PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TGFBR1 KLHL35 15761153 hprd,i2d exp G G G GP GP G GP GP G GP P GP G G P GP G G G G P G GP G G GSK3B KLHL35 19888210 i2d exp G G G G GP G G GP G G G G G GP G G GP G G G G G KLHL35 AXIN2 19888210 i2d exp G P G G GP GP G GP GP G GP P GP GP G P GP P GP G GP GP P P G GP GP G CSNK1E KLHL35 19888210 i2d exp G P G G G GP G GP GP G GP P GP GP G P GP GP G GP GP P P G GP GP G KLHL35 NKD1 19888210 i2d exp G G G G G P G G G G P GP MX1 KLHL35 25447205 biogrid exp G P G G GP GP G GP GP G GP P GP GP G P GP P GP G GP GP P G GP GP G CTNNB1 KLHL35 19888210 i2d exp G P G G GP GP G GP GP G GP P GP G G P GP P GP G GP GP P G GP GP G ACVR1 KLHL35 15761153 hprd,i2d exp G P G G G GP G GP GP G GP P GP GP G P GP P GP G GP G P P G GP GP G DVL2 KLHL35 19888210 i2d exp G P G G GP GP G GP GP G GP P GP GP G P GP P GP G GP GP P P G GP GP G CSNK1A1 KLHL35 19888210 i2d exp G G G G G G G G G G G G G G GP G G G G G G G ALAS1 KLHL35 25416956 innatedb,biogrid,intact exp G P G G GP GP G GP GP G GP P GP GP G P GP P GP G GP GP P P G GP GP G KLHL35 APPBP2 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G KLHL35 NUDCD3 25036637 intact exp G P G G GP GP G GP GP G GP P GP GP G P GP P GP G GP GP P P G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q6PF15 A0A024QZ47 two hybrid 25416956 direct interaction X 2 P13196 Q6PF15 two hybrid 25416956 direct interaction X 2 D3DPA4 Q6PF15 in vivo 15761153 - X 2 D3DPA4 Q6PF15 in vivo 15761153 - X 2 P36897-3 Q6PF15 in vivo 15761153 - X 2 P36897-3 Q6PF15 in vivo 15761153 - X 2 Q6PF15 A0A024QZ47 two hybrid prey pooling approach 25416956 physical association X 2 Q6PF15 A0A024QZ47 two hybrid array 25416956 physical association X 2 Q6PF15 A0A024QZ47 validated two hybrid 25416956 physical association X 2 P13196 Q6PF15 two hybrid prey pooling approach 25416956 physical association X 2 P13196 Q6PF15 two hybrid array 25416956 physical association X 2 P13196 Q6PF15 validated two hybrid 25416956 physical association X 2 Q8IVD9 Q6PF15 luminescence based mammalian interactome mapping 25036637 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality ALAS1 KLHL35 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT MX1 KLHL35 25447205 0018 LC KLHL35 NUDCD3 25036637 0729 HT KLHL35 APPBP2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8IVD9 Q6PF15 NUDCD3 KLHL35 0.126 25036637 Q92624 Q6PF15 APPBP2 KLHL35 0.583 25416956,unassigned1304 Q8WUN7 Q6PF15 UBTD2 KLHL35 0.236 unassigned1304 Q6PF15 P13196 KLHL35 ALAS1 0.454 25416956 Q6PF15 O43639 KLHL35 NCK2 0.236 unassigned1304 Q6PF15 A6NEM1 KLHL35 GOLGA6L9 {ECO:0000312|HGNC:HGNC:37229} 0.236 unassigned1304 Q6PF15 Q13137 KLHL35 CALCOCO2 0.236 unassigned1304 Q6PF15 P20591 KLHL35 MX1 0.309 25447205

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 ALAS1 KLHL35 MI:0045 experimental interaction detection MI:0461 interaction database MX1 KLHL35 MI:0045 experimental interaction detection MI:0461 interaction database GRIK2 KLHL35 MI:0362 inference MI:0461 interaction database KLHL35 NUDCD3 MI:0045 experimental interaction detection MI:0461 interaction database KLHL35 APPBP2 MI:0045 experimental interaction detection MI:0461 interaction database