PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus E2F3 RNF144A 12411495 biogrid exp G G G G G G G G G G G G G G G G G G G G G G RNF144A E2F2 12411495 biogrid exp G GP G G G GP G G G P P G G G GP GP G P P G G G GP P RNF144A UBE2H 19549727 biogrid,intact exp G GP G G GP GP G GP G G GP P GP GP G GP GP GP GP G P G GP GP GP GP GP P G UBE2L6 RNF144A 11722579,19549727 biogrid,intact exp G GP G G GP GP G G GP G GP P GP GP G GP GP GP GP G P G GP G GP GP GP P G RNF144A E2F4 12411495 biogrid exp G GP G G G GP G G GP G GP P GP G G GP GP G GP G P G GP G GP G GP G RNF144A UBE2K 19549727 biogrid,intact exp G GP G G GP GP G GP GP G GP P GP GP G GP GP GP GP G P G GP GP GP GP GP P G RNF144A USP32 23105109 biogrid exp G GP G G G GP G GP GP G GP P GP G G GP GP G GP G P G G G GP G GP P G RNF144A RNF144A 24979766 biogrid exp G GP G G GP GP G GP GP G GP P GP GP G GP GP GP GP G P G GP GP GP GP GP P G RNF144A USP21 23105109 biogrid exp G GP G G G GP G GP GP G GP P GP G G GP GP G GP G P G GP G GP G GP P G RNF144A UBE2V2 19549727 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G RNF144A E2F1 12411495 biogrid exp GP G G GP GP G GP GP G GP P GP GP GP GP GP GP G P GP P GP P GP P G RNF144A CKAP4 26186194 biogrid exp G GP G G GP GP G G GP G GP GP GP G GP GP GP GP G P G GP G GP GP GP P G RNF144A UBE2V1 19549727 biogrid,intact exp RNF144A PRKDC 24979766 biogrid exp G GP G G GP GP G GP GP G GP P GP GP G GP GP GP GP G P G GP GP GP GP GP P G RNF144A UBE2L3 24979766,19549727,10431818, 25402006 hprd,biogrid,intact exp, ortho, pred G G G G G GP G GP GP G GP G G G GP GP G GP G G GP GP GP G GP P G RNF144A DHRSX ortho G GP G GP P G G P G P GP G G GP P GP GP G P G G GP G GP P G RNF144A CALN1 23023127 pred GP G P GP P P G P P G P GP P P P P P P P P UBOX5 RNF144A 25402006 pred G GP G G G GP G GP P G G GP GP G P GP G G G G GP P GP GP GP G RNF144A RNF144B 25402006 pred G GP G G G GP G GP GP G GP P GP G G GP GP GP GP G P G G G GP G G P G ARIH2 RNF144A 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G RNF144A SSH2 23023127 pred G GP G G GP GP G GP GP G GP P GP G G GP GP GP GP G P G GP GP GP GP GP P G RNF144A RNF220 23023127 pred G GP G G GP GP G G GP G GP P GP G G G GP G GP G P G GP GP G G GP G RNF144A DTX4 23023127 pred G GP G G G GP G G GP G GP G G G G GP G GP G P G GP G G G GP G RNF144A ARIH1 25402006 pred G GP G G GP GP G GP GP G GP P GP GP G GP GP GP GP G P G GP GP GP GP GP P G RNF144A EFHD1 23023127 pred G GP G G GP GP G G GP G GP GP GP G GP GP G GP G P G G G GP GP GP P G RNF144A UBE3A 25402006 pred G GP G G GP GP G GP GP G GP P GP GP G GP GP GP GP G P G GP GP GP GP GP P G RNF103 RNF144A 23023127 pred G GP G G GP GP G G GP G GP GP GP G GP GP GP GP G G G G GP G GP P G RNF144A RNF165 23023127 pred P G P GP P P G P P P P P GP P G P G P G P GP P P RNF144A RNF125 23023127 pred G GP G G GP GP G G GP G GP GP GP G GP GP GP GP G P G GP GP GP GP GP P G BMI1 RNF144A 23023127 pred P P P P P P P P P P P P P P P P P P P P TPPP RNF144A 23023127 pred G G G G G GP G G GP G GP GP G G G GP G GP G G G G G G G G RNF144A SLC25A23 23023127 pred G G G P GP G GP GP G GP P GP G G GP GP G GP G G GP G GP G GP P G RNF144A RNF141 23023127 pred G GP G G GP GP G GP GP G GP P GP GP G GP GP GP GP G P G GP GP GP GP GP P G RNF144A UNC13A 23023127 pred P G P GP G P G P P GP P G P P P P P RNF144A CCNB1IP1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G RNF144A RNFT2 23023127 pred P G P GP G P G P P P GP P G P P P P RNF144A UBQLN2 23023127 pred G GP G G GP GP G GP GP G GP P GP GP G GP GP GP GP G P G GP GP GP GP GP P G CBL RNF144A 25402006 pred G GP G G GP GP G G GP G GP GP GP G G GP GP G G G G G G GP G P G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8NFA0 P50876 two hybrid 23105109 direct interaction X 2 P61086 P50876 two hybrid 19549727 direct interaction X 2 P68037 P50876 two hybrid 11722579 direct interaction X 2 P68037 P50876 affinity chromatography technology 10431818 physical association X 2 P50876 P78527-2 affinity chromatography technology 24979766 physical association X 2 P50876 P78527-2 pull down 24979766 direct interaction X 2 P50876 P50876 enzymatic study 24979766 direct interaction X 2 P50876 P78527-2 enzymatic study 24979766 direct interaction X 2 P50876 Q14209 two hybrid 12411495 direct interaction X 2 P50876 Q01094 two hybrid 12411495 direct interaction X 2 P50876 Q16254 two hybrid 12411495 direct interaction X 2 P50876 Q13404 two hybrid 19549727 direct interaction X 2 A0A024R1A4 P50876 pull down 24979766 direct interaction X 2 A0A024R1A4 P50876 two hybrid 19549727 direct interaction X 2 P50876 O14933-2 two hybrid 11722579 direct interaction X 2 P50876 Q9UK80 two hybrid 23105109 direct interaction X 2 P50876 O00716 two hybrid 12411495 direct interaction X 2 P50876 O14933-2 two hybrid 19549727 direct interaction X 2 P50876 two hybrid 19549727 direct interaction X 2 P50876 A0M8W4 two hybrid 19549727 direct interaction X 2 P0CG48 P50876 affinity chromatography technology 24979766 physical association X 2 P68036-3 P50876 two hybrid 10431818 - X 2 P68036-3 P50876 in vivo 10431818 - X 2 P68036-3 P50876 two hybrid 10431818 - X 2 P68036-3 P50876 in vivo 10431818 - X 2 P50876 Q13404 two hybrid array 19549727 physical association X 2 O14933 P50876 two hybrid array 19549727 physical association X 2 A0A024R1A4 P50876 two hybrid array 19549727 physical association X 2 P50876 A0M8W4 two hybrid array 19549727 physical association X 2 B3KSH4 P50876 two hybrid array 19549727 physical association X 2 A4D1L5 P50876 two hybrid array 19549727 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B RNF144A USP21 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248213 prey bait UBE2L6 RNF144A MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 11722579,19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(biogrid)|(biogrid) UniProt_101123|BIOGRID_124184|BIOGRID_207636 bait|bait|bait prey|prey|prey RNF144A E2F2 MI:0018(two hybrid) 12411495 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_99956 prey bait RNF144A UBE2L3 MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid) 10431818,19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0407(direct interaction) MI:0468(hprd)|(intact)|(biogrid) HPRD_12618|UniProt_101101|BIOGRID_124183 -|prey|prey -|bait|bait E2F3 RNF144A MI:0018(two hybrid) 12411495 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_99962 bait prey RNF144A UBE2V1 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101399|BIOGRID_124490 prey|prey bait|bait RNF144A UBE2K MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_124492 prey bait RNF144A E2F4 MI:0018(two hybrid) 12411495 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_99963 prey bait RNF144A UBE2H MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101338|BIOGRID_124489 prey|prey bait|bait RNF144A E2F1 MI:0018(two hybrid) 12411495 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_99958 prey bait RNF144A UBE2V2 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101413|BIOGRID_124491 prey|prey bait|bait RNF144A HIP2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_101195 prey bait RNF144A USP32 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248224 prey bait

PPI - HINT Gene A Gene B PMID Method Quality RNF144A CKAP4 26186194 0004 HT RNF144A CKAP4 26186194 0004 HT HIP2 RNF144A 19549727 0397 HT E2F3 RNF144A 12411495 0018 LC UBE2L6 RNF144A 11722579,19549727,19549727 0018,0397,0018 LC,HT RNF144A RNF144A 26216882,26216882,24979766 0415,0004,0415 LC RNF144A UBE2K 19549727 0018 HT RNF144A UBE2H 19549727,19549727 0397,0018 HT RNF144A UBE2L3 10431818,19549727,19549727 0018,0397,0018 LC,HT RNF144A PRKDC 24979766,24979766,24979766 0004,0415,0096 LC RNF144A E2F1 12411495 0018 LC RNF144A UBE2V1 19549727,19549727 0397,0018 HT RNF144A E2F2 12411495 0018 LC RNF144A UBE2V2 19549727,19549727 0397,0018 HT RNF144A E2F4 12411495 0018 LC RNF144A USP32 23105109 0018 LC RNF144A Q9BSD8 12411495 0018 LC RNF144A USP21 23105109 0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P61086 P50876 UBE2K RNF144A 0.183 19549727 Q8NFA0 P50876 USP32 RNF144A 0.183 23105109 Q96EQ0 P50876 SGTB RNF144A 0.236 unassigned1304 Q13404 P50876 UBE2V1 RNF144A 0.286 19549727 P68037 P50876 UBE2L3 RNF144A 0.454 10431818,11722579 P50876 O43765 RNF144A SGTA 0.236 unassigned1304 P50876 P50876 RNF144A RNF144A 0.659 26216882,24979766 P78527 P50876 PRKDC RNF144A 0.623 24979766 Q9UK80 P50876 USP21 RNF144A 0.183 23105109 Q14209 P50876 E2F2 RNF144A 0.309 12411495 Q01094 P50876 E2F1 RNF144A 0.309 12411495 P50876 B3KSH4 RNF144A HIP2 0.126 19549727 P50876 O14933 RNF144A UBE2L6 0.507 19549727,11722579 P62256 P50876 UBE2H RNF144A 0.376 19549727 P68036 P50876 UBE2L3 RNF144A 0.507 19549727,24979766 Q07065 P50876 CKAP4 RNF144A 0.126 26186194 Q15819 P50876 UBE2V2 RNF144A 0.376 19549727 Q16254 P50876 E2F4 RNF144A 0.309 12411495 P50876 O00716 RNF144A E2F3 0.309 12411495

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 E2F3 RNF144A MI:0045 experimental interaction detection MI:0461 interaction database UBE2L6 RNF144A MI:0045 experimental interaction detection MI:0461 interaction database UBC RNF144A MI:0045 experimental interaction detection MI:0461 interaction database RNF144A UBE2K MI:0045 experimental interaction detection MI:0461 interaction database RNF144A UBE2H MI:0045 experimental interaction detection MI:0461 interaction database RNF144A SKP1 MI:0362 inference MI:0461 interaction database RNF144A UBE2L3 MI:0045 experimental interaction detection MI:0461 interaction database RNF144A PRKDC MI:0045 experimental interaction detection MI:0461 interaction database RNF144A E2F1 MI:0045 experimental interaction detection MI:0461 interaction database RNF144A CKAP4 MI:0045 experimental interaction detection MI:0461 interaction database RNF144A UBE2V1 MI:0045 experimental interaction detection MI:0461 interaction database RNF144A E2F2 MI:0045 experimental interaction detection MI:0461 interaction database RNF144A UBE2V2 MI:0045 experimental interaction detection MI:0461 interaction database RNF144A E2F4 MI:0045 experimental interaction detection MI:0461 interaction database RNF144A SPG20 MI:0362 inference MI:0461 interaction database RNF144A USP32 MI:0045 experimental interaction detection MI:0461 interaction database RNF144A ACBD3 MI:0362 inference MI:0461 interaction database RNF144A USP21 MI:0045 experimental interaction detection MI:0461 interaction database