PTM - CPLM Gene Name UniProt ID Type Position Code USP1 O94782 Ubiquitination 689 K USP1 O94782 Ubiquitination 741 K USP1 O94782 Ubiquitination 746 K USP1 O94782 Ubiquitination 761 K USP1 O94782 Ubiquitination 783 K USP1 O94782 Ubiquitination 110 K USP1 O94782 Ubiquitination 48 K USP1 O94782 Ubiquitination 73 K USP1 O94782 Ubiquitination 360 K USP1 O94782 Ubiquitination 503 K USP1 O94782 Ubiquitination 523 K USP1 O94782 Ubiquitination 483 K USP1 O94782 Ubiquitination 610 K USP1 O94782 Ubiquitination 551 K

PTM - dbPAF Gene Name UniProt ID Position Type Species USP1 O94782 13 S Homo sapiens(Human) USP1 O94782 16 S Homo sapiens(Human) USP1 O94782 18 S Homo sapiens(Human) USP1 O94782 248 S Homo sapiens(Human) USP1 O94782 253 S Homo sapiens(Human) USP1 O94782 273 S Homo sapiens(Human) USP1 O94782 307 T Homo sapiens(Human) USP1 O94782 308 S Homo sapiens(Human) USP1 O94782 310 T Homo sapiens(Human) USP1 O94782 313 S Homo sapiens(Human) USP1 O94782 323 S Homo sapiens(Human) USP1 O94782 327 S Homo sapiens(Human) USP1 O94782 33 T Homo sapiens(Human) USP1 O94782 331 S Homo sapiens(Human) USP1 O94782 350 S Homo sapiens(Human) USP1 O94782 391 T Homo sapiens(Human) USP1 O94782 398 S Homo sapiens(Human) USP1 O94782 42 S Homo sapiens(Human) USP1 O94782 471 S Homo sapiens(Human) USP1 O94782 472 S Homo sapiens(Human) USP1 O94782 475 S Homo sapiens(Human) USP1 O94782 529 T Homo sapiens(Human) USP1 O94782 66 S Homo sapiens(Human) USP1 O94782 67 S Homo sapiens(Human) USP1 O94782 678 Y Homo sapiens(Human) USP1 O94782 681 Y Homo sapiens(Human) USP1 O94782 7 S Homo sapiens(Human) USP1 O94782 727 S Homo sapiens(Human) USP1 O94782 766 S Homo sapiens(Human) USP1 O94782 768 S Homo sapiens(Human) USP1 O94782 770 S Homo sapiens(Human) USP1 O94782 771 T Homo sapiens(Human) USP1 O94782 772 S Homo sapiens(Human) USP1 O94782 774 T Homo sapiens(Human) USP1 O94782 775 S Homo sapiens(Human) USP1 O94782 9 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA O94782 K130-ac Acetylation LkDEANQkDKGNCKE O94782 K716-ac Acetylation THESDRNkESSDQTG O94782 S7-p Phosphorylation _MPGVIPsESNGLsR O94782 S13-p Phosphorylation PsESNGLsRGsPSKK O94782 S16-p Phosphorylation SNGLsRGsPSKKNRL O94782 T33-p Phosphorylation KFFQKKEtKRALDFT O94782 S42-p Phosphorylation RALDFTDsQENEEKA O94782 S67-p Phosphorylation VVPAAQSsPINCEkR O94782 S273-p Phosphorylation KGNGKRKsDTEFGNM O94782 T307-p Phosphorylation TRSKRKAtsDtLEsP O94782 S308-p Phosphorylation RSKRKAtsDtLEsPP O94782 T310-p Phosphorylation KRKAtsDtLEsPPKI O94782 S313-p Phosphorylation AtsDtLEsPPKIIPK O94782 S323-p Phosphorylation KIIPKYIsENEsPRP O94782 S327-p Phosphorylation KYIsENEsPRPSQKK O94782 S350-p Phosphorylation KSATKQPsILSKFCS O94782 S398-p Phosphorylation TNGCGLEsPGNTVTP O94782 S475-p Phosphorylation VEESSEIsPEPKTEM O94782 T529-p Phosphorylation DKMPEVItIHLKCFA O94782 Y678-p Phosphorylation GQKSKADyELyNKAS O94782 Y681-p Phosphorylation SKADyELyNKASNPD O94782 S727-p Phosphorylation DQTGINIsGFENkIS O94782 S768-p Phosphorylation kDFLNSLsPSTsPTS O94782 S772-p Phosphorylation NSLsPSTsPTSTPYL O94782 K124-sm Sumoylation SRKKEALkDEANQkD O94782 K232-sm Sumoylation NVAELPTkVEEIPHP O94782 K73-ub Ubiquitination SsPINCEkRENLLPF O94782 K689-ub Ubiquitination NKASNPDkVASTAFA O94782 K732-ub Ubiquitination NIsGFENkISYVVQS O94782 K741-ub Ubiquitination SYVVQSLkEYEGkWL O94782 K746-ub Ubiquitination SLkEYEGkWLLFDDS O94782 K761-ub Ubiquitination EVKVTEEkDFLNSLs

PTM - dbPTM UniProt ID Position Code Type Resources References O94782 13 S Phosphorylation Swiss-Prot 1010711 17924679 O94782 42 S Phosphorylation Swiss-Prot 1010711 17525332 O94782 67 S Phosphorylation Swiss-Prot 1010711 18669648;19413330 O94782 313 S Phosphorylation Swiss-Prot 1010711 19413330 O94782 475 S Phosphorylation Swiss-Prot 1010711 19413330 O94782 42 S Phosphorylation PhosphoELM.10011 17525332 O94782 67 S Phosphorylation PhosphoELM.10011 18669648 O94782 313 S Phosphorylation PhosphoELM.10011 18669648 O94782 689 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 O94782 741 K Ubiquitylation Phosphositeplus.1010730 21906983 O94782 746 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 O94782 761 K Ubiquitylation Phosphositeplus.1010730 21890473 O94782 16 S Phosphorylation Phosphositeplus.1010730 20068231 O94782 313 S Phosphorylation Phosphositeplus.1010730 19276368;20068231 O94782 42 S Phosphorylation Phosphositeplus.1010730 17525332;20068231 O94782 475 S Phosphorylation Phosphositeplus.1010730 21406692 O94782 67 S Phosphorylation Phosphositeplus.1010730 18669648 O94782 768 S Phosphorylation Phosphositeplus.1010730 20068231 O94782 529 T Phosphorylation Phosphositeplus.1010730 20068231 O94782 7 S Phosphorylation HPRD 9.0 20068231 O94782 13 S Phosphorylation HPRD 9.0 17924679 O94782 16 S Phosphorylation HPRD 9.0 20068231 O94782 42 S Phosphorylation HPRD 9.0 17525332,20068231 O94782 67 S Phosphorylation HPRD 9.0 18669648,19413330,18452278 O94782 248 S Phosphorylation HPRD 9.0 20068231 O94782 313 S Phosphorylation HPRD 9.0 18669648,19413330,20068231 O94782 475 S Phosphorylation HPRD 9.0 17322306,19413330,19651622 O94782 768 S Phosphorylation HPRD 9.0 20068231 O94782 770 S Phosphorylation HPRD 9.0 20068231 O94782 772 S Phosphorylation HPRD 9.0 20068231 O94782 775 S Phosphorylation HPRD 9.0 20068231 O94782 529 T Phosphorylation HPRD 9.0 20068231 O94782 774 T Phosphorylation HPRD 9.0 20068231 O94782 67 S Phosphorylation SysPTM 1.1 18669648

PTM - HPRD Symbol Position Code Type References USP1 13 S Phosphorylation 17924679 USP1 16 S Phosphorylation 20068231 USP1 248 S Phosphorylation 20068231 USP1 313 S Phosphorylation 18669648,19413330,20068231 USP1 42 S Phosphorylation 17525332,20068231 USP1 475 S Phosphorylation 17322306,19413330,19651622 USP1 529 T Phosphorylation 20068231 USP1 67 S Phosphorylation 18669648,19413330,18452278 USP1 7 S Phosphorylation 20068231 USP1 768 S Phosphorylation 20068231 USP1 770 S Phosphorylation 20068231 USP1 772 S Phosphorylation 20068231 USP1 774 T Phosphorylation 20068231 USP1 775 S Phosphorylation 20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type O94782 313 S 18669648 HTP Phosphorylation O94782 67 S 18669648 HTP Phosphorylation O94782 42 S 17525332 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs O94782 16 Phosphoserine 23186163 O94782 42 Phosphoserine 17525332;20068231;23186163 O94782 67 Phosphoserine 18669648;23186163 O94782 313 Phosphoserine 23186163 O94782 475 Phosphoserine 21406692;23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type USP1 IPI00304379 S 16 NGLSRGpSPSKKNR phosphorylation USP1 IPI00304379 S 313 TSDTLEpSPPKIIP phosphorylation USP1 IPI00304379 S 42 ALDFTDpSQENEEK phosphorylation USP1 IPI00304379 S 768 DFLNSLpSPSTSPT phosphorylation USP1 IPI00304379 S 770 LNSLSPpSTSPTST phosphorylation USP1 IPI00304379 S 772 SLSPSTpSPTSTPY phosphorylation USP1 IPI00304379 T 310 RKATSDpTLESPPK phosphorylation USP1 IPI00304379 T 529 KMPEVIpTIHLKCF phosphorylation USP1 IPI00304379 T 774 SPSTSPpTSTPYLL phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 7398 113241 - K Ubiquitination 15694335 7398 113241 - K Ubiquitination 22118674 7398 113241 - K Sumoylation 21693764 7398 113241 - K Ubiquitination 21139048 7398 113241 - K Ubiquitination 21890473 7398 113241 - K Ubiquitination 21906983 7398 113241 - K Sumoylation 19471022 7398 113241 - K Ubiquitination 21963094 7398 113241 - K Ubiquitination 24816145 7398 113241 - K Sumoylation 25391492 7398 113241 - K Ubiquitination 21768287

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID USP1 Homo sapiens (Human) 746; 761; 783; 741; 689 "746,LKEYEGKWLLFDD; 761,VKVTEEKDFLNSL; 783,PYLLFYKKL; 741,YVVQSLKEYEGKW; 689,KASNPDKVASTAF" "746:21890473,21906983; 761:21890473; 783:21890473; 741:21890473,21906983; 689:21890473,21906983" USP1 Homo sapiens (Human) 746; 761; 783; 741; 689 "746,LKEYEGKWLLFDD; 761,VKVTEEKDFLNSL; 783,PYLLFYKKL; 741,YVVQSLKEYEGKW; 689,KASNPDKVASTAF" 746:21890473; 761:21890473; 783:21890473; 741:21890473; 689:21890473