PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SIK1 MKNK1 bci exp G G G G G G G G G G G G G G G G G G ZAP70 SIK1 bci exp G P G GP P G SIK1 MAPK11 bci exp GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP P P GP GP MAPK13 SIK1 bci exp GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP TEC SIK1 bci exp P P P P P P P P P P P P P P P P P P P SIK1 STK38 bci exp GP GP G P GP GP GP G P P GP P GP GP GP G GP GP GP GP P GP GP SIK1 TNIK bci exp GP G P GP GP GP G P P P GP P GP G GP G GP P GP GP GP P GP GP MAP3K7 SIK1 24061540 biogrid exp GP GP G GP G GP G P P G GP G GP G GP P G G G GP GP BLK SIK1 bci exp GP P P P P P P P GP P P P P P P P P SIK1 SRPK1 bci exp GP GP G GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP OXSR1 SIK1 bci exp GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SUPT5H SIK1 21988832 biogrid,intact exp GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 SPOCK2 bci exp GP GP G P GP G GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 DAPK2 bci exp G G G G G G G G G G G G G G G SIK1 MINK1 bci exp GP G G GP G GP G P P GP P GP GP GP G GP P GP G GP P GP GP SIK1 STK17A bci exp GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP TMEM8B SIK1 bci exp GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP G GP P GP GP SIK1 ELAVL1 19322201 biogrid exp GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP GP GP SIK1 NMNAT1 21988832 biogrid,intact exp GP GP G P GP GP GP G P P P G P GP GP GP G GP P GP G GP GP GP SIK1 MAP4K1 bci exp G G P G G G G P GP G G GP G P G G SIK1 CRTC2 16306228 hprd,intact exp GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP MAP4K4 SIK1 bci exp G G G GP GP G G P P P G P GP G G G G G G GP GP GP CD247 SIK1 24502978 intact exp G P G P GP G P G SIK1 PINK1 bci exp G G G G G G G G G G G G G G G G G G SIK1 SRPK2 bci exp GP GP G GP G GP G P P GP GP G G G GP G GP G P G GP RPL3 SIK1 21988832 biogrid,intact exp GP GP G P GP G GP G P P P GP P GP GP GP G GP P GP G GP P GP GP RPS6KA5 SIK1 bci exp GP GP G P GP GP GP G P P G P GP GP P G GP P GP GP GP GP GP PPP2R1B SIK1 bci exp GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 MAP3K12 bci exp GP GP G P GP G GP G P P GP P GP GP GP G GP P GP G GP GP GP SIK1 RPS6KA2 bci exp GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 MAP4K5 bci exp GP G G P GP G GP G P G GP GP GP G G G GP G GP GP FYB SIK1 bci exp G G P G G G GP G G G G G P G RPS6KA4 SIK1 bci exp GP GP G GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 TAB2 24061540 biogrid exp G G G G G G G G G G G G G G G G G G XPO1 SIK1 26673895 biogrid exp GP GP G P GP GP GP G P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 ICK bci exp G G G G G G G G G G G G SIK1 PRKAA1 16306228 biogrid exp GP GP P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 VAPA 9920726 hprd,bci exp GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 PPP2CA bci exp GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP FYN SIK1 bci exp G GP G P GP G GP G P P GP GP G G G G G G G P G G SIK1 WNK1 25402006 bci exp, pred G GP G P GP GP GP G P P P GP GP G GP G G G GP G P G GP PRKACA SIK1 23256157, 23023127 biogrid exp, pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 HDAC5 23256157, 21836163 biogrid exp, pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 YWHAZ 16306228, 25402006 hprd,biogrid,intact,bci exp, pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP STK17B SIK1 23023127 bci exp, pred GP GP P GP GP P GP P P G G G GP P GP P GP GP P SIK1 YWHAE 16306228, 25402006 intact,bci exp, pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 STK11 16396636, 23023127 biogrid exp, pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 STK4 23023127 bci exp, pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 RALGPS2 25402006 pred GP GP P P P GP P P P GP P P GP P P P P GP P GP GP SIK1 CAMKK1 23023127 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 TSSK1B 23023127 pred P GP SIK1 PSKH2 23023127 pred GP GP G P GP GP GP G P P P GP P GP GP G P G GP GP P GP SIK1 IL9R 25402006 pred GP GP G P GP GP GP P P P GP P GP GP GP G P P GP GP GP P GP P MAP3K6 SIK1 23023127 pred GP GP P P GP GP P P P GP P P GP GP P P GP GP GP P GP P CSNK1D SIK1 23023127 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 CDK13 23023127 pred G G G G GP G G P G P G G G G GP G G GP GP GP MAPKAPK2 SIK1 25402006 pred GP GP G P GP GP GP G P P P G P GP GP GP G GP P GP GP GP GP GP AKT1 SIK1 25402006, 23023127 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP ATF3 SIK1 25402006 pred GP GP G P GP G GP G P P P G P GP G GP G GP P GP G GP GP GP MARK3 SIK1 25402006, 23023127 pred GP GP G P GP G GP G P P GP P GP G GP G GP P GP G GP GP GP AKT2 SIK1 23023127 pred GP GP G P GP G GP G P P P GP P GP GP GP G GP P GP G GP P GP GP MAP2K6 SIK1 23023127 pred GP G G P GP G GP G P P P GP P GP GP GP G GP P GP GP GP P GP G SIK1 TSSK4 23023127 pred G G G G G G G MAPK4 SIK1 23023127 pred P P P P P P P P P P P P P GP P P P P P P P P SIK1 HIPK2 23023127 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP CDK1 SIK1 23023127 pred GP P G GP P P P P GP GP G GP P GP P GP GP CDK14 SIK1 23023127 pred GP GP G GP GP GP G P P P GP P GP G GP G GP P G G GP P GP GP SIK1 PDPK2P 23023127 pred SIK1 FSCN1 25402006 pred GP G G P GP G GP G P P GP GP GP G GP GP P GP GP SIK1 RIPK1 23023127 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP NEK2 SIK1 23023127 pred P P P GP P P P P P P P P GP P P GP RAF1 SIK1 25402006 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP NR4A1 SIK1 25402006 pred G G G G G G G G G G G G G G G G G G SIK1 MAP2K5 23023127 pred GP GP G P GP GP GP G P P P GP P GP GP P G P P GP GP GP P GP GP SIK1 CHMP4B 21836163 pred GP GP G GP GP GP G P P P GP P GP G GP G GP P G GP GP P GP GP SIK1 CDK10 23023127 pred G G G G G G G G G G G G G G G G CSNK1A1 SIK1 25402006 pred G G G G G G G G G G GP G G G G G G G SIK1 NEK11 23023127 pred G GP G P GP G GP G GP P GP G GP G GP GP G GP GP GP USP2 SIK1 21836163 pred GP G P GP GP P G P P P GP P GP GP GP G GP P GP GP GP P P GP SIK1 UHMK1 23023127 pred G G G G G G G G G G G G G G G G G G SIK1 BRSK2 23023127 pred G G G G G PIM1 SIK1 23023127 pred G GP G P GP G GP G P P G P GP G G G G P G GP GP GP GP SIK1 CDK18 25402006 pred P GP G P GP GP GP G P P P GP P GP P P G P P GP GP P GP GP MAPK1 SIK1 23023127 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP DAPK3 SIK1 23023127 pred P P P P P P P P P P P P P P P P P P P P MAP2K7 SIK1 23023127 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP G GP P GP GP SIK1 PIK3R4 23023127 pred GP GP G P GP GP GP G P P P GP P GP G GP G GP P GP G GP P GP GP SIK1 KIAA0930 25402006 pred GP GP G P GP G GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 MARK2 25402006, 23023127 pred P P G GP GP GP G P P P P GP P G GP P GP P P P GP P CHEK1 SIK1 23023127 pred G GP SIK1 MAP3K3 25402006 pred G G G P GP GP G G P P GP P GP G G G GP G G GP P GP G SIK1 CDK15 23023127 pred GP P G GP P P G P P P P GP GP GP G P P P GP GP P GP SIK1 HRNR 25402006 pred P P P P P P P P P P P P P P P P P P P P SIK1 PLK3 23023127 pred GP GP P P G P G P P P GP P P GP GP G GP P GP G GP P GP P SIK1 DCLK3 23023127 pred P P P P P P P P P P P P P P P P P SIK1 PLK2 23023127 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 TRIB3 23023127 pred GP GP G P GP G GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 TTN 23023127 pred GP GP G P GP GP GP G P GP P GP G G G P G GP GP G G SIK1 ING1 25402006 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 PRKCE 25402006 pred GP GP G GP G GP G P GP P GP GP GP G GP GP G GP GP GP SIK1 CDK16 25402006 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP PCYT1A SIK1 21836163 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP LATS1 SIK1 23023127 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP GP GP SIK1 MARK4 25402006, 23023127 pred GP GP G P GP GP GP G P P P GP P GP G GP G G P GP GP GP P GP GP TSC2 SIK1 25402006 pred G GP G GP GP GP G P P P G P GP GP GP G GP G G GP GP GP SIK1 STK24 23023127 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 NUAK2 23023127 pred P P P P P P P P P P P P P P P P P P P P P P HSP90AB1 SIK1 25402006 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 TSSK6 23023127 pred G MAPK12 SIK1 23023127 pred G GP G GP GP GP G P GP P GP G GP G P G GP GP P GP GP NADK SIK1 25402006 pred GP GP G P GP GP GP G P P P G P GP GP GP G GP G G GP P GP GP PRKACG SIK1 23023127 pred P P P P P P P P P P P GP GP G P P P P P P P GP FXYD2 SIK1 21836163 pred GP GP G P GP GP GP G P P P GP P GP G GP G GP P GP GP GP GP GP ATP1A3 SIK1 21836163 pred G GP GP G GP G G G G BUB1B SIK1 23023127 pred P P P P GP GP P P P GP P P GP P GP P P P GP P GP GP SIK1 RPL19 25402006 pred GP GP G P GP G GP G P P P GP P GP GP GP G GP P GP G GP P GP GP PRKCI SIK1 25402006, 23023127 pred GP GP G GP G GP G P P G P GP G GP G GP P G G GP GP GP SIK1 SNF8 21836163 pred GP GP G P GP GP GP G P P P GP P GP G GP G GP P GP GP GP P GP GP SIK1 LARP1 25402006 pred GP GP G GP GP GP G P P GP P GP GP GP G GP P GP G GP GP GP SIK1 BRSK1 23023127 pred GP G GP G G G GP G G GP P G G GP GP SGK1 SIK1 21836163 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 NOLC1 25402006 pred GP G G GP G GP G P P G P GP G G G G G G GP P GP GP SIK1 MAP3K19 23023127 pred P P P P P P P P P P P P P P P P P P P P P GP SIK1 MYLK3 23023127 pred P P P P GP P G P P P P P P GP GP P GP ROCK2 SIK1 23023127 pred GP GP G GP GP GP G P GP P GP GP GP G GP P GP GP GP P GP GP WEE1 SIK1 25402006 pred GP GP P P G GP P GP P P GP GP G GP G G GP P GP GP AURKA SIK1 23023127 pred P P G G GP P G P G G G GP DCLK1 SIK1 23023127 pred G G G GP G GP G GP P GP GP GP G P G G GP P GP P SIK1 AURKB 23023127 pred P P P GP P P P P P G P P GP P GP P INSR SIK1 23023127 pred GP GP G GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP CDK8 SIK1 23023127 pred G G G G G G G G G G G G G G G G G G SIK1 HIPK4 23023127 pred G G G GP GP GP G P G P GP G GP G GP GP GP GP GP GP DAPK1 SIK1 23023127 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 AKT3 23023127 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP GP GP CHEK2 SIK1 23023127 pred GP GP P P GP P P P P P P GP GP G P GP P P GP GP SIK1 MARK1 25402006, 23023127 pred GP GP G P GP GP GP G P P P GP P GP G GP G GP P GP GP GP P GP GP SIK1 PRKCZ 25402006 pred G GP G GP GP GP G P P P GP P GP GP G GP P GP P GP P GP GP PLK1 SIK1 23023127 pred P P G P P GP GP P P P GP P GP GP GP G GP P GP GP GP P P GP SIK1 NEK5 23023127 pred P P P P P P P P P P P P P P P P P P P P P SIK1 MAPK14 23023127 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP GP GP GP P GP GP PDC SIK1 25402006 pred P P P P P P P P P P P P P P P P P P SIK1 CAMK4 23023127 pred GP GP G P GP P GP G P P P GP P GP G GP G P GP G GP GP GP SIK1 FOXO4 25402006 pred G G G G GP G G G P G G GP G GP G GP GP G GP SIK1 ABCB5 21836163 pred P GP P P P GP P P P P P P P G P P P P P P STK16 SIK1 23023127 pred GP P G P GP GP GP G P P P G P GP G GP G GP P GP GP GP GP GP PRKCH SIK1 23023127 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 PABPC4 25402006 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 SIK2 23023127 pred GP GP G GP GP GP G P P P G P GP G GP G GP P GP GP GP GP GP SIK1 TRA2B 25402006 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP CDK11B SIK1 23023127 pred SIK1 SSH1 25402006 pred GP GP G GP G GP G P P P GP P GP G G G GP P G G GP P GP GP SIK1 WWTR1 25402006 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 CDK5 23023127 pred P GP G P GP P P G P P P GP P GP P P G P P P P P P APP SIK1 25402006 pred G GP G P GP G GP G G P GP G GP G GP P G G GP G GP SIK1 CDK17 25402006 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP G GP P GP GP SIK1 PAK7 23023127 pred GP G GP P P G P P P GP GP G P P P P P SIK1 ARHGEF2 25402006 pred GP GP G P GP GP GP G P P GP P GP GP GP G GP P GP GP GP P GP GP CCNA2 SIK1 23023127 pred G G G P G G GP G GP P G G G G G G GP P GP GP SIK1 CAMK1 23023127 pred GP GP G GP GP GP G P P P G P GP GP GP G P P G GP GP GP GP SIK1 PRKCD 25402006 pred GP GP G P GP GP GP P P P GP P GP GP GP GP P GP P GP P GP GP SIK1 ZFP36L1 25402006 pred GP G G P GP G GP G P P GP GP GP G G GP G GP G GP GP SIK1 CAMK1D 23023127 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 PRKCQ 23023127 pred G G G G G G G G G G G G G G G G G G GP1BB SIK1 25402006 pred SIK1 AURKC 23023127 pred G G G GP GP P G P P P G P GP G GP G G P GP G P P GP ATP1A1 SIK1 21836163 pred GP GP G GP G GP G P P P G P GP G GP G G P GP G GP GP GP SIK1 PAK2 23023127 pred GP GP G GP G GP G P P P GP P GP GP G G GP GP GP GP P GP G GSK3B SIK1 25402006 pred G G G GP G GP G G GP G G G GP G G G G G SGPL1 SIK1 21836163 pred GP G G P GP GP GP G P P P GP P GP GP GP G GP P GP G GP GP GP SIK1 PKMYT1 23023127 pred GP GP G GP GP GP G P P GP P GP G GP G GP P G GP GP GP GP ARAF SIK1 25402006 pred G G G G G G G G G G G G G G G G G G DYRK3 SIK1 25402006, 23023127 pred G G G G G G G G SIK1 MAP3K5 25402006 pred G GP G P GP G GP G P P GP GP GP GP G G P G G G P GP GP SIK1 TSSK3 23023127 pred P P P P P P P P P P P P P P GP SIK1 KSR1 25402006 pred GP GP G P GP GP GP G P P P GP P GP G GP G GP P GP GP GP P GP GP EGFR SIK1 25402006 pred GP GP G GP G GP G P P G P GP G G G GP P G GP GP GP GP CCND1 SIK1 23023127 pred GP GP G P GP G GP G P P G P GP G G G G GP G GP P GP P SIK1 MAPK7 23023127 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP P GP P GP GP TTK SIK1 23023127 pred P P P P P GP P P P P P P P P P P P P GP P GP GP SIK1 MRPS27 25402006 pred G G G G G G G G G G G G G G G G G G SIK1 CDK6 23023127 pred G GP G P GP G GP G P P GP P GP G GP G GP P G G GP P GP GP PAK4 SIK1 25402006 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 ZAK 23023127 pred GP GP G GP GP GP G P P G P GP G GP G GP P GP G GP GP GP SIK1 YWHAH 25402006 pred GP GP G P GP GP GP G P P P G P GP GP GP G GP P GP GP GP P GP GP SIK1 TRIB1 23023127 pred G G G G G G G G G G G G G G G G G G SIK1 MYLK2 23023127 pred P P P P P GP GP P SIK1 SNRK 23023127 pred G GP G P GP GP GP G P P P GP P GP G GP G GP GP G GP P GP GP SIK1 PAK1 23023127 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 SAMD4B 25402006 pred GP GP G GP GP GP G P P P GP P GP G GP G GP P GP GP GP P GP GP PLK4 SIK1 23023127 pred P P P P P GP P P P P P P P P P P P P GP GP NUAK1 SIK1 23023127, 21836163 pred GP GP G P GP G GP G P P P GP P GP G GP G GP P GP GP GP GP GP SIK1 KLC4 25402006 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP GP GP GRK5 SIK1 23023127 pred GP GP G P GP GP GP G P P GP P GP GP GP G GP P GP GP GP P GP GP NR4A2 SIK1 25402006 pred GP GP G P GP GP GP G P P P GP P GP GP GP G P P GP GP GP P GP P CREB1 SIK1 21836163 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 STK3 23023127 pred GP GP P GP GP GP G P P P G P GP G GP G GP P G GP GP P GP GP SIK1 SIK3 25402006, 21836163 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 AANAT 25402006 pred P P P P P P P P P P P P P P P P SIK1 CEP170 25402006 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 CAMK2B 23023127 pred G G GP GP G G GP G G G P GP G G GP HDAC4 SIK1 25402006 pred GP G G P GP G GP G P P P GP P GP GP GP G P P GP GP GP P GP GP STK25 SIK1 25402006 pred G GP G P GP G GP G P P GP P GP G G G GP G G GP GP GP REM1 SIK1 25402006 pred GP G G P GP G GP G P P P GP P GP G GP G GP P GP G GP P GP GP SIK1 ERN2 23023127 pred GP GP G GP GP GP G P P P P GP GP GP G GP P GP G G P GP GP SIK1 NIM1K 23023127 pred P P G P GP P GP G P P P P P GP P GP G GP GP GP P P GP P ERN1 SIK1 23023127 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP SIK1 PRKD2 23023127 pred G GP G P GP GP GP G P P GP P GP GP G G GP P G GP GP P GP GP ENO1 SIK1 25402006 pred GP GP G P GP GP GP G P P P GP P GP GP GP G GP P GP GP GP P GP GP

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P57059 Q9UQL6-3 enzymatic study 23256157 direct interaction X 2 P57059 Q9NYJ8 affinity chromatography technology 24061540 physical association X 2 P57059 Q9NYJ8 affinity chromatography technology 24061540 physical association X 2 O00267-2 P57059 two hybrid 21988832 direct interaction X 2 P0CG48 P57059 affinity chromatography technology 23256157 physical association X 2 P0CG48 P57059 affinity chromatography technology 23256157 physical association X 2 P0CG48 P57059 affinity chromatography technology 21963094 physical association X 2 P0CG48 P57059 affinity chromatography technology 21987572 physical association X 2 P57059 Q15831 enzymatic study 16396636 direct interaction X 2 P57059 P17612-2 enzymatic study 23256157 direct interaction X 2 P57059 two hybrid 21988832 direct interaction X 2 P57059 O43318-4 affinity chromatography technology 24061540 physical association X 2 P57059 O43318-4 affinity chromatography technology 24061540 physical association X 2 P57059 affinity chromatography technology 16306228 physical association X 2 D0PNI1 P57059 affinity chromatography technology 16306228 physical association X 2 A0A024R4E1 P57059 two hybrid 21988832 direct interaction X 2 P57059 in vivo 16306228 - C 4 P57059 in vivo 16306228 - C 4 P57059 in vivo 16306228 - C 4 P57059 in vivo 16306228 - C 4 P57059 in vivo 16306228 - C 4 P57059 in vivo 16306228 - C 4 P57059 in vivo 16306228 - C 4 P57059 in vivo 16306228 - C 4 P57059 in vivo 16306228 - C 5 P57059 in vivo 16306228 - C 5 P57059 in vivo 16306228 - C 5 P57059 in vivo 16306228 - C 5 P57059 in vivo 16306228 - C 5 P57059 in vivo 16306228 - C 5 P57059 in vivo 16306228 - C 5 P57059 in vivo 16306228 - C 5 P57059 in vivo 16306228 - C 5 P57059 in vivo 16306228 - C 5 P57059 in vivo 16306228 - C 5 P57059 in vivo 16306228 - C 5 P57059 in vivo 16306228 - C 6 P57059 in vivo 16306228 - C 6 P57059 in vivo 16306228 - C 6 P57059 in vivo 16306228 - C 6 P57059 in vivo 16306228 - C 6 P57059 in vivo 16306228 - C 6 P57059 in vivo 16306228 - C 6 P57059 in vivo 16306228 - C 6 P57059 in vivo 16306228 - C 6 P57059 in vivo 16306228 - C 6 P57059 in vivo 16306228 - C 6 P57059 in vivo 16306228 - C 6 P57059 in vivo 16306228 - X 2 P57059 in vitro 16306228 - X 2 P57059 in vitro 16306228 - X 2 P57059 in vivo 16306228 - X 2 P57059 Q9P0L0 in vitro 9920726 - X 2 P57059 Q9P0L0 in vitro 9920726 - X 2 P57059 in vivo 16306228 - C 4 P57059 in vivo 16306228 - C 4 P57059 Q53ET0 in vivo 16306228 - X 2 P57059 Q53ET0 in vitro 16306228 - X 2 P57059 Q53ET0 in vitro 16306228 - X 2 P57059 Q53ET0 in vivo 16306228 - X 2 P57059 tandem affinity purification 16306228 association C 3 P57059 pull down 16306228 association C 4 P57059 pull down 16306228 association C 4 P57059 P39023 two hybrid array 21988832 physical association X 2 P57059 pull down 24502978 association C 49 P57059 Q53ET0 protein kinase assay 16306228 phosphorylation reaction X 2 O00267 P57059 two hybrid array 21988832 physical association X 2 D0PNI1 P57059 pull down 16306228 direct interaction X 2 A0A024R4E1 P57059 two hybrid array 21988832 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B PRKACA SIK1 MI:0004(affinity chromatography technology) 23256157 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_260524 bait prey SIK1 TAB2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24061540 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_289107|BIOGRID_289102 prey|bait bait|prey SIK1 ELAVL1 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187085 prey bait MAP3K7 SIK1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24061540 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_289110|BIOGRID_289103 bait|prey prey|bait SIK1 VAPA MI:0492(in vitro) 9920726 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_15187 - - SIK1 LKB1 MI:0493(in vivo)|MI:0493(in vivo)|MI:0415(enzymatic study) 16306228,16396636 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|-|MI:0407(direct interaction) MI:0468(hprd)|MI:0468(hprd)|(biogrid) HPRD_39623|HPRD_39625|BIOGRID_199196 -|-|prey -|-|bait SIK1 NMNAT1 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_288803|UniProt_118479 prey|unspecified role bait|unspecified role SUPT5H SIK1 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_288683|UniProt_118307 prey|unspecified role bait|unspecified role SIK1 AMPKa1 MI:0004(affinity chromatography technology) 16306228 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_145577 prey bait UBC SIK1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology) 21963094,21987572,23256157 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_260523|BIOGRID_260528|BIOGRID_163856|BIOGRID_265842 prey|bait|bait|bait bait|prey|prey|prey SIK1 CRTC2 MI:0493(in vivo)|MI:0676(tandem affinity purification) 16306228 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0217(phosphorylation reaction) MI:0468(hprd)|(intact) HPRD_31097|UniProt_81920 -|unspecified role -|unspecified role SIK1 YWHAZ MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification)|MI:0493(in vivo)|MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0493(in vivo)|MI:0493(in vivo)|MI:0493(in vivo) 16306228 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0914(association)|MI:0914(association)|MI:0914(association)|-|-|- (biogrid)|(intact)|MI:0468(hprd)|(intact)|(intact)|(intact)|MI:0468(hprd)|MI:0468(hprd)|MI:0468(hprd) BIOGRID_145593|UniProt_81918|HPRD_31092|UniProt_81913|UniProt_81914|UniProt_81905|HPRD_39728|HPRD_39623|HPRD_39625 prey|bait|-|prey|prey|bait|-|-|- bait|prey|-|bait|bait|prey|-|-|- SIK1 HDAC5 MI:0004(affinity chromatography technology) 23256157 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_260527 bait prey RPL3 SIK1 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_118306|BIOGRID_286151 unspecified role|bait unspecified role|prey

PPI - HINT Gene A Gene B PMID Method Quality SUPT5H SIK1 21988832,21988832 0397,0018 HT PRKACA SIK1 23256157 0415 LC RPL3 SIK1 21988832,21988832 0397,0018 HT SIK1 STK11 16396636 0415 LC SIK1 CRTC2 16306228 0424 LC SIK1 NMNAT1 21988832,21988832 0397,0018 HT SIK1 HDAC5 23256157 0415 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P57059 O43318 SIK1 MAP3K7 0.376 24061540 P62258 P57059 YWHAE SIK1 0.126 16306228 Q9HAN9 P57059 NMNAT1 SIK1 0.286 21988832 Q9NYJ8 P57059 TAB2 SIK1 0.376 24061540 Q9UQL6 P57059 HDAC5 SIK1 0.309 23256157 Q6P5F9 P57059 XPO1 SIK1 0.126 26673895 P57059 P06428 SIK1 E6 0.126 22810586 P63104 P57059 YWHAZ SIK1 0.454 16306228 P57059 P39023 SIK1 RPL3 0.286 21988832 P57059 P17612 SIK1 PRKACA 0.309 23256157 Q13131 P57059 PRKAA1 SIK1 0.126 16306228 Q15717 P57059 ELAVL1 SIK1 0.126 19322201 Q15831 P57059 STK11 SIK1 0.309 16396636 P57059 O00267 SIK1 SUPT5H 0.286 21988832 P57059 P20963 SIK1 CD247 0.126 24502978 Q53ET0 P57059 CRTC2 SIK1 0.033 16306228

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 SUPT5H SIK1 MI:0045 experimental interaction detection MI:0461 interaction database XPO1 SIK1 MI:0045 experimental interaction detection MI:0461 interaction database SMAD7 SIK1 MI:0362 inference MI:1106 pathways database MAP3K7 SIK1 MI:0045 experimental interaction detection MI:0461 interaction database UBC SIK1 MI:0045 experimental interaction detection MI:0461 interaction database PRKACA SIK1 MI:0045 experimental interaction detection MI:0461 interaction database CD247 SIK1 MI:0045 experimental interaction detection MI:0461 interaction database MARK3 SIK1 MI:0362 inference MI:0461 interaction database TGFBR1 SIK1 MI:0362 inference MI:1106 pathways database RPL3 SIK1 MI:0045 experimental interaction detection MI:0461 interaction database SIK1 YWHAE MI:0045 experimental interaction detection MI:0461 interaction database SIK1 YWHAZ MI:0045 experimental interaction detection MI:0461 interaction database SIK1 PRKAA1 MI:0045 experimental interaction detection MI:0461 interaction database SIK1 ELAVL1 MI:0045 experimental interaction detection MI:0461 interaction database SIK1 STK11 MI:0045 experimental interaction detection MI:0461 interaction database SIK1 CRTC2 MI:0045 experimental interaction detection MI:0461 interaction database SIK1 MARK2 MI:0362 inference MI:0461 interaction database SIK1 MARK4 MI:0362 inference MI:0461 interaction database SIK1 NMNAT1 MI:0045 experimental interaction detection MI:0461 interaction database SIK1 TAB2 MI:0045 experimental interaction detection MI:0461 interaction database SIK1 MARK1 MI:0362 inference MI:0461 interaction database SIK1 HDAC5 MI:0045 experimental interaction detection MI:0461 interaction database SIK1 SIK3 MI:0362 inference MI:0461 interaction database SIK1 PPME1 MI:0362 inference MI:0461 interaction database