436 c.370C>T p.Q124* Substitution - Nonsense 6:30164054-30164054 + BD124T COSM5492022 c.1011G>A p.A337A Substitution - coding silent 6:30171962-30171962 + RK125_C01 COSM3702964 c.621A>T p.T207T Substitution - coding silent 6:30168443-30168443 + TCGA-ER-A194-01 COSM3624191 c.221C>T p.P74L Substitution - Missense 6:30163905-30163905 + SC_9032 COSM5554158 c.1021T>C p.F341L Substitution - Missense 6:30171972-30171972 + T3417 COSM4735932 c.541G>T p.E181* Substitution - Nonsense 6:30168363-30168363 + HCC37T COSM1621379 c.437delA p.D146fs*2 Deletion - Frameshift 6:30167231-30167231 + ESO-859 COSM1240513 c.1360G>A p.V454I Substitution - Missense 6:30172311-30172311 + P04-2641 COSM247975 c.371A>C p.Q124P Substitution - Missense 6:30164055-30164055 + CHC1734T COSM4800887 c.12C>T p.T4T Substitution - coding silent 6:30163696-30163696 + TCGA-GF-A6C9-06 COSM4901599 c.880+1G>A p.? Unknown 6:30171009-30171009 + TCGA-AZ-6598-01 COSM1442978 c.263_265delAGA p.K89delK Deletion - In frame 6:30163947-30163949 + TCGA-EE-A29R-06 COSM3624202 c.571C>T p.L191L Substitution - coding silent 6:30168393-30168393 + TCGA-DD-A11B-01 COSM4934097 c.733T>C p.C245R Substitution - Missense 6:30170502-30170502 + PD7305a COSM5792083 c.266A>G p.K89R Substitution - Missense 6:30163950-30163950 + PD11394a COSM5783071 c.380G>A p.R127Q Substitution - Missense 6:30164064-30164064 + TCGA-IH-A3EA-01 COSM3624193 c.229C>T p.P77S Substitution - Missense 6:30163913-30163913 + TCGA-AM-5820-01 COSM3761794 c.85A>G p.I29V Substitution - Missense 6:30163769-30163769 + T4 COSM5345129 c.1359C>T p.A453A Substitution - coding silent 6:30172310-30172310 + CHC433T COSM3669577 c.1202C>A p.S401Y Substitution - Missense 6:30172153-30172153 + LUAD-RT-S01813 COSM383451 c.345C>A p.T115T Substitution - coding silent 6:30164029-30164029 + DN110DC COSM5792083 c.266A>G p.K89R Substitution - Missense 6:30163950-30163950 + TCGA-D3-A3CB-06 COSM3624204 c.709G>A p.D237N Substitution - Missense 6:30169241-30169241 + 01-P1216 COSM3251161 c.478-1G>A p.? Unknown 6:30168299-30168299 + 1_PRE-TREATMENT COSM1720764 c.436G>A p.D146N Substitution - Missense 6:30167230-30167230 + TCGA-EE-A2M6-06 COSM3624199 c.463C>T p.L155F Substitution - Missense 6:30167257-30167257 + TCGA-DA-A1HV-06 COSM3624201 c.562C>T p.L188L Substitution - coding silent 6:30168384-30168384 + TCGA-EE-A3AA-06 COSM3624195 c.301C>T p.L101F Substitution - Missense 6:30163985-30163985 + B80-5-Tumor COSM4006270 c.1335C>T p.S445S Substitution - coding silent 6:30172286-30172286 + 2_PRE-TREATMENT COSM1722841 c.149C>T p.S50F Substitution - Missense 6:30163833-30163833 + CHC322T COSM3761794 c.85A>G p.I29V Substitution - Missense 6:30163769-30163769 + TCGA-22-5473-01 COSM741485 c.234G>T p.L78L Substitution - coding silent 6:30163918-30163918 + TCGA-AG-4021-01 COSM3430453 c.486C>T p.I162I Substitution - coding silent 6:30168308-30168308 + TCGA-EE-A29E-06 COSM3624207 c.1278G>A p.V426V Substitution - coding silent 6:30172229-30172229 + TCGA-FS-A1Z3-06 COSM3624189 c.187G>A p.E63K Substitution - Missense 6:30163871-30163871 + TCGA-GN-A262-06 COSM3624206 c.843C>T p.F281F Substitution - coding silent 6:30170612-30170612 + TCGA-A6-6781-01 COSM1442979 c.605G>T p.R202M Substitution - Missense 6:30168427-30168427 + S02290 COSM5686788 c.643C>A p.R215R Substitution - coding silent 6:30168465-30168465 + CSCC-29-T COSM3624198 c.385C>T p.R129C Substitution - Missense 6:30167179-30167179 + TCGA-EE-A2MD-06 COSM3624198 c.385C>T p.R129C Substitution - Missense 6:30167179-30167179 + TCGA-BT-A0YX-01 COSM420919 c.1037C>G p.S346C Substitution - Missense 6:30171988-30171988 + T2987 COSM4735933 c.856G>C p.A286P Substitution - Missense 6:30170984-30170984 + TCGA-39-5028-01 COSM741488 c.135G>C p.Q45H Substitution - Missense 6:30163819-30163819 + TCGA-23-2645-01 COSM1329115 c.141G>T p.G47G Substitution - coding silent 6:30163825-30163825 + C0100T COSM4155156 c.84C>A p.T28T Substitution - coding silent 6:30163768-30163768 + TCGA-AX-A05Z-01 COSM1077318 c.289G>T p.D97Y Substitution - Missense 6:30163973-30163973 + TCGA-HW-8321-01 COSM3928298 c.410T>C p.L137P Substitution - Missense 6:30167204-30167204 +

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.591789 6p21.3 2388125|CGAP|BC038585|C/T|non-coding||1693|Validated

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer A C Missense p.K457Q c.1369A>C 6 30140097 CM A G Missense p.K262R c.785A>G 6 30138331 CM C A Missense p.L289M c.865C>A 6 30138770 LUAD CC - Frameshift p.P41Rfs*102 c.122_123delCC 6 30131581 LUAD C G Missense p.N96K c.288C>G 6 30131749 LUAD C G Missense p.Q124E c.370C>G 6 30131831 HNSC C G Missense p.S346C c.1037C>G 6 30139765 BLCA - CTCT 5-UTRInsertion . c.1-143_1-142insCTCT 6 30131319 CM C T Missense p.H268Y c.802C>T 6 30138348 LUAD C T Missense p.L101F c.301C>T 6 30131762 CM C T Missense p.L155F c.463C>T 6 30135034 CM C T Missense p.L38F c.112C>T 6 30131573 CM C T Missense p.P2S c.4C>T 6 30131465 LUSC C T Missense p.P5L c.14C>T 6 30131475 CM C T Missense p.P74L c.221C>T 6 30131682 CM C T Missense p.P77S c.229C>T 6 30131690 CM C T Missense p.R129C c.385C>T 6 30134956 CM C T Missense p.S50F c.149C>T 6 30131610 CM C T Nonsense p.Q124* c.370C>T 6 30131831 BLCA C T Nonsense p.Q45* c.133C>T 6 30131594 LUAD C T Synonymous p.F100F c.300C>T 6 30131761 LUAD C T Synonymous p.F281F c.843C>T 6 30138389 CM C T Synonymous p.L119L c.355C>T 6 30131816 CM C T Synonymous p.L188L c.562C>T 6 30136161 CM C T Synonymous p.L191L c.571C>T 6 30136170 CM C T Synonymous p.Y421Y c.1263C>T 6 30139991 STAD G A Missense p.D237N c.709G>A 6 30137018 CM G A Missense p.E179K c.535G>A 6 30136134 CM G A Missense p.E63K c.187G>A 6 30131648 CM G A Missense p.G360D c.1079G>A 6 30139807 ESCA G A Missense p.G87S c.259G>A 6 30131720 LGG G A Missense p.M46I c.138G>A 6 30131599 CM G A Missense p.V251M c.751G>A 6 30138297 ESCA G A Missense p.V454I c.1360G>A 6 30140088 ESCA G A Nonsense p.W455* c.1365G>A 6 30140093 HNSC G A Synonymous p.E211E c.633G>A 6 30136232 CM G A Synonymous p.K221K c.663G>A 6 30136262 CM G A Synonymous p.R192R c.576G>A 6 30136175 CM G C Missense p.Q45H c.135G>C 6 30131596 LUSC G - Frameshift p.E370Rfs*3 c.1108delG 6 30139833 CM GG AA 5-UTRBlockSubstitution . c.1-29_1-28delinsAA 6 30131433 CM GG AA IntronicBlockSubstitution . c.708+46_708+47delinsAA 6 30136353 CM G T Synonymous p.L78L c.234G>T 6 30131695 LUSC T C Missense p.F250S c.749T>C 6 30138295 LGG T C Missense p.I264T c.791T>C 6 30138337 LGG T C Missense p.L78P c.233T>C 6 30131694 LUSC