PTM - CPLM Gene Name UniProt ID Type Position Code SACS; KIAA0730 Q9NZJ4 Acetylation 943 K SACS; KIAA0730 Q9NZJ4 Acetylation 2334 K SACS; KIAA0730 Q9NZJ4 Acetylation 2358 K SACS; KIAA0730 Q9NZJ4 Acetylation 4135 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 2414 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 714 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 1274 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 1733 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 514 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 434 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 4419 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 4439 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 722 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 2000 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 406 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 987 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 928 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 1465 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 361 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 943 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 905 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 854 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 625 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 982 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 4578 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 2043 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 853 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 289 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 291 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 3918 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 2709 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 1802 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 3894 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 2195 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 2197 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 1435 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 1989 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 955 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 533 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 1342 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 1715 K SACS; KIAA0730 Q9NZJ4 Ubiquitination 1797 K

PTM - dbPAF Gene Name UniProt ID Position Type Species SACS; KIAA0730 Q9NZJ4 1220 S Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 1706 S Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 1711 T Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 1779 S Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 1910 T Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 1911 T Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 1997 S Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 2139 Y Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 2320 Y Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 2322 Y Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 2509 Y Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 2511 S Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 3124 T Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 3177 Y Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 3367 Y Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 338 S Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 3435 S Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 3463 Y Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 3477 Y Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 3775 S Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 4177 Y Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 4181 Y Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 4251 S Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 4257 S Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 4260 S Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 4261 T Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 4263 T Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 4264 S Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 4266 T Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 4270 T Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 4289 S Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 4290 S Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 4294 S Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 4302 S Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 4333 Y Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 437 T Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 438 S Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 441 S Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 4428 Y Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 593 Y Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 621 T Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 898 T Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 909 S Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 914 S Homo sapiens(Human) SACS; KIAA0730 Q9NZJ4 989 T Homo sapiens(Human)

PTM - PhosSNP Gene Name dbSNP ID Gene Mutation AA Mutation Mutation Position Code Peptide Score Modification Type SACS; KIAA0730 rs17078605 GTC->GCC V->A 3367 Y SILKALHYMVQTSTF 3367 Phosphorylation TypeIII-

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q9NZJ4 K70-ac Acetylation KIGDLTSkNCHLFVN Q9NZJ4 K186-ac Acetylation RKKDDPLkVGRFGIG Q9NZJ4 K943-ac Acetylation QGISSYTkLKGCKVL Q9NZJ4 K1737-ac Acetylation SVLKEAAkLMKTCSS Q9NZJ4 K2334-ac Acetylation LMQNEITkMSIIDKL Q9NZJ4 K2358-ac Acetylation NAYVDSEkVSFHLNF Q9NZJ4 K2495-ac Acetylation IPREVAVkLGAVPkR Q9NZJ4 K2501-ac Acetylation VkLGAVPkRHKALER Q9NZJ4 K1435-m1 Methylation MKTAEWLkVPCLSTR Q9NZJ4 R4374-m1 Methylation FLDQNADrASRRTFS Q9NZJ4 K4439-m1 Methylation FFVPPTFkSVGNPVE Q9NZJ4 S338-p Phosphorylation FRVTSSEsKALKHER Q9NZJ4 T898-p Phosphorylation QITSLLPtHKDALRK Q9NZJ4 S909-p Phosphorylation ALRKFLAsLTDSsEK Q9NZJ4 S914-p Phosphorylation LAsLTDSsEKEKRII Q9NZJ4 T989-p Phosphorylation KIEQLKTtSCLKLVL Q9NZJ4 S1706-p Phosphorylation KIEETNPsLAQDtVI Q9NZJ4 T1711-p Phosphorylation NPsLAQDtVIIkKKS Q9NZJ4 S1779-p Phosphorylation RRIADLQsPLFRGPD Q9NZJ4 S1809-p Phosphorylation KKPSDELsQKTVECT Q9NZJ4 T1910-p Phosphorylation DTKGRWNttFMRHVI Q9NZJ4 T1911-p Phosphorylation TKGRWNttFMRHVIV Q9NZJ4 S1997-p Phosphorylation NVRFLDDsILKRRDV Q9NZJ4 Y2139-p Phosphorylation PYGSTQDyLNPIILI Q9NZJ4 Y2509-p Phosphorylation RHKALERyAsNVCFT Q9NZJ4 S2511-p Phosphorylation KALERyAsNVCFTTL Q9NZJ4 T3124-p Phosphorylation LPCRLQQtNLKLFHS Q9NZJ4 Y3177-p Phosphorylation RPKFLTTyHELIPSR Q9NZJ4 Y3367-p Phosphorylation SILKALHyMVQTSTF Q9NZJ4 S3435-p Phosphorylation TCYVLTKsIPSAEVE Q9NZJ4 Y3463-p Phosphorylation KIHLKELyEVIGCVP Q9NZJ4 Y3477-p Phosphorylation PVDDLEVyLKHLLPK Q9NZJ4 Y4177-p Phosphorylation MDPMNVFyPGEyVGY Q9NZJ4 Y4181-p Phosphorylation NVFyPGEyVGYLVDA Q9NZJ4 S4251-p Phosphorylation KFSRPEEsSQSRDsA Q9NZJ4 S4257-p Phosphorylation EsSQSRDsAPstPts Q9NZJ4 S4260-p Phosphorylation QSRDsAPstPtsPtE Q9NZJ4 T4261-p Phosphorylation SRDsAPstPtsPtEF Q9NZJ4 T4263-p Phosphorylation DsAPstPtsPtEFLt Q9NZJ4 S4264-p Phosphorylation sAPstPtsPtEFLtP Q9NZJ4 T4266-p Phosphorylation PstPtsPtEFLtPGL Q9NZJ4 T4270-p Phosphorylation tsPtEFLtPGLRSIP Q9NZJ4 S4302-p Phosphorylation PKKLKVNsLPEILKE Q9NZJ4 Y4333-p Phosphorylation KKIIRRLyLKWHPDK Q9NZJ4 Y4428-p Phosphorylation PPSAGQTySQRFFVP Q9NZJ4 K406-ub Ubiquitination GGRGISSkLDSLADE Q9NZJ4 K533-ub Ubiquitination LSVDVIYkLWPEASK Q9NZJ4 K1342-ub Ubiquitination VIQKIYLkSDQDLSE Q9NZJ4 K1435-ub Ubiquitination MKTAEWLkVPCLSTR Q9NZJ4 K1715-ub Ubiquitination AQDtVIIkKKSCSSK Q9NZJ4 K1797-ub Ubiquitination AALFEMAkSGQSKKP Q9NZJ4 K2414-ub Ubiquitination IDQERGTkQITEENF

PTM - dbPTM UniProt ID Position Code Type Resources References Q9NZJ4 338 S Phosphorylation Swiss-Prot 1010711 19413330 Q9NZJ4 943 K Acetylation Swiss-Prot 1010711 19608861 Q9NZJ4 4264 S Phosphorylation Swiss-Prot 1010711 19690332 Q9NZJ4 4333 Y Phosphorylation Swiss-Prot 1010711 18083107 Q9NZJ4 4264 S Phosphorylation PhosphoELM.10011 18669648 Q9NZJ4 4266 T Phosphorylation PhosphoELM.10011 18669648 Q9NZJ4 4333 Y Phosphorylation PhosphoELM.10011 18083107 Q9NZJ4 1342 K Ubiquitylation Phosphositeplus.1010730 21906983 Q9NZJ4 1715 K Ubiquitylation Phosphositeplus.1010730 21906983 Q9NZJ4 1797 K Ubiquitylation Phosphositeplus.1010730 21906983 Q9NZJ4 406 K Ubiquitylation Phosphositeplus.1010730 20972266;21906983 Q9NZJ4 533 K Ubiquitylation Phosphositeplus.1010730 21906983 Q9NZJ4 2334 K Acetylation Phosphositeplus.1010730 20167786 Q9NZJ4 2358 K Acetylation Phosphositeplus.1010730 20167786 Q9NZJ4 943 K Acetylation Phosphositeplus.1010730 19608861 Q9NZJ4 1779 S Phosphorylation Phosphositeplus.1010730 19664994;19690332;20068231;20393185;21659604 Q9NZJ4 1997 S Phosphorylation Phosphositeplus.1010730 21406692 Q9NZJ4 3435 S Phosphorylation Phosphositeplus.1010730 21406692 Q9NZJ4 4264 S Phosphorylation Phosphositeplus.1010730 19690332 Q9NZJ4 4302 S Phosphorylation Phosphositeplus.1010730 20068231 Q9NZJ4 4266 T Phosphorylation Phosphositeplus.1010730 18669648 Q9NZJ4 2320 Y Phosphorylation Phosphositeplus.1010730 18083107 Q9NZJ4 2322 Y Phosphorylation Phosphositeplus.1010730 18083107 Q9NZJ4 3177 Y Phosphorylation Phosphositeplus.1010730 19835603 Q9NZJ4 4333 Y Phosphorylation Phosphositeplus.1010730 18083107 Q9NZJ4 593 Y Phosphorylation Phosphositeplus.1010730 18083107 Q9NZJ4 943 K Acetylation HPRD 9.0 19608861 Q9NZJ4 338 S Phosphorylation HPRD 9.0 19413330 Q9NZJ4 1779 S Phosphorylation HPRD 9.0 19664994,20068231 Q9NZJ4 4264 S Phosphorylation HPRD 9.0 18669648,20068231 Q9NZJ4 4302 S Phosphorylation HPRD 9.0 20068231 Q9NZJ4 4266 T Phosphorylation HPRD 9.0 18669648 Q9NZJ4 4333 Y Phosphorylation HPRD 9.0 18083107

PTM - HPRD Symbol Position Code Type References SACS 1779 S Phosphorylation 19664994,20068231 SACS 338 S Phosphorylation 19413330 SACS 4264 S Phosphorylation 18669648,20068231 SACS 4266 T Phosphorylation 18669648 SACS 4302 S Phosphorylation 20068231 SACS 4333 Y Phosphorylation 18083107 SACS 943 K Acetylation 19608861

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q9NZJ4 4333 Y 18083107 HTP Phosphorylation Q9NZJ4 4264 S 18669648 HTP Phosphorylation Q9NZJ4 4266 T 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q9NZJ4 943 N6-acetyllysine 19608861 Q9NZJ4 1779 Phosphoserine 19690332;20068231;23186163 Q9NZJ4 3435 Phosphoserine 21406692 Q9NZJ4 4264 Phosphoserine 19690332;23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type SACS IPI00784002 K 796 GISSYTaKLKGCKV acetylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 26278 117661 - K Ubiquitination 20972266 26278 117661 - K Ubiquitination 21139048 26278 117661 - K Ubiquitination 21906983 26278 117661 - K Ubiquitination 23000965 26278 117661 - K Ubiquitination 24816145

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID SACS Homo sapiens (Human) 259; 1195; 386; 1650; 1568 "259,GRGISSKLDSLAD; 1195,IQKIYLKSDQDLS; 386,SVDVIYKLWPEAS; 1650,ALFEMAKSGQSKK; 1568,QDTVIIKKKSCSS" 259:21906983; 1195:21906983; 386:21906983; 1650:21906983; 1568:21906983 SACS Homo sapiens (Human) 533; 1715; 1342; 1797; 406 "533,SVDVIYKLWPEAS; 1715,QDTVIIKKKSCSS; 1342,IQKIYLKSDQDLS; 1797,ALFEMAKSGQSKK; 406,GRGISSKLDSLAD" 533:21906983; 1715:21906983; 1342:21906983; 1797:21906983; 406:21906983 SACS Homo sapiens (Human) 433 "433,SVDVIYKLWPEAS" 433:21906983 SACS Homo sapiens (Human) 406 "406,GRGISSKLDSLAD" 406:20972266 SACS Homo sapiens (Human) 157; 30 "157,SVDVIYKLWPEAS; 30,GRGISSKLDSLAD" 157:21906983; 30:21906983