PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TRIM4 TRIM4 17156811,21680743 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM41 TRIM4 22493164 biogrid,intact exp GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G P4HB TRIM4 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G MDM2 TRIM4 22493164 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RAB31 TRIM4 26186194 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G LTBR TRIM4 26186194 biogrid exp GP G G GP P G G G GP G GP GP G GP P G G G GP G GP G GP GP GP GP G TRIM6 TRIM4 23023127 pred G GP G G G GP GP G G G G G G GP G G G G G GP G RFPL4A TRIM4 23023127 pred P P P P P P P P P P P P P P P P P P P P P P TRIM27 TRIM4 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SCUBE3 TRIM4 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G SKIL TRIM4 23023127 pred GP GP G G GP GP G G GP G GP GP GP G G GP GP G G G GP GP GP GP GP G GP GP G LNX1 TRIM4 23023127 pred GP G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP P GP GP PDLIM5 TRIM4 23023127 pred GP GP P P G GP GP GP GP GP GP G GP P GP P G GP GP GP GP GP GP GP P G TRIM4 MID2 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP GP GP G GP GP G TRIM50 TRIM4 23023127 pred P P P P P GP P P P P P GP P P P P P GP GP TRIM65 TRIM4 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G TRAF2 TRIM4 23023127 pred P P P P P P P P P P P P P P P P P P P GP GP P TRIM5 TRIM4 23023127 pred GP GP G GP P G GP GP GP GP GP GP G GP P GP GP G GP GP GP P GP GP GP P G TRIM4 HSF4 23023127 pred G TRIM72 TRIM4 23023127 pred P P P GP G G P TRIM28 TRIM4 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PRKAG1 TRIM4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DGKH TRIM4 23023127 pred P P G P GP G GP P G P GP P P GP GP GP P GP P P GP GP P P P G FSD2 TRIM4 23023127 pred P P P P GP P P P P P P P P GP P P P GP GP P P P TRIM34 TRIM4 23023127 pred SKI TRIM4 23023127 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM21 TRIM4 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G LNX2 TRIM4 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G TRIM16L TRIM4 23023127 pred G GP G G G G GP GP G G G G G TRIM22 TRIM4 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q00987 Q9C037 two hybrid 22493164 direct interaction X 2 A0A024R3Z2 Q9C037 affinity chromatography technology 21110914 physical association X 2 Q9C037 O15205 affinity chromatography technology 22797925 physical association X 2 Q8WV44-2 Q9C037 two hybrid 22493164 direct interaction X 2 P0CG48 Q9C037 affinity chromatography technology 22053931 physical association X 2 P0CG48 Q9C037 affinity chromatography technology 22505724 physical association X 2 P0CG48 Q9C037 affinity chromatography technology 25147182 physical association X 2 P0CG48 Q9C037 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q9C037 affinity chromatography technology 21906983 physical association X 2 Q9C037 Q9C037 pull down 17156811 direct interaction X 2 Q9C037 Q9C037 affinity chromatography technology 21680743 physical association X 2 Q8WV44 Q9C037 two hybrid array 22493164 physical association X 2 Q00987 Q9C037 two hybrid array 22493164 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality P4HB TRIM4 26186194 0004 HT LTBR TRIM4 26186194 0004 HT RAB31 TRIM4 26186194 0004 HT TRIM4 TRIM4 17156811,21680743 0096,0004 LC P4HB TRIM4 26186194 0004 HT LTBR TRIM4 26186194 0004 HT RAB31 TRIM4 26186194 0004 HT TRIM4 TRIM4 17156811,21680743 0096,0004 LC MDM2 TRIM4 22493164,22493164 0018,0397 HT TRIM41 TRIM4 22493164,22493164 0018,0397 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9C037 Q86T82 TRIM4 USP37 0.126 26299517 Q9C037 P03468 TRIM4 NA 0.126 unassigned1333 Q9C037 Q8WV44 TRIM4 TRIM41 0.286 22493164 Q9C037 Q9C037 TRIM4 TRIM4 0.49 17156811,21680743 Q9C037 Q8BZQ7 TRIM4 ANAPC2 0.236 26496610 Q9C037 P36941 TRIM4 LTBR 0.126 26186194 Q9C037 P07237 TRIM4 P4HB 0.126 26186194 Q9C037 Q00987 TRIM4 MDM2 0.286 22493164 Q9C037 Q06830 TRIM4 PRDX1 0.376 26524401 Q9C037 Q13636 TRIM4 RAB31 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 UBD TRIM4 MI:0045 experimental interaction detection MI:0461 interaction database P4HB TRIM4 MI:0045 experimental interaction detection MI:0461 interaction database UBC TRIM4 MI:0045 experimental interaction detection MI:0461 interaction database LTBR TRIM4 MI:0045 experimental interaction detection MI:0461 interaction database HNF4A TRIM4 MI:0045 experimental interaction detection MI:0461 interaction database SUMO1 TRIM4 MI:0045 experimental interaction detection MI:0461 interaction database MDM2 TRIM4 MI:0045 experimental interaction detection MI:0461 interaction database PRDX1 TRIM4 MI:0045 experimental interaction detection MI:0461 interaction database RBL2 TRIM4 MI:0045 experimental interaction detection MI:0461 interaction database RAB31 TRIM4 MI:0045 experimental interaction detection MI:0461 interaction database USP37 TRIM4 MI:0045 experimental interaction detection MI:0461 interaction database TRIM41 TRIM4 MI:0045 experimental interaction detection MI:0461 interaction database TRIM4 ANAPC2 MI:0362 inference MI:0461 interaction database