PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus KCNN4 USP8 21828287 biogrid exp G G G G G G G G G G G G G G G G GP G G G G G USP8 LRIG1 24828152 biogrid exp G GP G G GP GP G G GP G GP G G G G G GP G GP G P GP G G G G G GP G USP8 UBA52 21209336 dip exp G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 UBE2I 26344197,22939629 biogrid exp G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G USP8 HTT 22863883 biogrid exp G GP G G GP GP G G GP G P G P G G GP GP G P G GP GP G G GP G GP GP SRC USP8 23333852 biogrid exp G GP G GP G G G GP G G G G GP GP G G G GP G G GP G GP GP G USP8 TRIM55 22626734 biogrid exp P P G P P G P P P P P GP GP P GP USP8 UBE2E1 26344197 biogrid exp G GP G G G GP G G GP G GP G G G G GP GP G G G GP G G GP GP G GP GP G USP8 SCNN1B 23297398 biogrid exp G GP G G P G G G GP G GP G P P GP GP GP G GP G GP P G USP8 HIF1A 24378640 intact exp G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP G G G GP G GP GP G USP8 FARSB 22939629 biogrid exp G G G G G GP G G GP G GP G G G G GP GP G GP G GP G G GP GP G GP GP G USP8 EPAS1 24378640 intact exp G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 ERBB4 23153581 biogrid exp G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP GP GP G USP8 NBR1 19427866 biogrid,mint,intact exp G GP G G G GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G SPP1 USP8 22779921 biogrid exp G GP G G GP G G G GP G GP G GP G G G G G GP G GP G G GP G GP G USP8 KRT31 19615732 biogrid,intact exp G G G GP G P P G P GP G P P G G GP P G USP8 MCPH1 25733871 biogrid exp G P G GP P GP P P G P P P G P P P GP GP P USP8 POLD3 22863883 biogrid exp G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 SLBP 10982817 hprd,bci exp G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP G G GP GP G GP GP G AKT1 USP8 17210635 biogrid exp G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G KRT36 USP8 19615732 biogrid,intact exp P USP8 PTEN 24270891 biogrid exp G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP G G G GP G GP GP G USP8 TARDBP 24825905 biogrid exp G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 UBE2G1 22939629 biogrid exp G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 OTUB1 14661020 biogrid exp G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 VAMP8 18388320 biogrid exp G GP G G GP G G G GP G GP G GP G G GP G G GP G GP GP G GP GP G GP GP G USP8 TATDN1 26344197 biogrid exp G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 SCNN1G 23297398 biogrid exp G G G G G G SCNN1A USP8 23297398 biogrid exp G GP P P GP GP GP G G GP P GP G P GP G P GP GP GP G USP8 BIRC6 25733871,18329369 hprd,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G USP8 TSEN2 22863883 biogrid exp G GP G G GP GP G G GP G GP G GP G G GP GP G GP G P GP G GP GP G GP GP G PLA2G2A USP8 22118674 biogrid exp G GP G GP P G G GP P G G G G GP GP G GP GP GP G GP GP G GP GP G USP8 PTPN23 23477725 biogrid exp G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 KRT85 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G USP8 STAT6 22863883 biogrid exp, ortho G GP G G GP GP G G GP G GP G GP G G GP GP G G G GP GP G G GP G GP GP G USP8 PJA1 22626734 biogrid exp, ortho G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 USP28 22626734 biogrid exp, ortho G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 ACAA2 26344197 biogrid exp, ortho G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP G G G GP G GP GP G USP8 RASGRF1 11500497 hprd,bci exp, ortho GP G G GP GP G P G P P P GP GP P P G P P P P G USP8 USP8 17035239,19615732,10982817 hprd,biogrid,intact exp, ortho G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 TRIM54 22626734 biogrid exp, ortho P P G P P P G P GP GP P P NTRK1 USP8 25921289 biogrid exp, ortho P P G P P P P P P P P P P P USP8 TRIM63 22626734 biogrid exp, ortho G G G G USP8 USP4 21415856 mint,intact exp, ortho G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP G G GP GP G GP GP G UBC USP8 25527291,22195557,23287719,17711858 biogrid exp, ortho G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G EGFR USP8 23333852,23153581,16120644,23477725, 25402006 biogrid exp, ortho, pred G GP G GP G G GP G GP G G G G GP GP G G G GP GP G GP GP G GP GP G USP8 USP21 22626734, 23023127 biogrid exp, ortho, pred G GP G G G GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G USP8 STAM 20736164,10982817,16520378, 25402006, 21836163 hprd,biogrid,bci exp, ortho, pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G GRAP2 USP8 12176364,26186194,12773374, 25402006 hprd,biogrid,bci exp, ortho, pred P P P P P P P P P P P P USP8 USP15 22626734, 23023127 biogrid exp, ortho, pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 USP22 19615732, 23023127 biogrid,intact exp, ortho, pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 RNF41 15314180,17035239, 25402006, 21836163 hprd,biogrid,bci exp, ortho, pred G GP G G G GP G G GP G GP P G G GP GP P G P G GP GP G GP P STAM2 USP8 20736164,10982817,13129930, 25402006, 21836163 hprd,biogrid,bci exp, ortho, pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G YWHAB USP8 15324660,24255178,17353931, 25402006 biogrid,mint,intact exp, ortho, pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 GRB2 10982817,13129930, 25402006 hprd,biogrid,bci exp, ortho, pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 YWHAE 25675982,19608861,17979178, 25402006 biogrid exp, ortho, pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 YWHAZ 15161933,15324660,17353931, 25402006 biogrid,mint,intact exp, ortho, pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 YWHAG 15324660,17353931, 25402006 hprd,biogrid,mint,intact exp, pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 CHMP4B 19302785, 25402006, 21836163 mint,intact exp, pred G GP G G G GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 YWHAH 17979178, 25402006 intact exp, pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 CHMP3 19302785, 21836163 mint,intact exp, pred P P P P P P P P P P P P P P P USP8 EPS15 16771824, 25402006 biogrid exp, pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 CHMP4C 19302785,17711858, 21836163 biogrid,mint,intact exp, pred G GP P G GP GP G GP G GP P GP G GP GP G P GP G GP P G USP8 CHMP1B 19302785,17711858, 25402006 biogrid,mint,intact exp, pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G YWHAQ USP8 23333852,15161933,15324660,17353931, 25402006 hprd,biogrid,mint,intact,bci exp, pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G USP8 RNF128 14661020, 21836163 biogrid exp, pred G GP G P GP G GP G GP G GP G G GP GP GP G GP GP G GP GP GP P USP8 CHMP7 17711858, 21836163 biogrid exp, pred G GP G G GP GP G G GP G GP G GP G G GP GP G G G GP GP G GP GP G GP GP G SFN USP8 15778465, 25402006 biogrid,mint,intact exp, pred G G G G G G G G G G G G GP G G G G G G G G GP G G G G G G G USP8 CHMP6 19302785, 21836163 mint,intact exp, pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 CHMP5 19302785, 21836163 mint,intact exp, pred G GP G G G GP G G GP G GP G G G G GP GP G GP G GP GP G G GP G GP GP G DNAJB6 USP8 15342353, 25402006 hprd,bci exp, pred G GP G G G GP G G G G G G GP G G G GP G G G G G G G G G GP G USP8 CHMP2B 19302785, 25402006, 21836163 biogrid,mint,intact exp, pred G G G G GP G G G GP G GP G GP G G GP G G GP G G G G G GP G G G G VPS4B USP8 22939629, 21836163 biogrid exp, pred G G G G GP GP G G GP G GP G G G G GP GP G GP G GP GP G G GP G GP GP G USP8 KIF23 18329369, 25402006 hprd,biogrid exp, pred P G GP P P P P P P P P P P P P GP USP8 CHMP1A 19302785,17711858, 25402006, 21836163 biogrid,mint,intact exp, pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G CHMP2A USP8 19302785, 25402006 biogrid,mint,intact exp, pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 HDAC6 ortho G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 FZD4 ortho G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G USP8 PSMD4 25402006 ortho, pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 RAI14 25402006 pred G GP GP G G GP G GP G GP G G G GP G GP G GP GP G P G G GP GP G USP8 CEP55 21836163 pred P G G P GP P P GP P P P P GP GP GP USP8 IQGAP1 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G USP8 LCP2 25402006 pred G G G GP G G G GP G G G G G G G G G USP8 CHMP4A 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G STAMBP USP8 25402006, 21836163 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 GAPVD1 25402006 pred G GP G G G GP G G GP G GP G G G G GP GP G GP G GP GP G G GP G GP GP G CASK USP8 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 USP3 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G USP8 USP9X 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 RIN1 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 RPS6KC1 23023127 pred G GP G G GP GP G G GP G GP G G G G GP GP G GP G GP G G GP GP G GP GP G NCK2 USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 MICALL1 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 EIF3A 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G CDC25A USP8 25402006 pred G GP P P P P P P P P P P P GP PFKFB2 USP8 25402006 pred G GP G G G GP G G GP G GP G GP G G GP GP G GP G G G G G GP G GP GP G USP8 GABARAPL2 25402006 pred G GP G G GP GP G G GP G GP G G G G GP GP G GP G G GP G G GP G GP GP G USP8 SRSF3 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G HNRNPA2B1 USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 RAB5B 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 MED28 25402006 pred G G G G G GP G G GP G G G GP G G G GP G GP G GP G G G G G GP GP G USP8 NDFIP1 21836163 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 EDC3 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 SNX15 21836163 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G TNFAIP3 USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G HSPA5 USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G KCNK3 USP8 25402006 pred G G G G G G G G G G G G G G G G G G G P G G G G USP8 UHRF2 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 YOD1 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G P G GP GP G GP GP G GP GP G ARRB2 USP8 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G MAPT USP8 25402006 pred G GP G G G GP G G GP G GP G G G G G GP G GP G G GP G GP G G GP GP G USP8 TWF1 25402006 pred G GP G G G G G G GP G GP G G G G GP G G GP G GP GP G G GP G GP GP G PSMB10 USP8 16082366 pred G G G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP G G USP8 PAK1 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 GAB2 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 USP40 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP G G GP GP G GP GP G USP8 PIK3CA 23023127 pred G GP G P GP G G GP G GP G GP G G P GP G GP G P GP G GP GP G GP GP USP8 KAT2A 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 CDKN1B 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 PARD3 25402006 pred G G G G GP GP G G GP G GP G GP G G GP GP G GP G GP G G G GP G GP GP G USP8 RABGEF1 25402006 pred P P P GP G GP P GP P GP G P P G P P G P P USP8 RABGEF1 25402006 pred P P P GP G GP P GP P GP G P P G P P G P P CDC25B USP8 25402006 pred G G G G GP GP G G GP G GP G GP G G GP GP G G G GP G G GP GP G GP GP G USP8 UBXN4 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 BAP1 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 RNPS1 25402006 pred G G G G G GP G G G G GP G G G G G GP G G G GP G G G G G G GP G USP8 BCLAF1 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G NDUFB6 USP8 21836163 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 USP48 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G UFL1 USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G USP8 SUMO2 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G CTNNB1 USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G USP8 RAB5C 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 GAB1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G USP8 SQSTM1 25402006, 23023127 pred G GP G G GP G G G GP G GP G GP G G GP G G GP G GP GP G GP GP G GP GP G USP8 OSBPL3 25402006 pred G G G G GP G G GP G GP GP G G G GP G G G GP G G G G P G USP8 COPB1 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 MAP4K1 25402006 pred G G G GP G G G G G G GP G G G G G GP G G G G USP8 PI4KB 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 MYSM1 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 PPIG 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 BCAR1 25402006 pred G GP G P GP G G GP G GP G GP G GP GP G GP G GP GP G GP GP G GP GP G TP53 USP8 25402006 pred G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G APP USP8 25402006 pred G GP G G GP GP G G GP G G G G G G GP GP G GP G GP GP G G GP G G GP G USP8 PRKCI 25402006 pred G GP G G G GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G USP8 VPS37A 21836163 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G PIK3R1 USP8 25402006, 21836163 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G JAK1 USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G AXIN1 USP8 23023127 pred G GP G GP GP G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G JAK2 USP8 25402006 pred G GP G G GP GP G G GP G GP GP G G P GP G P P G G G GP G GP GP USP8 TRA2B 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 ING1 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 TICAM1 21836163 pred G GP G P G G GP GP G GP G G GP P G GP GP GP G GP GP G GP P G USP8 SRPK1 25402006 pred G GP G G G GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 USP16 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 CDK16 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G MYCBP2 USP8 25402006 pred G GP G G G GP G G GP G G G GP G G GP GP G GP G G GP G G GP G G GP G GAS7 USP8 16082366 pred G G G G GP GP G G G G G G G G G G GP G G G G G G G G G G GP G USP8 PRKCZ 25402006 pred G GP G GP G G GP G GP G GP G G GP GP GP G GP GP G P GP G GP GP USP8 LBR 25402006 pred G G G G GP G G G GP G G G G G G GP G G G G G G G G GP G GP GP G USP8 HNRNPK 25402006 pred P P P P P P P P P P P P P P P LAT USP8 25402006 pred G G G G GP G G G G G G G G G G G G G G G G G G G G G G G G HSPD1 USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G USP8 LARP1 25402006 pred G GP G G G GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G FOXO3 USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 NCKIPSD 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G PDHB USP8 16082366 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 TSC2 25402006 pred G GP G G G GP G G GP G GP G GP G G GP GP G GP G GP G G G GP G GP GP G SNX4 USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP G G G GP G GP GP G USP8 KIAA0930 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 MPRIP 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 USP44 23023127 pred P P P P P P P P GP G P P P P P GP PARK2 USP8 23023127 pred GP G P GP G G GP G GP P G P GP G P G P G GP GP P GP G USP8 SRRM2 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 MAP3K5 25402006 pred G GP G G GP GP G G GP G GP G GP G G G GP G GP G G GP G G G G GP GP G SON USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G STXBP3 USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G HNRNPC USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 RALGPS2 25402006 pred G GP G GP P G GP GP G P G G GP P G P GP P GP G GP GP USP8 ARHGEF2 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 PRPF4B 25402006 pred G GP G G G GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G USP8 RABEPK 21836163 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP17L7 USP8 23023127 pred USP8 TSG101 21836163 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G IGF1R USP8 25402006 pred G GP G G G G G G GP G GP G GP G G GP G G GP G GP GP G G GP G GP GP G CBL USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G G GP G G G G G G G G G G GP G USP8 SUMO3 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G DNAJB2 USP8 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 MAGOH 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G MDM4 USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 VPS4A 25402006, 21836163 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 TNPO1 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G ERBB3 USP8 25402006, 21836163 pred G GP G P GP G G GP G GP G GP G G GP GP GP G GP GP G P GP GP GP G USP8 USP10 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G ATP5B USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 USP46 23023127 pred G GP G P GP G G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G SRSF10 USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 DENND4A 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G NCL USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G UBR5 USP8 23023127 pred G G G G G GP G G GP G GP G GP G G G GP G G G GP G G G G G GP GP G USP8 ACIN1 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 CENPJ 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G VPS37C USP8 21836163 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 TPD52L1 25402006 pred G GP G G GP GP G G GP G GP G G G G GP GP G GP G GP GP G G GP G GP G G USP8 PDCD6IP 25402006, 21836163 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP12 USP8 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 ELL 21836163 pred G G G G P P P P P P G G G GP G G P P GP G USP8 NCKAP1 25402006 pred G GP G G G GP G G GP G GP G G G G GP GP G GP G GP GP G G GP G GP GP G USP8 KRT17 25402006 pred P P USP8 MLLT4 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 CEP170 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G DARS USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G USP8 SEC62 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G TOM1L1 USP8 25402006 pred G GP P P G G GP GP G GP G G GP P G GP G P GP G GP GP GP G USP8 COPS5 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 RACGAP1 25402006 pred G G G GP G G G GP G GP G G G G GP G G G GP G G G GP G GP GP G NCK1 USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G USP8 EPB41L3 25402006 pred G GP G GP G G GP G GP G G G GP GP G GP G GP G GP G GP USP8 USP7 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 KHDRBS1 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 USP5 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 NRIP1 25402006 pred G GP G G GP GP G G GP G GP G G G G GP GP G GP G GP GP G GP GP G GP GP G USP8 DNAJC15 21836163 pred G G G G GP G G G GP G GP G GP G G G G G G GP GP G G G G GP GP G USP8 PSMB7 16082366 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 FRMD6 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G P G G GP G G GP G GP GP G USP8 TSC1 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 THRAP3 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G P G GP GP G GP GP G GP GP G TIMM8A USP8 25402006 pred P G G G GP G GP GP G G P GP G GP G P GP G G GP GP P G HNRNPR USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G KIF5B USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 HDAC4 25402006 pred G G G G GP GP G G GP G GP G GP G G GP GP G GP G P GP G GP GP G GP GP G USP8 RGS3 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 SNF8 21836163 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 SAMD4B 25402006 pred G GP G G G GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G ABL1 USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 CYLD 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G P G GP GP G GP GP G GP GP USP8 CRTC2 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 YAP1 25402006 pred G GP G P GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 JAK3 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G USP17L8 USP8 23023127 pred USP8 MST1R 25402006 pred G GP G P GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 BLNK 25402006 pred G P G G GP GP G GP G GP G G G G GP GP G GP G GP G G GP G GP P G USP8 ADAM22 25402006 pred G GP G GP G GP G GP P G GP GP G P G P GP P G P P G CFL1 USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G MARK3 USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G USP8 ALS2 23023127 pred G GP G G G GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 DUSP16 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G G G GP G G GP GP G GP GP G DFFA USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G RAF1 USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G CDK14 USP8 25402006 pred G GP G G G GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G USP8 AKAP13 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G HGS USP8 25402006, 21836163 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G FRYL USP8 25402006 pred G G G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 LSR 25402006 pred G GP P P GP GP G GP G G GP P GP G GP GP G P GP G GP GP G USP8 USP34 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G G G GP GP G GP GP G GP GP G USP8 RBBP5 16082366 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP USP8 CD2AP 25402006 pred G GP G GP P G G GP GP G GP G G GP GP G GP G GP GP G G GP G GP GP USP8 LRSAM1 21836163 pred GP G P GP G GP G GP G P G P GP G GP G P GP P P G P P G USP8 RAB22A 23023127 pred G GP G G G GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 USP33 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP1 USP8 25402006 pred G GP G G GP GP G G GP G GP G G G G GP GP G G G GP G G GP GP G GP GP G USP8 MFAP1 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP G G GP GP G GP GP G EPB41L2 USP8 25402006 pred G G G G GP GP G G GP G GP G GP G G G GP G G G G G G G G G G GP G CDC25C USP8 25402006 pred P G GP P GP P P GP P P P P P GP P GP G USP8 WNK1 25402006 pred G GP G G GP GP G G GP G GP G GP G G G GP G GP G G G G GP G G G GP G PAK4 USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 USP20 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 DYRK1A 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 RMDN3 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G PIK3R2 USP8 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G USP8 VPS25 21836163 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G TUBB USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 ALG2 21836163 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G STX6 USP8 23023127 pred G GP G G G GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G BCR USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 MAP3K3 25402006 pred G G G G GP GP G G G G GP G GP G G GP GP G G G GP G G G GP G GP G G USP8 VPS37B 21836163 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 PPFIBP1 25402006 pred G GP G G GP GP G G G G GP G GP G G G GP G G G G GP G G G G GP GP G USP8 NOLC1 25402006 pred G G G G G GP G G GP G G G GP G G GP GP G G G G G G G GP G GP GP G USP8 GAB3 25402006 pred G G GP P G GP P GP G G G P P GP P P G GP GP BRAF USP8 25402006 pred G GP G G GP GP G G GP G GP G GP G P GP G GP G GP GP G GP P G GP GP G USP8 CAPN7 23023127 pred G G G G GP GP G G GP G GP G G G G GP GP G GP G GP G G G GP G GP GP G KRT18 USP8 25402006 pred G GP G G G G G GP G GP G GP G G GP G G GP G GP GP G G GP G GP G G PTPN3 USP8 25402006 pred G GP G G G GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP GP GP G USP8 VPS28 21836163 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 TJP2 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G CD28 USP8 25402006 pred G G G G G USP8 CDK17 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G USP2 USP8 23023127 pred GP G P GP G G P G GP G GP G P GP G GP G GP P G GP GP P GP G USP8 USP18 23023127 pred G P G G GP G G G G G P G P G G G GP G USP8 KLC2 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 IRS2 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G USP8 PNN 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G ARAF USP8 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G USP8 ARRB1 25402006 pred G G G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G USP8 BAD 25402006 pred G GP G P GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G USP8 PTPN11 25402006 pred G GP G G G GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G USP8 HDAC7 25402006 pred G G G G GP GP G G GP G GP G G G G G GP G G G GP G G G G G GP GP G WEE1 USP8 25402006 pred G GP G GP P G G GP G G GP G G GP P G GP G GP G G G GP G GP GP G USP8 CDC5L 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G SNRNP200 USP8 25402006 pred G G G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G USP8 USP17L2 23023127 pred P P P P P P P P P P P P P P P

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B USP8 KRT31 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100701|BIOGRID_119554 bait|bait prey|prey USP8 ERBB4 MI:0004(affinity chromatography technology) 23153581 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_248436 bait prey USP8 STAM MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0492(in vitro)|MI:0004(affinity chromatography technology)|MI:0096(pull down) 10982817,16520378,17711858,20736164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|(biogrid) BIOGRID_130376|BIOGRID_161158|BIOGRID_154811|HPRD_10037|BIOGRID_154809|BIOGRID_99827 prey|bait|bait|-|prey|bait bait|prey|prey|-|bait|prey KRT36 USP8 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100701|BIOGRID_119974 prey|prey bait|bait USP8 KRT85 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100701|BIOGRID_119564 bait|bait prey|prey USP8 USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223076 prey bait USP8 POLD3 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_302049 bait prey USP8 TRIM55 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223027 prey bait USP8 TRIM54 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223045 prey bait USP8 USP22 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120312|UniProt_100701 bait|bait prey|prey USP8 HIF1A MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 24378640 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact) UniProt_131894|UniProt_131895 bait|bait prey|prey UBC USP8 MI:0686(unspecified method)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0686(unspecified method)|MI:0686(unspecified method)|MI:0415(enzymatic study) 16771824,21139048,22118674,22195557,23287719 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_249559|BIOGRID_123328|BIOGRID_160449|BIOGRID_171785|BIOGRID_249578|BIOGRID_249574|BIOGRID_199461 prey|bait|bait|bait|bait|bait|prey bait|prey|prey|prey|prey|prey|bait USP8 TSEN2 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304882 prey bait USP8 PJA1 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222989 prey bait USP8 CHMP7 MI:0018(two hybrid) 17711858 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_130372 bait prey USP8 EPAS1 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 24378640 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact) UniProt_131893|UniProt_131896 bait|bait prey|prey VPS4B USP8 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_243854 prey bait USP8 CHMP1B MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0096(pull down)|MI:0493(in vivo) 17711858,19302785 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|- MI:0471(mint)|(intact)|(biogrid)|(intact)|(biogrid)|MI:0471(mint)|(intact)|(intact)|(biogrid)|(biogrid)|(intact)|MI:0468(hprd) MINT_69977|UniProt_92569|BIOGRID_130361|UniProt_92566|BIOGRID_130375|MINT_40556|UniProt_92576|UniProt_92560|BIOGRID_130369|BIOGRID_199666|UniProt_99982|HPRD_40084 bait|bait|bait|bait|prey|bait|bait|bait|bait|bait|bait|- prey|prey|prey|prey|bait|prey|prey|prey|prey|prey|prey|- SFN USP8 MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology) 15778465 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|MI:0471(mint)|(biogrid) UniProt_81342|MINT_52048|MINT_84511|BIOGRID_85012 bait|bait|bait|bait prey|prey|prey|prey USP8 PTEN MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24270891 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_310056|BIOGRID_310050 prey|bait bait|prey USP8 CHMP4C MI:0018(two hybrid)|MI:0096(pull down)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0096(pull down) 17711858,19302785 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|MI:0471(mint)|(intact)|(intact)|MI:0471(mint) BIOGRID_130371|BIOGRID_199669|MINT_40561|UniProt_92574|UniProt_99987|MINT_69982 bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey USP8 TRIM63 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223003 prey bait STAM2 USP8 MI:0686(unspecified method)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0492(in vitro)|MI:0096(pull down)|MI:0096(pull down) 10982817,13129930,20736164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|(biogrid) BIOGRID_88058|BIOGRID_154812|BIOGRID_99824|HPRD_12092|BIOGRID_99825|BIOGRID_99828 bait|prey|bait|-|prey|prey prey|bait|prey|-|bait|bait USP8 YWHAG MI:0006(anti bait coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0493(in vivo)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology) 15324660,17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|(intact)|MI:0468(hprd)|MI:0471(mint)|(biogrid) UniProt_145851|MINT_58530|UniProt_79442|HPRD_12091|MINT_55707|BIOGRID_150225 prey|prey|prey|-|prey|prey bait|bait|bait|-|bait|bait USP8 USP28 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223118 prey bait USP8 KIF23 MI:0493(in vivo)|MI:0004(affinity chromatography technology) 18329369 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_33292|BIOGRID_117259 -|bait -|prey USP8 OTUB1 MI:0493(in vivo)|MI:0018(two hybrid) 14661020 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_40482|BIOGRID_87290 -|bait -|prey USP8 CHMP6 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 19302785 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|MI:0471(mint)|MI:0471(mint) UniProt_99989|MINT_40563|MINT_69984 bait|bait|bait prey|prey|prey USP8 UBE2I MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_238977 prey bait USP8 RNF41 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0493(in vivo) 15314180,17035239 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0407(direct interaction)|- (biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_85916|BIOGRID_85914|BIOGRID_199266|BIOGRID_199265|HPRD_12095 prey|prey|bait|bait|- bait|bait|prey|prey|- USP8 YWHAZ MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0096(pull down)|MI:0006(anti bait coimmunoprecipitation) 15161933,15324660,17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(intact)|(biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact) UniProt_77424|BIOGRID_82194|UniProt_79539|BIOGRID_150306|MINT_83770|MINT_58651|MINT_55820|MINT_51426|UniProt_145578 prey|prey|prey|prey|prey|prey|prey|prey|prey bait|bait|bait|bait|bait|bait|bait|bait|bait USP8 PTPN23 MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology) 19523899,23477725 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|-|MI:0915(physical association) MI:0465(dip)|MI:0465(dip)|(biogrid) DIP_54643|DIP_708|BIOGRID_272449 -|-|prey -|-|bait USP8 CHMP4B MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 19302785 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) MI:0471(mint)|MI:0471(mint)|(intact) MINT_40560|MINT_69981|UniProt_99986 bait|bait|bait prey|prey|prey DNAJB6 USP8 MI:0492(in vitro) 15342353 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_12093 - - USP8 CHMP1A MI:0096(pull down)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0096(pull down) 17711858,19302785 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|(intact)|(biogrid)|(biogrid) MINT_69976|UniProt_92575|MINT_40555|UniProt_92570|UniProt_99981|BIOGRID_130370|BIOGRID_199665 bait|bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey|prey USP8 CHMP3 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 19302785 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) MI:0471(mint)|(intact)|MI:0471(mint) MINT_40559|UniProt_99985|MINT_69980 bait|bait|bait prey|prey|prey USP8 USP15 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223098 prey bait USP8 GRB2 MI:0492(in vitro)|MI:0096(pull down) 10982817 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_4368|BIOGRID_99829 -|bait -|prey KCNN4 USP8 MI:0004(affinity chromatography technology) 21828287 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_142308 prey bait USP8 RNF128 MI:0493(in vivo)|MI:0018(two hybrid) 14661020 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_40482|BIOGRID_87291 -|bait -|prey USP8 YWHAE MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17979178,19608861 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_256881|BIOGRID_288934 prey|prey bait|bait USP8 UBE2G1 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_239655 prey bait PLA2G2A USP8 MI:0415(enzymatic study) 22118674 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_160307 prey bait USP8 RASGRF1 MI:0493(in vivo) 11500497 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_12094 - - YWHAB USP8 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0019(coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 15324660,17353931,24255178 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association) (intact)|(biogrid)|MI:0471(mint)|(biogrid)|(biogrid)|MI:0471(mint)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_176935|BIOGRID_150108|MINT_58591|BIOGRID_81939|BIOGRID_293576|MINT_55760|UniProt_150476|UniProt_79497|UniProt_176956|UniProt_131110|UniProt_131089 bait|bait|bait|bait|bait|bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey|prey|prey|prey|prey|prey USP8 USP4 MI:0107(surface plasmon resonance) 21415856 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (intact) UniProt_112890 prey bait CHMP2A USP8 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 19302785 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) MI:0471(mint)|MI:0471(mint)|(intact)|(biogrid) MINT_69978|MINT_40557|UniProt_99983|BIOGRID_199667 prey|prey|prey|prey bait|bait|bait|bait YWHAQ USP8 MI:0006(anti bait coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0415(enzymatic study)|MI:0493(in vivo) 15161933,15324660,17353931,23333852 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|- (intact)|MI:0471(mint)|MI:0471(mint)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) UniProt_148143|MINT_58154|MINT_55392|UniProt_79323|BIOGRID_82955|BIOGRID_150326|BIOGRID_291777|BIOGRID_247627|HPRD_35968 bait|bait|bait|bait|bait|bait|bait|bait|- prey|prey|prey|prey|prey|prey|prey|prey|- SRC USP8 MI:0415(enzymatic study) 23333852 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_247625 bait prey SPP1 USP8 MI:0018(two hybrid) 22779921 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_196461 bait prey USP8 CHMP5 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 19302785 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|MI:0471(mint)|MI:0471(mint) UniProt_99988|MINT_40562|MINT_69983 bait|bait|bait prey|prey|prey USP8 STAT6 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304179 bait prey USP8 EPS15 MI:0004(affinity chromatography technology) 16771824 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_123332 prey bait USP8 FARSB MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241364 prey bait USP8 SLBP MI:0492(in vitro) 10982817 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_10818 - - USP8 NBR1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 19427866 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association) (biogrid)|(biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|(intact)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint) BIOGRID_197593|BIOGRID_197596|MINT_40902|MINT_70477|MINT_70478|UniProt_169292|UniProt_101908|UniProt_169290|UniProt_99844|UniProt_101900|MINT_70468|MINT_40912|MINT_40911 prey|bait|prey|bait|neutral component|bait|neutral component|prey|prey|bait|prey|neutral component|bait bait|prey|bait|prey|neutral component|prey|neutral component|bait|bait|prey|bait|neutral component|prey USP8 HTT MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_300489 bait prey AKT1 USP8 MI:0004(affinity chromatography technology) 17210635 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_121928 prey bait EGFR USP8 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study) 16120644,23153581,23333852,23477725 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_248435|BIOGRID_272448|BIOGRID_126490|BIOGRID_247626 prey|bait|bait|bait bait|prey|prey|prey USP8 BIRC6 MI:0004(affinity chromatography technology)|MI:0493(in vivo) 18329369 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_117260|HPRD_33286 bait|- prey|- USP8 CHMP2B MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 19302785 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|MI:0471(mint)|MI:0471(mint)|(intact) BIOGRID_199668|MINT_69979|MINT_40558|UniProt_99984 bait|bait|bait|bait prey|prey|prey|prey GRAP2 USP8 MI:0096(pull down)|MI:0096(pull down)|MI:0493(in vivo) 12176364 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|- (biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_209928|BIOGRID_209924|HPRD_31572 prey|bait|- bait|prey|-

PPI - HINT Gene A Gene B PMID Method Quality VPS4B USP8 22939629 0401 HT GRAP2 USP8 26186194,12176364,26214742 0004,0096,0004 HT,LC KRT36 USP8 19615732,19615732 0004,0007 HT EGFR USP8 16120644,25485838,23153581,25853104,25485838,23477725,23333852 0004,0004,0004,0004,0415,0004,0004 LC UBC USP8 16771824,22118674 0004,0004 LC YWHAQ USP8 15161933,15324660,15324660,15161933,17353931,23333852,17353931 0004,0004,0019,0096,0006,0004,0004 LC,HT YWHAB USP8 24255178,17353931,15324660,15324660,17353931 0007,0006,0004,0019,0004 HT USP8 STAT6 22863883 0401 HT USP8 ACAA2 26344197 0401 HT USP8 HTT 22863883 0401 HT USP8 UBE2E1 26344197 0401 HT USP8 YWHAG 17353931,15324660,15324660 0006,0004,0019 HT USP8 UBE2G1 22939629 0401 HT USP8 YWHAZ 17353931,15324660,15324660,15161933,17353931 0006,0004,0019,0096,0004 HT,LC USP8 UBE2I 26344197,22939629 0401,0401 HT USP8 KRT85 19615732,19615732 0004,0007 HT USP8 POLD3 22863883 0401 HT USP8 KRT31 19615732,19615732 0004,0007 HT USP8 TATDN1 26344197 0401 HT USP8 CHMP1B 17711858,17711858,17711858,19302785,17711858 0018,0007,0004,0096,0096 LC USP8 TSEN2 22863883 0401 HT USP8 STAM 20736164,20736164,16520378,10982817 0004,0090,0004,0096 LC USP8 CHMP4C 19302785,17711858 0096,0096 LC USP8 RNF41 15314180,17035239,17035239 0004,0096,0114 LC USP8 CHMP1A 17711858,19302785,17711858 0007,0096,0096 LC USP8 BIRC6 18329369,25733871,26683461 0004,0004,0004 LC USP8 FARSB 22939629 0401 HT USP8 USP22 19615732,19615732 0004,0007 HT USP8 HEL2 25675982,25485838,17979178,19608861,25485838 0096,0096,0004,0004,0004 LC USP8 HEL-S-1 26214742,15324660,24255178,17353931 0004,0004,0004,0004 LC,HT VPS4B USP8 22939629 0401 HT GRAP2 USP8 26186194 0004 HT KRT36 USP8 19615732,19615732 0004,0007 HT YWHAQ USP8 15324660,15324660,17353931,17353931 0004,0019,0006,0004 HT YWHAB USP8 24255178,17353931,15324660,15324660,17353931 0007,0006,0004,0019,0004 HT USP8 STAT6 22863883 0401 HT USP8 ACAA2 26344197 0401 HT USP8 HTT 22863883 0401 HT USP8 UBE2E1 26344197 0401 HT USP8 YWHAG 17353931,15324660,15324660 0006,0004,0019 HT USP8 UBE2G1 22939629 0401 HT USP8 YWHAZ 17353931,15324660,15324660,17353931 0006,0004,0019,0004 HT USP8 UBE2I 26344197,22939629 0401,0401 HT USP8 KRT85 19615732,19615732 0004,0007 HT USP8 POLD3 22863883 0401 HT USP8 KRT31 19615732,19615732 0004,0007 HT USP8 TATDN1 26344197 0401 HT USP8 TSEN2 22863883 0401 HT USP8 FARSB 22939629 0401 HT USP8 USP22 19615732,19615732 0004,0007 HT USP8 HEL-S-1 15324660,24255178,17353931 0004,0004,0004 HT GRAP2 USP8 12176364,26214742 0096,0004 LC EGFR USP8 16120644,25485838,23153581,25853104,25485838,23477725,23333852 0004,0004,0004,0004,0415,0004,0004 LC UBC USP8 16771824,22118674 0004,0004 LC YWHAQ USP8 15161933,15161933,23333852 0004,0096,0004 LC USP8 YWHAZ 15161933 0096 LC USP8 CHMP1B 17711858,17711858,17711858,19302785,17711858 0018,0007,0004,0096,0096 LC USP8 STAM 20736164,20736164,16520378,10982817 0004,0090,0004,0096 LC USP8 CHMP4C 19302785,17711858 0096,0096 LC USP8 RNF41 15314180,17035239,17035239 0004,0096,0114 LC USP8 CHMP1A 17711858,19302785,17711858 0007,0096,0096 LC USP8 BIRC6 18329369,25733871,26683461 0004,0004,0004 LC USP8 HEL2 25675982,25485838,17979178,19608861,25485838 0096,0096,0004,0004,0004 LC USP8 HEL-S-1 26214742 0004 LC VPS4B USP8 22939629 0401 LC STAM2 USP8 20736164 0090 LC EGFR USP8 25485838,25485838 0004,0415 LC UBC USP8 25527291,22056774,23287719,25485838,17711858,22195557,21209336 0415,0998,0114,0415,0415,0415,0998 LC SRC USP8 23333852 0415 LC PLA2G2A USP8 22118674 0415 LC YWHAQ USP8 15324660,15324660 0004,0019 LC YWHAB USP8 15324660,15324660 0004,0019 LC USP8 USP8 17035239 0114 LC USP8 STAT6 22863883 0401 LC USP8 EPS15 16771824,16771824 0004,0415 LC USP8 ACAA2 26344197 0401 LC USP8 HTT 22863883 0401 LC USP8 UBE2E1 26344197 0401 LC USP8 YWHAG 15324660,15324660 0004,0019 LC USP8 UBE2G1 22939629 0401 LC USP8 YWHAZ 15324660,15324660 0004,0019 LC USP8 UBE2I 26344197,22939629 0401,0401 LC USP8 USP4 21415856 0107 LC USP8 TARDBP 24825905,24825905 0018,0004 LC USP8 RASGRF1 11500497 0018 LC USP8 NBR1 19427866,19427866,19427866 0018,0416,0096 LC USP8 POLD3 22863883 0401 LC USP8 HIST2H2AC 26507658 0415 LC USP8 HIST2H2BE 26507658 0415 LC USP8 OPN 22779921 0018 LC USP8 TATDN1 26344197 0401 LC USP8 CHMP1B 17711858,17711858,17711858,17711858 0018,0007,0004,0096 LC USP8 TSEN2 22863883 0401 LC USP8 PJA1 22626734 0415 HT USP8 STAM 20736164,17711858,20736164 0004,0415,0090 LC USP8 TRIM63 22626734 0415 HT USP8 USP28 22626734 0415 HT USP8 TRIM54 22626734 0415 HT USP8 TRIM55 22626734 0415 HT USP8 RNF41 17035239,17035239 0096,0114 LC USP8 FARSB 22939629 0401 LC USP8 USP21 22626734 0415 HT USP8 USP15 22626734 0415 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P62253 P40818 UBE2G1 USP8 0.081 22939629 P62259 P40818 YWHAE USP8 0.21 17720156 Q04917 P40818 YWHAH USP8 0.126 17979178 Q8NCE0 P40818 TSEN2 USP8 0.081 22863883 Q9HD42 P40818 CHMP1A USP8 0.671 19302785,17711858 Q8NEM0 P40818 MCPH1 USP8 0.454 25733871 Q8NG27 P40818 PJA1 USP8 0.183 22626734 Q9NSD9 P40818 FARSB USP8 0.081 22939629 Q9H4P4 P40818 RNF41 USP8 0.623 17035239,15314180 Q9H3S7 P40818 PTPN23 USP8 0.21 23477725 Q9Y3E7 P40818 CHMP3 USP8 0.309 19302785 Q9Y4E8 P40818 USP15 USP8 0.183 22626734 P40818 P10451 USP8 SPP1 0.183 22779921 P40818 P12931 USP8 SRC 0.309 23333852 P40818 P04629 USP8 NTRK1 0.126 25921289 Q9JLQ0 P40818 CD2AP USP8 0.236 26496610 Q9NR09 P40818 BIRC6 USP8 0.61 25733871,26683461,18329369 Q9D8B3 P40818 CHMP4B USP8 0.236 26496610 Q7LBR1 P40818 CHMP1B USP8 0.82 19302785,17711858 P40818 O75791 USP8 GRAP2 0.671 26186194,26214742,12176364 P40818 O76013 USP8 KRT36 0.236 19615732 P40818 O89100 USP8 GRAP2 0.702 19523899,12773374,12176364 P63104 P40818 YWHAZ USP8 0.49 15161933,15324660,17353931 P78386 P40818 KRT85 USP8 0.236 19615732 Q15323 P40818 KRT31 USP8 0.236 19615732 Q9UPT9 P40818 USP22 USP8 0.236 19615732 P40818 O75886 USP8 STAM2 0.82 20736164,13129930,10982817 P63279 P40818 UBE2I USP8 0.155 26344197,22939629 P40818 P00533 USP8 EGFR 0.832 16120644,23153581,23477725,23333852,25485838,25853104 P40818 P31946 USP8 YWHAB 0.648 15324660,24255178,17353931,26214742 P40818 P0CG48 USP8 UBC 0.891 25527291,23287719,25485838,22195557,17711858 Q969Q1 P40818 TRIM63 USP8 0.183 22626734 Q92783 P40818 STAM USP8 0.702 20736164,10982817,16520378 Q96CF2 P40818 CHMP4C USP8 0.671 19302785,17711858 Q96FZ7 P40818 CHMP6 USP8 0.523 19302785 P40818 P31947 USP8 SFN 0.236 15778465 Q96JA1 P40818 LRIG1 USP8 0.21 24828152 Q9BV40 P40818 VAMP8 USP8 0.21 18388320 Q96RU2 P40818 USP28 USP8 0.183 22626734 Q9BYV2 P40818 TRIM54 USP8 0.183 22626734 Q9BYV6 P40818 TRIM55 USP8 0.183 22626734 Q99814 P40818 EPAS1 USP8 0.454 24378640 Q9UK80 P40818 USP21 USP8 0.183 22626734 Q9UQN3 P40818 CHMP2B USP8 0.523 19302785 Q13148 P40818 TARDBP USP8 0.569 24825905 P40818 O43633 USP8 CHMP2A 0.309 19302785 P40818 O15554 USP8 KCNN4 0.21 21828287 Q02241 P40818 KIF23 USP8 0.21 18329369 P40818 O75351 USP8 VPS4B 0.081 22939629 P40818 P14555 USP8 PLA2G2A 0.309 22118674 P62993 P40818 GRB2 USP8 0.309 10982817 P40818 P31749 USP8 AKT1 0.21 17210635 P40818 P27348 USP8 YWHAQ 0.623 15324660,15161933,17353931,23333852 P40818 P27671 USP8 RASGRF1 0.21 11500497 P42226 P40818 STAT6 USP8 0.081 22863883 P40818 P40818 USP8 USP8 0.332 17035239 P62258 P40818 YWHAE USP8 0.74 25675982,19608861,25485838,17979178 P42858 P40818 HTT USP8 0.081 22863883 P42566 P40818 EPS15 USP8 0.454 16771824 P42765 P40818 ACAA2 USP8 0.081 26344197 P61981 P40818 YWHAG USP8 0.332 15324660,17353931 P51965 P40818 UBE2E1 USP8 0.081 26344197 P60484 P40818 PTEN USP8 0.376 24270891 Q16778 P40818 HIST2H2BE USP8 0.309 26507658 Q15054 P40818 POLD3 USP8 0.081 22863883 Q14596 P40818 NBR1 USP8 0.772 19427866 Q16777 P40818 HIST2H2AC USP8 0.309 26507658 Q15303 P40818 ERBB4 USP8 0.21 23153581 Q16665 P40818 HIF1A USP8 0.454 24378640 Q8WUX9 P40818 CHMP7 USP8 0.309 17711858 Q62925 P40818 MAP3K1 USP8 0.033 25260751 Q8TEB7 P40818 RNF128 USP8 0.21 14661020 Q9NZZ3 P40818 CHMP5 USP8 0.523 19302785 Q96FW1 P40818 OTUB1 USP8 0.21 14661020 Q9H444 P40818 CHMP4B USP8 0.309 19302785 Q96QF0 P40818 RAB3IP USP8 0.126 unassigned1312 Q9Y3M2 P40818 CBY1 USP8 0.126 unassigned1312 Q13107 P40818 USP4 USP8 0.309 21415856

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 HGS USP8 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database CLOCK USP8 MI:0362 inference MI:0461 interaction database KCNN4 USP8 MI:0045 experimental interaction detection MI:0461 interaction database CHMP2A USP8 MI:0045 experimental interaction detection MI:0461 interaction database LRP6 USP8 MI:0362 inference MI:1106 pathways database GRAP2 USP8 MI:0045 experimental interaction detection MI:0461 interaction database STAM2 USP8 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database KRT36 USP8 MI:0045 experimental interaction detection MI:0461 interaction database SEC24D USP8 MI:0362 inference MI:0461 interaction database EGFR USP8 MI:0045 experimental interaction detection MI:0461 interaction database ALDOA USP8 MI:0362 inference MI:0461 interaction database NTRK1 USP8 MI:0045 experimental interaction detection MI:0461 interaction database ALDOB USP8 MI:0362 inference MI:0461 interaction database ATP5B USP8 MI:0362 inference MI:0461 interaction database RHOC USP8 MI:0362 inference MI:0461 interaction database UBB USP8 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database UBC USP8 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SPP1 USP8 MI:0045 experimental interaction detection MI:0461 interaction database SRC USP8 MI:0045 experimental interaction detection MI:0461 interaction database PLA2G2A USP8 MI:0045 experimental interaction detection MI:0461 interaction database CBL USP8 MI:0362 inference MI:0461 interaction database YWHAQ USP8 MI:0045 experimental interaction detection MI:0461 interaction database CDC25C USP8 MI:0362 inference MI:0461 interaction database AKT1 USP8 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database YWHAB USP8 MI:0045 experimental interaction detection MI:0461 interaction database SFN USP8 MI:0045 experimental interaction detection MI:0461 interaction database MCM5 USP8 MI:0362 inference MI:0461 interaction database SCNN1A USP8 MI:0045 experimental interaction detection MI:0461 interaction database USP8 EPS15 MI:0045 experimental interaction detection MI:0461 interaction database USP8 DNM2 MI:0362 inference MI:0461 interaction database USP8 SCNN1B MI:0045 experimental interaction detection MI:0461 interaction database USP8 SCNN1G MI:0045 experimental interaction detection MI:0461 interaction database USP8 SEC24C MI:0362 inference MI:0461 interaction database USP8 PSMD4 MI:0362 inference MI:0461 interaction database USP8 WNT3A MI:0362 inference MI:1106 pathways database USP8 PTEN MI:0045 experimental interaction detection MI:0461 interaction database USP8 RHOA MI:0362 inference MI:0461 interaction database USP8 YWHAG MI:0045 experimental interaction detection MI:0461 interaction database USP8 YWHAE MI:0045 experimental interaction detection MI:0461 interaction database USP8 RPS27A MI:0362 inference MI:0461,MI:1106 interaction database,pathways database USP8 UBA52 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database USP8 GRB2 MI:0045 experimental interaction detection MI:0461 interaction database USP8 YWHAZ MI:0045 experimental interaction detection MI:0461 interaction database USP8 RACK1 MI:0362 inference MI:0461 interaction database USP8 KRT85 MI:0045 experimental interaction detection MI:0461 interaction database USP8 SET MI:0362 inference MI:0461 interaction database USP8 KIF23 MI:0045 experimental interaction detection MI:0461 interaction database USP8 YWHAH MI:0045 experimental interaction detection MI:0461 interaction database USP8 LCP2 MI:0362 inference MI:0461 interaction database USP8 USP4 MI:0045 experimental interaction detection MI:0461 interaction database USP8 TARDBP MI:0045 experimental interaction detection MI:0461 interaction database USP8 MAP3K1 MI:0362 inference MI:0461 interaction database USP8 RASGRF1 MI:0362 inference MI:0461 interaction database USP8 NBR1 MI:0045 experimental interaction detection MI:0461 interaction database USP8 ERBB4 MI:0045 experimental interaction detection MI:0461 interaction database USP8 KRT31 MI:0045 experimental interaction detection MI:0461 interaction database USP8 HIF1A MI:0045 experimental interaction detection MI:0461 interaction database USP8 HIST2H2AC MI:0045 experimental interaction detection MI:0461 interaction database USP8 HIST2H2BE MI:0045 experimental interaction detection MI:0461 interaction database USP8 CHMP1B MI:0045 experimental interaction detection MI:0461 interaction database USP8 MCPH1 MI:0045 experimental interaction detection MI:0461 interaction database USP8 PJA1 MI:0045 experimental interaction detection MI:0461 interaction database USP8 RNF128 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP8 CHMP7 MI:0045 experimental interaction detection MI:0461 interaction database USP8 STAM MI:0045 experimental interaction detection MI:0461 interaction database USP8 TRIM63 MI:0045 experimental interaction detection MI:0461 interaction database USP8 CHMP4C MI:0045 experimental interaction detection MI:0461 interaction database USP8 OTUB1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP8 CHMP6 MI:0045 experimental interaction detection MI:0461 interaction database USP8 LRIG1 MI:0045 experimental interaction detection MI:0461 interaction database USP8 USP28 MI:0045 experimental interaction detection MI:0461 interaction database USP8 EPAS1 MI:0045 experimental interaction detection MI:0461 interaction database USP8 SMO MI:0362 inference MI:0461 interaction database USP8 VAMP8 MI:0045 experimental interaction detection MI:0461 interaction database USP8 TRIM54 MI:0045 experimental interaction detection MI:0461 interaction database USP8 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database USP8 PTPN23 MI:0045 experimental interaction detection MI:0461 interaction database USP8 CHMP4B MI:0045 experimental interaction detection MI:0461 interaction database USP8 RNF41 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP8 CHMP1A MI:0045 experimental interaction detection MI:0461 interaction database USP8 BIRC6 MI:0045 experimental interaction detection MI:0461 interaction database USP8 CHMP5 MI:0045 experimental interaction detection MI:0461 interaction database USP8 USP21 MI:0045 experimental interaction detection MI:0461 interaction database USP8 FZD4 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database USP8 USP22 MI:0045 experimental interaction detection MI:0461 interaction database USP8 CHMP2B MI:0045 experimental interaction detection MI:0461 interaction database USP8 CHMP3 MI:0045 experimental interaction detection MI:0461 interaction database USP8 USP15 MI:0045 experimental interaction detection MI:0461 interaction database USP8 CD2AP MI:0362 inference MI:0461 interaction database