PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TRIM43 UBE2D4 19549727 biogrid,intact exp P P P P P P P P P P P P P P TRIM43 CACYBP 25036637 intact exp P P P P P P P P P P P P P P P P P ENOX1 TRIM43 25416956 biogrid,intact exp P P P P P P P P P P P P P P P P P UBE2D1 TRIM43 19549727 biogrid,intact exp P P P P P P P P P P P P P P UBE2D2 TRIM43 19549727 biogrid,intact exp P P P P P P P P P P P P P P UBE2K TRIM43 19549727 biogrid,intact exp P P P P P P P P P P P P P P P P P P UBE2D3 TRIM43 19549727 biogrid,intact exp P P P P P P P P P P P P P P TRIM43 TRIM8 22493164 biogrid,intact exp P P P P P P P P P P P P P P P P P P MLF1 TRIM43 25036637 intact exp P P P P P P P P P P P P P P P P UBE2G2 TRIM43 19690564 biogrid,intact exp P P P P P P P P P P P P P P P MYOG TRIM43 21988832 biogrid,intact exp P P P P P P P P P P P P P P P P P P TRIM27 TRIM43 22493164 biogrid,intact exp P P P P P P P P P P P P P P P P P P TRIM65 TRIM43 23023127 pred P P P P P P P P P P P P P P P P P BSPRY TRIM43 23023127 pred P P P P P P P TRIM63 TRIM43 23023127 pred TRIM26 TRIM43 23023127 pred P P P P P P P P P P P P P P P P P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P61077-3 Q96BQ3 two hybrid 19549727 direct interaction X 2 Q9BZR9 Q96BQ3 two hybrid 22493164 direct interaction X 2 A0A087WW00 Q96BQ3 two hybrid 19549727 direct interaction X 2 A0A024RDT8 Q96BQ3 two hybrid 25416956 direct interaction X 2 P15173 Q96BQ3 two hybrid 21988832 direct interaction X 2 Q96BQ3 P62837 two hybrid 19549727 direct interaction X 2 P0CG48 Q96BQ3 affinity chromatography technology 21139048 physical association X 2 Q96BQ3 P60604-2 two hybrid 19690564 direct interaction X 2 Q96BQ3 A0A024RA90 two hybrid 19549727 direct interaction X 2 P61086 Q96BQ3 two hybrid 19549727 direct interaction X 2 P14373 Q96BQ3 two hybrid 22493164 direct interaction X 2 Q9BZR9 Q96BQ3 two hybrid array 22493164 physical association X 2 P60604 Q96BQ3 two hybrid array 19690564 physical association X 2 A0A024RDT8 Q96BQ3 two hybrid prey pooling approach 25416956 physical association X 2 A0A024RDT8 Q96BQ3 two hybrid array 25416956 physical association X 2 A0A024RDT8 Q96BQ3 validated two hybrid 25416956 physical association X 2 P15173 Q96BQ3 two hybrid array 21988832 physical association X 2 Q96BQ3 P62837 two hybrid array 19549727 physical association X 2 P58340 Q96BQ3 luminescence based mammalian interactome mapping 25036637 physical association X 2 A0A024RDH2 Q96BQ3 two hybrid array 19549727 physical association X 2 A0A024QZJ2 Q96BQ3 two hybrid array 19549727 physical association X 2 Q96BQ3 A0A024RA90 two hybrid array 19549727 physical association X 2 P14373 Q96BQ3 two hybrid array 22493164 physical association X 2 A0A024R904 Q96BQ3 luminescence based mammalian interactome mapping 25036637 physical association X 2 B3KSH4 Q96BQ3 two hybrid array 19549727 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBE2G2 TRIM43 MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123583|UniProt_102572 bait|bait prey|prey TRIM43 UBE2D4 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124226|UniProt_101163 prey|prey bait|bait UBE2D1 TRIM43 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124223|UniProt_101016 bait|bait prey|prey MYOG TRIM43 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_118290|BIOGRID_288670 unspecified role|bait unspecified role|prey TRIM43 TRIM8 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284034|UniProt_122609 bait|bait prey|prey TRIM43 HIP2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_101215 prey bait UBE2K TRIM43 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_124555 bait prey UBE2D2 TRIM43 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101044|BIOGRID_124224 bait|bait prey|prey TRIM27 TRIM43 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122608|BIOGRID_283987 prey|prey bait|bait UBE2D3 TRIM43 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124225|UniProt_101066 bait|bait prey|prey UBC TRIM43 MI:0004(affinity chromatography technology) 21139048 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_169328 bait prey

PPI - HINT Gene A Gene B PMID Method Quality HIP2 TRIM43 19549727 0397 HT TRIM27 TRIM43 22493164,22493164 0018,0397 HT MYOG TRIM43 21988832,21988832 0397,0018 HT UBE2D1 TRIM43 19549727,19549727 0397,0018 HT MLF1 TRIM43 25036637 0729 HT UBE2G2 TRIM43 19690564,19690564 0397,0018 HT UBE2D3 TRIM43 19549727,19549727 0397,0018 HT UBE2K TRIM43 19549727 0018 HT UBE2D2 TRIM43 19549727,19549727 0397,0018 HT ENOX1 TRIM43 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TRIM43 TRIM8 22493164,22493164 0018,0397 HT TRIM43 CACYBP 25036637 0729 HT TRIM43 UBE2D4 19549727,19549727 0397,0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q96BQ3 P61086 TRIM43 UBE2K 0.183 19549727 Q96BQ3 P15173 TRIM43 MYOG 0.286 21988832 Q96BQ3 Q8TC92 TRIM43 ENOX1 0.583 25416956,unassigned1304 Q96BQ3 Q49A26 TRIM43 GLYR1 0.236 unassigned1304 Q96BQ3 P14373 TRIM43 TRIM27 0.286 22493164 Q96BQ3 Q14451 TRIM43 GRB7 0.236 unassigned1304 Q96BQ3 B3KSH4 TRIM43 HIP2 0.236 19549727 Q96BQ3 P51668 TRIM43 UBE2D1 0.376 19549727 Q96BQ3 P58340 TRIM43 MLF1 0.126 25036637 Q96BQ3 P60604 TRIM43 UBE2G2 0.376 19690564 Q96BQ3 P61077 TRIM43 UBE2D3 0.286 19549727 Q96BQ3 P62837 TRIM43 UBE2D2 0.286 19549727 Q9BZR9 Q96BQ3 TRIM8 TRIM43 0.286 22493164 Q9HB71 Q96BQ3 CACYBP TRIM43 0.126 25036637 Q9Y2X8 Q96BQ3 UBE2D4 TRIM43 0.376 19549727

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 UBC TRIM43 MI:0045 experimental interaction detection MI:0461 interaction database TRIM27 TRIM43 MI:0045 experimental interaction detection MI:0461 interaction database MYOG TRIM43 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D1 TRIM43 MI:0045 experimental interaction detection MI:0461 interaction database MLF1 TRIM43 MI:0045 experimental interaction detection MI:0461 interaction database UBE2G2 TRIM43 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 TRIM43 MI:0045 experimental interaction detection MI:0461 interaction database UBE2K TRIM43 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 TRIM43 MI:0045 experimental interaction detection MI:0461 interaction database ENOX1 TRIM43 MI:0045 experimental interaction detection MI:0461 interaction database TRIM43 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database TRIM43 CACYBP MI:0045 experimental interaction detection MI:0461 interaction database TRIM43 UBE2D4 MI:0045 experimental interaction detection MI:0461 interaction database