PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus NSMCE2 USP28 25359778 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RAD21 NSMCE2 22751501 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NSMCE2 SORT1 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NSMCE2 NDNL2 18086888,26344197 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ILK NSMCE2 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SMC5 NSMCE2 16055714,26344197,22751501 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SMC1A NSMCE2 22751501 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NSMCE2 SMC3 22751501 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PDS5A NSMCE2 22751501 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EWSR1 NSMCE2 24999758 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SAMD1 NSMCE2 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G SYNCRIP NSMCE2 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NSMCE2 PDS5B 22751501 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G WAPAL NSMCE2 22751501 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NSMCE2 NIPSNAP1 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PAN2 NSMCE2 23398456 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZNF597 NSMCE2 26186194 biogrid exp G TM9SF4 NSMCE2 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TXLNA NSMCE2 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NSMCE2 SMC6 18086888,26344197,22751501,26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G ETV1 NSMCE2 16055714 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G STAG2 NSMCE2 22751501 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NSMCE2 TSNAX 16055714 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EID3 NSMCE2 26186194 biogrid exp, ortho G G G G G G G G NSMCE1 NSMCE2 18086888,26344197,26186194, 21836163 biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SLURP1 NSMCE2 21836163 pred G NSMCE2 TRIB1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B ETV1 NSMCE2 MI:0004(affinity chromatography technology) 16055714 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_218287 prey bait WAPAL NSMCE2 MI:0004(affinity chromatography technology) 22751501 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_217935 prey bait RAD21 NSMCE2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22751501 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_217927|BIOGRID_217925|BIOGRID_217924 prey|bait|prey bait|prey|bait STAG2 NSMCE2 MI:0004(affinity chromatography technology) 22751501 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_217928 prey bait NSMCE2 SMC3 MI:0004(affinity chromatography technology) 22751501 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_217932 bait prey NSMCE2 NSMCE1 MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18086888 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(biogrid) UniProt_92534|BIOGRID_217881|BIOGRID_217898|BIOGRID_217870 prey|prey|prey|prey bait|bait|bait|bait SUMO2 NSMCE2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19471022,21693764 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_165390|BIOGRID_182984 bait|bait prey|prey SMC1A NSMCE2 MI:0004(affinity chromatography technology) 22751501 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_217931 prey bait NSMCE2 TSNAX MI:0004(affinity chromatography technology) 16055714 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_218288 bait prey NSMCE2 PDS5B MI:0004(affinity chromatography technology) 22751501 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_217934 bait prey NSMCE2 SMC6 MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 18086888,22751501 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0914(association) (biogrid)|(intact)|(biogrid)|(intact)|(intact)|(intact)|(intact) BIOGRID_217871|UniProt_92535|BIOGRID_217930|UniProt_92537|UniProt_92536|UniProt_92543|UniProt_92542 prey|prey|bait|prey|prey|neutral component|prey bait|bait|prey|prey|bait|neutral component|prey UBC NSMCE2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473,21906983,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_178099|BIOGRID_176360|BIOGRID_168743|BIOGRID_268804 bait|bait|bait|bait prey|prey|prey|prey SMC5 NSMCE2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16055714,22751501 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(biogrid) BIOGRID_218285|BIOGRID_217929 bait|prey prey|bait SUMO1 NSMCE2 MI:0004(affinity chromatography technology) 18086888 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_217901 bait prey PAN2 NSMCE2 MI:0004(affinity chromatography technology) 23398456 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_273258 bait prey PDS5A NSMCE2 MI:0004(affinity chromatography technology) 22751501 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_217933 prey bait

PPI - HINT Gene A Gene B PMID Method Quality SYNCRIP NSMCE2 26496610 0007 HT ILK NSMCE2 26496610 0007 HT Q59GL1 NSMCE2 26496610 0004 HT SAMD1 NSMCE2 26496610,26496610 0007,0004 HT SMC5 NSMCE2 16055714,22751501,26344197 0004,0401,0401 LC,HT EID3 NSMCE2 26186194 0004 HT NSMCE1 NSMCE2 18086888,18086888,18086888,26344197,26186194,18086888 0006,0401,0071,0401,0004,0004 LC,HT TM9SF4 NSMCE2 26496610,26496610 0007,0004 HT ZNF597 NSMCE2 26186194 0004 HT NSMCE2 NSMCE3 26344197 0401 HT NSMCE2 SMC6 18086888,26344197,26496610,26496610,22751501,18086888 0006,0401,0004,0007,0401,0004 LC,HT NSMCE2 SORT1 26496610,26496610 0007,0004 HT NSMCE2 NIPSNAP1 26496610,26496610 0007,0004 HT NSMCE2 HEL-S-28 26496610 0004 HT SYNCRIP NSMCE2 26496610 0007 HT ILK NSMCE2 26496610 0007 HT Q59GL1 NSMCE2 26496610 0004 HT SAMD1 NSMCE2 26496610,26496610 0007,0004 HT SMC5 NSMCE2 26344197 0401 HT EID3 NSMCE2 26186194 0004 HT NSMCE1 NSMCE2 26344197,26186194 0401,0004 HT TM9SF4 NSMCE2 26496610,26496610 0007,0004 HT ZNF597 NSMCE2 26186194 0004 HT NSMCE2 NSMCE3 26344197 0401 HT NSMCE2 SMC6 26344197,26496610,26496610 0401,0004,0007 HT NSMCE2 SORT1 26496610,26496610 0007,0004 HT NSMCE2 NIPSNAP1 26496610,26496610 0007,0004 HT NSMCE2 HEL-S-28 26496610 0004 HT SMC5 NSMCE2 16055714,22751501 0004,0401 LC NSMCE1 NSMCE2 18086888,18086888,18086888,18086888 0006,0401,0071,0004 LC NSMCE2 SMC6 18086888,22751501,18086888 0006,0401,0004 LC RAD21 NSMCE2 22751501,22751501,22751501 0415,0401,0004 LC TXLNA NSMCE2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT ETV1 NSMCE2 16055714 0415 LC SMC1A NSMCE2 22751501 0401 LC PDS5A NSMCE2 22751501 0401 LC WAPL NSMCE2 22751501 0401 LC SMC5 NSMCE2 22751501,26344197 0401,0401 LC STAG2 NSMCE2 22751501 0401 LC NSMCE1 NSMCE2 18086888,18086888,18086888,26344197,18086888 0006,0401,0071,0401,0004 LC NSMCE2 NSMCE3 26344197 0401 LC NSMCE2 USP28 25359778 0415 LC NSMCE2 SMC6 26344197,22751501 0401,0401 LC NSMCE2 TSNAX 16055714 0415 LC NSMCE2 PDS5B 22751501 0401 LC NSMCE2 SMC3 22751501 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q96MF7 Q8N140 NSMCE2 EID3 0.126 26186194 Q96MF7 O60216 NSMCE2 RAD21 0.523 22751501 Q96MF7 Q924W5 NSMCE2 SMC6 0.236 20360068 Q96MF7 Q92544 NSMCE2 TM9SF4 0.236 26496610 Q96MF7 P06240 NSMCE2 LCK 0.236 26496610 Q99523 Q96MF7 SORT1 NSMCE2 0.236 26496610 Q9BPW8 Q96MF7 NIPSNAP1 NSMCE2 0.236 26496610 Q9CWZ3 Q96MF7 RBM8A NSMCE2 0.236 26496610 Q96MF7 Q13418 NSMCE2 ILK 0.236 26496610 Q96MF7 Q64729 NSMCE2 TGFBR1 0.236 26496610 Q96MF7 Q6SPF0 NSMCE2 SAMD1 0.236 26496610 Q96MF7 O60506 NSMCE2 SYNCRIP 0.236 26496610 Q96MF7 P40222 NSMCE2 TXLNA 0.583 25416956,unassigned1304 Q96MF7 Q96LX8 NSMCE2 ZNF597 0.126 26186194 Q9UQE7 Q96MF7 SMC3 NSMCE2 0.126 22751501 Q96MF7 P50549 NSMCE2 ETV1 0.309 16055714 Q9NTI5 Q96MF7 PDS5B NSMCE2 0.126 22751501 Q96MF7 Q7Z5K2 NSMCE2 WAPAL 0.126 22751501 Q96MF7 Q14683 NSMCE2 SMC1A 0.126 22751501 Q96MF7 Q29RF7 NSMCE2 PDS5A 0.126 22751501 Q99598 Q96MF7 TSNAX NSMCE2 0.309 16055714 Q96MF7 Q8N3U4 NSMCE2 STAG2 0.126 22751501 Q96MF7 Q8IY18 NSMCE2 SMC5 0.309 16055714,22751501 Q96SB8 Q96MF7 SMC6 NSMCE2 0.472 22751501,26496610,18086888 Q96MF7 Q8WV22 NSMCE2 NSMCE1 0.445 18086888,26186194,26344197 Q96RU2 Q96MF7 USP28 NSMCE2 0.309 25359778 Q9DUG7 Q96MF7 Q9DUG7 NSMCE2 0.126 22810586 Q96MF7 Q01844 NSMCE2 EWSR1 0.126 24999758 Q96MF7 Q2PRM9 NSMCE2 Q2PRM9 0.126 22810586 Q96MF7 Q504Q3 NSMCE2 PAN2 0.126 23398456

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 NACA NSMCE2 MI:0362 inference MI:0461 interaction database RAD21 NSMCE2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SYNCRIP NSMCE2 MI:0045 experimental interaction detection MI:0461 interaction database LCK NSMCE2 MI:0362 inference MI:0461 interaction database UBC NSMCE2 MI:0045 experimental interaction detection MI:0461 interaction database TGFBR1 NSMCE2 MI:0362 inference MI:0461 interaction database TXLNA NSMCE2 MI:0045 experimental interaction detection MI:0461 interaction database MAGEA1 NSMCE2 MI:0362 inference MI:0461 interaction database ETV1 NSMCE2 MI:0045 experimental interaction detection MI:0461 interaction database SUMO3 NSMCE2 MI:0045 experimental interaction detection MI:0461 interaction database SUMO2 NSMCE2 MI:0045 experimental interaction detection MI:0461 interaction database SUMO1 NSMCE2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database UBE2I NSMCE2 MI:0362 inference MI:1106 pathways database EWSR1 NSMCE2 MI:0045 experimental interaction detection MI:0461 interaction database ILK NSMCE2 MI:0045 experimental interaction detection MI:0461 interaction database NACA NSMCE2 MI:0362 inference MI:0461 interaction database SMC1A NSMCE2 MI:0362 inference MI:1106 pathways database PAN2 NSMCE2 MI:0045 experimental interaction detection MI:0461 interaction database SAMD1 NSMCE2 MI:0045 experimental interaction detection MI:0461 interaction database SMC5 NSMCE2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database EID3 NSMCE2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database STAG2 NSMCE2 MI:0362 inference MI:1106 pathways database NSMCE1 NSMCE2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database STAG1 NSMCE2 MI:0362 inference MI:1106 pathways database TM9SF4 NSMCE2 MI:0045 experimental interaction detection MI:0461 interaction database ZNF597 NSMCE2 MI:0045 experimental interaction detection MI:0461 interaction database NSMCE2 NSMCE3 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database NSMCE2 USP28 MI:0045 experimental interaction detection MI:0461 interaction database NSMCE2 SMC6 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database NSMCE2 SORT1 MI:0045 experimental interaction detection MI:0461 interaction database NSMCE2 TSNAX MI:0045 experimental interaction detection MI:0461 interaction database NSMCE2 NIPSNAP1 MI:0045 experimental interaction detection MI:0461 interaction database NSMCE2 NSMCE4A MI:0362 inference MI:0461,MI:1106 interaction database,pathways database NSMCE2 SMC3 MI:0362 inference MI:1106 pathways database NSMCE2 RBM8A MI:0362 inference MI:0461 interaction database