PTM - CPLM Gene Name UniProt ID Type Position Code MYSM1; KIAA1915 Q5VVJ2 Ubiquitination 84 K MYSM1; KIAA1915 Q5VVJ2 Ubiquitination 135 K MYSM1; KIAA1915 Q5VVJ2 Ubiquitination 675 K MYSM1; KIAA1915 Q5VVJ2 Ubiquitination 173 K MYSM1; KIAA1915 Q5VVJ2 Ubiquitination 78 K MYSM1; KIAA1915 Q5VVJ2 Ubiquitination 79 K MYSM1; KIAA1915 Q5VVJ2 Ubiquitination 90 K MYSM1; KIAA1915 Q5VVJ2 Ubiquitination 95 K MYSM1; KIAA1915 Q5VVJ2 Ubiquitination 98 K MYSM1; KIAA1915 Q5VVJ2 Ubiquitination 810 K MYSM1; KIAA1915 Q5VVJ2 Ubiquitination 67 K MYSM1; KIAA1915 Q5VVJ2 Ubiquitination 284 K MYSM1; KIAA1915 Q5VVJ2 Ubiquitination 533 K

PTM - dbPAF Gene Name UniProt ID Position Type Species MYSM1; KIAA1915 Q5VVJ2 110 S Homo sapiens(Human) MYSM1; KIAA1915 Q5VVJ2 112 T Homo sapiens(Human) MYSM1; KIAA1915 Q5VVJ2 118 S Homo sapiens(Human) MYSM1; KIAA1915 Q5VVJ2 149 S Homo sapiens(Human) MYSM1; KIAA1915 Q5VVJ2 175 T Homo sapiens(Human) MYSM1; KIAA1915 Q5VVJ2 218 S Homo sapiens(Human) MYSM1; KIAA1915 Q5VVJ2 226 T Homo sapiens(Human) MYSM1; KIAA1915 Q5VVJ2 233 S Homo sapiens(Human) MYSM1; KIAA1915 Q5VVJ2 234 S Homo sapiens(Human) MYSM1; KIAA1915 Q5VVJ2 236 T Homo sapiens(Human) MYSM1; KIAA1915 Q5VVJ2 242 S Homo sapiens(Human) MYSM1; KIAA1915 Q5VVJ2 265 S Homo sapiens(Human) MYSM1; KIAA1915 Q5VVJ2 267 S Homo sapiens(Human) MYSM1; KIAA1915 Q5VVJ2 340 S Homo sapiens(Human) MYSM1; KIAA1915 Q5VVJ2 40 S Homo sapiens(Human) MYSM1; KIAA1915 Q5VVJ2 405 T Homo sapiens(Human) MYSM1; KIAA1915 Q5VVJ2 409 Y Homo sapiens(Human) MYSM1; KIAA1915 Q5VVJ2 41 S Homo sapiens(Human) MYSM1; KIAA1915 Q5VVJ2 74 Y Homo sapiens(Human) MYSM1; KIAA1915 Q5VVJ2 75 Y Homo sapiens(Human)

PTM - PhosSNP Gene Name dbSNP ID Gene Mutation AA Mutation Mutation Position Code Peptide Score Modification Type MYSM1; KIAA1915 rs12139511 ACT->GCT T->A 267 S GEFITSDSQEALFSK 267 Phosphorylation TypeIII-

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q5VVJ2 K411-ac Acetylation KtPERyLkIRNYILD Q5VVJ2 Y74-p Phosphorylation kMLLEEEyyLSkkSQ Q5VVJ2 Y75-p Phosphorylation MLLEEEyyLSkkSQP Q5VVJ2 S110-p Phosphorylation TAKIMVHsPtKPASY Q5VVJ2 T112-p Phosphorylation KIMVHsPtKPASYsV Q5VVJ2 S118-p Phosphorylation PtKPASYsVKWTIEE Q5VVJ2 S149-p Phosphorylation KISKLIGsRTVLQVK Q5VVJ2 T175-p Phosphorylation KCGLDKEtPNQKTGH Q5VVJ2 T197-p Phosphorylation DKGTKAWtPSCLRGR Q5VVJ2 S218-p Phosphorylation AVKIEKLsDDEEVDI Q5VVJ2 S234-p Phosphorylation DEVDELSsQtPQKNS Q5VVJ2 T236-p Phosphorylation VDELSsQtPQKNSsS Q5VVJ2 S242-p Phosphorylation QtPQKNSsSDLLLDF Q5VVJ2 S267-p Phosphorylation GEFITSDsQEALFSK Q5VVJ2 S340-p Phosphorylation VDARQLPsPEPCEIQ Q5VVJ2 T405-p Phosphorylation FEGRQAKtPERyLkI Q5VVJ2 Y409-p Phosphorylation QAKtPERyLkIRNYI Q5VVJ2 K187-sm Sumoylation TGHNLQVkNEDKGTK Q5VVJ2 K67-ub Ubiquitination ENRAVIEkMLLEEEy Q5VVJ2 K78-ub Ubiquitination EEEyyLSkkSQPEkV Q5VVJ2 K79-ub Ubiquitination EEyyLSkkSQPEkVW Q5VVJ2 K84-ub Ubiquitination SkkSQPEkVWLDQkE Q5VVJ2 K90-ub Ubiquitination EkVWLDQkEDDKKYM Q5VVJ2 K135-ub Ubiquitination LFEQGLAkFGRRWTK Q5VVJ2 K284-ub Ubiquitination RGCLQNEkQDETLSS Q5VVJ2 K533-ub Ubiquitination LSAEELAkRREEEKG Q5VVJ2 K675-ub Ubiquitination RDIDTQAkYQSYFSR

PTM - dbPTM UniProt ID Position Code Type Resources References Q5VVJ2 218 S Phosphorylation Swiss-Prot 1010711 17525332;18669648;19690332 Q5VVJ2 234 S Phosphorylation Swiss-Prot 1010711 17525332 Q5VVJ2 236 T Phosphorylation Swiss-Prot 1010711 19690332 Q5VVJ2 267 S Phosphorylation Swiss-Prot 1010711 17525332 Q5VVJ2 218 S Phosphorylation PhosphoELM.10011 18669648;17525332 Q5VVJ2 234 S Phosphorylation PhosphoELM.10011 18669648;17525332 Q5VVJ2 267 S Phosphorylation PhosphoELM.10011 17525332 Q5VVJ2 226 T Phosphorylation PhosphoELM.10011 18669648 Q5VVJ2 135 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q5VVJ2 284 K Ubiquitylation Phosphositeplus.1010730 21906983 Q5VVJ2 533 K Ubiquitylation Phosphositeplus.1010730 21906983 Q5VVJ2 67 K Ubiquitylation Phosphositeplus.1010730 21906983 Q5VVJ2 675 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q5VVJ2 78 K Ubiquitylation Phosphositeplus.1010730 21906983 Q5VVJ2 84 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q5VVJ2 90 K Ubiquitylation Phosphositeplus.1010730 21906983 Q5VVJ2 110 S Phosphorylation Phosphositeplus.1010730 21406692 Q5VVJ2 149 S Phosphorylation Phosphositeplus.1010730 21406692 Q5VVJ2 218 S Phosphorylation Phosphositeplus.1010730 17525332;18669648;19690332;21406692;21659604 Q5VVJ2 234 S Phosphorylation Phosphositeplus.1010730 17525332 Q5VVJ2 267 S Phosphorylation Phosphositeplus.1010730 17525332;20068231 Q5VVJ2 340 S Phosphorylation Phosphositeplus.1010730 21406692 Q5VVJ2 236 T Phosphorylation Phosphositeplus.1010730 19690332 Q5VVJ2 110 S Phosphorylation HPRD 9.0 20068231 Q5VVJ2 218 S Phosphorylation HPRD 9.0 17525332,18669648 Q5VVJ2 234 S Phosphorylation HPRD 9.0 17525332,18669648 Q5VVJ2 267 S Phosphorylation HPRD 9.0 17525332,20068231 Q5VVJ2 226 T Phosphorylation HPRD 9.0 18669648 Q5VVJ2 218 S Phosphorylation SysPTM 1.1 18669648

PTM - HPRD Symbol Position Code Type References MYSM1 110 S Phosphorylation 20068231 MYSM1 218 S Phosphorylation 17525332,18669648 MYSM1 226 T Phosphorylation 18669648 MYSM1 234 S Phosphorylation 17525332,18669648 MYSM1 267 S Phosphorylation 17525332,20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q5VVJ2 234 S 18669648 HTP Phosphorylation Q5VVJ2 234 S 17525332 HTP Phosphorylation Q5VVJ2 267 S 17525332 HTP Phosphorylation Q5VVJ2 218 S 18669648 HTP Phosphorylation Q5VVJ2 218 S 17525332 HTP Phosphorylation Q5VVJ2 226 T 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q5VVJ2 110 Phosphoserine 23186163 Q5VVJ2 218 Phosphoserine 17525332;18669648;19690332;23186163 Q5VVJ2 236 Phosphothreonine 19690332 Q5VVJ2 242 Phosphoserine 23186163 Q5VVJ2 267 Phosphoserine 23186163 Q5VVJ2 340 Phosphoserine 21406692

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 114803 125363 - K Sumoylation 21693764 114803 125363 - K Ubiquitination 21963094 114803 125363 - K Ubiquitination 21139048 114803 125363 - K Ubiquitination 21890473 114803 125363 - K Ubiquitination 21906983 114803 125363 - K Sumoylation 19471022 114803 125363 - K Ubiquitination 22505724 114803 125363 - K Ubiquitination 22053931 114803 125363 - K Ubiquitination 23000965 114803 125363 - K Ubiquitination 25015289 114803 125363 - K Ubiquitination 25147182 114803 125363 - K Sumoylation 25391492

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID MYSM1 Homo sapiens (Human) 280; 31; 422 "280,SAEELAKRREEEK; 31,GCLQNEKQDETLS; 422,DIDTQAKYQSYFS" "280:21906983; 31:21906983; 422:21890473,21906983" MYSM1 Homo sapiens (Human) 533; 84; 67; 78; 675; 135; 90; 284 "533,SAEELAKRREEEK; 84,KKSQPEKVWLDQK; 67,NRAVIEKMLLEEE; 78,EEYYLSKKSQPEK; 675,DIDTQAKYQSYFS; 135,FEQGLAKFGRRWT; 90,KVWLDQKEDDKKY; 284,GCLQNEKQDETLS" "533:21906983; 84:21890473,21906983; 67:21890473,21906983; 78:21906983; 675:21890473,21906983; 135:21890473,21906983; 90:21906983; 284:21906983" MYSM1 Homo sapiens (Human) 81 "81,DIDTQAKYQSYFS" "81:21906983,21890473"