PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus PSME3 USP43 19615732 biogrid,intact exp GP P G G GP GP P P G P GP GP P G GP GP GP GP GP GP GP GP GP P GP GP SFN USP43 15778465 mint,intact exp GP G G G G G G GP G G G GP G G GP G G G G G USP43 CDK5RAP2 26496610 biogrid,intact exp GP P G G GP GP P P G P GP GP P G GP GP GP GP GP GP GP GP GP GP GP USP43 FN3KRP 19615732 biogrid,intact exp G P G G G GP P P G P GP GP P G GP GP G GP GP GP G GP GP P GP GP YWHAB USP43 19615732 biogrid,intact exp GP P G G GP GP P G P GP GP P G GP GP GP GP GP GP GP GP GP P GP GP PDCD2 USP43 19615732 biogrid,intact exp GP P G G GP GP P P G P GP GP P G GP GP GP GP GP GP GP GP GP P GP GP YWHAE USP43 19615732 biogrid,intact exp GP P G G GP GP P P G P GP GP P G GP GP GP GP GP GP GP GP GP P GP GP USP43 VPS35 19615732 biogrid,intact exp GP P G G GP GP P P G P GP GP P G GP GP GP GP GP GP GP G GP GP GP USP43 TRIM56 26496610 biogrid,intact exp GP P G G GP GP P P G P G GP P G GP GP GP GP GP GP G P GP P GP GP HAUS5 USP43 26496610 biogrid,intact exp GP P G G G GP P P G P G GP G GP GP GP GP GP G GP G GP GP GP STX10 USP43 26496610 biogrid,intact exp GP P G G GP GP P P G P G GP P G GP GP GP GP GP GP GP GP GP P GP GP YWHAH USP43 19615732 biogrid,intact exp GP P G G GP GP P P G P GP GP G GP GP GP GP GP GP GP GP GP P GP GP NCOA4 USP43 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G USP43 INTS1 26496610 biogrid,intact exp GP P G G GP GP P P G P GP GP P G GP GP GP GP GP GP GP G GP P GP GP MAPT USP43 26496610 biogrid,intact exp G P G G G GP P P G P GP G P G G GP G GP G GP GP GP G GP GP USP43 TMEM165 26496610 biogrid,intact exp GP P G G GP GP P P G P G GP P G GP GP GP GP GP GP GP GP GP P GP GP MAGI3 USP43 19615732 biogrid,intact exp G P G G G GP P G P GP GP G GP GP GP GP GP GP G GP GP GP GP USP43 DDX11 26496610 biogrid,intact exp GP P G G GP GP P P G P G GP P G GP GP GP GP GP GP GP GP GP P GP GP PSMA2 USP43 26496610 biogrid,intact exp GP P G G GP GP P P G P GP GP P G GP GP GP GP GP GP GP G GP P GP GP USP43 WDR3 19615732 biogrid,intact exp GP P G G G GP P P G P G G P G G GP G GP GP GP G G G GP GP USP43 SSR3 26496610 biogrid,intact exp GP P G G GP GP P P G P GP GP P G GP GP GP GP GP GP GP GP GP P GP GP NHS USP43 26496610 biogrid,intact exp GP P G P GP P P G P P P P G P GP GP GP GP GP P P P P GP GP MRPS12 USP43 26496610 biogrid,intact exp GP P G G GP GP P P G P GP GP P G GP GP G GP GP GP GP GP GP P GP GP USP43 LCOR 26496610 biogrid,intact exp GP P G G GP GP P P G P GP GP P G GP GP GP GP GP GP GP GP GP P GP GP CSNK2B USP43 26496610 biogrid,intact exp GP P G G GP GP P P G P GP GP P G GP GP GP GP GP GP GP GP GP P GP GP USP43 FTSJ1 26496610 biogrid,intact exp GP G G G GP P P G P GP GP P G GP GP GP GP GP GP GP GP GP GP GP USP1 USP43 26496610 biogrid,intact exp GP P G G GP GP P G P GP G P G GP GP G G GP G GP GP GP P GP GP USP43 ATG4A 26496610 biogrid,intact exp GP P G G GP GP P P G P GP GP P G GP GP G GP GP GP GP GP GP P GP GP USP43 TRMT6 26496610 biogrid,intact exp GP P G G GP GP P P G P GP GP P G GP GP GP GP GP GP GP GP GP P GP GP USP43 CEP57 26496610 biogrid,intact exp GP P G G GP GP P P G P GP GP P G GP GP GP GP GP GP GP GP GP P GP GP POLD1 USP43 26496610 biogrid,intact exp GP P G GP P P P P GP GP P G GP GP GP GP GP GP GP GP GP P GP GP TXNL4A USP43 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q70EL4 Q16342-5 affinity chromatography technology 19615732 physical association X 2 Q70EL4 P62258 affinity chromatography technology 19615732 physical association X 2 Q70EL4 A0A024R1K7 affinity chromatography technology 19615732 physical association X 2 Q70EL4 Q5TDG3 affinity chromatography technology 19615732 physical association X 2 Q70EL4 P31946 affinity chromatography technology 19615732 physical association X 2 Q70EL4 P61289-2 affinity chromatography technology 19615732 physical association X 2 Q70EL4 Q96QK1 affinity chromatography technology 19615732 physical association X 2 Q70EL4 Q9HA64 affinity chromatography technology 19615732 physical association X 2 Q70EL4 Q5TCQ9-4 affinity chromatography technology 19615732 physical association X 2 Q70EL4 anti tag coimmunoprecipitation 19615732 physical association C 10 Q70EL4 P31947 tandem affinity purification 15778465 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B MAGI3 USP43 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120863|UniProt_100676 prey|prey bait|bait SFN USP43 MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification) 15778465 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|MI:0471(mint) MINT_84542|UniProt_81372|MINT_52079 bait|bait|bait prey|prey|prey PSME3 USP43 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100676|BIOGRID_120140 prey|prey bait|bait YWHAB USP43 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119861|UniProt_100676 prey|prey bait|bait USP43 WDR3 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100676|BIOGRID_120207 bait|bait prey|prey YWHAE USP43 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100676|BIOGRID_119864 prey|prey bait|bait YWHAH USP43 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100676|BIOGRID_119866 prey|prey bait|bait PDCD2 USP43 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119630|UniProt_100676 prey|prey bait|bait USP43 FN3KRP MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100676|BIOGRID_120667 bait|bait prey|prey USP43 VPS35 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100676|BIOGRID_120554 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality DKFZP586J0619 USP43 26496610 0007 HT MRPS12 USP43 26496610,26496610 0007,0004 HT STX10 USP43 26496610,26496610 0007,0004 HT USP1 USP43 26496610,26496610 0007,0004 HT HAUS5 USP43 26496610,26496610 0007,0004 HT MAPT USP43 26496610,26496610 0007,0004 HT PSMA2 USP43 26496610,26496610 0007,0004 HT POLD1 USP43 26496610 0007 HT YWHAB USP43 19615732,19615732 0004,0007 HT PSME3 USP43 19615732,19615732 0004,0007 HT YWHAE USP43 19615732,19615732 0004,0007 HT CSNK2B USP43 26496610,26496610 0007,0004 HT TXNL4A USP43 26496610,26496610 0007,0004 HT YWHAH USP43 19615732,19615732 0004,0007 HT NCOA4 USP43 26496610 0007 HT PDCD2 USP43 19615732,19615732 0004,0007 HT Q59FA0 USP43 26496610 0004 HT MAGI3 USP43 19615732,19615732 0004,0007 HT NHS USP43 26496610,26496610 0007,0004 HT USP43 CEP57 26496610,26496610 0007,0004 HT USP43 INTS1 26496610 0004 HT USP43 ATG4A 26496610,26496610 0007,0004 HT USP43 Q96E88 26496610 0004 HT USP43 DDX11 26496610,26496610 0007,0004 HT USP43 LCOR 26496610,26496610 0007,0004 HT USP43 VPS35 19615732,19615732 0004,0007 HT USP43 CDK5RAP2 26496610,26496610 0007,0004 HT USP43 TRIM56 26496610,26496610 0007,0004 HT USP43 Q9H4N8 19615732 0004 HT USP43 FN3KRP 19615732,19615732 0004,0007 HT USP43 TMEM165 26496610,26496610 0007,0004 HT USP43 FTSJ1 26496610,26496610 0007,0004 HT USP43 TRMT6 26496610,26496610 0007,0004 HT USP43 SSR3 26496610,26496610 0007,0004 HT USP43 WDR3 19615732,19615732 0004,0007 HT USP43 HEL2 19615732 0004 HT USP43 HEL-S-1 19615732 0004 HT USP43 HEL-S-283 19615732 0004 HT DKFZP586J0619 USP43 26496610 0007 HT MRPS12 USP43 26496610,26496610 0007,0004 HT STX10 USP43 26496610,26496610 0007,0004 HT USP1 USP43 26496610,26496610 0007,0004 HT HAUS5 USP43 26496610,26496610 0007,0004 HT MAPT USP43 26496610,26496610 0007,0004 HT PSMA2 USP43 26496610,26496610 0007,0004 HT POLD1 USP43 26496610 0007 HT YWHAB USP43 19615732,19615732 0004,0007 HT PSME3 USP43 19615732,19615732 0004,0007 HT YWHAE USP43 19615732,19615732 0004,0007 HT CSNK2B USP43 26496610,26496610 0007,0004 HT TXNL4A USP43 26496610,26496610 0007,0004 HT YWHAH USP43 19615732,19615732 0004,0007 HT NCOA4 USP43 26496610 0007 HT PDCD2 USP43 19615732,19615732 0004,0007 HT Q59FA0 USP43 26496610 0004 HT MAGI3 USP43 19615732,19615732 0004,0007 HT NHS USP43 26496610,26496610 0007,0004 HT USP43 CEP57 26496610,26496610 0007,0004 HT USP43 INTS1 26496610 0004 HT USP43 ATG4A 26496610,26496610 0007,0004 HT USP43 Q96E88 26496610 0004 HT USP43 DDX11 26496610,26496610 0007,0004 HT USP43 LCOR 26496610,26496610 0007,0004 HT USP43 VPS35 19615732,19615732 0004,0007 HT USP43 CDK5RAP2 26496610,26496610 0007,0004 HT USP43 TRIM56 26496610,26496610 0007,0004 HT USP43 Q9H4N8 19615732 0004 HT USP43 FN3KRP 19615732,19615732 0004,0007 HT USP43 TMEM165 26496610,26496610 0007,0004 HT USP43 FTSJ1 26496610,26496610 0007,0004 HT USP43 TRMT6 26496610,26496610 0007,0004 HT USP43 SSR3 26496610,26496610 0007,0004 HT USP43 WDR3 19615732,19615732 0004,0007 HT USP43 HEL2 19615732 0004 HT USP43 HEL-S-1 19615732 0004 HT USP43 HEL-S-283 19615732 0004 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q70EL4 A4D212 USP43 DKFZP586J0619 {ECO:0000313|EMBL:EAL23941.1} 0.126 26496610 Q70EL4 C9JA28 USP43 SSR3 {ECO:0000313|ENSEMBL:ENSP00000417530} 0.126 26496610 Q70EL4 F5GYW0 USP43 CEP57 {ECO:0000313|ENSEMBL:ENSP00000441392} 0.126 26496610 Q70EL4 O60499 USP43 STX10 0.126 26496610 Q70EL4 O94782 USP43 USP1 0.126 26496610 Q70EL4 P31947 USP43 SFN 0.126 15778465 Q70EL4 Q5U8S2 USP43 Q5U8S2 0.126 26496610 Q70EL4 Q6T4R5 USP43 NHS 0.126 26496610 Q8N201 Q70EL4 INTS1 USP43 0.126 26496610 Q96FC9 Q70EL4 DDX11 USP43 0.126 26496610 Q96SN8 Q70EL4 CDK5RAP2 USP43 0.126 26496610 Q9HC07 Q70EL4 TMEM165 USP43 0.126 26496610 Q9UET6 Q70EL4 FTSJ1 USP43 0.126 26496610 Q9UNL2 Q70EL4 SSR3 USP43 0.126 26496610 Q70EL4 P31946 USP43 YWHAB 0.236 19615732 Q70EL4 P28340 USP43 POLD1 0.236 26496610 Q70EL4 O15235 USP43 MRPS12 0.236 26496610 Q70EL4 P25787 USP43 PSMA2 0.236 26496610 Q70EL4 O94927 USP43 HAUS5 0.236 26496610 Q70EL4 P10636 USP43 MAPT 0.236 26496610 Q9UNX4 Q70EL4 WDR3 USP43 0.236 19615732 Q70EL4 Q16342 USP43 PDCD2 0.236 19615732 Q70EL4 P67870 USP43 CSNK2B 0.236 26496610 Q70EL4 P61289 USP43 PSME3 0.236 19615732 Q70EL4 P62258 USP43 YWHAE 0.236 19615732 Q70EL4 Q13772 USP43 NCOA4 0.236 26496610 Q70EL4 P83876 USP43 TXNL4A 0.236 26496610 Q70EL4 Q04917 USP43 YWHAH 0.236 19615732 Q9UJA5 Q70EL4 TRMT6 USP43 0.236 26496610 Q96JN0 Q70EL4 LCOR USP43 0.236 26496610 Q70EL4 Q5TCQ9 USP43 MAGI3 0.236 19615732 Q8WYN0 Q70EL4 ATG4A USP43 0.236 26496610 Q9HA64 Q70EL4 FN3KRP USP43 0.236 19615732 Q96QK1 Q70EL4 VPS35 USP43 0.236 19615732 Q9BRZ2 Q70EL4 TRIM56 USP43 0.236 26496610

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MRPS12 USP43 MI:0045 experimental interaction detection MI:0461 interaction database STX10 USP43 MI:0045 experimental interaction detection MI:0461 interaction database USP1 USP43 MI:0045 experimental interaction detection MI:0461 interaction database HAUS5 USP43 MI:0045 experimental interaction detection MI:0461 interaction database ISG15 USP43 MI:0362 inference MI:1106 pathways database MAPT USP43 MI:0045 experimental interaction detection MI:0461 interaction database PCNA USP43 MI:0362 inference MI:1106 pathways database RPA2 USP43 MI:0362 inference MI:1106 pathways database PSMA2 USP43 MI:0045 experimental interaction detection MI:0461 interaction database RPA1 USP43 MI:0362 inference MI:1106 pathways database POLD1 USP43 MI:0045 experimental interaction detection MI:0461 interaction database YWHAB USP43 MI:0045 experimental interaction detection MI:0461 interaction database SFN USP43 MI:0045 experimental interaction detection MI:0461 interaction database RPA3 USP43 MI:0362 inference MI:1106 pathways database RFC4 USP43 MI:0362 inference MI:1106 pathways database RFC2 USP43 MI:0362 inference MI:1106 pathways database RFC1 USP43 MI:0362 inference MI:1106 pathways database RFC5 USP43 MI:0362 inference MI:1106 pathways database RFC3 USP43 MI:0362 inference MI:1106 pathways database PSME3 USP43 MI:0045 experimental interaction detection MI:0461 interaction database YWHAE USP43 MI:0045 experimental interaction detection MI:0461 interaction database CSNK2B USP43 MI:0045 experimental interaction detection MI:0461 interaction database TXNL4A USP43 MI:0045 experimental interaction detection MI:0461 interaction database YWHAH USP43 MI:0045 experimental interaction detection MI:0461 interaction database NCOA4 USP43 MI:0045 experimental interaction detection MI:0461 interaction database PDCD2 USP43 MI:0045 experimental interaction detection MI:0461 interaction database MAGI3 USP43 MI:0045 experimental interaction detection MI:0461 interaction database NHS USP43 MI:0045 experimental interaction detection MI:0461 interaction database USP43 CEP57 MI:0045 experimental interaction detection MI:0461 interaction database USP43 INTS1 MI:0045 experimental interaction detection MI:0461 interaction database USP43 ATG4A MI:0045 experimental interaction detection MI:0461 interaction database USP43 DDX11 MI:0045 experimental interaction detection MI:0461 interaction database USP43 LCOR MI:0045 experimental interaction detection MI:0461 interaction database USP43 VPS35 MI:0045 experimental interaction detection MI:0461 interaction database USP43 CDK5RAP2 MI:0045 experimental interaction detection MI:0461 interaction database USP43 TRIM56 MI:0045 experimental interaction detection MI:0461 interaction database USP43 FN3KRP MI:0045 experimental interaction detection MI:0461 interaction database USP43 TMEM165 MI:0045 experimental interaction detection MI:0461 interaction database USP43 FTSJ1 MI:0045 experimental interaction detection MI:0461 interaction database USP43 TRMT6 MI:0045 experimental interaction detection MI:0461 interaction database USP43 SSR3 MI:0045 experimental interaction detection MI:0461 interaction database USP43 WDR3 MI:0045 experimental interaction detection MI:0461 interaction database