PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus UBE3A SACS 23671107 biogrid exp G GP G G GP GP G GP GP G P P GP GP G GP GP GP GP G P GP GP GP GP GP GP GP G PTBP3 SACS 22575643 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G PSMA3 SACS 19208651 biogrid exp G GP G G GP GP G GP GP G P P GP G G GP GP G GP G P GP GP G GP G GP GP G SACS ZNRD1 16713569 hprd,biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G ACTN4 SACS 16713569 hprd,biogrid,mint,intact exp G GP G G GP GP G GP GP G P P GP GP G GP GP GP GP G P GP GP GP GP GP GP GP G PLK1 SACS 26496610 biogrid,intact exp P G G GP P G GP GP P P P GP GP GP GP GP G P P GP GP GP P P GP TRIM29 SACS 26496610 biogrid,intact exp G G G G G GP G G G G GP G G GP G GP G P GP GP G G G G G G TP63 SACS 20085233 biogrid,intact exp G G G G G G G G G G G G G G G G G P GP G G G G G SACS TSC22D4 16713569 hprd,biogrid,mint,intact exp G G G G GP G G G GP G P P GP GP G GP G GP GP G P GP GP G GP GP GP GP G ALB SACS 15174051 biogrid,intact exp P P P P P P P P P GP P P G GP P MYC SACS 21150319 i2d,intact exp G GP G GP P G GP GP P P GP GP G GP P GP GP P GP GP GP GP GP GP GP G ENPP6 SACS 26186194 biogrid exp GP G P GP G P P GP GP G G G P P P PPP1CA SACS 19389623 intact exp G GP G G GP GP G G GP G P GP GP G GP GP G GP G P GP GP G GP GP GP GP G PICK1 SACS 16713569 hprd,biogrid,mint,intact exp G GP G G G GP G GP GP G P P GP GP G GP GP GP GP G P GP GP GP GP G GP GP G CCDC8 SACS 24711643 biogrid exp G GP G G GP GP G GP GP G P P GP GP G GP GP GP GP G P GP GP GP GP GP GP GP G SHROOM2 SACS 23023127 pred G GP G G GP GP G GP GP G P P GP GP G GP GP GP GP G P GP GP GP GP GP GP GP G SACS BAG5 23023127 pred G GP G G GP GP G GP GP G P P GP GP G GP GP GP GP G P GP GP GP GP GP GP GP G PARK2 SACS 23023127 pred GP G P GP G GP GP G P P P G P GP GP P G P GP GP GP P GP G BAG4 SACS 23023127 pred G GP G G GP GP G GP GP G P P GP GP G GP GP GP GP G P GP GP GP GP GP GP GP G HSPA1A, HSPA1B SACS 23023127 pred P P P P P P P P P P P P P P P P P P P P P SACS BAIAP2 23023127 pred P G G GP GP G GP P G P P GP GP P GP GP GP G P GP P P P P GP GP G TERF1 SACS 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G SGCG SACS 21836163 pred G GP G G GP G DNAJB2 SACS 23023127 pred G GP G G GP GP G G GP G P P GP G G GP GP GP GP G P GP GP GP GP GP GP GP G SACS SNCAIP 23023127 pred G GP G P GP P GP P P P GP G P GP GP P P GP P P P GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9Y3Q8 Q9NZJ4 two hybrid 16713569 direct interaction X 2 P0CG48 Q9NZJ4 affinity chromatography technology 19208651 physical association X 2 P0CG48 Q9NZJ4 affinity chromatography technology 23000965 physical association X 2 P0CG48 Q9NZJ4 affinity chromatography technology 24816145 physical association X 2 P0CG48 Q9NZJ4 affinity chromatography technology 20972266 physical association X 2 P0CG48 Q9NZJ4 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q9NZJ4 affinity chromatography technology 21906983 physical association X 2 Q9NZJ4 Q2L6J2 two hybrid 16713569 direct interaction X 2 Q9NZJ4 A0A024R1J5 two hybrid 16713569 direct interaction X 2 Q9NZJ4 Q9H3D4-7 affinity chromatography technology 20085233 physical association X 2 Q9NZJ4 affinity chromatography technology 19389623 physical association X 2 O43707 Q9NZJ4 two hybrid 16713569 direct interaction X 2 P02768 Q9NZJ4 affinity chromatography technology 15174051 physical association X 2 Q9H0W5 Q9NZJ4 affinity chromatography technology 24711643 physical association X 2 Q9NZJ4 Q05086 pull down 23671107 direct interaction X 2 P25788-2 Q9NZJ4 affinity chromatography technology 19208651 physical association X 2 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 129 Q9NZJ4 - 15174051 - C 128 Q9NZJ4 - 15174051 - C 128 Q9Y3Q8 Q9NZJ4 two hybrid 16713569 - X 2 Q9Y3Q8 Q9NZJ4 two hybrid 16713569 - X 2 Q9NZJ4 A0A024R1J5 two hybrid 16713569 - X 2 Q9NZJ4 Q2L6J2 two hybrid 16713569 - X 2 Q9NZJ4 Q2L6J2 two hybrid 16713569 - X 2 Q9NZJ4 A0A024R1J5 two hybrid 16713569 - X 2 O43707 Q9NZJ4 two hybrid 16713569 - X 2 O43707 Q9NZJ4 two hybrid 16713569 - X 2 Q9NZJ4 - 15174051 - C 128 Q9NZJ4 anti tag coimmunoprecipitation 20085233 association C 49 Q9NZJ4 anti bait coimmunoprecipitation 22575643 association C 122 Q9NZJ4 anti bait coimmunoprecipitation 15174051 association C 64 Q9Y3Q8 Q9NZJ4 two hybrid array 16713569 physical association X 2 Q9NZJ4 A0A024R1J5 two hybrid 16713569 physical association X 2 Q9NZJ4 Q2L6J2 two hybrid array 16713569 physical association X 2 O43707 Q9NZJ4 two hybrid 16713569 physical association X 2 P62136 Q9NZJ4 pull down 19389623 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B PICK1 SACS MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0096(pull down)|MI:0096(pull down) 16713569 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|(intact)|MI:0471(mint)|MI:0471(mint) HPRD_34417|BIOGRID_215912|UniProt_86491|MINT_50460|MINT_82748 -|prey|prey|prey|prey -|bait|bait|bait|bait TP63 SACS MI:0004(affinity chromatography technology) 20085233 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_256003 bait prey TSC22D4 SACS MI:0096(pull down)|MI:0096(pull down) 16713569 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint) MINT_83157|MINT_50869 prey|prey bait|bait ACTN4 SACS MI:0096(pull down)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0397(two hybrid array)|MI:0018(two hybrid) 16713569 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|- MI:0471(mint)|(biogrid)|MI:0471(mint)|(intact)|MI:0468(hprd) MINT_50043|BIOGRID_215911|MINT_82331|UniProt_86490|HPRD_27227 prey|prey|prey|prey|- bait|bait|bait|bait|- NRF1 SACS MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_296229 bait prey SACS ZNRD1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0397(two hybrid array) 16713569 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|(intact) HPRD_34648|BIOGRID_215393|UniProt_85816 -|bait|prey -|prey|bait UBE3A SACS MI:0096(pull down) 23671107 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_282411 prey bait SACS TSC22D4 MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0018(two hybrid) 16713569 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0407(direct interaction) MI:0468(hprd)|(intact)|(biogrid) HPRD_34655|UniProt_85815|BIOGRID_215392 -|prey|bait -|bait|prey PPP1CA SACS MI:0047(far western blotting) 19389623 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (intact) UniProt_98407 bait prey Q5SRJ4 SACS MI:0096(pull down)|MI:0096(pull down) 16713569 taxid:0() taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint) MINT_82994|MINT_50706 prey|prey bait|bait PSMA3 SACS MI:0004(affinity chromatography technology) 19208651 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_209728 prey bait ALB SACS MI:0493(in vivo)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology) 15174051 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0914(association)|MI:0915(physical association) MI:0468(hprd)|(intact)|(biogrid) HPRD_39998|UniProt_77086|BIOGRID_252149 -|bait|bait -|prey|prey UBC SACS MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19208651,20972266,21139048,21906983,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_164274|BIOGRID_172151|BIOGRID_181256|BIOGRID_270365|BIOGRID_209729 bait|bait|bait|bait|prey prey|prey|prey|prey|bait

PPI - HINT Gene A Gene B PMID Method Quality PLK1 SACS 26496610,26496610 0007,0004 HT TRIM29 SACS 26496610,26496610 0007,0004 HT ENPP6 SACS 26186194 0004 HT PLK1 SACS 26496610,26496610 0007,0004 HT TRIM29 SACS 26496610,26496610 0007,0004 HT ENPP6 SACS 26186194 0004 HT ACTN4 SACS 16713569 0018 HT PICK1 SACS 16713569 0018 HT SACS SACS 21507954 0114 LC SACS ZNRD1 16713569,16713569 0397,0018 HT SACS TSC22D4 16713569,16713569 0397,0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NZJ4 P62139 SACS PPP1CA 0.126 19389623 Q9NZJ4 O43707 SACS ACTN4 0.454 16713569 Q9NZJ4 Q9NRD5 SACS PICK1 0.332 16713569 Q9NZJ4 Q9H0W5 SACS CCDC8 0.126 24711643 Q9NZJ4 P25788 SACS PSMA3 0.21 19208651 Q9NZJ4 Q05086 SACS UBE3A 0.309 23671107 Q9NZJ4 Q6UWR7 SACS ENPP6 0.126 26186194 Q9NZJ4 P01106 SACS MYC 0.126 21150319 Q9NZJ4 O95758 SACS PTBP3 0.126 22575643 Q9QY36 Q9NZJ4 NAA10 SACS 0.236 26496610 Q9P1U0 Q9NZJ4 ZNRD1 SACS 0.286 16713569 Q9Y3Q8 Q9NZJ4 TSC22D4 SACS 0.286 16713569 Q9NZJ4 P02768 SACS ALB 0.236 15174051 Q9NZJ4 Q9H3D4 SACS TP63 0.236 20085233 Q9NZJ4 Q14134 SACS TRIM29 0.126 26496610 Q9NZJ4 P53350 SACS PLK1 0.126 26496610

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 ACTN4 SACS MI:0045 experimental interaction detection MI:0461 interaction database PTBP3 SACS MI:0045 experimental interaction detection MI:0461 interaction database MYC SACS MI:0045 experimental interaction detection MI:0461 interaction database ALB SACS MI:0045 experimental interaction detection MI:0461 interaction database UBC SACS MI:0045 experimental interaction detection MI:0461 interaction database PSMA3 SACS MI:0045 experimental interaction detection MI:0461 interaction database NAA10 SACS MI:0362 inference MI:0461 interaction database PLK1 SACS MI:0045 experimental interaction detection MI:0461 interaction database ATXN3 SACS MI:0362 inference MI:0461 interaction database PPP1CA SACS MI:0045 experimental interaction detection MI:0461 interaction database UBE3A SACS MI:0045 experimental interaction detection MI:0461 interaction database TRIM29 SACS MI:0045 experimental interaction detection MI:0461 interaction database ENPP6 SACS MI:0045 experimental interaction detection MI:0461 interaction database CCDC8 SACS MI:0045 experimental interaction detection MI:0461 interaction database TP63 SACS MI:0045 experimental interaction detection MI:0461 interaction database ATXN3L SACS MI:0362 inference MI:0461 interaction database PICK1 SACS MI:0045 experimental interaction detection MI:0461 interaction database SACS ZNRD1 MI:0045 experimental interaction detection MI:0461 interaction database SACS TSC22D4 MI:0045 experimental interaction detection MI:0461 interaction database