PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CRMP1 OTUD6B 22863883 biogrid exp G G G G G GP G G G G G G G G G GP GP G G G G G GP G GP G G G G MTDH OTUD6B 19615732 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ELAVL1 OTUD6B 19322201 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G OTUD6B PARVA 22863883 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G OTUD6B LIMCH1 26186194 biogrid exp G GP G GP G GP GP G GP G GP GP G G GP GP GP G GP GP GP G G G GP GP BASP1 OTUD6B 26344197 biogrid exp GP G G G GP GP G G G G G G G GP G G GP GP G G GP GP G G G GP GP G G OTUD6B SPC24 22863883 biogrid exp P P G GP P P P GP P P P P P PTK2 OTUD6B 26344197 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ASCC3 OTUD6B 19615732 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HDDC2 OTUD6B 26344197 biogrid exp GP GP G G G GP G G GP G GP GP GP GP G GP GP GP G G GP GP GP G GP G GP GP G SEC24C OTUD6B 22863883 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G OTUD6B MCTS1 26344197 biogrid exp G G G G G GP G G G G GP G GP G G G GP G G G GP G G G G G G G G OTUD6B OTUB1 26344197,22939629,19615732 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G OTUD6B RPF2 19615732 biogrid,intact exp GP GP G G G GP G GP GP G GP G G GP G GP GP G GP G GP G G GP GP G GP GP G MYH14 OTUD6B 22863883 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G OTUD6B CORO1B 22863883 biogrid exp G GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G OTUD6B AP2M1 26344197 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP G G G GP G GP GP G MYH9 OTUD6B 22863883 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G METAP2 OTUD6B 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APEX1 OTUD6B 26344197 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G GALC OTUD6B 26186194 biogrid exp GP G G G GP GP G GP GP G GP GP GP G G GP GP G GP G G GP GP GP GP G GP GP G OTUD6B SWAP70 22863883 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP G G G GP GP G GP GP GP GP GP G AKAP5 OTUD6B 26496610 biogrid,intact exp G GP GP CHD3 OTUD6B 26344197 biogrid exp GP GP G G G GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G OTUD6B BTBD1 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP GP GP GP GP G YWHAE OTUD6B ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B SEC24C OTUD6B MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_301626 bait prey OTUD6B RPF2 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120722|UniProt_100646 bait|bait prey|prey OTUD6B CORO1B MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_299123 bait prey SUMO1 OTUD6B MI:0004(affinity chromatography technology) 21110914 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_186110 bait prey MTDH OTUD6B MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120772|UniProt_100646 prey|prey bait|bait ELAVL1 OTUD6B MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187027 bait prey MYH9 OTUD6B MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_301233 prey bait UBC OTUD6B MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20972266,21139048,22118674,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_168483|BIOGRID_160657|BIOGRID_164272|BIOGRID_269518 bait|bait|bait|bait prey|prey|prey|prey OTUD6B SPC24 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304109 bait prey OTUD6B OTUB1 MI:0401(biochemical)|MI:0004(affinity chromatography technology) 19615732,22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_235822|BIOGRID_120537 bait|bait prey|prey MYH14 OTUD6B MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_301625 bait prey NRF1 OTUD6B MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_295582 bait prey OTUD6B SWAP70 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304233 bait prey OTUD6B PARVA MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_301776 bait prey ASCC3 OTUD6B MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120223|UniProt_100646 prey|prey bait|bait CRMP1 OTUD6B MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_301624 bait prey

PPI - HINT Gene A Gene B PMID Method Quality B4DPD5 OTUD6B 19615732 0007 HT AKAP5 OTUD6B 26496610,26496610 0007,0004 HT APEX1 OTUD6B 26344197 0401 HT MYH9 OTUD6B 22863883 0401 HT METAP2 OTUD6B 26186194 0004 HT SEC24C OTUD6B 22863883 0401 HT GALC OTUD6B 26186194 0004 HT BASP1 OTUD6B 26344197 0401 HT CHD3 OTUD6B 26344197 0401 HT CRMP1 OTUD6B 22863883 0401 HT DKFZP666O0110 OTUD6B 26344197 0401 HT MYH14 OTUD6B 22863883 0401 HT HDDC2 OTUD6B 26344197 0401 HT MTDH OTUD6B 19615732,19615732 0004,0007 HT ASCC3 OTUD6B 19615732,19615732 0004,0007 HT OTUD6B SPC24 22863883 0401 HT OTUD6B AP2M1 26344197 0401 HT OTUD6B OTUB1 19615732,26344197,22939629 0004,0401,0401 HT OTUD6B CORO1B 22863883 0401 HT OTUD6B BTBD1 26186194 0004 HT OTUD6B RPF2 19615732,19615732 0004,0007 HT OTUD6B PARVA 22863883 0401 HT OTUD6B SWAP70 22863883 0401 HT OTUD6B MCTS1 26344197 0401 HT OTUD6B LIMCH1 26186194 0004 HT B4DPD5 OTUD6B 19615732 0007 HT AKAP5 OTUD6B 26496610,26496610 0007,0004 HT APEX1 OTUD6B 26344197 0401 HT MYH9 OTUD6B 22863883 0401 HT METAP2 OTUD6B 26186194 0004 HT SEC24C OTUD6B 22863883 0401 HT GALC OTUD6B 26186194 0004 HT BASP1 OTUD6B 26344197 0401 HT CHD3 OTUD6B 26344197 0401 HT CRMP1 OTUD6B 22863883 0401 HT DKFZP666O0110 OTUD6B 26344197 0401 HT MYH14 OTUD6B 22863883 0401 HT HDDC2 OTUD6B 26344197 0401 HT MTDH OTUD6B 19615732,19615732 0004,0007 HT ASCC3 OTUD6B 19615732,19615732 0004,0007 HT OTUD6B SPC24 22863883 0401 HT OTUD6B AP2M1 26344197 0401 HT OTUD6B OTUB1 19615732,26344197,22939629 0004,0401,0401 HT OTUD6B CORO1B 22863883 0401 HT OTUD6B BTBD1 26186194 0004 HT OTUD6B RPF2 19615732,19615732 0004,0007 HT OTUD6B PARVA 22863883 0401 HT OTUD6B SWAP70 22863883 0401 HT OTUD6B MCTS1 26344197 0401 HT OTUD6B LIMCH1 26186194 0004 HT APEX1 OTUD6B 26344197 0401 LC MYH9 OTUD6B 22863883 0401 LC SEC24C OTUD6B 22863883 0401 LC BASP1 OTUD6B 26344197 0401 LC CHD3 OTUD6B 26344197 0401 LC CRMP1 OTUD6B 22863883 0401 LC DKFZP666O0110 OTUD6B 26344197 0401 LC MYH14 OTUD6B 22863883 0401 LC HDDC2 OTUD6B 26344197 0401 LC OTUD6B SPC24 22863883 0401 LC OTUD6B AP2M1 26344197 0401 LC OTUD6B OTUB1 26344197,22939629 0401,0401 LC OTUD6B CORO1B 22863883 0401 LC OTUD6B SMURF1 20804422 0415 LC OTUD6B PARVA 22863883 0401 LC OTUD6B SWAP70 22863883 0401 LC OTUD6B MCTS1 26344197 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8N6M0 B4DPD5 OTUD6B B4DPD5 0.126 19615732 Q8N6M0 P27695 OTUD6B APEX1 0.081 26344197 Q8N6M0 P35579 OTUD6B MYH9 0.081 22863883 Q8N6M0 P50579 OTUD6B METAP2 0.126 26186194 Q8N6M0 P54803 OTUD6B GALC 0.126 26186194 Q8N6M0 P80723 OTUD6B BASP1 0.081 26344197 Q8N6M0 Q05397 OTUD6B PTK2 0.081 26344197 Q8N6M0 Q12873 OTUD6B CHD3 0.081 26344197 Q8N6M0 Q7Z4H3 OTUD6B HDDC2 0.081 26344197 Q8NBT2 Q8N6M0 SPC24 OTUD6B 0.081 22863883 Q96CW1 Q8N6M0 AP2M1 OTUD6B 0.081 26344197 Q9BR76 Q8N6M0 CORO1B OTUD6B 0.081 22863883 Q9H0C5 Q8N6M0 BTBD1 OTUD6B 0.126 26186194 Q9NVD7 Q8N6M0 PARVA OTUD6B 0.081 22863883 Q9UH65 Q8N6M0 SWAP70 OTUD6B 0.081 22863883 Q9ULC4 Q8N6M0 MCTS1 OTUD6B 0.081 26344197 Q9UPQ0 Q8N6M0 LIMCH1 OTUD6B 0.126 26186194 Q9HCE7 Q8N6M0 SMURF1 OTUD6B 0.183 20804422 Q8N6M0 Q7Z406 OTUD6B MYH14 0.081 22863883 Q8VE38 Q8N6M0 OXNAD1 OTUD6B 0.236 26496610 Q9H7B2 Q8N6M0 RPF2 OTUD6B 0.236 19615732 Q96FW1 Q8N6M0 OTUB1 OTUD6B 0.196 19615732,26344197 Q8N6M0 Q8N3C0 OTUD6B ASCC3 0.236 19615732 Q8N6M0 Q86UE4 OTUD6B MTDH 0.236 19615732 Q91XU3 Q8N6M0 PIP4K2C OTUD6B 0.236 26496610 Q8N6M0 A0A0G2JQ02 OTUD6B A0A0G2JQ02 0.236 unassigned1304 Q8N6M0 Q3UDE2 OTUD6B TTLL12 0.236 26496610 Q8N6M0 Q3UJU9 OTUD6B RMDN3 0.236 26496610 Q8N6M0 Q505B8 OTUD6B SYCE2 0.236 26496610 Q8N6M0 P24588 OTUD6B AKAP5 0.236 26496610 Q8N6M0 E9Q4K7 OTUD6B KIF13B 0.126 26496610 Q8N6M0 Q14194 OTUD6B CRMP1 0.081 22863883 Q8N6M0 Q15717 OTUD6B ELAVL1 0.126 19322201 Q8N6M0 P53992 OTUD6B SEC24C 0.081 22863883

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 XPO1 OTUD6B MI:0362 inference MI:0461 interaction database ULK1 OTUD6B MI:0362 inference MI:0461 interaction database HSPA4L OTUD6B MI:0362 inference MI:0461 interaction database UBC OTUD6B MI:0045 experimental interaction detection MI:0461 interaction database HSPA1B OTUD6B MI:0362 inference MI:0461 interaction database HSPA8 OTUD6B MI:0362 inference MI:0461 interaction database HSPA6 OTUD6B MI:0362 inference MI:0461 interaction database PRKACA OTUD6B MI:0362 inference MI:0461 interaction database RCC1 OTUD6B MI:0362 inference MI:0461 interaction database PRKACG OTUD6B MI:0362 inference MI:0461 interaction database PRKACB OTUD6B MI:0362 inference MI:0461 interaction database AKAP5 OTUD6B MI:0045 experimental interaction detection MI:0461 interaction database HSPA1L OTUD6B MI:0362 inference MI:0461 interaction database HSPA4 OTUD6B MI:0362 inference MI:0461 interaction database HNF4A OTUD6B MI:0045 experimental interaction detection MI:0461 interaction database PIP4K2A OTUD6B MI:0362 inference MI:0461 interaction database CSNK1D OTUD6B MI:0362 inference MI:0461 interaction database METAP2 OTUD6B MI:0045 experimental interaction detection MI:0461 interaction database PRKX OTUD6B MI:0362 inference MI:0461 interaction database HSPA2 OTUD6B MI:0362 inference MI:0461 interaction database GALC OTUD6B MI:0045 experimental interaction detection MI:0461 interaction database CNBP OTUD6B MI:0362 inference MI:0461 interaction database SUMO1 OTUD6B MI:0045 experimental interaction detection MI:0461 interaction database PIP4K2B OTUD6B MI:0362 inference MI:0461 interaction database TTLL12 OTUD6B MI:0362 inference MI:0461 interaction database ELAVL1 OTUD6B MI:0045 experimental interaction detection MI:0461 interaction database SYCE2 OTUD6B MI:0362 inference MI:0461 interaction database MTDH OTUD6B MI:0045 experimental interaction detection MI:0461 interaction database ULK2 OTUD6B MI:0362 inference MI:0461 interaction database ASCC3 OTUD6B MI:0045 experimental interaction detection MI:0461 interaction database OTUD6B PIP4K2C MI:0362 inference MI:0461 interaction database OTUD6B ZCCHC13 MI:0362 inference MI:0461 interaction database OTUD6B HSPH1 MI:0362 inference MI:0461 interaction database OTUD6B KAT5 MI:0362 inference MI:0461 interaction database OTUD6B OTUB1 MI:0045 experimental interaction detection MI:0461 interaction database OTUD6B AURKB MI:0362 inference MI:0461 interaction database OTUD6B OXNAD1 MI:0362 inference MI:0461 interaction database OTUD6B RMDN3 MI:0362 inference MI:0461 interaction database OTUD6B BTBD1 MI:0045 experimental interaction detection MI:0461 interaction database OTUD6B RPF2 MI:0045 experimental interaction detection MI:0461 interaction database OTUD6B KIF13B MI:0362 inference MI:0461 interaction database OTUD6B GLTSCR2 MI:0362 inference MI:0461 interaction database OTUD6B ONECUT1 MI:0045 experimental interaction detection MI:0461 interaction database OTUD6B LIMCH1 MI:0045 experimental interaction detection MI:0461 interaction database OTUD6B AURKC MI:0362 inference MI:0461 interaction database