PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus UBE2M DCUN1D5 24192928,23201271 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP G GP GP GP GP GP GP G CAND1 DCUN1D5 24192928 biogrid exp G GP G G G G G G GP G GP GP G G G GP G GP G G G G GP GP GP G G GP G RCHY1 DCUN1D5 21988832 biogrid,intact exp G GP G G G GP G GP GP G GP G GP G G GP GP G GP G G G GP G GP G GP G G FOXL2 DCUN1D5 25609649 intact exp G G G G G DCUN1D5 HECW2 24163370 biogrid exp GP GP G G GP GP G GP GP G GP G GP G G P GP P GP G GP GP GP GP GP G GP GP RBX1 DCUN1D5 24192928 biogrid exp G G G G G GP G GP G G G G GP G G G GP G GP G GP GP G G G G G GP G UBL7 DCUN1D5 26344197 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G FOXL1 DCUN1D5 25609649 intact exp G G CUL3 DCUN1D5 24192928,23201271 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CUL2 DCUN1D5 24192928,23201271 biogrid exp GP GP G G G GP G G GP G GP GP GP GP G G GP GP GP G GP GP GP G G G GP GP G PNKD DCUN1D5 26186194 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G G GP GP GP GP G GP GP G CUL5 DCUN1D5 23201271 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAPK14 DCUN1D5 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP GP GP GP G GNAI3 DCUN1D5 26186194 biogrid exp G GP G G G GP G GP GP G G G GP G G GP GP G GP G G G G G GP G GP GP G CUL4B DCUN1D5 23201271 biogrid exp GP GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP GP GP GP GP GP G SAC3D1 DCUN1D5 26344197 biogrid exp GP GP G G G GP G P GP G GP GP GP G GP GP P P G P GP GP GP GP P GP GP UBE2F DCUN1D5 23201271 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G CUL1 DCUN1D5 24192928,23201271 biogrid exp GP G G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G TEAD2 DCUN1D5 25609649 intact exp G G G G G G G G G G G G G G G G G G G G G G LNX1 DCUN1D5 25416956 biogrid,intact exp GP G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP P GP GP CUL4A DCUN1D5 23201271 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DCUN1D5 TLN2 26344197 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP P GP GP G FAM177A1 DCUN1D5 26186194 biogrid exp GP GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP GP G GP G GP GP G LYPD3 DCUN1D5 26186194 biogrid exp GP G G G G G G G G G G YWHAH DCUN1D5 ortho GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G MYCBP2 DCUN1D5 23023127 pred G GP G G G GP G GP GP G G G GP GP G GP GP G GP G G GP G G GP G G GP G DCUN1D5 SLC25A23 23023127 pred G G G P GP G GP GP G GP GP GP G G GP GP G GP G G GP G GP G GP GP G MICU3 DCUN1D5 23023127 pred GP G G GP G G G G G G G G G GP G G G GP G G G G G G G REPS2 DCUN1D5 23023127 pred G G G G GP GP G GP G GP GP GP GP GP GP GP GP G GP GP G P GP P GP P DCUN1D5 CALN1 23023127 pred P GP G P GP P P G P P G P GP P P P P P P P P DCUN1D5 UBQLN2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SLC25A12 DCUN1D5 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q86VP6 Q9BTE7 affinity chromatography technology 24192928 physical association X 2 Q969M7 Q9BTE7 pull down 23201271 direct interaction X 2 Q9BTE7 A0A090N7U0 pull down 23201271 direct interaction X 2 Q9BTE7 Q13617 pull down 23201271 direct interaction X 2 Q9BTE7 A0A024R475 pull down 23201271 direct interaction X 2 Q9BTE7 A0A024R4T4 pull down 23201271 direct interaction X 2 Q9BTE7 Q9P2P5 affinity chromatography technology 24163370 physical association X 2 Q9BTE7 A0A090N7U0 affinity chromatography technology 24192928 physical association X 2 Q9BTE7 Q13617 affinity chromatography technology 24192928 physical association X 2 Q9BTE7 A0A024R475 affinity chromatography technology 24192928 physical association X 2 Q9BTE7 A0A024R4T4 affinity chromatography technology 24192928 physical association X 2 Q9BTE7 Q8TBB1 two hybrid 25416956 direct interaction X 2 Q9BTE7 A0A090N7U0 enzymatic study 23201271 direct interaction X 2 Q9BTE7 Q13617 enzymatic study 23201271 direct interaction X 2 Q9BTE7 A0A024R475 enzymatic study 23201271 direct interaction X 2 Q9BTE7 A0A024R4T4 pull down 23201271 direct interaction X 2 P0CG48 Q9BTE7 affinity chromatography technology 22505724 physical association X 2 P0CG48 Q9BTE7 affinity chromatography technology 16196087 physical association X 2 P0CG48 Q9BTE7 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q9BTE7 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q9BTE7 affinity chromatography technology 21906983 physical association X 2 Q9BTE7 B2RBV7 pull down 23201271 direct interaction X 2 Q9BTE7 Q13620-3 pull down 23201271 direct interaction X 2 Q9BTE7 Q93034 pull down 23201271 direct interaction X 2 Q9BTE7 Q96PM5-2 two hybrid 21988832 direct interaction X 2 Q9BTE7 P62877 affinity chromatography technology 24192928 physical association X 2 Q9BTE7 B2RBV7 enzymatic study 23201271 direct interaction X 2 Q9BTE7 Q13620-3 enzymatic study 23201271 direct interaction X 2 Q9BTE7 Q93034 enzymatic study 23201271 direct interaction X 2 Q9BTE7 P61956-2 affinity chromatography technology 19471022 physical association X 2 Q9BTE7 Q8TBB1 two hybrid prey pooling approach 25416956 physical association X 2 Q9BTE7 Q8TBB1 two hybrid array 25416956 physical association X 2 Q9BTE7 Q8TBB1 validated two hybrid 25416956 physical association X 2 Q96PM5 Q9BTE7 two hybrid array 21988832 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CAND1 DCUN1D5 MI:0004(affinity chromatography technology) 24192928 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_297140 prey bait CUL1 DCUN1D5 MI:0004(affinity chromatography technology)|MI:0096(pull down) 23201271,24192928 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_297141|BIOGRID_248842 prey|prey bait|bait UBC DCUN1D5 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16196087,21139048,21890473,21906983,22505724 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_180560|BIOGRID_225318|BIOGRID_142982|BIOGRID_176085|BIOGRID_171403 bait|bait|bait|bait|bait prey|prey|prey|prey|prey CUL3 DCUN1D5 MI:0004(affinity chromatography technology)|MI:0096(pull down) 23201271,24192928 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_297143|BIOGRID_248852 prey|prey bait|bait CUL2 DCUN1D5 MI:0004(affinity chromatography technology)|MI:0096(pull down) 23201271,24192928 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_297142|BIOGRID_248847 prey|prey bait|bait RBX1 DCUN1D5 MI:0004(affinity chromatography technology) 24192928 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_297144 prey bait CUL4A DCUN1D5 MI:0096(pull down) 23201271 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248857 prey bait UBE2M DCUN1D5 MI:0096(pull down)|MI:0004(affinity chromatography technology) 23201271,24192928 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_248870|BIOGRID_297150 bait|prey prey|bait CUL4B DCUN1D5 MI:0096(pull down) 23201271 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248862 prey bait SUMO2 DCUN1D5 MI:0004(affinity chromatography technology) 19471022 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_182940 bait prey DCUN1D5 HECW2 MI:0004(affinity chromatography technology) 24163370 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_293974 prey bait RCHY1 DCUN1D5 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_118358|BIOGRID_288720 unspecified role|prey unspecified role|bait CUL5 DCUN1D5 MI:0096(pull down) 23201271 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248867 prey bait

PPI - HINT Gene A Gene B PMID Method Quality SAC3D1 DCUN1D5 26344197 0401 HT LYPD3 DCUN1D5 26186194 0004 HT GNAI3 DCUN1D5 26186194 0004 HT FOXL2 DCUN1D5 25609649,25609649 0676,0004 HT UBE2M DCUN1D5 26906416,23201271,24192928 0096,0096,0004 LC RBX1 DCUN1D5 24192928,26906416 0004,0004 LC FOXL1 DCUN1D5 25609649,25609649 0676,0004 HT CUL1 DCUN1D5 23201271,23201271,24192928,26906416 0415,0096,0004,0004 LC CUL2 DCUN1D5 23201271,23201271,24192928,26906416 0415,0096,0004,0004 LC CUL3 DCUN1D5 23201271,26906416,26906416,23201271,24192928,26906416 0096,0096,0415,0415,0004,0004 LC CUL4A DCUN1D5 23201271,23201271,26906416 0415,0096,0004 LC CUL4B DCUN1D5 23201271,23201271,26906416 0415,0096,0004 LC TEAD2 DCUN1D5 25609649,25609649 0676,0004 HT MAPK14 DCUN1D5 26186194 0004 HT CAND1 DCUN1D5 26906416,24192928,26906416 0096,0004,0004 LC FAM177A1 DCUN1D5 26186194 0004 HT PNKD DCUN1D5 26186194 0004 HT CUL5 DCUN1D5 23201271,23201271,26906416 0415,0096,0004 LC UBL7 DCUN1D5 26344197 0401 HT DCUN1D5 TLN2 26344197 0401 HT SAC3D1 DCUN1D5 26344197 0401 HT LYPD3 DCUN1D5 26186194 0004 HT GNAI3 DCUN1D5 26186194 0004 HT FOXL2 DCUN1D5 25609649,25609649 0676,0004 HT FOXL1 DCUN1D5 25609649,25609649 0676,0004 HT TEAD2 DCUN1D5 25609649,25609649 0676,0004 HT MAPK14 DCUN1D5 26186194 0004 HT FAM177A1 DCUN1D5 26186194 0004 HT PNKD DCUN1D5 26186194 0004 HT UBL7 DCUN1D5 26344197 0401 HT DCUN1D5 TLN2 26344197 0401 HT UBE2M DCUN1D5 26906416,23201271,24192928 0096,0096,0004 LC RBX1 DCUN1D5 24192928,26906416 0004,0004 LC CUL1 DCUN1D5 23201271,23201271,24192928,26906416 0415,0096,0004,0004 LC CUL2 DCUN1D5 23201271,23201271,24192928,26906416 0415,0096,0004,0004 LC CUL3 DCUN1D5 23201271,26906416,26906416,23201271,24192928,26906416 0096,0096,0415,0415,0004,0004 LC CUL4A DCUN1D5 23201271,23201271,26906416 0415,0096,0004 LC CUL4B DCUN1D5 23201271,23201271,26906416 0415,0096,0004 LC CAND1 DCUN1D5 26906416,24192928,26906416 0096,0004,0004 LC CUL5 DCUN1D5 23201271,23201271,26906416 0415,0096,0004 LC SAC3D1 DCUN1D5 26344197 0401 LC CUL1 DCUN1D5 23201271,23201271 0415,0096 LC CUL2 DCUN1D5 23201271,23201271 0415,0096 LC CUL3 DCUN1D5 23201271,26906416,26906416,23201271,26906416 0096,0096,0415,0415,0004 LC CUL4A DCUN1D5 23201271,23201271 0415,0096 LC CUL4B DCUN1D5 23201271,23201271 0415,0096 LC LNX1 DCUN1D5 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT CUL5 DCUN1D5 23201271,23201271 0415,0096 LC RCHY1 DCUN1D5 21988832,21988832 0397,0018 HT UBL7 DCUN1D5 26344197 0401 LC DCUN1D5 TLN2 26344197 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9BTE7 P61081 DCUN1D5 UBE2M 0.569 26906416,23201271,24192928 Q9BTE7 Q8N128 DCUN1D5 FAM177A1 0.126 26186194 Q9BTE7 Q8N490 DCUN1D5 PNKD 0.126 26186194 Q9BTE7 Q8TBB1 DCUN1D5 LNX1 0.454 25416956 Q9BTE7 P08754 DCUN1D5 GNAI3 0.126 26186194 Q9BTE7 O95274 DCUN1D5 LYPD3 0.126 26186194 Q9BTE7 P62877 DCUN1D5 RBX1 0.309 24192928,26906416 Q9BTE7 Q8NFW5 DCUN1D5 DMBX1 0.236 unassigned1304 Q9BTE7 Q49A26 DCUN1D5 GLYR1 0.236 unassigned1304 Q9NRD5 Q9BTE7 PICK1 DCUN1D5 0.236 unassigned1304 Q9BTE7 Q15562 DCUN1D5 TEAD2 0.236 25609649 Q9BTE7 A0A0G2JQ02 DCUN1D5 A0A0G2JQ02 0.236 unassigned1304 Q9BTE7 Q12952 DCUN1D5 FOXL1 0.236 25609649 Q9BTE7 Q58EX7 DCUN1D5 PLEKHG4 0.236 unassigned1304 Q9BTE7 O60921 DCUN1D5 HUS1 0.236 unassigned1304 Q9BTE7 P58012 DCUN1D5 FOXL2 0.236 25609649 Q9BTE7 Q93034 DCUN1D5 CUL5 0.416 26906416,23201271 Q9BTE7 Q13620 DCUN1D5 CUL4B 0.416 26906416,23201271 Q9BTE7 Q13619 DCUN1D5 CUL4A 0.416 26906416,23201271 Q9BTE7 Q86VP6 DCUN1D5 CAND1 0.436 26906416,24192928 Q9BTE7 Q13617 DCUN1D5 CUL2 0.539 26906416,23201271,24192928 Q9BTE7 Q13616 DCUN1D5 CUL1 0.539 26906416,23201271,24192928 Q9BTE7 Q13618 DCUN1D5 CUL3 0.692 26906416,23201271,24192928 Q9BTE7 Q96PM5 DCUN1D5 RCHY1 0.286 21988832 Q9BTE7 P49748 DCUN1D5 ACADVL 0.126 26906416 Q9BTE7 Q16531 DCUN1D5 DDB1 0.126 26906416 Q9BTE7 Q969M7 DCUN1D5 UBE2F 0.183 23201271 Q9BTE7 Q96S82 DCUN1D5 UBL7 0.081 26344197 Q9UBF6 Q9BTE7 RNF7 DCUN1D5 0.126 26906416 Q9Y4G6 Q9BTE7 TLN2 DCUN1D5 0.081 26344197 Q9P2P5 Q9BTE7 HECW2 DCUN1D5 0.126 24163370 Q9BTE7 C5E519 DCUN1D5 M2 {ECO:0000313|EMBL:ACQ84469.1} 0.126 unassigned1333 Q9BTE7 Q16539 DCUN1D5 MAPK14 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 LYPD3 DCUN1D5 MI:0045 experimental interaction detection MI:0461 interaction database GNAI3 DCUN1D5 MI:0045 experimental interaction detection MI:0461 interaction database UBC DCUN1D5 MI:0045 experimental interaction detection MI:0461 interaction database ACADVL DCUN1D5 MI:0045 experimental interaction detection MI:0461 interaction database FOXL2 DCUN1D5 MI:0045 experimental interaction detection MI:0461 interaction database UBE2M DCUN1D5 MI:0045 experimental interaction detection MI:0461 interaction database SUMO2 DCUN1D5 MI:0045 experimental interaction detection MI:0461 interaction database YWHAG DCUN1D5 MI:0362 inference MI:0461 interaction database RBX1 DCUN1D5 MI:0045 experimental interaction detection MI:0461 interaction database YWHAH DCUN1D5 MI:0362 inference MI:0461 interaction database FOXL1 DCUN1D5 MI:0045 experimental interaction detection MI:0461 interaction database CUL1 DCUN1D5 MI:0045 experimental interaction detection MI:0461 interaction database CUL2 DCUN1D5 MI:0045 experimental interaction detection MI:0461 interaction database CUL3 DCUN1D5 MI:0045 experimental interaction detection MI:0461 interaction database CUL4A DCUN1D5 MI:0045 experimental interaction detection MI:0461 interaction database CUL4B DCUN1D5 MI:0045 experimental interaction detection MI:0461 interaction database TEAD2 DCUN1D5 MI:0045 experimental interaction detection MI:0461 interaction database DDB1 DCUN1D5 MI:0045 experimental interaction detection MI:0461 interaction database MAPK14 DCUN1D5 MI:0045 experimental interaction detection MI:0461 interaction database CAND1 DCUN1D5 MI:0045 experimental interaction detection MI:0461 interaction database FAM177A1 DCUN1D5 MI:0045 experimental interaction detection MI:0461 interaction database PNKD DCUN1D5 MI:0045 experimental interaction detection MI:0461 interaction database LNX1 DCUN1D5 MI:0045 experimental interaction detection MI:0461 interaction database CUL5 DCUN1D5 MI:0045 experimental interaction detection MI:0461 interaction database UBE2F DCUN1D5 MI:0045 experimental interaction detection MI:0461 interaction database RCHY1 DCUN1D5 MI:0045 experimental interaction detection MI:0461 interaction database DCUN1D5 HECW2 MI:0045 experimental interaction detection MI:0461 interaction database DCUN1D5 RNF7 MI:0045 experimental interaction detection MI:0461 interaction database