PTM - CPLM Gene Name UniProt ID Type Position Code USP8; KIAA0055; UBPY P40818 Acetylation 538 K USP8; KIAA0055; UBPY P40818 Acetylation 601 K

PTM - dbPAF Gene Name UniProt ID Position Type Species USP8; KIAA0055; UBPY P40818 1015 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 1016 Y Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 1068 Y Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 108 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 1106 Y Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 113 Y Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 12 Y Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 153 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 160 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 351 T Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 355 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 378 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 379 T Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 387 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 389 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 392 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 400 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 410 T Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 434 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 452 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 454 T Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 577 T Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 597 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 599 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 611 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 618 T Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 641 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 653 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 668 Y Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 671 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 673 T Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 675 T Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 686 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 687 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 691 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 692 T Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 695 T Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 711 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 716 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 717 Y Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 718 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 719 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 723 T Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 737 T Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 739 T Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 810 Y Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 842 Y Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 951 Y Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 958 S Homo sapiens(Human) USP8; KIAA0055; UBPY P40818 959 T Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA P40818 K538-ac Acetylation EQAKKEDkETSAKRG P40818 K601-ac Acetylation TGDsGsGkPFKIKGQ P40818 R51-m1 Methylation FKTAEECrLDrDEER P40818 R54-m1 Methylation AEECrLDrDEERAYV P40818 K1012-m1 Methylation PVLLVHLkRFsyDGR P40818 S6-p Phosphorylation __MPAVAsVPKELYL P40818 S108-p Phosphorylation EAERLSEsLKLRyEE P40818 Y113-p Phosphorylation SEsLKLRyEEAEVRK P40818 S153-p Phosphorylation GGTLAKGsLENVLDs P40818 S160-p Phosphorylation sLENVLDsKDKTQKS P40818 T351-p Phosphorylation PSKPAAQtPPASIEV P40818 S378-p Phosphorylation RMGPLNIstPVEPVA P40818 T379-p Phosphorylation MGPLNIstPVEPVAA P40818 S389-p Phosphorylation EPVAASKsDVsPIIQ P40818 S392-p Phosphorylation AASKsDVsPIIQPVP P40818 S400-p Phosphorylation PIIQPVPsIKNVPQI P40818 T410-p Phosphorylation NVPQIDRtKKPAVKL P40818 S434-p Phosphorylation STNHEQQsPQSGKVI P40818 S452-p Phosphorylation STKPVVFsPtLMLTD P40818 T454-p Phosphorylation KPVVFsPtLMLTDEE P40818 T577-p Phosphorylation DRGKRCPtPEIQKKS P40818 S597-p Phosphorylation HTSVTGDsGsGkPFK P40818 S599-p Phosphorylation SVTGDsGsGkPFKIK P40818 S611-p Phosphorylation KIKGQPEsGILRTGt P40818 T618-p Phosphorylation sGILRTGtFREDTDD P40818 S641-p Phosphorylation EPLTRARsEEMGRIV P40818 S653-p Phosphorylation RIVPGLPsGWAKFLD P40818 Y668-p Phosphorylation PITGTFRyYHsPtNt P40818 S671-p Phosphorylation GTFRyYHsPtNtVHM P40818 T673-p Phosphorylation FRyYHsPtNtVHMYP P40818 T675-p Phosphorylation yYHsPtNtVHMYPPE P40818 S686-p Phosphorylation YPPEMAPssAPPstP P40818 S687-p Phosphorylation PPEMAPssAPPstPP P40818 S691-p Phosphorylation APssAPPstPPtHKA P40818 T692-p Phosphorylation PssAPPstPPtHKAK P40818 T695-p Phosphorylation APPstPPtHKAKPQI P40818 S711-p Phosphorylation AERDREPsKLKRsys P40818 S716-p Phosphorylation EPsKLKRsyssPDIt P40818 Y717-p Phosphorylation PsKLKRsyssPDItQ P40818 S718-p Phosphorylation sKLKRsyssPDItQA P40818 S719-p Phosphorylation KLKRsyssPDItQAI P40818 T723-p Phosphorylation syssPDItQAIQEEE P40818 T737-p Phosphorylation EKRKPTVtPtVNREN P40818 T739-p Phosphorylation RKPTVtPtVNRENKP P40818 Y810-p Phosphorylation DYFNRNCyQDDINRS P40818 Y842-p Phosphorylation KALWTGQyRYISPKD P40818 Y951-p Phosphorylation RTFEAFMyLSLPLAS P40818 S1015-p Phosphorylation LVHLkRFsyDGRWKQ P40818 Y1016-p Phosphorylation VHLkRFsyDGRWKQK P40818 Y1068-p Phosphorylation GGLDGGHyTAYCKNA P40818 Y1106-p Phosphorylation SAAYILFyTSLGPRV P40818 K566-ub Ubiquitination HETSDAKkSVEDRGK

PTM - dbPTM UniProt ID Position Code Type Resources References P40818 434 S Phosphorylation Swiss-Prot 1010711 17924679 P40818 452 S Phosphorylation Swiss-Prot 1010711 18669648;19413330 P40818 718 S Phosphorylation Swiss-Prot 1010711 18669648;19690332 P40818 719 S Phosphorylation Swiss-Prot 1010711 18669648 P40818 378 S Phosphorylation PhosphoELM.10011 18669648 P40818 389 S Phosphorylation PhosphoELM.10011 18669648 P40818 392 S Phosphorylation PhosphoELM.10011 18669648 P40818 452 S Phosphorylation PhosphoELM.10011 18669648 P40818 718 S Phosphorylation PhosphoELM.10011 18669648;18220336 P40818 719 S Phosphorylation PhosphoELM.10011 18669648 P40818 717 Y Phosphorylation PhosphoELM.10011 18669648 P40818 538 K Acetylation Phosphositeplus.1010730 20167786 P40818 108 S Phosphorylation Phosphositeplus.1010730 20068231 P40818 153 S Phosphorylation Phosphositeplus.1010730 20363803 P40818 160 S Phosphorylation Phosphositeplus.1010730 20068231 P40818 378 S Phosphorylation Phosphositeplus.1010730 18669648 P40818 389 S Phosphorylation Phosphositeplus.1010730 19415658 P40818 392 S Phosphorylation Phosphositeplus.1010730 16964243;19415658;20068231 P40818 452 S Phosphorylation Phosphositeplus.1010730 18669648;19276368 P40818 653 S Phosphorylation Phosphositeplus.1010730 20068231 P40818 716 S Phosphorylation Phosphositeplus.1010730 20166139 P40818 718 S Phosphorylation Phosphositeplus.1010730 17720156;18220336;18669648;19276368;19362540;19664994;19690332;20068231;20166139;20230923;20363803;20562096;20815410;21406692;22115753 P40818 719 S Phosphorylation Phosphositeplus.1010730 18669648;20815410 P40818 454 T Phosphorylation Phosphositeplus.1010730 19276368 P40818 577 T Phosphorylation Phosphositeplus.1010730 19664994;21406692 P40818 601 K Acetylation HPRD 9.0 19608861 P40818 108 S Phosphorylation HPRD 9.0 20068231 P40818 160 S Phosphorylation HPRD 9.0 20068231 P40818 378 S Phosphorylation HPRD 9.0 18669648 P40818 389 S Phosphorylation HPRD 9.0 18669648,20068231 P40818 392 S Phosphorylation HPRD 9.0 17322306,18669648,19415658,20068231 P40818 434 S Phosphorylation HPRD 9.0 17924679,19651622,20068231 P40818 452 S Phosphorylation HPRD 9.0 18669648,19413330,20068231 P40818 653 S Phosphorylation HPRD 9.0 20068231 P40818 716 S Phosphorylation HPRD 9.0 19651622,18452278,20166139,20068231 P40818 718 S Phosphorylation HPRD 9.0 18669648,19651622,19664994,18452278,20230923,20166139,20068231 P40818 719 S Phosphorylation HPRD 9.0 18669648,18767875 P40818 577 T Phosphorylation HPRD 9.0 19664994 P40818 692 T Phosphorylation HPRD 9.0 20068231 P40818 668 Y Phosphorylation HPRD 9.0 20068231 P40818 717 Y Phosphorylation HPRD 9.0 18669648 P40818 392 S Phosphorylation SysPTM 1.1 16964243 P40818 452 S Phosphorylation SysPTM 1.1 18669648 P40818 718 S Phosphorylation SysPTM 1.1 15345747;18669648 P40818 719 S Phosphorylation SysPTM 1.1 18669648;18785766 P40818 717 Y Phosphorylation SysPTM 1.1 17081983

PTM - HPRD Symbol Position Code Type References USP8 108 S Phosphorylation 20068231 USP8 160 S Phosphorylation 20068231 USP8 378 S Phosphorylation 18669648 USP8 389 S Phosphorylation 18669648,20068231 USP8 392 S Phosphorylation 17322306,18669648,19415658,20068231 USP8 434 S Phosphorylation 17924679,19651622,20068231 USP8 452 S Phosphorylation 18669648,19413330,20068231 USP8 577 T Phosphorylation 19664994 USP8 601 K Acetylation 19608861 USP8 653 S Phosphorylation 20068231 USP8 668 Y Phosphorylation 20068231 USP8 692 T Phosphorylation 20068231 USP8 716 S Phosphorylation 19651622,18452278,20166139,20068231 USP8 717 Y Phosphorylation 18669648 USP8 718 S Phosphorylation 18669648,19651622,19664994,18452278,20230923,20166139,20068231 USP8 719 S Phosphorylation 18669648,18767875

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type P40818 719 S 18669648 HTP Phosphorylation P40818 392 S 18669648 HTP Phosphorylation P40818 389 S 18669648 HTP Phosphorylation P40818 452 S 18669648 HTP Phosphorylation P40818 718 S 18669648 HTP Phosphorylation P40818 718 S 18220336 HTP Phosphorylation P40818 717 Y 18669648 HTP Phosphorylation P40818 378 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs P40818 160 Phosphoserine 20068231;23186163 P40818 392 Phosphoserine 23186163 P40818 400 Phosphoserine 23186163 P40818 452 Phosphoserine 18669648;23186163 P40818 577 Phosphothreonine 21406692;23186163 P40818 718 Phosphoserine 18669648;20068231;21406692;23186163 P40818 719 Phosphoserine 18669648

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type USP8 IPI00030915 K 601 GDSGSGaKPFKIKG acetylation USP8 IPI00030915 S 108 AERLSEpSLKLRYE phosphorylation USP8 IPI00030915 S 160 LENVLDpSKDKTQK phosphorylation USP8 IPI00030915 S 378 MGPLNIpSTPVEPV phosphorylation USP8 IPI00030915 S 387 VEPVAApSKSDVSP phosphorylation USP8 IPI00030915 S 653 IVPGLPpSGWAKFL phosphorylation USP8 IPI00030915 S 716 PSKLKRpSYSSPDI phosphorylation USP8 IPI00030915 S 718 KLKRSYpSSPDITQ phosphorylation USP8 IPI00030915 T 379 GPLNISpTPVEPVA phosphorylation USP8 IPI00030915 Y 12 SVPKELpYLSSSLK phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 9101 114555 - K Ubiquitination 22118674 9101 114555 - K Ubiquitination 21139048 9101 114555 - K Ubiquitination 23287719 9101 114555 - K Ubiquitination 24816145