PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SORBS2 BAG3 23824909 biogrid exp GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 ADAM15 16374509 hprd,biogrid,mint,intact exp GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G GP GP G GP P G SORBS2 YWHAB 24255178 biogrid,intact exp GP GP G P GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 PKM 15128873 hprd exp GP GP G P GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP G GP P G SORBS2 MYO18A 26496610 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P SORBS2 SYNPO 26496610 biogrid,intact exp G GP G GP G G GP G GP G G G G GP GP GP G G GP G G GP GP G GP G SORBS2 PALLD 16125169 biogrid,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G SORBS2 DLGAP2 10521485 hprd exp P GP G P GP G GP GP G GP G P P P GP G GP G P P GP P P P P G SORBS2 LIMA1 26496610 biogrid,intact exp GP GP G P G G G GP G GP G GP G G GP G G GP G GP GP GP GP GP G GP P G SORBS2 ATPAF2 25416956 biogrid,intact exp GP GP P GP G GP GP G GP G GP GP G P GP GP GP G P GP P GP P GP P G SORBS2 MAP4K3 20936779 i2d exp G G G P GP G G GP G GP G GP GP G GP GP G GP G GP G G GP GP G GP P G SORBS2 SUZ12 24457600 innatedb,biogrid exp G G G P G G G GP G GP G G GP G GP G G G G GP G G G GP G GP G SORBS2 MYH9 26496610 biogrid,intact exp GP GP G P GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 ANLN 26496610 biogrid,intact exp P G P GP GP G P P P GP G P GP P P GP P SORBS2 AKT2 21988832 biogrid,intact exp GP GP G P GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP P G SORBS2 NR1H2 21900206 biogrid,mint,intact exp GP GP G GP G G GP G GP G G G G GP GP G GP G GP G G GP GP G GP P G SORBS2 SEMA6A 12421765 hprd,biogrid,i2d,intact exp GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G EFS SORBS2 25416956 biogrid,intact exp GP G G GP G G GP G GP GP G G G GP GP GP G GP GP GP G G G G G SORBS2 MAPRE1 26496610 biogrid,intact exp GP GP G GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP P G SORBS2 CLTC 26496610 biogrid,intact exp GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP G GP P G SORBS2 TRAF4 12023963 hprd,i2d exp G GP G GP G P GP G GP G GP G G GP GP G GP G GP G GP P GP G GP P G SORBS2 WAS 25416956 biogrid,intact exp GP GP G P GP G G GP G G G GP GP G G GP G GP G GP G G GP G G GP P G SORBS2 CAPZA2 26496610 biogrid,intact exp GP GP G P GP G G GP G G G GP GP G GP GP G GP G GP GP G G GP G GP P G SORBS2 DBN1 26496610 biogrid,intact exp G G G P GP G G GP G GP G GP G G GP GP GP G GP GP G G G GP P G SORBS2 PTPN12 18559503 biogrid exp GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G MYO1C SORBS2 26496610 biogrid,intact exp GP GP G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP P G SORBS2 SH2D4A 25416956 biogrid,intact exp GP G G GP G GP GP G GP G GP G GP GP GP GP G GP GP GP G GP GP P G SORBS2 PPP1CB 26496610 biogrid,intact exp GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G VPS37C SORBS2 25416956 biogrid,intact exp GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 FLNA 26496610 biogrid,intact exp G G G P GP G G GP G GP G GP GP G G GP GP GP G GP G G G G G GP P G SORBS2 IQGAP1 26496610 biogrid,intact exp GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP P G SORBS2 SFN 15778465 biogrid,mint,intact exp GP G G G G G G G G G GP G G G G GP G G G GP G G G G G G SORBS2 RPL9, RPL9P7, RPL9P8, RPL9P9 16169070 hprd,biogrid,i2d,mint exp GP GP G P GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP P G SORBS2 ACTN1 16125169 biogrid exp, ortho G G G P GP G G G G G G GP GP G G GP G G G GP G GP GP G G G G SORBS2 VCL 10521485 hprd,biogrid exp, ortho GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G FLOT1 SORBS2 15128873 hprd,biogrid,i2d exp, ortho GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 YWHAE 25416956,16189514 hprd,biogrid,mint,intact exp, ortho GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 PTK2B 15128873 hprd,biogrid,i2d exp, ortho GP GP G GP G GP GP G GP G GP GP G GP GP G GP G P GP G G GP G GP P G SORBS2 DLGAP4 10521485, 25402006 hprd,biogrid exp, ortho, pred GP GP G P GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP P G SORBS2 CBL 15128873,12475393, 25402006, 21836163 hprd,biogrid,i2d exp, ortho, pred G GP G P GP G G GP G GP G GP GP G G GP GP G G G G G G G G G P G SORBS2 MLLT4 10521485, 25402006 hprd,biogrid exp, ortho, pred GP GP G P GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP P G DLGAP1 SORBS2 10521485, 25402006 hprd,biogrid exp, ortho, pred P GP G P GP P P G P P P GP P P G P P GP P P P SORBS2 YWHAZ 21988832,15161933, 25402006 biogrid,mint,intact exp, ortho, pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SYNJ1 SORBS2 11292345, 25402006 hprd,mint,intact exp, ortho, pred GP P G P GP G G GP G GP G GP GP G GP GP GP P G GP GP G GP GP G GP P SORBS2 ABL1 18559503,12475393,9211900, 25402006, 21836163 hprd,biogrid exp, pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 MDM2 21988832, 25402006 biogrid,intact exp, pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G NCK2 SORBS2 25416956, 25402006 biogrid,intact exp, pred G GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 EGFR 20029029, 25402006 biogrid,i2d,intact exp, pred GP GP G GP G G GP G GP G G G G GP GP G G G GP GP G GP GP G GP P G SORBS2 SORBS2 25416956, 23023127 biogrid,intact exp, pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 PAK1 15784622, 25402006 hprd,mint,intact exp, pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 WASF1 18559503,11130076, 25402006 biogrid,intact exp, pred GP GP G P GP G GP GP G GP G P GP G GP GP GP P G GP GP GP P GP G GP P G SORBS2 AKT1 15784622, 25402006 hprd,mint,intact exp, pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 PAK2 16374509, 25402006 hprd,mint,intact exp, pred GP GP G GP G G GP G GP G GP GP G GP GP GP G G GP G GP GP GP G GP G SORBS2 ABL2 9211900, 25402006, 21836163 hprd,biogrid exp, pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 SPTA1 ortho P P P G P P P G P P P P G G GP P P P G SORBS2 PXN ortho GP GP G P GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G G P G SORBS2 PGLS ortho GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP P G SORBS2 SH3GL1 25402006 ortho, pred GP GP G P GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 DNM2 25402006 ortho, pred GP GP G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP G GP P G SORBS2 DLGAP3 25402006 ortho, pred G GP P P G P P GP P SORBS2 DNM1 25402006 ortho, pred G G GP G G GP G G G GP G G G GP G G G G G G G G SORBS2 SPTAN1 25402006, 21836163 ortho, pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 SYNJ2BP 25402006 ortho, pred G GP G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP G GP G GP P G SORBS2 PIWIL1 25402006 ortho, pred P P P P P P P P P P P P P P GP P P SORBS2 SORBS1 25402006, 23023127 pred GP GP G P GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 EPS8L3 23023127 pred G G G P GP G GP GP G P G GP G G GP GP GP GP G G G GP GP G P G SORBS2 UBXN11 23023127 pred G GP G GP G GP P G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP P G BIN1 SORBS2 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 MAP3K10 23023127 pred P P P P P P P P P P P P P P P P P P P SORBS2 LCK 25402006 pred G P G G G G G G GP G G G G G G G SORBS2 NSFL1C 23023127 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP P G SORBS2 CTTN 25402006, 23023127 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 SH3GL3 25402006 pred G G GP G G G G G G G G G GP G GP G G G G G G GP P G SORBS2 GRB10 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 ITSN1 25402006, 23023127 pred G GP G GP G GP GP G GP G GP GP G GP GP G G G GP G GP GP GP G GP P G SORBS2 HCK 25402006 pred GP G G P GP G G G G P G GP G G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 SHC1 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 ERBB3 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP P GP G GP GP GP P GP GP P G SORBS2 LIMK1 25402006 pred P GP P GP G P P G P P P P GP P GP G P P P P P P SORBS2 PIK3R1 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 BZRAP1 23023127 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G P GP GP GP GP G GP P G SORBS2 SH3RF2 23023127 pred P P P GP P P P P P P P P P P SASH3 SORBS2 23023127 pred GP G G GP G G GP G G G GP GP G G GP G GP G GP GP GP G G G GP P G SORBS2 UBASH3B 23023127 pred P P G P GP G P P G P GP P P GP P GP P P P P G P P SORBS2 EPS8L1 23023127 pred GP GP G G GP GP GP G G GP G G GP G GP G G GP GP GP G SORBS2 SYN1 25402006 pred G G GP G G GP G G G G GP G G G G P G SORBS2 MAPT 25402006 pred G GP G GP G GP GP G GP G G GP G G GP G GP G G GP GP GP G G GP P G SH2D7 SORBS2 23023127 pred P P P P P P P P P SORBS2 CSK 25402006 pred G G G P GP G G GP G G G GP GP G GP GP G GP G GP G G G GP G GP P G SORBS2 MAPK8IP2 23023127 pred G GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP P G SORBS2 TDRD1 23023127 pred P P P P P P P P P P P P P P P P P P P P SORBS2 RAF1 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 FYN 25402006 pred G GP G P GP G G GP G GP G G GP G G GP G G G G G G G G G G G SORBS2 MYLK 25402006 pred G G G G G G GP G GP G G G G G G G G G G G G G G G G G SORBS2 SH3GLB2 23023127 pred G GP G GP G G GP G GP G GP G G GP G GP G GP G G G G G GP P G SORBS2 TMUB1 23023127 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 SH3BP1 25402006 pred GP P P P P P GP GP P P P P GP G P P G SORBS2 UBXN10 23023127 pred GP GP G P GP G GP GP G GP G GP GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 BTK 25402006 pred G P G G GP GP G G G G SORBS2 ERBB2 25402006 pred GP G G G G G GP G GP G G G G GP G G G G GP GP G G GP G G G SORBS2 BRAF 25402006 pred GP GP G P GP G GP GP G GP G GP GP P GP GP GP G GP GP GP GP P G GP P G SORBS2 YTHDC1 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 PTEN 25402006 pred GP GP G P GP G G GP G GP G GP GP G GP GP G GP G GP G GP G GP G GP P G SORBS2 SUMO4 23023127 pred GP GP G P GP G GP GP G GP G GP GP G G GP GP GP G GP GP GP GP G G GP P G SORBS2 MYO15A 23023127 pred GP G G GP G G GP G GP G G G G GP GP GP GP G GP G G GP GP GP P G SORBS2 SH3RF3 25402006, 23023127 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 NF2 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 LIMS2 23023127 pred G G G GP G GP GP G GP G G G G G GP G G G G G G G G G G G SORBS2 CRK 25402006 pred GP G G G G GP GP G GP G G G G GP G G GP G GP GP GP GP GP G GP G SORBS2 SAMSN1 23023127 pred G GP P P G P GP P GP GP GP GP P P P P GP G GP P SORBS2 UBASH3A 23023127 pred P P G P P P G SORBS2 ARHGEF19 23023127 pred G G G G G G G G G G G SORBS2 UBL4B 23023127 pred P P P P P P P P P P P P P P P P P P P SORBS2 AMPH 25402006, 23023127 pred G G GP G G GP G G G G G GP G GP G G G G G G G G ARHGEF37 SORBS2 23023127 pred GP GP G GP G GP GP G GP G G G G GP GP G P G GP G GP G GP G GP P G SORBS2 UBXN2A 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G SORBS2 NCK1 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP P G SH3D21 SORBS2 23023127 pred P GP G P P G GP GP G GP G P GP GP GP P GP G GP P GP GP GP P P G SORBS3 SORBS2 25402006, 23023127 pred G G G GP G GP GP G GP G G G G GP GP G GP G GP GP GP GP GP G GP G SORBS2 UBQLN2 23023127 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 PGM1 25402006 pred GP GP G P GP G GP GP G GP G G G G GP GP G GP G GP G GP GP GP G GP P G SORBS2 SASH1 23023127 pred GP GP G P GP G GP GP G GP G GP G G G GP G GP G GP GP GP GP G G GP P G SORBS2 BCAR1 25402006, 23023127 pred GP GP G P GP G GP GP G GP G GP GP GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 UBXN2B 23023127 pred G GP G G G G GP G GP G GP G G GP G GP G G G GP G G GP G GP P G SORBS2 SLA 25402006 pred G GP G P GP G G GP G GP G GP GP G GP GP G GP G GP G GP GP GP G GP P G SORBS2 FOXO1 25402006 pred GP GP G P GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 RUSC1 23023127 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP P G SORBS2 AHI1 23023127 pred GP GP G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G G GP G GP P G SORBS2 CDK5 25402006 pred P GP G P GP G P P G GP G P GP GP GP P P G P G P P P P P SORBS2 ARHGEF6 25402006 pred G GP G P GP G G GP G GP G GP GP G GP GP G GP G G G G G GP G GP G SORBS2 EPCAM 23023127 pred P G G GP G GP G G GP GP G G G GP G P G SORBS2 PDLIM3 21836163 pred G GP G GP GP GP G G G GP G GP GP GP GP G GP G G GP GP G GP P G SORBS2 SKAP1 23023127 pred G G G P G G G G G G G GP GP G G G G G G G G G G G G G G SORBS2 CASP3 25402006 pred GP G G P G G GP G G G GP GP G GP G G GP G GP G G G GP G GP P G INPPL1 SORBS2 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 BAG6 23023127 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 ILK 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 PKN2 25402006 pred GP GP G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP P G SRGAP3 SORBS2 23023127 pred GP G G GP G GP GP G GP G G G G G GP G G G G G G GP G G PDPK1 SORBS2 25402006 pred GP GP G P GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP P G SORBS2 OBSCN 23023127 pred GP P P P GP GP GP P GP G P P P P G P GP GP GP GP G GP P PPL SORBS2 25402006 pred GP G G GP G G G GP G GP G G G GP G GP G G GP GP G G GP G NEBL SORBS2 23023127 pred GP GP G G G GP GP G GP G GP GP G GP G G GP G G G G G GP GP G SORBS2 BRCA1 25402006 pred P P P P P P P P P GP P P P P P P P P P P SORBS2 FGR 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G P GP GP G GP G GP P G RIMBP3B SORBS2 23023127 pred SORBS2 PPP1R13B 23023127 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 GRB2 25402006 pred GP GP G P GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 STAC3 23023127 pred G G G G G G G G G G G SORBS2 RIN1 25402006 pred GP GP G P GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 ELF3 25402006 pred GP G G G G G GP G GP G G G G GP G G GP G GP G GP G GP G GP G SORBS2 CD2AP 25402006, 23023127 pred GP GP P P G G GP GP G GP GP G GP GP G GP G GP GP GP G GP G GP P SORBS2 MYO15B 23023127 pred SORBS2 LYN 25402006 pred GP G G P GP G G GP G G G GP GP G GP GP G GP G GP GP GP GP G GP G SORBS2 NGEF 23023127 pred P GP G P GP G P GP G GP G P GP G GP GP G GP P GP P P GP GP P G SORBS2 MAPK8IP1 23023127 pred P P G P GP G P P G P P P P GP P G P P P P P P P SORBS2 RUSC2 23023127 pred GP GP G P GP G GP GP G GP G GP GP G P GP GP P G P P GP GP GP G GP P G SORBS2 BAIAP2 23023127 pred P P G P GP G GP P G GP G GP GP P GP GP GP G GP GP P P P GP P G SORBS2 UBC 23023127 pred SORBS2 CDK11A 25402006 pred P P P P P P P P P P P P P P P P P P P P FCHSD2 SORBS2 23023127 pred GP GP G P GP G GP GP G GP G GP G G GP GP G GP G GP GP P GP GP G GP G SORBS2 CDC42 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 ITSN2 23023127 pred G G G GP G G GP G GP G G G G GP GP G GP G GP GP G G GP G GP P G SORBS2 CRKL 25402006 pred GP G G P GP G G GP G G G GP GP G GP GP G GP G GP GP G G GP G GP G SORBS2 MIA2 23023127 pred P P P P GP G P P G GP P P GP P P P G SORBS2 UBQLNL 23023127 pred P P P P P P P G P P P P P RIMBP3C SORBS2 23023127 pred P P P P SORBS2 RAC1 25402006 pred GP GP G P G G G GP G G G GP G G GP G G GP G GP GP G GP GP G GP P G SORBS2 SOS2 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 SH3PXD2A 23023127 pred GP GP G P GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 PLCG1 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 SH2D5 23023127 pred P P G P GP GP GP G P P G GP GP P P G GP P GP P P P P SORBS2 NOXO1 23023127 pred G G G SORBS2 EPS8L2 23023127 pred GP GP G GP P GP G GP G GP G G GP GP G GP G GP GP GP P GP GP P G SRGAP2 SORBS2 23023127 pred G G G G G G G G G G G G G G G G RIMBP2 SORBS2 23023127 pred P P G P GP G P P G GP P G GP GP GP G P P P GP P GP P G UBFD1 SORBS2 23023127 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G PAK3 SORBS2 25402006 pred G G G GP G G G G G G GP G G GP G GP G GP G G G G G G G SORBS2 FLNC 25402006 pred G GP G GP G GP GP G GP G GP G G GP GP G GP G GP G GP GP GP G GP P G SORBS2 JAK1 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP P G SORBS2 MIDN 23023127 pred GP GP G P GP G GP GP G GP G G G G GP GP G G G GP GP GP GP GP G GP P G SORBS2 SLA2 25402006 pred G G G G G G G G G G G G G G SORBS2 TMUB2 23023127 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 ARHGEF7 25402006, 23023127 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G GP GP G GP P G SORBS2 ABI2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G PIK3R2 SORBS2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G SORBS2 UBTD1 23023127 pred GP GP G GP G GP GP G GP G GP G G G GP GP GP G P G GP G G G P G SORBS2 VAV1 25402006 pred GP GP P GP G P P G P G GP GP G GP GP G GP G GP G GP P P G GP P G SORBS2 STAC2 23023127 pred GP GP G P GP G G GP G GP G GP GP G GP GP GP GP G GP P GP G GP G GP P G SORBS2 SH3RF1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G SORBS2 BAD 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP G GP P G SORBS2 FCHSD1 23023127 pred P P P P P P P P GP P P P P G P P P P P G P P SORBS2 SH3GL2 25402006, 23023127 pred G GP G G G GP GP G SORBS2 RIMBP3 23023127 pred SORBS2 SRC 25402006 pred GP GP G GP GP G G GP G G G G GP GP G G G GP GP G GP G GP P G SORBS2 DCTN1 23023127 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 BMX 25402006 pred GP P P P G GP GP P P G GP P GP P P P GP P P SORBS2 H3F3A, H3F3B 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP P G SORBS2 SH3KBP1 25402006, 23023127 pred G G G P GP G G G G G G G GP G G GP G G G GP G G G G G G G SORBS2 UBL7 23023127 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP P G SORBS2 BLK 25402006 pred GP P P P P P P GP P P P P P G P P SORBS2 CAT 25402006 pred G GP G P G G G G G GP G GP G G GP G G G G G GP G G GP G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O94875 O75955 - 15128873 - X 2 A0A024QZ59 O94875 - 12023963 - X 2 O94875 coimmunoprecipitation 15128873 association C 3 O94875 O41958 two hybrid 22028648 direct interaction X 2 O94875 Q92558 two hybrid 11130076 physical association X 2 O94875 Q13444 filter binding 16374509 physical association X 2 O94875 P00533 ubiquitin reconstruction 20029029 physical association X 2 O94875 P55055 two hybrid 21900206 physical association X 2 O94875 anti tag coimmunoprecipitation 24255178 association C 142 O43426 O94875 phage display 11292345 direct interaction X 2 O43426 O94875 pull down 11292345 direct interaction X 2 Q9H2E6 O94875 two hybrid 12421765 physical association X 2 P00520 O94875 phage display 18768933 physical association X 2 D0PNI1 O94875 pull down 15161933 physical association X 2 Q13177 O94875 phage display 16374509 physical association X 2 Q13177 O94875 filter binding 16374509 physical association X 2 Q5NGV7 O94875 two hybrid pooling approach 20711500 physical association X 2 A5D8V6 O94875 two hybrid prey pooling approach 25416956 physical association X 2 A5D8V6 O94875 two hybrid array 25416956 physical association X 2 A5D8V6 O94875 validated two hybrid 25416956 physical association X 2 O94875 P62258 two hybrid pooling approach 16189514 physical association X 2 O94875 Q7CIS8 two hybrid pooling approach 20711500 physical association X 2 O94875 O94875 two hybrid array 25416956 physical association X 2 O94875 P62258 two hybrid prey pooling approach 25416956 physical association X 2 O94875 Q8N5M1 two hybrid prey pooling approach 25416956 physical association X 2 O94875 Q9H788-2 two hybrid prey pooling approach 25416956 physical association X 2 O94875 P62258 two hybrid array 25416956 physical association X 2 O94875 Q8N5M1 two hybrid array 25416956 physical association X 2 O94875 Q9H788-2 two hybrid array 25416956 physical association X 2 O94875 Q9H788-2 validated two hybrid 25416956 physical association X 2 O94875 P62258 validated two hybrid 25416956 physical association X 2 O94875 Q8N5M1 validated two hybrid 25416956 physical association X 2 O43639 O94875 two hybrid prey pooling approach 25416956 physical association X 2 O43639 O94875 two hybrid array 25416956 physical association X 2 O43639 O94875 validated two hybrid 25416956 physical association X 2 P31947 O94875 tandem affinity purification 15778465 physical association X 2 Q8WX93 O94875 two hybrid 16125169 physical association X 2 Q8WX93 O94875 pull down 16125169 physical association X 2 A0A024QYX8 O94875 two hybrid prey pooling approach 25416956 physical association X 2 A0A024QYX8 O94875 two hybrid array 25416956 physical association X 2 A0A024QYX8 O94875 validated two hybrid 25416956 physical association X 2 O43281 O94875 two hybrid prey pooling approach 25416956 physical association X 2 O43281 O94875 two hybrid array 25416956 physical association X 2 O43281 O94875 validated two hybrid 25416956 physical association X 2 B0LPE5 O94875 anti tag coimmunoprecipitation 15784622 physical association X 2 B0LPE5 O94875 pull down 15784622 physical association X 2 B0LPE5 O94875 anti tag coimmunoprecipitation 15784622 physical association X 2 B0LPE5 O94875 anti bait coimmunoprecipitation 15784622 physical association X 2 B0LPE5 O94875 anti bait coimmunoprecipitation 15784622 physical association X 2 B0LPE5 O94875 pull down 15784622 physical association X 2 B0LPE5 O94875 pull down 15784622 physical association X 2 B0LPE5 O94875 two hybrid pooling approach 15784622 physical association X 2 B0LPE5 O94875 experimental interaction detection 15784622 phosphorylation reaction X 2 B0LPE5 O94875 anti tag coimmunoprecipitation 15784622 physical association X 2 B0LPE5 O94875 affinity chromatography technology 15784622 phosphorylation reaction X 2 B0LPE5 O94875 anti tag coimmunoprecipitation 15784622 physical association X 2 Q9WMX2 O94875 two hybrid prey pooling approach 18985028 physical association X 2 Q9WMX2 O94875 pull down 18985028 physical association X 2 A0A024R5P0 O94875 anti tag coimmunoprecipitation 15784622 physical association X 2 A0A024R5P0 O94875 anti tag coimmunoprecipitation 15784622 physical association X 2 A0A024R5P0 O94875 anti tag coimmunoprecipitation 15784622 physical association X 2 A0A024R5P0 O94875 pull down 15784622 physical association X 2 A0A024R5P0 O94875 pull down 15784622 physical association X 2 A0A024R5P0 O94875 anti bait coimmunoprecipitation 15784622 physical association X 2 A0A024R5P0 O94875 anti bait coimmunoprecipitation 15784622 physical association X 2 A0A024R5P0 O94875 anti tag coimmunoprecipitation 15784622 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B SYNJ1 SORBS2 MI:0084(phage display)|MI:0096(pull down)|MI:0084(phage display)|MI:0096(pull down)|MI:0096(pull down)|MI:0492(in vitro)|MI:0084(phage display)|MI:0084(phage display)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 11292345 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|-|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|(intact)|MI:0468(hprd)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|(intact) MINT_56380|UniProt_68771|MINT_56381|UniProt_181484|UniProt_181490|HPRD_15130|MINT_85396|MINT_85395|UniProt_161036|UniProt_68765|UniProt_161042 bait|bait|bait|bait|bait|-|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|-|prey|prey|prey|prey|prey SORBS2 PTK2B MI:0492(in vitro)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15128873 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0407(direct interaction) MI:0468(hprd)|(biogrid)|(biogrid) HPRD_8625|BIOGRID_86556|BIOGRID_86564 -|bait|bait -|prey|prey SORBS2 PALLD MI:0018(two hybrid)|MI:0096(pull down)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0096(pull down) 16125169 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(intact)|(biogrid) UniProt_83614|BIOGRID_196904|BIOGRID_196896|UniProt_83615|BIOGRID_196900 prey|prey|bait|bait|prey bait|bait|prey|prey|bait SORBS2 AKT2 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_118573|BIOGRID_287021 unspecified role|prey unspecified role|bait SORBS2 AKT1 MI:0493(in vivo)|MI:0493(in vivo)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0493(in vivo)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 15784622 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|-|MI:0217(phosphorylation reaction)|MI:0217(phosphorylation reaction)|MI:0217(phosphorylation reaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0217(phosphorylation reaction)|MI:0217(phosphorylation reaction)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0217(phosphorylation reaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|MI:0468(hprd)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|(intact)|(intact)|(intact)|MI:0471(mint)|MI:0468(hprd)|(intact)|MI:0471(mint)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint) HPRD_39720|HPRD_39724|MINT_31610|UniProt_80850|MINT_60381|UniProt_80830|MINT_60380|UniProt_80835|UniProt_80834|UniProt_80839|UniProt_80838|MINT_31600|HPRD_31516|UniProt_80840|MINT_31590|UniProt_80841|UniProt_80842|MINT_31592|MINT_60372|MINT_31591|MINT_60371|UniProt_80843|MINT_31594|MINT_31593|MINT_60391|MINT_31596|MINT_31595|MINT_60378|UniProt_80848|MINT_31598|MINT_60377|UniProt_80849|MINT_31597|MINT_31599|MINT_60379|MINT_60374|MINT_60373|MINT_60376|MINT_60375 -|-|unspecified role|unspecified role|unspecified role|bait|bait|bait|prey|prey|unspecified role|unspecified role|-|prey|prey|prey|prey|prey|prey|prey|prey|bait|bait|prey|unspecified role|bait|prey|bait|bait|bait|bait|bait|bait|bait|bait|prey|prey|prey|bait -|-|unspecified role|unspecified role|unspecified role|prey|prey|prey|bait|bait|unspecified role|unspecified role|-|bait|bait|bait|bait|bait|bait|bait|bait|prey|prey|bait|unspecified role|prey|bait|prey|prey|prey|prey|prey|prey|prey|prey|bait|bait|bait|prey SORBS2 PKM MI:0492(in vitro) 15128873 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_2273 - - SORBS2 SFN MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology) 15778465 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|MI:0471(mint)|(biogrid) MINT_84507|UniProt_81338|MINT_52044|BIOGRID_84931 prey|prey|prey|prey bait|bait|bait|bait SORBS2 YWHAB MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 24255178 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association)|MI:0914(association) (biogrid)|(intact)|(intact) BIOGRID_293559|UniProt_176935|UniProt_131089 prey|prey|prey bait|bait|bait SORBS2 CBL MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid) 12475393,15128873 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|(biogrid) BIOGRID_86561|BIOGRID_86555|BIOGRID_108611|BIOGRID_108610|HPRD_26564|BIOGRID_108614|BIOGRID_108609 prey|bait|prey|bait|-|bait|prey bait|prey|bait|prey|-|prey|bait DLGAP1 SORBS2 MI:0096(pull down)|MI:0492(in vitro) 10521485 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_107211|HPRD_15174 prey|- bait|- SORBS2 PAK2 MI:0049(filter binding)|MI:0049(filter binding)|MI:0049(filter binding)|MI:0049(filter binding)|MI:0049(filter binding)|MI:0049(filter binding)|MI:0492(in vitro) 16374509 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|MI:0468(hprd) MINT_49595|MINT_81803|MINT_49565|MINT_81773|UniProt_84572|UniProt_84602|HPRD_31284 prey|prey|prey|prey|prey|prey|- bait|bait|bait|bait|bait|bait|- SORBS2 PAK1 MI:0493(in vivo)|MI:0493(in vivo)|MI:0493(in vivo)|MI:0493(in vivo)|MI:0493(in vivo)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0493(in vivo) 15784622 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|-|-|-|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- MI:0468(hprd)|MI:0468(hprd)|MI:0468(hprd)|MI:0468(hprd)|MI:0468(hprd)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|(intact)|(intact)|MI:0468(hprd) HPRD_39720|HPRD_39724|HPRD_39719|HPRD_39723|HPRD_31521|MINT_31608|MINT_31605|MINT_31606|UniProt_80831|MINT_60383|MINT_60382|UniProt_80832|MINT_31609|MINT_60387|MINT_60386|UniProt_80836|MINT_60385|MINT_60384|MINT_60389|UniProt_80837|MINT_31601|MINT_31602|MINT_31603|MINT_31604|MINT_60390|UniProt_80844|UniProt_80845|UniProt_80846|UniProt_80847|HPRD_39721 -|-|-|-|-|prey|bait|bait|bait|bait|prey|bait|prey|bait|bait|prey|prey|bait|prey|bait|prey|bait|bait|prey|prey|prey|bait|prey|prey|- -|-|-|-|-|bait|prey|prey|prey|prey|bait|prey|bait|prey|prey|bait|bait|prey|bait|prey|bait|prey|prey|bait|bait|bait|prey|bait|bait|- SORBS2 ADAM15 MI:0049(filter binding)|MI:0049(filter binding)|MI:0492(in vitro)|MI:0049(filter binding)|MI:0096(pull down) 16374509 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0471(mint)|MI:0468(hprd)|MI:0471(mint)|(biogrid) UniProt_84593|MINT_81794|HPRD_31314|MINT_49586|BIOGRID_219259 prey|prey|-|prey|prey bait|bait|-|bait|bait FLOT1 SORBS2 MI:0492(in vitro)|MI:0004(affinity chromatography technology) 15128873 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_14065|BIOGRID_86566 -|bait -|prey SORBS2 RPL9 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0492(in vitro)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0915(physical association) (biogrid)|MI:0471(mint)|MI:0468(hprd)|MI:0471(mint) BIOGRID_93929|MINT_62775|HPRD_29314|MINT_33834 prey|prey|-|prey bait|bait|-|bait SORBS2 SEMA6A MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 12421765 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|(biogrid)|(intact) HPRD_14511|BIOGRID_184048|BIOGRID_184044|UniProt_69972 -|prey|bait|prey -|bait|prey|bait SORBS2 MLLT4 MI:0096(pull down)|MI:0492(in vitro) 10521485 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_107213|HPRD_37754 bait|- prey|- SORBS2 MDM2 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_119109|BIOGRID_287593 unspecified role|prey unspecified role|bait SORBS2 VCL MI:0096(pull down)|MI:0492(in vitro) 10521485 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_107212|HPRD_4872 bait|- prey|- SORBS2 NR1H2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact) BIOGRID_158379|UniProt_179890|UniProt_159292 prey|prey|prey bait|bait|bait SORBS2 YWHAE MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association) (biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0468(hprd)|(intact) BIOGRID_79688|MINT_67120|MINT_37937|HPRD_22536|UniProt_152534 prey|prey|prey|-|unspecified role bait|bait|bait|-|unspecified role SORBS2 DLGAP2 MI:0492(in vitro) 10521485 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_15173 - - SORBS2 SUZ12 MI:0004(affinity chromatography technology) 24457600 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_305880 prey bait SORBS2 ABL2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo)|MI:0018(two hybrid) 9211900 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|-|MI:0407(direct interaction) (biogrid)|(biogrid)|MI:0468(hprd)|(biogrid) BIOGRID_108086|BIOGRID_108085|HPRD_38738|BIOGRID_108089 bait|prey|-|prey prey|bait|-|bait SORBS2 BAG3 MI:0004(affinity chromatography technology) 23824909 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_283113 prey bait SORBS2 YWHAZ MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 15161933,21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0471(mint)|MI:0471(mint)|(intact)|(biogrid) UniProt_77267|MINT_83605|MINT_51261|UniProt_119331|BIOGRID_287863 prey|prey|prey|unspecified role|bait bait|bait|bait|unspecified role|prey SORBS2 PTPN12 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18559503 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_220250|BIOGRID_220246|BIOGRID_220248 prey|bait|bait bait|prey|prey SORBS2 ABL1 MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo)|MI:0018(two hybrid) 12475393,18559503,9211900 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid) BIOGRID_220249|BIOGRID_108087|BIOGRID_108613|HPRD_3932|BIOGRID_108088 bait|bait|bait|-|prey prey|prey|prey|-|bait SORBS2 EGFR MI:0112(ubiquitin reconstruction)|MI:0090(protein complementation assay) 20029029 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_103173|BIOGRID_123250 prey|prey bait|bait SORBS2 TRAF4 MI:0493(in vivo) 12023963 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_35389 - - SORBS2 WASF1 MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 11130076,18559503 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid)|(biogrid) UniProt_67875|BIOGRID_220245|BIOGRID_220247 prey|bait|bait bait|prey|prey SORBS2 ACTN1 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 16125169 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_196905|BIOGRID_196906|BIOGRID_196902|BIOGRID_207858 bait|prey|prey|prey prey|bait|bait|bait SORBS2 DLGAP4 MI:0492(in vitro)|MI:0096(pull down) 10521485 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_16014|BIOGRID_107210 -|bait -|prey

PPI - HINT Gene A Gene B PMID Method Quality MYO1C SORBS2 26496610,26496610 0007,0004 HT SORBS2 FLNA 26496610,26496610 0007,0004 HT SORBS2 CBL 12475393,15128873,12475393,12475393 0096,0004,0004,0018 LC SORBS2 YWHAB 24255178 0007 HT SORBS2 MYH9 26496610,26496610 0007,0004 HT SORBS2 IQGAP1 26496610,26496610 0007,0004 HT SORBS2 CAPZA2 26496610,26496610 0007,0004 HT SORBS2 PPP1CB 26496610 0007 HT SORBS2 CLTC 26496610,26496610 0007,0004 HT SORBS2 MAPRE1 26496610,26496610 0007,0004 HT SORBS2 DBN1 26496610,26496610 0007,0004 HT SORBS2 Q59FK4 9211900,9211900,18559503,12475393 0096,0415,0004,0004 LC SORBS2 SYNPO 26496610,26496610 0007,0004 HT SORBS2 MYO18A 26496610 0007 HT SORBS2 ANLN 26496610,26496610 0007,0004 HT SORBS2 MAJN 26496610 0004 HT SORBS2 LIMA1 26496610,26496610 0007,0004 HT SORBS2 HEL-S-80P 26496610 0004 HT SORBS2 HEL-S-1 24255178 0004 HT MYO1C SORBS2 26496610,26496610 0007,0004 HT SORBS2 FLNA 26496610,26496610 0007,0004 HT SORBS2 YWHAB 24255178 0007 HT SORBS2 MYH9 26496610,26496610 0007,0004 HT SORBS2 IQGAP1 26496610,26496610 0007,0004 HT SORBS2 CAPZA2 26496610,26496610 0007,0004 HT SORBS2 PPP1CB 26496610 0007 HT SORBS2 CLTC 26496610,26496610 0007,0004 HT SORBS2 MAPRE1 26496610,26496610 0007,0004 HT SORBS2 DBN1 26496610,26496610 0007,0004 HT SORBS2 SYNPO 26496610,26496610 0007,0004 HT SORBS2 MYO18A 26496610 0007 HT SORBS2 ANLN 26496610,26496610 0007,0004 HT SORBS2 MAJN 26496610 0004 HT SORBS2 LIMA1 26496610,26496610 0007,0004 HT SORBS2 HEL-S-80P 26496610 0004 HT SORBS2 HEL-S-1 24255178 0004 HT SORBS2 CBL 12475393,15128873,12475393,12475393 0096,0004,0004,0018 LC SORBS2 Q59FK4 9211900,9211900,18559503,12475393 0096,0415,0004,0004 LC VPS37C SORBS2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT EFS SORBS2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT SYNJ1 SORBS2 11292345,11292345 0084,0096 LC NCK2 SORBS2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT SORBS2 SORBS2 25416956,25416956 0397,0018 HT SORBS2 EGFR 20029029,20029029 0090,0112 LC SORBS2 ACTN1 16125169,16125169,16125169 0004,0018,0096 LC SORBS2 CBL 12475393,12475393,12475393 0096,0004,0018 LC SORBS2 AKT1 15784622,15784622,15784622,15784622,15784622,15784622,15784622 0398,0004,0006,0007,0018,0096,0045 LC SORBS2 AKT2 21988832 0018 HT SORBS2 RPL9|RPL9P7|RPL9P8|RPL9P9 16169070 0018 HT SORBS2 ABL2 9211900,9211900,9211900 0096,0415,0018 LC SORBS2 WAS 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT SORBS2 NR1H2 21900206 0018 HT SORBS2 YWHAE 16189514,16189514 0398,0018 HT SORBS2 YWHAZ 21988832 0018 HT SORBS2 MDM2 21988832 0018 HT SORBS2 PAK2 16374509,16374509 0049,0084 LC SORBS2 ADAM15 16374509,16374509 0096,0049 LC SORBS2 Q59FK4 9211900,9211900 0096,0415 LC SORBS2 ATPAF2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT SORBS2 PALLD 16125169,16125169,16125169 0004,0018,0096 LC SORBS2 WASF1 11130076 0018 LC SORBS2 TRAF4 12023963 0018 LC SORBS2 SEMA6A 12421765 0018 HT SORBS2 SH2D4A 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT SORBS2 HEL2 25416956,25416956,25416956,16189514,25416956 1112,0397,0018,0018,1356 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5NGV7 O94875 KATG SORBS2 0.126 20711500 Q05209 O94875 PTPN12 SORBS2 0.569 18559503 O94875 O43281 SORBS2 EFS 0.583 25416956,unassigned1304 P62140 O94875 PPP1CB SORBS2 0.126 26496610 O94875 O41958 SORBS2 GAMMAHV.ORF42 0.126 22028648 Q8N3V7 O94875 SYNPO SORBS2 0.126 26496610 Q8N5M1 O94875 ATPAF2 SORBS2 0.636 25416956,25910212 Q9NQW6 O94875 ANLN SORBS2 0.126 26496610 Q9H2E6 O94875 SEMA6A SORBS2 0.454 12421765 V9HW98 O94875 HEL2 {ECO:0000313|EMBL:ACJ13635.1} SORBS2 0.332 25416956 O94875 O75955 SORBS2 FLOT1 0.21 15128873 Q7CIS8 O94875 PYKF SORBS2 0.126 20711500 O94875 O14490 SORBS2 DLGAP1 0.309 10521485 O94875 O43639 SORBS2 NCK2 0.454 25416956 P00520 O94875 ABL1 SORBS2 0.21 18768933 P00533 O94875 EGFR SORBS2 0.286 20029029 P12814 O94875 ACTN1 SORBS2 0.74 16125169 P18206 O94875 VCL SORBS2 0.309 10521485 P42684 O94875 ABL2 SORBS2 0.671 9211900 P55196 O94875 MLLT4 SORBS2 0.309 10521485 P62258 O94875 YWHAE SORBS2 0.416 25416956,16189514 Q9H788 O94875 SH2D4A SORBS2 0.454 25416956 P04601 O94875 NEF SORBS2 0.183 16374509 O95817 O94875 BAG3 SORBS2 0.126 23824909 P00519 O94875 ABL1 SORBS2 0.702 12475393,18559503,9211900 Q9JHJ0 O94875 TMOD3 SORBS2 0.236 26496610 Q9WTI7 O94875 MYO1C SORBS2 0.236 26496610 Q9WUM4 O94875 CORO1C SORBS2 0.236 26496610 Q8VDD5 O94875 MYH9 SORBS2 0.236 26496610 Q13444 O94875 ADAM15 SORBS2 0.286 16374509 Q9D6P8 O94875 CALML3 SORBS2 0.236 26496610 O94875 A5D8V6 SORBS2 VPS37C 0.583 25416956,unassigned1304 Q13177 O94875 PAK2 SORBS2 0.236 16374509 P42768 O94875 WAS SORBS2 0.454 25416956 P31946 O94875 YWHAB SORBS2 0.236 24255178 Q61879 O94875 MYH10 SORBS2 0.236 26496610 Q13191 O94875 CBLB SORBS2 0.236 unassigned1304 Q14289 O94875 PTK2B SORBS2 0.454 15128873 Q8IZP0 O94875 ABI1 SORBS2 0.236 unassigned1304 Q8WX93 O94875 PALLD SORBS2 0.794 16125169 Q92558 O94875 WASF1 SORBS2 0.454 18559503 O94875 O43426 SORBS2 SYNJ1 0.523 11292345 O94875 A0A0G2JQ02 SORBS2 A0A0G2JQ02 0.236 unassigned1304 Q80X90 O94875 FLNB SORBS2 0.236 26496610 P55055 O94875 NR1H2 SORBS2 0.332 21900206 P60710 O94875 ACTB SORBS2 0.236 26496610 O94875 O15372 SORBS2 EIF3H 0.236 unassigned1304 O94875 O14512 SORBS2 SOCS7 0.236 unassigned1304 O94875 O00401 SORBS2 WASL 0.236 unassigned1304 O94875 A0A0C4DGS5 SORBS2 A0A0C4DGS5 0.236 unassigned1304 P62141 O94875 PPP1CB SORBS2 0.236 26496610 P63104 O94875 YWHAZ SORBS2 0.416 15161933,21988832 Q9Y2H0 O94875 DLGAP4 SORBS2 0.472 unassigned1304,10521485 Q13153 O94875 PAK1 SORBS2 0.757 15784622 P22681 O94875 CBL SORBS2 0.814 12475393,15128873 O94875 O94875 SORBS2 SORBS2 0.523 25416956,unassigned1304 O94875 O43707 SORBS2 ACTN4 0.416 25910212 P31749 O94875 AKT1 SORBS2 0.82 15784622 Q92614 O94875 MYO18A SORBS2 0.126 26496610 P31751 O94875 AKT2 SORBS2 0.332 21988832 P31947 O94875 SFN SORBS2 0.236 15778465 P35579 O94875 MYH9 SORBS2 0.126 26496610 P32969 O94875 RPL9P9 SORBS2 0.183 16169070 Q9UHB6 O94875 LIMA1 SORBS2 0.126 26496610 P46940 O94875 IQGAP1 SORBS2 0.126 26496610 P47755 O94875 CAPZA2 SORBS2 0.126 26496610 Q00610 O94875 CLTC SORBS2 0.126 26496610 Q00987 O94875 MDM2 SORBS2 0.332 21988832 Q15691 O94875 MAPRE1 SORBS2 0.126 26496610 O94875 O00159 SORBS2 MYO1C 0.126 26496610 Q16643 O94875 DBN1 SORBS2 0.126 26496610 P21333 O94875 FLNA SORBS2 0.126 26496610

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 VPS37C SORBS2 MI:0045 experimental interaction detection MI:0461 interaction database MYO1C SORBS2 MI:0045 experimental interaction detection MI:0461 interaction database DLGAP1 SORBS2 MI:0045 experimental interaction detection MI:0461 interaction database EFS SORBS2 MI:0045 experimental interaction detection MI:0461 interaction database SYNJ1 SORBS2 MI:0045 experimental interaction detection MI:0461 interaction database NCK2 SORBS2 MI:0045 experimental interaction detection MI:0461 interaction database ACTN4 SORBS2 MI:0362 inference MI:0461 interaction database FLNB SORBS2 MI:0362 inference MI:0461 interaction database FLOT1 SORBS2 MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 BAG3 MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 ABL1 MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 EGFR MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 SPTA1 MI:0362 inference MI:0461 interaction database SORBS2 ACTN1 MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 VCL MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 FLNA MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 CBL MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 CALML3 MI:0362 inference MI:0461 interaction database SORBS2 TMOD1 MI:0362 inference MI:0461 interaction database SORBS2 AKT1 MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 AKT2 MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 YWHAB MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 SFN MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 RPL9 MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 MYH9 MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 MYH10 MI:0362 inference MI:0461 interaction database SORBS2 ACTN2 MI:0362 inference MI:0461 interaction database SORBS2 MYH11 MI:0362 inference MI:0461 interaction database SORBS2 ABL2 MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 WAS MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 IQGAP1 MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 CAPZA2 MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 PXN MI:0362 inference MI:0461 interaction database SORBS2 MTNR1B MI:0362 inference MI:0461 interaction database SORBS2 DNM2 MI:0362 inference MI:0461 interaction database SORBS2 NR1H2 MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 MLLT4 MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 SYNJ2BP MI:0362 inference MI:0461 interaction database SORBS2 ACTB MI:0362 inference MI:0461 interaction database SORBS2 PPP1CB MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 YWHAE MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 YWHAZ MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 CLTC MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 MDM2 MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 DNM1 MI:0362 inference MI:0461 interaction database SORBS2 PTPN12 MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 PAK1 MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 PAK2 MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 ADAM15 MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 SPTAN1 MI:0362 inference MI:0461 interaction database SORBS2 PTK2B MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 SUZ12 MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 MAPRE1 MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 DBN1 MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 SYNPO MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 ATPAF2 MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 PALLD MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 WASF1 MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 MYO18A MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 SH3GL1 MI:0362 inference MI:0461 interaction database SORBS2 TRAF4 MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 SEMA6A MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 SH2D4A MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 ANLN MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 TMOD3 MI:0362 inference MI:0461 interaction database SORBS2 TMOD2 MI:0362 inference MI:0461 interaction database SORBS2 LIMA1 MI:0045 experimental interaction detection MI:0461 interaction database SORBS2 CORO1C MI:0362 inference MI:0461 interaction database SORBS2 DLGAP4 MI:0045 experimental interaction detection MI:0461 interaction database