PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus PENK ANAPC1 26186194 biogrid exp P P P P P P P P P P P P P P P P P P P KNG1 ANAPC1 26186194 biogrid exp P P TTLL1 ANAPC1 26186194 biogrid exp P P P P P P P P P P P P P P P P P P COPS2 ANAPC1 19535905 biogrid exp P P P P P P P P P P P P P P P P P P GRAP2 ANAPC1 26186194 biogrid exp P P P P P P P P P P P P P ANAPC1 PHF8 23979597 biogrid exp P P P P P P P P P P P P P P P P P P P LIPH ANAPC1 26186194 biogrid exp P P P P P P P P P P P P PIFO ANAPC1 26186194 biogrid exp P P P P P P P P P P P P P ANAPC1 TRIM33 23160376 biogrid exp P P P P P P P P P P P P P P P P P P FOXQ1 ANAPC1 25609649 intact exp P P P P P P P P P P P P P P P ANAPC1 LATS2 24255178 biogrid exp P P P P P P P P P P P P P P P P P P ANAPC1 CFAP97 26496610 biogrid,intact exp P P P P P P P P P P P P P P P P P P P CDC5L ANAPC1 20467437 intact exp P P P P P P P P P P P P P P P P P P P TCF4 ANAPC1 25609649 intact exp P P P P P P P P P P P P P P P P P P P CEP19 ANAPC1 26638075 biogrid,intact exp P P P P P P P P NCL ANAPC1 26344197 biogrid exp P P P P P P P P P P P P P P P P P P P NTRK1 ANAPC1 25921289 biogrid exp P P P P P P P P P P P P P P P P SNW1 ANAPC1 20467437 intact exp P P P P P P P P P P P P P P P P P P P ANAPC1 MAGIX 26186194 biogrid exp TAF4 ANAPC1 26344197 biogrid exp P P P P P P P P P P P P P P P P P P P NAP1L4 ANAPC1 26344197 biogrid exp P P P P P P P P P P P P P P P P P P SOX2 ANAPC1 23667531 biogrid exp P P P P P P P P P P P P P P P P P P ANAPC1 NXF1 22658674 biogrid exp P P P P P P P P P P P P P P P P P P P ANAPC1 HECW2 24163370 biogrid exp P P P P P P P P P P P P P P P P P P MED19 ANAPC1 15175163 intact exp P P P P P P P P P P P P P P P P P P P SIRT6 ANAPC1 24169447 biogrid exp BUB3 ANAPC1 20360068 intact exp P P P P P P P P P P P P P P P P P P P PAXIP1 ANAPC1 22990118 biogrid exp P P P P P P P P P P P P P P P P P P P CCDC13 ANAPC1 24816561 intact exp P P P P P P P P P P P P P P P P P ANAPC1 SMARCAD1 21549307 biogrid exp P P P P P P P P P P P P P P P P P P P CEP120 ANAPC1 26638075 biogrid,intact exp P P P P P TP53BP1 ANAPC1 22990118 biogrid exp P P P P P P P P P P P P P P P P P P P MAP1LC3B ANAPC1 20562859 intact exp P P P P P P P P P P P P ANAPC1 RPAP3 17643375 biogrid exp P P P P P P P P P P P P P P P P P P P RPAP1 ANAPC1 17643375 biogrid exp P P P P P P P P P P P P P P P P P P P ANAPC1 SIRT7 22586326 biogrid exp P P P P P P P P P P P P P P P P P UBC ANAPC1 23314748 biogrid exp P P P P P P P P P P P P P P P P P P P MDC1 ANAPC1 17827148,22990118,19826003 biogrid exp P P P P P P P P P P P P P P P P P P P USP1 ANAPC1 21768287 biogrid exp P P P P P P P P P P P P P P P ANAPC15 ANAPC1 26496610,23007861 biogrid,intact exp P P P P P P P P P P P P P P P P P P ANAPC1 MOV10 22658674 biogrid exp NOTCH1 ANAPC1 23022380 biogrid exp, ortho P P P P P P P P P P P P P P P P P P P ANAPC1 ANAPC7 11076961,26344197,22939629,20360068, 25402006 biogrid,intact exp, pred P P P P P P P P P P P P P P P P P P P CDC16 ANAPC1 11076961,26344197,22939629,26496610,20360068, 25402006, 21836163 biogrid,intact exp, pred P P P P P P P P P P P P P P P P P P P ANAPC1 CDC23 11076961,22939629,26496610,20360068, 25402006, 16082366 biogrid,intact exp, pred P P P P P P P P P P P P P P P P P P ANAPC1 ANAPC2 10922056,11076961,22939629,12956947,20360068, 25402006 biogrid,intact exp, pred P P P P P P P P P P P P P P P P P ANAPC1 FZR1 12956947, 25402006 biogrid exp, pred P P P P P P P P P P P P P P BUB1B ANAPC1 25852190,20360068, 25402006, 21836163 biogrid,intact exp, pred P P P P P P P P P P P P P P P P P P P MAD2L1 ANAPC1 26496610, 25402006 biogrid,intact exp, pred P P P P P P P P P P P P P P P P CDC26 ANAPC1 26344197,22939629,20360068, 25402006 biogrid,intact exp, pred P P P P P P P P P P P P P P P P P P NEK2 ANAPC1 23288039, 25402006 intact exp, pred P P P P P P P P P P P P P P ANAPC16 ANAPC1 26344197,20360068, 25402006 biogrid,intact exp, pred P P P P P P P P P P P P P P P P P P P ANAPC1 ANAPC4 25490258,26344197,22939629,12956947,25043029,23078409,20360068,26083744,11076961,24464857, 25402006 biogrid,intact exp, pred P P P P P P P P P P P P P P P P P P P ANAPC1 ANAPC10 22939629,20360068, 25402006 biogrid,intact exp, pred P P P P P P P P P P P P P P P P P ANAPC1 ANAPC5 11076961,26344197,22939629,12956947,20360068, 25402006 biogrid,intact exp, pred P P P P P P P P P P P P P P P P P P P CDC27 ANAPC1 26344197,22939629,20686030,12956947,20360068,16364912,11076961,21043528,17942546,22193957, 25402006 biogrid,intact exp, pred P P P P P P P P P P P P P P P P P P ANAPC13 ANAPC1 20360068, 25402006 intact exp, pred P P P P P P P P P P P P P P P P P P P ANAPC1 FBXO5 16921029, 25402006 biogrid exp, pred P P P P P P P P P P P P P P P P P P P CDC20 ANAPC1 24464857,11438673,18997788,20360068, 25402006, 21836163 hprd,biogrid,intact exp, pred P P P P P P P P P P DYNLT1 ANAPC1 ortho YWHAE ANAPC1 ortho P P P P P P P P P P P P P P P P P P P NTN1 ANAPC1 ortho P P P P P P P P P P P P P P P P NCAM1 ANAPC1 ortho P P P P P P P ANAPC1 INO80 ortho PPP5C ANAPC1 ortho P P P P P P P P P P P P P P P P P P P ADAM19 ANAPC1 ortho P P P P P P CTNNB1 ANAPC1 ortho P P P P P P P P P P P P P P P P P ANAPC1 PPARGC1A 25402006 ortho, pred PSMD3 ANAPC1 21836163 pred P P P P P P P P P P P P P P P P P P P UBE2S ANAPC1 25402006, 23023127 pred P P P PSMB2 ANAPC1 21836163 pred P P P P P P P P P P P P P P P P P P P ANAPC1 ANAPC11 25402006 pred P P P P P P P P P P P P P P P P P P P PSMB1 ANAPC1 21836163 pred P P P P P P P P P P P P P P P P P P P PSMD9 ANAPC1 21836163 pred P P P P P P P P P P P P P P P P P P P CCNB1 ANAPC1 25402006 pred P P P P P P P P P P P PSMA6 ANAPC1 21836163 pred P P P P P P P P P P P P P P P P P P PSMD1 ANAPC1 21836163 pred P P P P P P P P P P P P P P P P P P P PSMA1 ANAPC1 21836163 pred P P P P P P P P P P P P P P P P P P P PSMD8 ANAPC1 21836163 pred P P P P P P P P P P P P P P P P P P PSMC2 ANAPC1 21836163 pred P P P P P P P P P P P P P P P P P P P ANAPC1 RASSF1 25402006 pred P P P P P P P P P P P P P P P P P P P PSMA5 ANAPC1 21836163 pred P P P P P P P P P P P P P P P P P P P UBE2C ANAPC1 25402006 pred P P P P P P P P P P P P P P P P P P P PSMB6 ANAPC1 21836163 pred P P P P P P P P P P P P P P P P P P P PSMA2 ANAPC1 21836163 pred P P P P P P P P P P P P P P P P P P ANAPC1 MAD2L2 25402006 pred P P P P P P P P P P P P P P P P P P PSMB10 ANAPC1 21836163 pred P P P P P P P P P P P P P P PSMA3 ANAPC1 21836163 pred P P P P P P P P P P P P P P P P P PSMB5 ANAPC1 21836163 pred P P P P P P P P P PSMB8 ANAPC1 21836163 pred PSMC3 ANAPC1 21836163 pred P P P P P P P P P P P P P P P P P P P APC2 ANAPC1 25402006 pred PABPC1 ANAPC1 25402006 pred P P P P P P P P P P P P P P P P P PSME3 ANAPC1 21836163 pred P P P P P P P P P P P P P P P P P P P ANAPC1 PSMD13 21836163 pred P P P P P P P P P P P P P P P P P P P PSMD11 ANAPC1 21836163 pred P P P P P P P P P P CDH1 ANAPC1 25402006 pred P P P P P P P P P P P PSMB4 ANAPC1 21836163 pred P P P P P P P P P P P P P P P P PSMC4 ANAPC1 21836163 pred P P P P P P P P P P P P P P P P P P P PSMD4 ANAPC1 21836163 pred P P P P P P P P P P P P P P P P P P P PSMC1 ANAPC1 21836163 pred P P P P P P P P P P P P P P P P P PSMB7 ANAPC1 21836163 pred P P P P P P P P P P P P P P P P P P P PSMD14 ANAPC1 21836163 pred P P P P P P P P P P P P P P P P PSMB3 ANAPC1 21836163 pred PSMA7 ANAPC1 21836163 pred P P P P P P P P P P P PSMA4 ANAPC1 21836163 pred P P P P P P P P P P P P P P P P P P P PIN1 ANAPC1 25402006 pred P P P P P P P P P P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9H1A4 - 11076961 - C 8 Q9H1A4 - 15175163 - C 122 Q9H1A4 P61201-2 affinity chromatography technology 19535905 physical association X 2 Q9H1A4 P61201-2 affinity chromatography technology 19535905 physical association X 2 Q9H1A4 Q9UKT4-2 affinity chromatography technology 16921029 physical association X 2 Q9H1A4 Q9UKT4-2 pull down 16921029 direct interaction X 2 Q9H1A4 Q9UJX2 biochemical 22939629 colocalization X 2 Q9H1A4 Q9UJX6 biochemical 22939629 colocalization X 2 Q9H1A4 Q13042-2 biochemical 22939629 colocalization X 2 Q9H1A4 Q9UJX5 biochemical 22939629 colocalization X 2 Q9H1A4 biochemical 22939629 colocalization X 2 Q9H1A4 A0A024R5G0 affinity chromatography technology 23007861 physical association X 2 Q9H1A4 Q8VDQ8-3 affinity chromatography technology 22014574 physical association X 2 Q9H1A4 Q8VDQ8-3 affinity chromatography technology 22014574 physical association X 2 Q9H1A4 affinity chromatography technology 22190034 physical association X 2 Q9H1A4 Q9UJX5 biochemical 23078409 association X 2 Q9H1A4 Q9UJX5 biochemical 25043029 association X 2 Q9H1A4 Q16763 pull down 25306923 direct interaction X 2 Q9H1A4 Q9UJX6 affinity chromatography technology 10922056 physical association X 2 Q9H1A4 Q9UJX5 affinity chromatography technology 24464857 physical association X 2 Q9H1A4 O94782 affinity chromatography technology 21768287 physical association X 2 Q9H1A4 Q9NYG5 pull down 12956947 direct interaction X 2 Q9H1A4 Q9UJX6 pull down 12956947 direct interaction X 2 Q9H1A4 Q9UJX5 pull down 12956947 direct interaction X 2 Q9H1A4 pull down 12956947 direct interaction X 2 Q9H1A4 O95996 affinity chromatography technology 12956947 physical association X 2 Q9H1A4 Q9UJX5 affinity chromatography technology 12956947 physical association X 2 Q9H1A4 P12830 pull down 12956947 direct interaction X 2 Q9H1A4 Q9UJX5 biochemical 11076961 association X 2 Q9H1A4 Q13042-2 biochemical 11076961 association X 2 Q9H1A4 Q9UJX2 biochemical 11076961 association X 2 Q9H1A4 Q9UJX6 biochemical 11076961 association X 2 Q9H1A4 biochemical 11076961 association X 2 Q9H1A4 Q9H6T3 affinity chromatography technology 17643375 physical association X 2 Q9H1A4 Q13042-2 affinity chromatography technology 20360068 physical association X 2 Q9H1A4 Q3UFC2 affinity chromatography technology 20360068 physical association X 2 Q9H1A4 P11440 affinity chromatography technology 20360068 physical association X 2 Q9H1A4 Q9JJ66 affinity chromatography technology 20360068 physical association X 2 Q9H1A4 Q8BZQ7 affinity chromatography technology 20360068 physical association X 2 Q9H1A4 Q9CPV2 affinity chromatography technology 20360068 physical association X 2 Q9UM11 Q9H1A4 pull down 12956947 direct interaction X 2 P0CG48 Q9H1A4 affinity chromatography technology 22505724 physical association X 2 P0CG48 Q9H1A4 pull down 23314748 direct interaction X 2 P0CG48 Q9H1A4 affinity chromatography technology 21987572 physical association X 2 P0CG48 Q9H1A4 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q9H1A4 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q9H1A4 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q9H1A4 affinity chromatography technology 21906983 physical association X 2 Q12834 Q9H1A4 affinity chromatography technology 24464857 physical association X 2 Q12834 Q9H1A4 affinity chromatography technology 18997788 physical association X 2 A0A024RDM3 Q9H1A4 affinity chromatography technology 24255178 physical association X 2 A0A024RDM3 Q9H1A4 proximity labelling technology 24255178 physical association X 2 Q9BWH6 Q9H1A4 affinity chromatography technology 17643375 physical association X 2 Q9H1A4 Q9NRC8 affinity chromatography technology 22586326 physical association X 2 Q9H1A4 affinity chromatography technology 17942546 physical association X 2 Q9H1A4 affinity chromatography technology 16364912 physical association X 2 Q9H1A4 Q14676 pull down 19826003 direct interaction X 2 Q9H1A4 biochemical 21043528 association X 2 Q9H1A4 biochemical 22939629 colocalization X 2 Q9H1A4 Q9UJX4-2 biochemical 22939629 colocalization X 2 Q9H1A4 Q9UM13 biochemical 22939629 colocalization X 2 Q9H1A4 A0A024R832 biochemical 22939629 colocalization X 2 Q9H1A4 Q14676 affinity chromatography technology 22990118 physical association X 2 Q9H1A4 Q6ZW49 affinity chromatography technology 22990118 physical association X 2 Q9H1A4 Q12888 affinity chromatography technology 22990118 physical association X 2 Q9H1A4 P46531 affinity chromatography technology 23022380 physical association X 2 Q9H1A4 Q9UPN9-2 affinity chromatography technology 23160376 physical association X 2 Q9H1A4 P48431 affinity chromatography technology 23667531 physical association X 2 Q9H1A4 affinity chromatography technology 23979597 physical association X 2 Q9H1A4 Q9P2P5 affinity chromatography technology 24163370 physical association X 2 Q9H1A4 Q9UJX4-2 pull down 12956947 direct interaction X 2 Q9H1A4 affinity chromatography technology 12956947 physical association X 2 Q9H1A4 biochemical 11076961 association X 2 Q9H1A4 Q9UJX4-2 biochemical 11076961 association X 2 Q9H1A4 Q14676 affinity chromatography technology 17827148 physical association X 2 Q9H1A4 P53995 affinity chromatography technology 20360068 physical association X 2 Q9H1A4 Q8R349 affinity chromatography technology 20360068 physical association X 2 Q9H1A4 Q8R034 affinity chromatography technology 20360068 physical association X 2 Q9H1A4 Q9Z1S0 affinity chromatography technology 20360068 physical association X 2 Q9H1A4 Q5HZH8 affinity chromatography technology 20360068 physical association X 2 Q9H1A4 affinity chromatography technology 22193957 physical association X 2 Q9H1A4 Q9H4L7-3 affinity chromatography technology 21549307 physical association X 2 Q9H1A4 affinity chromatography technology 20360068 physical association X 2 Q9H1A4 coimmunoprecipitation 9469815 association C 8 Q9H1A4 coimmunoprecipitation 10318877 association C 9 Q9H1A4 electron tomography 25043029 physical association C 13 Q9H1A4 electron tomography 25043029 physical association C 16 Q9H1A4 anti tag coimmunoprecipitation 21186364 - C 11 Q9H1A4 electron tomography 25043029 physical association C 14 P34244 Q9H1A4 anti tag coimmunoprecipitation 21186364 physical association X 2 Q9H1A4 in vivo 10922056 - C 11 Q9H1A4 in vivo 10922056 - C 11 Q9H1A4 in vivo 10922056 - C 11 Q9H1A4 in vivo 10922056 - C 11 Q9H1A4 in vivo 10922056 - C 11 Q9H1A4 in vivo 10922056 - C 11 Q9H1A4 in vivo 10922056 - C 11 Q9H1A4 in vivo 10922056 - C 11 Q9H1A4 in vivo 10922056 - C 11 Q9H1A4 in vivo 10922056 - C 11 Q9H1A4 in vivo 10922056 - C 11 Q9H1A4 in vivo 10500174 - C 9 Q9H1A4 in vivo 10500174 - C 9 Q9H1A4 in vivo 10500174 - C 9 Q9H1A4 in vivo 10500174 - C 9 Q9H1A4 in vivo 10500174 - C 9 Q9H1A4 in vivo 10500174 - C 9 Q9H1A4 in vivo 10500174 - C 9 Q9H1A4 in vivo 10500174 - C 9 Q9H1A4 in vivo 10500174 - C 9 Q9H1A4 in vivo 16648845 - C 11 Q9H1A4 in vivo 16648845 - C 11 Q9H1A4 in vivo 16648845 - C 11 Q9H1A4 in vivo 16648845 - C 11 Q9H1A4 in vivo 16648845 - C 11 Q9H1A4 in vivo 16648845 - C 11 Q9H1A4 in vivo 16648845 - C 11 Q9H1A4 in vivo 16648845 - C 11 Q9H1A4 in vivo 16648845 - C 11 Q9H1A4 in vivo 16648845 - C 11 Q9H1A4 in vivo 16648845 - C 11 Q12834 Q9H1A4 in vitro 11438673 - X 2 Q12834 Q9H1A4 in vivo 11438673 - X 2 Q12834 Q9H1A4 in vitro 11438673 - X 2 Q12834 Q9H1A4 in vivo 11438673 - X 2 Q9H1A4 in vivo 10318877 - C 9 Q9H1A4 in vivo 10318877 - C 9 Q9H1A4 in vivo 10318877 - C 9 Q9H1A4 in vivo 10318877 - C 9 Q9H1A4 in vivo 10318877 - C 9 Q9H1A4 in vivo 10318877 - C 9 Q9H1A4 in vivo 10318877 - C 9 Q9H1A4 in vivo 10318877 - C 9 Q9H1A4 in vivo 10318877 - C 9 Q9H1A4 in vivo 12956947 - C 5 Q9H1A4 in vivo 12956947 - C 5 Q9H1A4 in vivo 12956947 - C 5 Q9H1A4 in vivo 12956947 - C 5 Q9H1A4 in vivo 12956947 - C 5 Q9H1A4 proximity-dependent biotin identification 24255178 colocalization C 74 Q9H1A4 anti tag coimmunoprecipitation 24255178 association C 14 Q9H1A4 anti tag coimmunoprecipitation 24255178 association C 32 Q9H1A4 anti tag coimmunoprecipitation 15175163 association C 113 Q9H1A4 tandem affinity purification 20360068 association C 17 Q9H1A4 pull down 22190034 association C 39 Q9H1A4 tandem affinity purification 20360068 association C 11 Q9H1A4 tandem affinity purification 20360068 association C 8 Q9H1A4 tandem affinity purification 20360068 physical association C 22 Q9H1A4 proximity-dependent biotin identification 24255178 colocalization C 50 Q9H1A4 tandem affinity purification 20360068 physical association C 10 Q9H1A4 tandem affinity purification 20360068 association C 13 Q9H1A4 anti tag coimmunoprecipitation 22014574 association C 7 Q9H1A4 tandem affinity purification 20360068 physical association C 4 Q9H1A4 tandem affinity purification 20360068 physical association C 23 Q9H1A4 tandem affinity purification 20360068 association C 18 Q9H1A4 anti bait coimmunoprecipitation 20360068 association C 8 Q9H1A4 anti bait coimmunoprecipitation 20360068 association C 8 Q9H1A4 tandem affinity purification 20360068 association C 20 Q9H1A4 tandem affinity purification 20360068 physical association C 30 Q9H1A4 anti tag coimmunoprecipitation 22190034 association C 37 Q9H1A4 tandem affinity purification 20360068 physical association C 19 Q9H1A4 tandem affinity purification 20360068 association C 15 Q9H1A4 anti tag coimmunoprecipitation 23288039 association C 4 Q9H1A4 tandem affinity purification 20360068 association C 14 Q9H1A4 anti tag coimmunoprecipitation 22014574 association C 9 Q9H1A4 pull down 19124460 association C 14 Q9H1A4 tandem affinity purification 20360068 physical association C 19

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B COPS2 ANAPC1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19535905 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_200421|BIOGRID_200424 bait|prey prey|bait UBE2C ANAPC1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20080579,22193957 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_222943|BIOGRID_221600 prey|prey bait|bait ANAPC15 ANAPC1 MI:0004(affinity chromatography technology) 23007861 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_247770 bait prey CDH1 ANAPC1 MI:0096(pull down) 12956947 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_85240 bait prey SOX2 ANAPC1 MI:0004(affinity chromatography technology) 23667531 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_274975 bait prey PTTG1 ANAPC1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20080579,22193957 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_159927|BIOGRID_146743 prey|prey bait|bait CDC16 ANAPC1 MI:0493(in vivo)|MI:0493(in vivo)|MI:0493(in vivo)|MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0401(biochemical)|MI:0401(biochemical)|MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0493(in vivo) 10318877,10500174,10922056,11076961,16648845,20360068,22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|-|-|MI:0914(association)|MI:0914(association)|MI:0403(colocalization)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|- MI:0468(hprd)|MI:0468(hprd)|MI:0468(hprd)|(intact)|(intact)|(biogrid)|(biogrid)|(intact)|(biogrid)|(intact)|(intact)|(intact)|MI:0468(hprd) HPRD_39295|HPRD_39519|HPRD_39294|UniProt_170229|UniProt_170231|BIOGRID_230268|BIOGRID_105786|UniProt_106540|BIOGRID_151546|UniProt_106538|UniProt_106286|UniProt_169995|HPRD_39911 -|-|-|prey|bait|prey|prey|bait|bait|prey|bait|bait|- -|-|-|bait|prey|bait|bait|prey|prey|bait|prey|prey|- CDC26 ANAPC1 MI:0493(in vivo)|MI:0676(tandem affinity purification)|MI:0401(biochemical)|MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0493(in vivo) 10922056,16648845,20360068,22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0914(association)|MI:0403(colocalization)|MI:0914(association)|MI:0914(association)|MI:0914(association)|- MI:0468(hprd)|(intact)|(biogrid)|(intact)|(intact)|(intact)|MI:0468(hprd) HPRD_39295|UniProt_170229|BIOGRID_232966|UniProt_170233|UniProt_106542|UniProt_106538|HPRD_39911 -|prey|prey|bait|bait|prey|- -|bait|bait|prey|prey|bait|- MDC1 ANAPC1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17827148,19826003,22990118 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_137173|BIOGRID_200282|BIOGRID_246174 bait|prey|bait prey|bait|prey UBE2D1 ANAPC1 MI:0004(affinity chromatography technology) 20080579 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_222956 prey bait NRF1 ANAPC1 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_296165 bait prey RPAP1 ANAPC1 MI:0415(enzymatic study) 17643375 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_121690 bait prey CDC27 ANAPC1 MI:0493(in vivo)|MI:0493(in vivo)|MI:0493(in vivo)|MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0401(biochemical)|MI:0401(biochemical)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0401(biochemical)|MI:0676(tandem affinity purification)|MI:0493(in vivo) 10318877,10500174,10922056,11076961,12956947,16364912,16648845,17942546,20360068,21043528,22193957,22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|-|-|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0914(association)|- MI:0468(hprd)|MI:0468(hprd)|MI:0468(hprd)|(intact)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|MI:0468(hprd) HPRD_39295|HPRD_39519|HPRD_39294|UniProt_170229|UniProt_106537|BIOGRID_197778|BIOGRID_85238|BIOGRID_105783|BIOGRID_207324|BIOGRID_199373|BIOGRID_159906|BIOGRID_230210|UniProt_106538|HPRD_39911 -|-|-|prey|bait|bait|bait|prey|bait|bait|bait|prey|prey|- -|-|-|bait|prey|prey|prey|bait|prey|prey|prey|bait|bait|- ANAPC1 HECW2 MI:0004(affinity chromatography technology) 24163370 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_293954 prey bait UBC ANAPC1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0096(pull down) 21139048,21890473,21906983,21963094,21987572,22505724,23314748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_224874|BIOGRID_180597|BIOGRID_176246|BIOGRID_166244|BIOGRID_163253|BIOGRID_171449|BIOGRID_247992 bait|bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey|prey ANAPC1 RPAP3 MI:0415(enzymatic study) 17643375 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_121662 prey bait ANAPC1 SMARCAD1 MI:0004(affinity chromatography technology) 21549307 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_165301 prey bait ANAPC1 ANAPC11 MI:0493(in vivo)|MI:0096(pull down)|MI:0492(in vitro)|MI:0493(in vivo) 10922056,12956947,16648845 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|-|- MI:0468(hprd)|(biogrid)|MI:0468(hprd)|MI:0468(hprd) HPRD_39295|BIOGRID_84791|HPRD_39948|HPRD_39911 -|bait|-|- -|prey|-|- CDC20 ANAPC1 MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification) 11438673,18997788,20360068 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0914(association)|-|MI:0915(physical association)|MI:0914(association) (intact)|(intact)|(intact)|MI:0468(hprd)|(biogrid)|(intact) UniProt_170234|UniProt_106543|UniProt_170229|HPRD_32672|BIOGRID_116330|UniProt_106538 bait|bait|prey|-|bait|prey prey|prey|bait|-|prey|bait NOTCH1 ANAPC1 MI:0004(affinity chromatography technology) 23022380 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_246674 bait prey APC2 ANAPC1 MI:0096(pull down)|MI:0493(in vivo) 12956947,16648845 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_85237|HPRD_39911 bait|- prey|- ANAPC1 TRIM33 MI:0004(affinity chromatography technology) 23160376 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_248535 bait prey ANAPC1 PHF8 MI:0004(affinity chromatography technology) 23979597 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_289133 prey bait ANAPC1 FBXO5 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16921029 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_221073|BIOGRID_221068 prey|prey bait|bait ANAPC1 ANAPC4 MI:0493(in vivo)|MI:0493(in vivo)|MI:0493(in vivo)|MI:0676(tandem affinity purification)|MI:0492(in vitro)|MI:0096(pull down)|MI:0401(biochemical)|MI:0096(pull down)|MI:0401(biochemical)|MI:0676(tandem affinity purification)|MI:0493(in vivo) 10318877,10500174,10922056,11076961,12956947,16648845,20360068,22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|-|-|MI:0914(association)|-|MI:0915(physical association)|MI:0403(colocalization)|MI:0407(direct interaction)|MI:0914(association)|MI:0914(association)|- MI:0468(hprd)|MI:0468(hprd)|MI:0468(hprd)|(intact)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|MI:0468(hprd) HPRD_39295|HPRD_39519|HPRD_39294|UniProt_170229|HPRD_39948|BIOGRID_85239|BIOGRID_230273|BIOGRID_84796|BIOGRID_105784|UniProt_106538|HPRD_39911 -|-|-|bait|-|prey|bait|bait|bait|bait|- -|-|-|prey|-|bait|prey|prey|prey|prey|- ANAPC1 ANAPC2 MI:0493(in vivo)|MI:0493(in vivo)|MI:0493(in vivo)|MI:0676(tandem affinity purification)|MI:0492(in vitro)|MI:0096(pull down)|MI:0401(biochemical)|MI:0401(biochemical)|MI:0676(tandem affinity purification) 10318877,10500174,10922056,11076961,12956947,20360068,22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|-|-|MI:0914(association)|-|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0914(association)|MI:0914(association) MI:0468(hprd)|MI:0468(hprd)|MI:0468(hprd)|(intact)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(intact) HPRD_39295|HPRD_39519|HPRD_39294|UniProt_170229|HPRD_39948|BIOGRID_84792|BIOGRID_230262|BIOGRID_105788|UniProt_106538 -|-|-|bait|-|bait|prey|bait|bait -|-|-|prey|-|prey|bait|prey|prey ANAPC1 ANAPC5 MI:0493(in vivo)|MI:0493(in vivo)|MI:0676(tandem affinity purification)|MI:0493(in vivo)|MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0492(in vitro)|MI:0401(biochemical)|MI:0401(biochemical)|MI:0096(pull down)|MI:0676(tandem affinity purification)|MI:0493(in vivo) 10318877,10500174,10922056,11076961,12956947,16648845,20360068,22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|-|MI:0914(association)|-|MI:0914(association)|MI:0914(association)|-|MI:0403(colocalization)|MI:0914(association)|MI:0407(direct interaction)|MI:0914(association)|- MI:0468(hprd)|MI:0468(hprd)|(intact)|MI:0468(hprd)|(intact)|(intact)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(intact)|MI:0468(hprd) HPRD_39295|HPRD_39519|UniProt_106539|HPRD_39294|UniProt_170229|UniProt_170230|HPRD_39948|BIOGRID_230266|BIOGRID_105785|BIOGRID_84798|UniProt_106538|HPRD_39911 -|-|prey|-|bait|prey|-|bait|bait|bait|bait|- -|-|bait|-|prey|bait|-|prey|prey|prey|prey|- ANAPC1 ANAPC7 MI:0493(in vivo)|MI:0493(in vivo)|MI:0493(in vivo)|MI:0676(tandem affinity purification)|MI:0096(pull down)|MI:0401(biochemical)|MI:0401(biochemical)|MI:0676(tandem affinity purification)|MI:0493(in vivo) 10318877,10500174,10922056,11076961,12956947,16648845,20360068,22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|-|-|MI:0914(association)|MI:0407(direct interaction)|MI:0914(association)|MI:0403(colocalization)|MI:0914(association)|- MI:0468(hprd)|MI:0468(hprd)|MI:0468(hprd)|(intact)|(biogrid)|(biogrid)|(biogrid)|(intact)|MI:0468(hprd) HPRD_39295|HPRD_39519|HPRD_39294|UniProt_170229|BIOGRID_85055|BIOGRID_105789|BIOGRID_230313|UniProt_106538|HPRD_39911 -|-|-|bait|bait|bait|bait|bait|- -|-|-|prey|prey|prey|prey|prey|- ANAPC1 CDC23 MI:0493(in vivo)|MI:0493(in vivo)|MI:0493(in vivo)|MI:0676(tandem affinity purification)|MI:0401(biochemical)|MI:0401(biochemical)|MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0493(in vivo) 10318877,10500174,10922056,11076961,16648845,20360068,22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|-|-|MI:0914(association)|MI:0914(association)|MI:0403(colocalization)|MI:0914(association)|MI:0914(association)|MI:0914(association)|- MI:0468(hprd)|MI:0468(hprd)|MI:0468(hprd)|(intact)|(biogrid)|(biogrid)|(intact)|(intact)|(intact)|MI:0468(hprd) HPRD_39295|HPRD_39519|HPRD_39294|UniProt_170229|BIOGRID_105787|BIOGRID_230208|UniProt_106541|UniProt_106538|UniProt_170232|HPRD_39911 -|-|-|bait|bait|bait|prey|bait|prey|- -|-|-|prey|prey|prey|bait|prey|bait|- ANAPC1 FZR1 MI:0493(in vivo)|MI:0096(pull down) 10500174,12956947 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_39294|BIOGRID_84793 -|bait -|prey ANAPC1 ANAPC10 MI:0493(in vivo)|MI:0493(in vivo)|MI:0676(tandem affinity purification)|MI:0401(biochemical)|MI:0676(tandem affinity purification)|MI:0493(in vivo) 10318877,10922056,16648845,20360068,22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|-|MI:0914(association)|MI:0403(colocalization)|MI:0914(association)|- MI:0468(hprd)|MI:0468(hprd)|(intact)|(biogrid)|(intact)|MI:0468(hprd) HPRD_39295|HPRD_39519|UniProt_170229|BIOGRID_230334|UniProt_106538|HPRD_39911 -|-|bait|prey|bait|- -|-|prey|bait|prey|- CCNB1 ANAPC1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20080579,22193957 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_159919|BIOGRID_146756 prey|prey bait|bait TP53BP1 ANAPC1 MI:0004(affinity chromatography technology) 22990118 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_246459 bait prey ANAPC1 LATS2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24255178 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_292921|BIOGRID_292920 prey|prey bait|bait ANAPC1 SIRT7 MI:0004(affinity chromatography technology) 22586326 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_189736 prey bait PAXIP1 ANAPC1 MI:0004(affinity chromatography technology) 22990118 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_246388 bait prey

PPI - HINT Gene A Gene B PMID Method Quality B4DL80 ANAPC1 12956947,22193957,16364912,11076961,17942546 0004,0004,0004,0401,0004 LC TAF4 ANAPC1 26344197 0401 HT BUB1B ANAPC1 25852190,20360068,25852190,25482201 0004,0676,0007,0004 HT,LC GRAP2 ANAPC1 26186194 0004 HT TTLL1 ANAPC1 26186194 0004 HT KNG1 ANAPC1 26186194 0004 HT PENK ANAPC1 26186194 0004 HT UBC ANAPC1 21963094,23314748 0004,0096 LC TCF4 ANAPC1 25609649,25609649 0676,0004 HT NCL ANAPC1 26344197 0401 HT CDC27 ANAPC1 26344197,20360068,17942546,20360068,20686030,27114510,22193957,11076961,16364912,12956947,21043528,22939629 0401,0006,0004,0676,0004,0004,0004,0401,0004,0004,0401,0401 HT,LC ANAPC15 ANAPC1 26496610,23007861,26496610 0007,0004,0004 HT,LC CDC20 ANAPC1 18997788,25482201,20360068,27114510,24464857,25306918,26811472 0004,0004,0676,0004,0004,0004,0004 LC CDC16 ANAPC1 26344197,26496610,26496610,20360068,20360068,11076961,22939629 0401,0004,0007,0676,0004,0401,0401 HT,LC MAD2L1 ANAPC1 26496610,26496610,26986935 0007,0004,0004 HT,LC MDC1 ANAPC1 19826003,22990118,17827148 0096,0004,0004 LC CEP120 ANAPC1 26638075,26638075 1314,1313 HT CDC26 ANAPC1 26344197,20360068,22939629 0401,0676,0401 HT,LC PIFO ANAPC1 26186194 0004 HT LIPH ANAPC1 26186194 0004 HT ANAPC16 ANAPC1 26344197,20360068,20360068 0401,0676,0006 HT,LC CEP19 ANAPC1 26638075,26638075 1314,1313 HT NAP1L4 ANAPC1 26344197 0401 HT RPAP1 ANAPC1 17643375 0004 HT FOXQ1 ANAPC1 25609649,25609649 0676,0004 HT MAP1LC3B ANAPC1 20562859 0007 HT ANAPC1 RPAP3 17643375 0004 HT ANAPC1 MAGIX 26186194 0004 HT ANAPC1 LATS2 24255178,24255178 0004,1313 HT ANAPC1 CFAP97 26496610,26496610 0007,0004 HT ANAPC1 CDC23 26496610,20360068,11076961,22939629,26496610 0007,0676,0401,0401,0004 HT,LC ANAPC1 ANAPC7 26344197,20360068,11076961,22939629 0401,0676,0401,0401 HT,LC ANAPC1 ANAPC5 26344197,12956947,20360068,11076961,12956947,22939629 0401,0096,0676,0401,0004,0401 HT,LC ANAPC1 ANAPC4 26344197,23078409,25043029,20360068,25490258,26083744,11076961,12956947,24464857,22939629,12956947 0401,0401,0401,0676,0004,0401,0401,0004,0004,0401,0096 HT,LC ANAPC1 ANAPC2 20360068,10922056,12956947,11076961,12956947,22939629 0676,0004,0096,0401,0004,0401 LC,HT ANAPC1 ANAPC10 20360068,22939629 0676,0401 LC,HT TAF4 ANAPC1 26344197 0401 HT BUB1B ANAPC1 25852190,25852190 0004,0007 HT GRAP2 ANAPC1 26186194 0004 HT TTLL1 ANAPC1 26186194 0004 HT KNG1 ANAPC1 26186194 0004 HT PENK ANAPC1 26186194 0004 HT TCF4 ANAPC1 25609649,25609649 0676,0004 HT NCL ANAPC1 26344197 0401 HT CDC27 ANAPC1 26344197,22939629 0401,0401 HT ANAPC15 ANAPC1 26496610,26496610 0007,0004 HT CDC16 ANAPC1 26344197,26496610,26496610,22939629 0401,0004,0007,0401 HT MAD2L1 ANAPC1 26496610,26496610 0007,0004 HT CEP120 ANAPC1 26638075,26638075 1314,1313 HT CDC26 ANAPC1 26344197,22939629 0401,0401 HT PIFO ANAPC1 26186194 0004 HT LIPH ANAPC1 26186194 0004 HT ANAPC16 ANAPC1 26344197 0401 HT CEP19 ANAPC1 26638075,26638075 1314,1313 HT NAP1L4 ANAPC1 26344197 0401 HT RPAP1 ANAPC1 17643375 0004 HT FOXQ1 ANAPC1 25609649,25609649 0676,0004 HT MAP1LC3B ANAPC1 20562859 0007 HT ANAPC1 RPAP3 17643375 0004 HT ANAPC1 MAGIX 26186194 0004 HT ANAPC1 LATS2 24255178,24255178 0004,1313 HT ANAPC1 CFAP97 26496610,26496610 0007,0004 HT ANAPC1 CDC23 26496610,22939629,26496610 0007,0401,0004 HT ANAPC1 ANAPC7 26344197,22939629 0401,0401 HT ANAPC1 ANAPC5 26344197,22939629 0401,0401 HT ANAPC1 ANAPC4 26344197,22939629 0401,0401 HT ANAPC1 ANAPC2 22939629 0401 HT ANAPC1 ANAPC10 22939629 0401 HT B4DL80 ANAPC1 12956947,22193957,16364912,11076961,17942546 0004,0004,0004,0401,0004 LC BUB1B ANAPC1 20360068,25482201 0676,0004 LC UBC ANAPC1 21963094,23314748 0004,0096 LC CDC27 ANAPC1 20360068,17942546,20360068,20686030,27114510,22193957,11076961,16364912,12956947,21043528 0006,0004,0676,0004,0004,0004,0401,0004,0004,0401 LC ANAPC15 ANAPC1 23007861 0004 LC CDC20 ANAPC1 18997788,25482201,20360068,27114510,24464857,25306918,26811472 0004,0004,0676,0004,0004,0004,0004 LC CDC16 ANAPC1 20360068,20360068,11076961 0676,0004,0401 LC MAD2L1 ANAPC1 26986935 0004 LC MDC1 ANAPC1 19826003,22990118,17827148 0096,0004,0004 LC CDC26 ANAPC1 20360068 0676 LC ANAPC16 ANAPC1 20360068,20360068 0676,0006 LC ANAPC1 CDC23 20360068,11076961 0676,0401 LC ANAPC1 ANAPC7 20360068,11076961 0676,0401 LC ANAPC1 ANAPC5 12956947,20360068,11076961,12956947 0096,0676,0401,0004 LC ANAPC1 ANAPC4 23078409,25043029,20360068,25490258,26083744,11076961,12956947,24464857,12956947 0401,0401,0676,0004,0401,0401,0004,0004,0096 LC ANAPC1 ANAPC2 20360068,10922056,12956947,11076961,12956947 0676,0004,0096,0401,0004 LC ANAPC1 ANAPC10 20360068 0676 LC B4DL80 ANAPC1 11076961 0401 LC TAF4 ANAPC1 26344197 0401 LC PTTG1 ANAPC1 20080579,22193957 0415,0415 LC CCNB1 ANAPC1 20080579,22193957 0415,0415 LC NCL ANAPC1 26344197 0401 LC CDC27 ANAPC1 26344197,11076961,21043528,22939629 0401,0401,0401,0401 LC CDC16 ANAPC1 26344197,11076961,22939629 0401,0401,0401 LC CDC26 ANAPC1 26344197,22939629 0401,0401 LC ANAPC16 ANAPC1 26344197 0401 LC NAP1L4 ANAPC1 26344197 0401 LC ANAPC1 CDC23 11076961,22939629 0401,0401 LC ANAPC1 ANAPC7 26344197,11076961,22939629 0401,0401,0401 LC ANAPC1 ANAPC5 26344197,11076961,22939629 0401,0401,0401 LC ANAPC1 ANAPC4 26344197,23078409,25043029,26083744,11076961,22939629 0401,0401,0401,0401,0401,0401 LC ANAPC1 ANAPC2 11076961,22939629 0401,0401 LC ANAPC1 ANAPC10 22939629 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9H1A4 P61201 ANAPC1 COPS2 0.376 19535905 Q9H1A4 Q8N6T7 ANAPC1 SIRT6 0.126 24169447 Q9H1A4 Q8N960 ANAPC1 CEP120 0.126 26638075 Q9HCE1 Q9H1A4 MOV10 ANAPC1 0.126 22658674 Q9H1A4 Q9GZQ8 ANAPC1 MAP1LC3B 0.126 20562859 Q9H4L7 Q9H1A4 SMARCAD1 ANAPC1 0.126 21549307 Q9NRC8 Q9H1A4 SIRT7 ANAPC1 0.126 22586326 Q9H6T3 Q9H1A4 RPAP3 ANAPC1 0.126 17643375 Q9H1A4 O94782 ANAPC1 USP1 0.21 21768287 Q9H1A4 O60566 ANAPC1 BUB1B 0.539 25852190,20360068,25482201 Q9H1A4 Q99733 ANAPC1 NAP1L4 0.081 26344197 Q9H1A4 Q8NHZ8 ANAPC1 CDC26 0.332 20360068 Q9H1A4 Q14676 ANAPC1 MDC1 0.523 17827148,19826003,22990118 Q9UM13 Q9H1A4 ANAPC10 ANAPC1 0.298 20360068,22939629 Q9UPN9 Q9H1A4 TRIM33 ANAPC1 0.21 23160376 Q9H1A4 Q8TCI5 ANAPC1 PIFO 0.126 26186194 Q9H1A4 Q8IYE1 ANAPC1 CCDC13 {ECO:0000312|HGNC:HGNC:26358} 0.21 24816561 Q9H6Y5 Q9H1A4 MAGIX ANAPC1 0.126 26186194 Q9Y468 Q9H1A4 L3MBTL1 ANAPC1 0.126 27705803 Q9Y4E8 Q9H1A4 USP15 ANAPC1 0.21 26884171 Q9H1A4 O75791 ANAPC1 GRAP2 0.126 26186194 Q9H1A4 Q6ZW49 ANAPC1 PAXIP1 0.126 22990118 Q9H1A4 P0CG48 ANAPC1 UBC 0.183 23314748 Q9H1A4 Q86T82 ANAPC1 USP37 0.126 26299517 Q9H1A4 P01042 ANAPC1 KNG1 0.126 26186194 Q9H1A4 P01210 ANAPC1 PENK 0.126 26186194 Q9H1A4 P04585 ANAPC1 GAG-POL 0.126 22190034 Q9H1A4 P04629 ANAPC1 NTRK1 0.126 25921289 Q9H1A4 O95922 ANAPC1 TTLL1 0.126 26186194 Q9P2B7 Q9H1A4 KIAA1430 ANAPC1 0.236 26496610 Q9Z1B5 Q9H1A4 MAD2L1 ANAPC1 0.236 20360068 Q9NRM7 Q9H1A4 LATS2 ANAPC1 0.236 24255178 Q9Q2G4 Q9H1A4 ORF ANAPC1 0.236 22190034 Q9UKT4 Q9H1A4 FBXO5 ANAPC1 0.454 16921029 Q9UM11 Q9H1A4 FZR1 ANAPC1 0.332 12956947 Q9H1A4 P15884 ANAPC1 TCF4 0.236 25609649 Q9H1A4 Q8VDQ8 ANAPC1 SIRT2 0.236 22014574 Q9H1A4 P11440 ANAPC1 CDK1 0.236 20360068 Q9H1A4 Q13573 ANAPC1 SNW1 0.236 20467437 Q9H1A4 Q99459 ANAPC1 CDC5L 0.236 20467437 Q9H1A4 Q96LK0 ANAPC1 CEP19 0.236 26638075 Q9H1A4 Q9C009 ANAPC1 FOXQ1 0.236 25609649 Q9H1A4 O43684 ANAPC1 BUB3 0.236 20360068 Q9H1A4 Q12834 ANAPC1 CDC20 0.837 18997788,25306918,26811472,24464857,20360068,25482201,27114510 Q9H1A4 Q96DE5 ANAPC1 ANAPC16 0.531 20360068,26344197 Q9H1A4 Q7TSJ6 ANAPC1 LATS2 0.196 24255178 Q9H1A4 O35942 ANAPC1 NEK2 0.236 26496610 Q9H1A4 P60006 ANAPC1 ANAPC15 0.396 26496610,23007861 Q9H1A4 Q8BTZ4 ANAPC1 ANAPC5 0.332 26496610,20360068 Q9H1A4 Q8BZQ7 ANAPC1 ANAPC2 0.332 26496610,20360068 Q9H1A4 Q8R034 ANAPC1 ANAPC13 0.332 26496610,20360068 Q9H1A4 Q13257 ANAPC1 MAD2L1 0.396 26496610,26986935 Q9UJX2 Q9H1A4 CDC23 ANAPC1 0.629 20360068,26496610,11076961,22939629 Q9UJX4 Q9H1A4 ANAPC5 ANAPC1 0.61 20360068,26344197,11076961,12956947,22939629 Q9UJX6 Q9H1A4 ANAPC2 ANAPC1 0.617 10922056,20360068,11076961,12956947,22939629 Q9H1A4 Q99JP4 ANAPC1 CDC26 0.332 26496610,20360068 Q9H1A4 P30260 ANAPC1 CDC27 0.91 21043528,17942546,11076961,12956947,22939629,22193957,20360068,27114510,16364912,20686030 Q9H1A4 Q9CPV2 ANAPC1 ANAPC16 0.416 26496610,20360068 Q9H1A4 Q13042 ANAPC1 CDC16 0.717 20360068,26496610,11076961,22939629 Q9JJ66 Q9H1A4 CDC20 ANAPC1 0.416 26496610,20360068 Q9Z1S0 Q9H1A4 BUB1B ANAPC1 0.416 26496610,20360068 Q9H1A4 Q8BGZ4 ANAPC1 CDC23 0.416 26496610,20360068 Q9H1A4 Q8R349 ANAPC1 CDC16 0.416 26496610,20360068 Q9UJX5 Q9H1A4 ANAPC4 ANAPC1 0.863 24464857,11076961,12956947,22939629,23078409,25043029,25490258,20360068,26344197,26083744 Q9H1A4 Q8WWY8 ANAPC1 LIPH 0.126 26186194 Q9H1A4 Q9BS18 ANAPC1 ANAPC13 0.236 20360068 Q9H1A4 Q9BWH6 ANAPC1 RPAP1 0.126 17643375 Q9UBU9 Q9H1A4 NXF1 ANAPC1 0.126 22658674 Q9P2P5 Q9H1A4 HECW2 ANAPC1 0.126 24163370 Q9UJX3 Q9H1A4 ANAPC7 ANAPC1 0.49 22939629,20360068,26344197,11076961 Q9UPP1 Q9H1A4 PHF8 ANAPC1 0.21 23979597 Q9H1A4 P46531 ANAPC1 NOTCH1 0.126 23022380 Q9H1A4 P48431 ANAPC1 SOX2 0.126 23667531 Q9H1A4 Q12888 ANAPC1 TP53BP1 0.126 22990118 Q9H1A4 P19338 ANAPC1 NCL 0.081 26344197 Q9H1A4 P51955 ANAPC1 NEK2 0.21 23288039 Q9H1A4 O00268 ANAPC1 TAF4 0.081 26344197 Q9H1A4 P53995 ANAPC1 ANAPC1 0.126 20360068 Q9H1A4 Q16763 ANAPC1 UBE2S 0.309 25306923 Q9H1A4 A0JLT2 ANAPC1 MED19 0.126 15175163

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MED19 ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database NTN3 ANAPC1 MI:0362 inference MI:0461 interaction database UBE2C ANAPC1 MI:0362 inference MI:1106 pathways database AURKA ANAPC1 MI:0362 inference MI:1106 pathways database BUB3 ANAPC1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database BUB1B ANAPC1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database GRAP2 ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database USP1 ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database NTN1 ANAPC1 MI:0362 inference MI:0461 interaction database TTLL1 ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database APC2 ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database PTTG1 ANAPC1 MI:0362 inference MI:1106 pathways database KNG1 ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database PENK ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database NTRK1 ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database CDK1 ANAPC1 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database UBB ANAPC1 MI:0362 inference MI:1106 pathways database UBC ANAPC1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database CDH1 ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database CCNB1 ANAPC1 MI:0362 inference MI:1106 pathways database TCF4 ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database CDK2 ANAPC1 MI:0362 inference MI:1106 pathways database CDC27 ANAPC1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database CTNNB1 ANAPC1 MI:0362 inference MI:0461 interaction database NOTCH1 ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database SOX2 ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D1 ANAPC1 MI:0362 inference MI:1106 pathways database NEK2 ANAPC1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database UBE2E1 ANAPC1 MI:0362 inference MI:1106 pathways database PPP5C ANAPC1 MI:0362 inference MI:0461 interaction database PLK1 ANAPC1 MI:0362 inference MI:1106 pathways database ANAPC15 ANAPC1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database COPS2 ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database RPS27A ANAPC1 MI:0362 inference MI:1106 pathways database UBA52 ANAPC1 MI:0362 inference MI:1106 pathways database NOTCH2 ANAPC1 MI:0362 inference MI:0461 interaction database CDC20 ANAPC1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TP53BP1 ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database CDC16 ANAPC1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database MAD2L1 ANAPC1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SKP2 ANAPC1 MI:0362 inference MI:1106 pathways database SNW1 ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database MDC1 ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2S ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database PAXIP1 ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database USP37 ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database SIRT2 ANAPC1 MI:0362 inference MI:0461 interaction database CCDC13 ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database SIRT6 ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database CEP120 ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database CDC26 ANAPC1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PIFO ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database LIPH ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database ANAPC16 ANAPC1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database AURKB ANAPC1 MI:0362 inference MI:1106 pathways database EHMT2 ANAPC1 MI:0362 inference MI:1106 pathways database CEP19 ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database CDC5L ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database ANAPC13 ANAPC1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RPAP1 ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database FOXQ1 ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database MAP1LC3B ANAPC1 MI:0045 experimental interaction detection MI:0461 interaction database ADAM19 ANAPC1 MI:0362 inference MI:0461 interaction database ANAPC1 SMARCAD1 MI:0045 experimental interaction detection MI:0461 interaction database ANAPC1 RPAP3 MI:0045 experimental interaction detection MI:0461 interaction database ANAPC1 MAGIX MI:0045 experimental interaction detection MI:0461 interaction database ANAPC1 EHMT1 MI:0362 inference MI:1106 pathways database ANAPC1 MOV10 MI:0045 experimental interaction detection MI:0461 interaction database ANAPC1 SIRT7 MI:0045 experimental interaction detection MI:0461 interaction database ANAPC1 LATS2 MI:0045 experimental interaction detection MI:0461 interaction database ANAPC1 ANAPC11 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ANAPC1 CFAP97 MI:0045 experimental interaction detection MI:0461 interaction database ANAPC1 HECW2 MI:0045 experimental interaction detection MI:0461 interaction database ANAPC1 NXF1 MI:0045 experimental interaction detection MI:0461 interaction database ANAPC1 CDC23 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ANAPC1 ANAPC7 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ANAPC1 ANAPC5 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ANAPC1 ANAPC4 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ANAPC1 ANAPC2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ANAPC1 FBXO5 MI:0045 experimental interaction detection MI:0461 interaction database ANAPC1 INO80 MI:0362 inference MI:0461 interaction database ANAPC1 FZR1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ANAPC1 ANAPC10 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ANAPC1 NOTCH3 MI:0362 inference MI:0461 interaction database ANAPC1 TRIM33 MI:0045 experimental interaction detection MI:0461 interaction database ANAPC1 PHF8 MI:0045 experimental interaction detection MI:0461 interaction database