DNA & RNA Element - UTRdb Gene Name Type ASPicDB UTRaspic Refseq ID Genome INTS12 3'UTR 74d9cee785 BA053274 NM_001142471 chr4:106823233-106840610:- INTS12 3'UTR f194925f91 BA053275 NM_001142471 chr4:106823248-106840610:- INTS12 3'UTR 6a0255d63f BA053276 NM_001142471 chr4:106823248-106840610:- INTS12 3'UTR 14864e88fa BA053277 NM_001142471 chr4:106823248-106840610:- INTS12 3'UTR 090eeb3df4 BA053278 NM_001142471 chr4:106823248-106840610:- INTS12 3'UTR dc3d40e5aa BA053279 NM_001142471 chr4:106823248-106840610:- INTS12 5'UTR 74d9cee785 CA082220 NM_001142471 chr4:106823340-106849278:- INTS12 5'UTR f194925f91 CA082221 NM_001142471 chr4:106823340-106849294:- INTS12 5'UTR 6a0255d63f CA082222 NM_001142471 chr4:106823340-106849294:- INTS12 5'UTR 14864e88fa CA082223 NM_001142471 chr4:106823340-106849268:- INTS12 5'UTR 090eeb3df4 CA082224 NM_001142471 chr4:106823340-106849714:- INTS12 5'UTR dc3d40e5aa CA082225 NM_001142471 chr4:106823340-106849239:- INTS12 5'UTR 7bad31d7a7 NM_001142471 chr4:106832582-106849714:-

DNA & RNA Element - AREsite Gene Name Motif CDS Area ARE Area Evidence INTS12; PHF22; SBBI22 ATTTA 12-1400 1481-1485 INTS12; PHF22; SBBI22 WWATTTAWW 12-1400 1479-1487

DNA & RNA Element - circBase circRNA ID Chrom Start End Strand hsa_circ_0007668 chr4 106613132 106616825 - hsa_circ_0070573 chr4 106613132 106614643 - hsa_circ_0070574 chr4 106614455 106616825 - hsa_circ_0070572 chr4 106607848 106614643 -

DNA & RNA Element - circRNADb circRNA ID Chrom Start End Strand Samples hsa_circ_00858 chr4 106613132 106616825 - H9 hESCs,Hs68

DNA & RNA Element - CircNet Circ ID GITPosition Express Symbol Entrez Category Strand Refered Name hsa-circ-INTS12-overlap.1 NM_020395Tchr4:106607848-106610437 expressed INTS12 57117 protein-coding - hsa_circ_0124946 hsa-circ-INTS12-overlap.2 NM_001142471Tchr4:106610287-106614643 expressed INTS12 57117 protein-coding - hsa_circ_0124948 hsa-circ-INTS12.1 NM_001142471Tchr4:106603889-106621161 none INTS12 57117 protein-coding - not_available hsa-circ-INTS12.10 NM_001142471Tchr4:106613133-106616825 none INTS12 57117 protein-coding not_available not_available hsa-circ-INTS12.13 NM_001142471Tchr4:106613133-106614643 none INTS12 57117 protein-coding not_available not_available hsa-circ-INTS12.14 NM_001142471Tchr4:106614455-106616825 expressed INTS12 57117 protein-coding - hsa_circ_0070574 hsa-circ-INTS12.16 NM_001142471Tchr4:106607848-106613292 expressed INTS12 57117 protein-coding - hsa_circ_0124947 hsa-circ-INTS12.18 NM_001142471Tchr4:106613132-106621171 expressed INTS12 57117 protein-coding - hsa_circ_0124949 hsa-circ-INTS12.19 NM_020395Tchr4:106614455-106614643 expressed INTS12 57117 protein-coding x chr4:106614455-106614643_PA1_RNaseR hsa-circ-INTS12.6 NM_020395Tchr4:106607848-106614643 expressed INTS12 57117 protein-coding - hsa_circ_0070572

DNA & RNA Element - miRTarBase Target Gene (Entrez ID) miRTarBase ID miRNA Species (miRNA) Target Gene Species (Target Gene) Experiments Support Type References (PMID) MIRT052640 hsa-let-7a-5p Homo sapiens INTS12 57117 Homo sapiens CLASH Functional MTI (Weak) 23622248

DNA & RNA Element - microRNA Mirbase Acc miRNA Name Gene ID Gene Symbol miRNA Alignment Alignment Gene Alignment miRNA Start miRNA End Gene Start Gene End Genome Coordinates Conservation Align Score Seed Cat Energy mirSVR Score MIMAT0000079 hsa-miR-24-1* 57117 INTS12 ugacuAUAGUCGAGUCAUCCGu |:| :|| ||||||: -----UGU-GGCCAAGUAGGUu 2 18 1 16 [hg19:4:106603874-106603889:-] 0.4895 131 0 -13.00 -0.1860 MIMAT0004497 hsa-miR-24-2* 57117 INTS12 gacacaAAGUCGAGUCAUCCGu | ::|| ||||||: ------UGUGGCCAAGUAGGUu 2 17 1 16 [hg19:4:106603874-106603889:-] 0.4895 132 0 -14.08 -0.1860 MIMAT0004556 hsa-miR-10b* 57117 INTS12 uaagggGAUCUUAGCUUAGACa :|| :|| |||||| uuauuaUUAUGAUAUAAUCUGu 2 17 48 69 [hg19:4:106603821-106603842:-] 0.5187 124 6 -8.95 -0.1367 MIMAT0004570 hsa-miR-223* 57117 INTS12 uugaGUCGAACAGUUUAUGUGc :| : ||| ||||||| gauaUAAUCUGU--AAUACACu 2 19 58 77 [hg19:4:106603813-106603832:-] 0.5412 143 7 -6.50 -1.2161 MIMAT0004600 hsa-miR-144* 57117 INTS12 gaaugucAU-AUACUACUAUAgg || ||| ||||||| aaaggcuUAUUAUUAUGAUAUaa 3 16 42 64 [hg19:4:106603826-106603848:-] 0.5187 138 0 -9.44 -0.1788 MIMAT0000444 hsa-miR-126* 57117 INTS12 gcgcaUGGU-UUUCAUUAUUac ||:: || |||||| aauacACUGUAAUUUAAUAAaa 3 17 70 91 [hg19:4:106603799-106603820:-] 0.5412 127 0 -3.04 -0.2067 MIMAT0000453 hsa-miR-154* 57117 INTS12 uuauccaguuggcacAUACUAa |||||| ugaaaggcuuauuauUAUGAUa 2 8 40 61 [hg19:4:106603829-106603850:-] 0.5187 120 6 -6.57 -0.1749 MIMAT0002178 hsa-miR-487a 57117 INTS12 uugaccuacagggacAUACUAa |||||| ugaaaggcuuauuauUAUGAUa 2 8 40 61 [hg19:4:106603829-106603850:-] 0.5187 120 6 -4.70 -0.1749 MIMAT0003247 hsa-miR-582-5p 57117 INTS12 ucAUUGACCAACUUGU-UGACAUu |||: || ||:| |||||| uaUAAUCUGU--AAUACACUGUAa 2 22 60 81 [hg19:4:106603809-106603830:-] 0.5412 122 6 -11.83 -1.3354 MIMAT0003255 hsa-miR-588 57117 INTS12 caagauuggguaACACCGGUu |||||||| ------------UGUGGCCAa 2 10 1 9 [hg19:4:106603881-106603889:-] 0.4895 145 7 -15.00 -0.6085 MIMAT0003268 hsa-miR-600 57117 INTS12 cucguUCCGAGAACAGACAUUca | | | | ||||||| uuauuAUGAUAUAAUCUGUAAua 3 19 51 73 [hg19:4:106603817-106603839:-] 0.5187 130 0 -9.18 -0.1635 MIMAT0003268 hsa-miR-600 57117 INTS12 cucguuccgagaacaGACAUUca |||||| auaaucuguaauacaCUGUAAuu 3 9 61 83 [hg19:4:106603807-106603829:-] 0.5412 120 0 -8.50 -0.2493 MIMAT0003323 hsa-miR-548d-3p 57117 INTS12 cguuuucuuugaCA-CCAAAAAc || ||||||| ---uguggccaaGUAGGUUUUUg 2 11 1 20 [hg19:4:106603870-106603889:-] 0.4895 141 7 -11.24 -0.6835 MIMAT0005458 hsa-miR-1224-5p 57117 INTS12 gguggagggcUCAGGAGUg ||||:||| auuuaauaaaAGUCUUCAu 2 10 81 99 [hg19:4:106603791-106603809:-] 0.5638 129 0 -11.26 -0.1196 MIMAT0015013 hsa-miR-548u 57117 INTS12 gcguUUUCAUUAACGUCAGAAac || |||| |||||| cuguAAUUUAAUAAAAGUCUUca 3 20 76 98 [hg19:4:106603792-106603814:-] 0.5638 135 0 -10.34 -0.6142 MIMAT0015027 hsa-miR-3074 57117 INTS12 gccaCGGAUGACUCGACUAUAg ||:||:| |||||| aaagGCUUAUUAUUAUGAUAUa 2 19 42 63 [hg19:4:106603827-106603848:-] 0.5187 126 6 -13.16 -0.2272 MIMAT0016855 hsa-miR-4302 57117 INTS12 gagcGACUCGGUGUGACc ||| :|||||| uaauCUGUAAUACACUGu 2 15 62 79 [hg19:4:106603811-106603828:-] 0.5412 130 6 -14.37 -0.4234 MIMAT0016905 hsa-miR-4275 57117 INTS12 uuucuucacCAUUAAcc |||||| uaauacacuGUAAUUua 3 9 69 85 [hg19:4:106603805-106603821:-] 0.5412 120 0 -1.72 -0.2941 MIMAT0016911 hsa-miR-4280 57117 INTS12 cgAGACGAGUCUUGAUGUGAg | | || | | |||||| gaUAUAAUCUGUAAUACACUg 2 20 58 78 [hg19:4:106603812-106603832:-] 0.5412 123 6 -9.70 -0.4369 MIMAT0000231 hsa-miR-199a-5p 57117 INTS12 cuuguccAUCAGAC--U-UGUGACcc || |||| | |||||| uaugauaUAAUCUGUAAUACACUGua 3 17 55 80 [hg19:4:106603810-106603835:-] 0.5412 130 0 -12.06 -0.5918 MIMAT0000250 hsa-miR-139-5p 57117 INTS12 gaccucugugcACGUGACAUcu | ||||||| auaaucuguaaUACACUGUAau 3 12 61 82 [hg19:4:106603808-106603829:-] 0.5412 127 0 -9.52 -0.2090 MIMAT0000252 hsa-miR-7 57117 INTS12 ugUUGUUUUAGUGAUCAGAAGgu ||: ||| | ||||||| guAAUUUAAU-AAAAGUCUUCau 3 22 78 99 [hg19:4:106603791-106603812:-] 0.5638 135 0 -12.63 -0.3424 MIMAT0000263 hsa-miR-199b-5p 57117 INTS12 cuugUCUAUCAG--AUU-UGUGACcc | ||| || ||| |||||| uaugAUAUAAUCUGUAAUACACUGua 3 20 55 80 [hg19:4:106603810-106603835:-] 0.5412 137 0 -11.86 -0.5918 MIMAT0000424 hsa-miR-128 57117 INTS12 uuucucuggccAAGUGACAcu | |||||| auaaucuguaaUACACUGUaa 3 11 61 81 [hg19:4:106603809-106603829:-] 0.5412 122 0 -8.57 -0.6040 MIMAT0002870 hsa-miR-499-5p 57117 INTS12 uuuguAGUGACGUUCAGAAuu |:| | ||||||| guaauUUAAUAAAAGUCUUca 3 17 78 98 [hg19:4:106603792-106603812:-] 0.5638 132 0 -7.06 -0.6216

DNA & RNA Element - TRANSFAC Accession AS Description Species Entrez Pubmed Binding Info G020669 INTS12 Homo sapiens 57117

DNA & RNA Element - TargetScan Gene Name UTR Region Start UTR Region End AIR Total Normalized 3P-seq-tags & Pseudocounts Strand hg19_chromosome Genome Start Genome End INTS12; PHF22; SBBI22 1 104 100 236.564 - chr4 106603785 106603889 INTS12; PHF22; SBBI22 105 106 2.749 236.564 - chr4 106603783 106603785 INTS12; PHF22; SBBI22 107 719 0.635 236.564 - chr4 106603170 106603783 INTS12; PHF22; SBBI22 720 720 0.01 236.564 - chr4 106603169 106603170

DNA & RNA Element - RepTar Gene Name miRNA Begin End Profile INTS12 ebv-miR-BART20-3p beg:89 end:100 pic:3' CCATTGTCCGACACGGAAGTAC 5'& |.|||||| &5' -------------GTCTTCAT- 3' INTS12 hsa-miR-548d-3p beg:7 end:21 pic:3' CGTTTTCTTTGACA-CCAAAAAC 5'& || |||||||| &5' ------------GTAGGTTTTTG 3' INTS12 hsa-miR-588 beg:0 end:10 pic:3' CAAGATTGGGTAACACCGGTT 5'& ||||||||| &5' ------------TGTGGCCAA 3' INTS12 hsa-miR-1179 beg:30 end:50 pic:3' GGTTGGTTACTTTCTTACGAA 5'& |.|| .||||||| |||| &5' CTAAA-GATGAAAG---GCTT 3' INTS12 hsa-miR-24-2star beg:0 end:16 pic:3' GACACAAAGTCGAGTCATCCGT 5'& |||| || ||||||. &5' -TGTG-----GCCAAGTAGGT- 3' INTS12 hsa-miR-300 beg:6 end:24 pic:3' TCTCTCTCAGACGGGAACATAT 5'& ||| |...|||||| &5' ------AGTAGGTTTTTGTAT- 3' INTS12 hsa-miR-3142 beg:30 end:50 pic:3' AGACTTCCAAGTCTTTCCGGAA 5'& || ||| |||||||.| &5' -CTAAAGAT---GAAAGGCTT- 3' INTS12 hsa-miR-548s beg:0 end:9 pic:3' TTTTATTGACGTCAAAACCGGTA 5'& |||||| &5' ----------------TGGCCA- 3' INTS12 hsa-miR-890 beg:0 end:13 pic:3' GTTGACTACGGAAAGGTTCAT 5'& ||. ||||||| &5' -------TGTGG--CCAAGTA 3'

DNA & RNA Element - miRcode Gene Name Type microRNA Seed Position Seed Type Total Cons% Tr Region INTS12 High_conserved miR-503 chr4:106621153 7-mer-A1 42 CDS INTS12 High_conserved miR-7/7ab chr4:106604115 7-mer-m8 53 CDS INTS12 High_conserved miR-7/7ab chr4:106616748 7-mer-m8 56 CDS INTS12 High_conserved miR-9/9ab chr4:106614604 7-mer-A1 69 CDS INTS12 High_conserved miR-96/507/1271 chr4:106629914 7-mer-A1 20 5pUTR INTS12 High_conserved miR-138/138ab chr4:106604024 7-mer-A1 16 CDS INTS12 High_conserved miR-139-5p chr4:106624133 7-mer-A1 11 5pUTR INTS12 High_conserved miR-141/200a chr4:106629297 8-mer 9 5pUTR INTS12 High_conserved miR-143/1721/4770 chr4:106614567 7-mer-m8 4 CDS INTS12 High_conserved miR-143/1721/4770 chr4:106621011 7-mer-A1 38 CDS INTS12 High_conserved miR-145 chr4:106604402 7-mer-m8 44 CDS, ncRNA INTS12 High_conserved miR-150/5127 chr4:106629720 7-mer-A1 27 5pUTR INTS12 High_conserved miR-15abc/16/16abc/195/322/424/497/1907 chr4:106621153 7-mer-A1 42 CDS INTS12 High_conserved miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d chr4:106761416 7-mer-m8 13 5pUTR INTS12 High_conserved miR-182 chr4:106624850 7-mer-m8 11 5pUTR INTS12 High_conserved miR-182 chr4:106629914 7-mer-A1 20 5pUTR INTS12 High_conserved miR-183 chr4:106613240 8-mer 62 CDS INTS12 High_conserved miR-184 chr4:106621016 7-mer-A1 38 CDS INTS12 High_conserved miR-18ab/4735-3p chr4:106630003 7-mer-A1 0 5pUTR INTS12 High_conserved miR-193/193b/193a-3p chr4:106629855 7-mer-m8 11 5pUTR INTS12 High_conserved miR-1ab/206/613 chr4:106629394 7-mer-m8 16 5pUTR INTS12 High_conserved miR-203 chr4:106608078 7-mer-m8 16 ncRNA INTS12 High_conserved miR-203 chr4:106616801 7-mer-A1 51 CDS INTS12 High_conserved miR-204/204b/211 chr4:106629946 8-mer 11 5pUTR INTS12 High_conserved miR-205/205ab chr4:106614620 7-mer-A1 53 CDS INTS12 High_conserved miR-214/761/3619-5p chr4:106616677 8-mer 60 CDS INTS12 High_conserved miR-214/761/3619-5p chr4:106621077 7-mer-A1 71 CDS INTS12 High_conserved miR-216a chr4:106624072 7-mer-A1 4 5pUTR INTS12 High_conserved miR-216a chr4:106629080 7-mer-m8 16 5pUTR INTS12 High_conserved miR-216b/216b-5p chr4:106624072 8-mer 4 5pUTR INTS12 High_conserved miR-218/218a chr4:106616795 8-mer 49 CDS INTS12 High_conserved miR-22/22-3p chr4:106604393 7-mer-m8 56 CDS, ncRNA INTS12 High_conserved miR-23abc/23b-3p chr4:106629144 7-mer-A1 4 5pUTR INTS12 High_conserved miR-27abc/27a-3p chr4:106621146 8-mer 60 CDS INTS12 High_conserved miR-33a-3p/365/365-3p chr4:106621033 7-mer-m8 47 CDS INTS12 High_conserved miR-34ac/34bc-5p/449abc/449c-5p chr4:106627056 7-mer-m8 13 5pUTR INTS12 High_conserved miR-34ac/34bc-5p/449abc/449c-5p chr4:106629916 8-mer 16 5pUTR INTS12 High_conserved miR-375 chr4:106629196 7-mer-A1 9 5pUTR INTS12 High_conserved miR-425/425-5p/489 chr4:106613216 7-mer-A1 7 CDS INTS12 High_conserved miR-128/128ab chr4:106621147 7-mer-A1 47 CDS INTS12 High_conserved miR-129-5p/129ab-5p chr4:106607986 7-mer-A1 47 CDS, ncRNA INTS12 High_conserved miR-129-5p/129ab-5p chr4:106616791 7-mer-A1 13 CDS INTS12 Medium_conserved miR-543 chr4:106626966 7-mer-m8 11 5pUTR INTS12 Medium_conserved miR-544/544ab/544-3p chr4:106607966 7-mer-A1 2 CDS, ncRNA INTS12 Medium_conserved miR-544/544ab/544-3p chr4:106624894 8-mer 27 5pUTR INTS12 Medium_conserved miR-592/599 chr4:106604333 7-mer-A1 31 CDS, ncRNA INTS12 Medium_conserved miR-615-3p chr4:106621039 7-mer-m8 56 CDS INTS12 Medium_conserved miR-653 chr4:106604339 8-mer 38 CDS, ncRNA INTS12 Medium_conserved miR-653 chr4:106604357 7-mer-m8 4 CDS, ncRNA INTS12 Medium_conserved miR-136 chr4:106614481 7-mer-A1 64 CDS INTS12 Medium_conserved miR-136 chr4:106624918 7-mer-m8 27 5pUTR INTS12 Medium_conserved miR-224 chr4:106626889 8-mer 9 5pUTR INTS12 Medium_conserved miR-224 chr4:106629502 7-mer-m8 9 5pUTR INTS12 Medium_conserved miR-290-5p/292-5p/371-5p/293 chr4:106629083 7-mer-A1 18 5pUTR INTS12 Medium_conserved miR-320abcd/4429 chr4:106604391 7-mer-m8 56 CDS, ncRNA INTS12 Medium_conserved miR-320abcd/4429 chr4:106629368 7-mer-m8 11 5pUTR INTS12 Medium_conserved miR-326/330/330-5p chr4:106624870 7-mer-A1 16 5pUTR INTS12 Medium_conserved miR-339b/339-5p/3586-5p chr4:106627088 7-mer-m8 9 5pUTR INTS12 Medium_conserved miR-361-5p chr4:106616674 7-mer-A1 62 CDS INTS12 Medium_conserved miR-376abd/376b-3p chr4:106603942 7-mer-A1 22 CDS INTS12 Medium_conserved miR-376c/741-5p chr4:106626954 7-mer-A1 11 5pUTR INTS12 Medium_conserved miR-376c/741-5p chr4:106629146 7-mer-m8 4 5pUTR INTS12 Medium_conserved miR-377 chr4:106629420 7-mer-m8 11 5pUTR INTS12 Medium_conserved miR-379/1193-5p/3529 chr4:106613230 7-mer-A1 67 CDS INTS12 Medium_conserved miR-382 chr4:106607877 7-mer-m8 49 CDS, ncRNA INTS12 Medium_conserved miR-410/344de/344b-1-3p chr4:106761378 7-mer-A1 22 5pUTR INTS12 Medium_conserved miR-431 chr4:106604472 7-mer-A1 33 CDS, ncRNA INTS12 Medium_conserved miR-431 chr4:106627068 7-mer-m8 11 5pUTR INTS12 Medium_conserved miR-431 chr4:106816936 7-mer-A1 13 5pUTR INTS12 Medium_conserved miR-433 chr4:106629203 7-mer-A1 13 5pUTR INTS12 Medium_conserved miR-488 chr4:106629626 7-mer-m8 13 5pUTR INTS12 Medium_conserved miR-496 chr4:106629988 7-mer-m8 9 5pUTR

DNA & RNA Element - RAID2 Gene Name RAID ID Interactor 1 Category 1 ID 1 Interactor 2 Category 2 ID 2 Methods Score INTS12 RAID00221614 hsa-miR-6083 miRNA MIMAT0023708 INTS12 mRNA 57117 Prediction 0.1828 INTS12 RAID00377166 hsa-miR-377-3p miRNA MIMAT0000730 INTS12 mRNA 57117 Prediction 0.1828 INTS12 RAID00515007 hsa-miR-499a-5p miRNA MIMAT0002870 INTS12 mRNA 57117 CLIP-seq//Prediction 0.6308 INTS12 RAID01313500 hsa-miR-9-5p miRNA MIMAT0000441 INTS12 mRNA 57117 Prediction 0.1828 INTS12 RAID01743553 hsa-miR-139-5p miRNA MIMAT0000250 INTS12 mRNA 57117 CLIP-seq//Prediction 0.6308 INTS12 RAID02992243 hsa-miR-199a-5p miRNA MIMAT0000231 INTS12 mRNA 57117 CLIP-seq//Prediction 0.6308 INTS12 RAID03075595 hsa-miR-128-3p miRNA MIMAT0000424 INTS12 mRNA 57117 CLIP-seq//Prediction 0.6308 INTS12 RAID03161033 hsa-miR-223-5p miRNA MIMAT0004570 INTS12 mRNA 57117 Prediction 0.1828 INTS12 RAID03238872 hsa-let-7a-5p miRNA MIMAT0000062 INTS12 mRNA 57117 CLASH 0.5483 INTS12 RAID03497133 hsa-miR-7-5p miRNA MIMAT0000252 INTS12 mRNA 57117 CLIP-seq//Prediction 0.6308 INTS12 RAID03597622 hsa-miR-6504-3p miRNA MIMAT0025465 INTS12 mRNA 57117 Prediction 0.1828 INTS12 RAID03821010 hsa-miR-199b-5p miRNA MIMAT0000263 INTS12 mRNA 57117 CLIP-seq//Prediction 0.6308 INTS12 RAID03974801 hsa-miR-124-3p miRNA MIMAT0000422 INTS12 mRNA 57117 Prediction 0.1828 INTS12 RAID04889182 FENDRR lncRNA 400550 INTS12 protein 57117 Microarray//RNA-seq 0.6606