PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TRIP12 RNF168 22884692 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GTF2F2 RNF168 20195357 intact exp G G G G G G G G G G G G G G G G UBE2D3 RNF168 19500350,22373579 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF168 TACC3 26496610 biogrid,intact exp G G G G G G G G G RNF168 NUB1 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBR5 RNF168 22884692 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KIF5B RNF168 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HIST2H2BE RNF168 21041483 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF168 RNF169 21252943 intact exp UBE2E1 RNF168 22492721 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF168 RABGEF1 16499958 hprd exp G G G G G G G G RNF168 RABGEF1 16499958 hprd exp G G G G G G G G UBA52 RNF168 22266820 dip exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSMD11 RNF168 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBB RNF168 16499958 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF168 RPRD1B 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CCDC174 RNF168 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DCTN1 RNF168 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF168 TAF15 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HIST2H2AA3, HIST2H2AA4 RNF168 21041483 biogrid exp G G G G G G G G G G RNF168 FAM45A 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G JMJD1C RNF168 24240613 biogrid,dip exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HERC2 RNF168 20023648 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BCL10 RNF168 24732096 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TBP RNF168 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LAPTM5 RNF168 15231748 hprd,biogrid,i2d,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF168 DDX1 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SRCAP RNF168 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KDM4A RNF168 22373579 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ECM29 RNF168 20682791 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF168 RNF168 19203578 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2G2 RNF168 19690564 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KDM1A RNF168 25999347,24217620 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HIST2H2AC RNF168 22980979,19203578,22492721,21041483 biogrid exp EWSR1 RNF168 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF168 POC1A 22939629 biogrid exp G G G G G G G G SMARCA5 RNF168 23264744 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TP53BP1 RNF168 25999347,22884692,20016603,21552324, 25402006 biogrid,intact exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF168 RNF11 15231748, 25402006 hprd,biogrid,i2d,mint,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G H2AFX RNF168 19500350,19203578, 25402006 biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2N RNF168 19203578,24732096,23255131,20725033, 25402006 biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBC RNF168 22742833,22266820, 21836163 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MDC1 RNF168 25402006 ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF168 RNF2 25402006 pred G TRAF2 RNF168 25402006 pred G G HNRNPR RNF168 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HLTF RNF168 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF168 ZNRF1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NONO RNF168 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF168 TDP1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRIM32 RNF168 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TMEM189 RNF168 25402006 pred UBE2V2 RNF168 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF168 TRAF6 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF8 RNF168 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF168 AMFR 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF168 BARD1 25402006 pred G G G G G G G G G G G G G LRSAM1 RNF168 25402006 pred G G G G G G G G G G G G G G G G RAD51 RNF168 25402006 pred G G G G G G G G G G G G G TP53 RNF168 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF168 KAT5 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G XIAP RNF168 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2V1 RNF168 25402006 pred AURKA RNF168 25402006 pred G G G G G G G G G G G G G G PARP1 RNF168 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8IYW5 Q13571 - 15231748 - X 2 Q8IYW5 Q9Y3C5 - 15231748 - X 2 Q8IYW5 Q16777 enzymatic study 22492721 direct interaction X 2 Q8IYW5 P61088 pull down 19203578 direct interaction X 2 Q8IYW5 Q14203-4 biochemical 22939629 colocalization X 2 Q8IYW5 P61088 affinity chromatography technology 23255131 physical association X 2 Q8IYW5 Q16777 enzymatic study 22980979 direct interaction X 2 Q8IYW5 Q13571 two hybrid 15231748 direct interaction X 2 Q8IYW5 Q9Y3C5 two hybrid 15231748 direct interaction X 2 Q8IYW5 O60341 affinity chromatography technology 24217620 physical association X 2 Q8IYW5 O60341 affinity chromatography technology 24217620 physical association X 2 Q8IYW5 P61088 affinity chromatography technology 24732096 physical association X 2 Q8IYW5 P61088 affinity chromatography technology 19203578 physical association X 2 Q8IYW5 Q16777 affinity chromatography technology 19203578 physical association X 2 Q8IYW5 Q16777 enzymatic study 19203578 direct interaction X 2 Q8IYW5 P16104 enzymatic study 19500350 direct interaction X 2 Q8IYW5 P61088 affinity chromatography technology 20725033 physical association X 2 Q8IYW5 Q16777 affinity chromatography technology 21041483 physical association X 2 Q8IYW5 Q6FI13 affinity chromatography technology 21041483 physical association X 2 Q8IYW5 Q16778 affinity chromatography technology 21041483 physical association X 2 Q8IYW5 P61956-2 affinity chromatography technology 21252943 physical association X 2 Q8IYW5 A0A024R3Z2 affinity chromatography technology 22508508 physical association X 2 P33176 Q8IYW5 biochemical 22939629 colocalization X 2 P0CG48 Q8IYW5 pull down 22742833 direct interaction X 2 P0CG48 Q8IYW5 affinity chromatography technology 22505724 physical association X 2 P0CG48 Q8IYW5 affinity chromatography technology 22884692 physical association X 2 P0CG48 Q8IYW5 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q8IYW5 affinity chromatography technology 23000965 physical association X 2 P0CG48 Q8IYW5 affinity chromatography technology 24634510 physical association X 2 P0CG48 Q8IYW5 affinity chromatography technology 24816145 physical association X 2 P0CG48 Q8IYW5 pull down 22266820 direct interaction X 2 P0CG48 Q8IYW5 affinity chromatography technology 22266820 physical association X 2 P0CG48 Q8IYW5 affinity chromatography technology 18781797 physical association X 2 P0CG48 Q8IYW5 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q8IYW5 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q8IYW5 affinity chromatography technology 21906983 physical association X 2 J3KN16 Q8IYW5 two hybrid 20682791 direct interaction X 2 O95071 Q8IYW5 affinity chromatography technology 22884692 physical association X 2 Q8IYW5 P61077-3 pull down 22373579 direct interaction X 2 Q8IYW5 A0A024R2K3 pull down 22492721 direct interaction X 2 Q8IYW5 P61077-3 pull down 19500350 direct interaction X 2 Q8IYW5 A3RJH1 biochemical 22939629 colocalization X 2 Q8IYW5 Q8NBT0-3 biochemical 22939629 colocalization X 2 Q8IYW5 Q92804-2 biochemical 22939629 colocalization X 2 Q8IYW5 Q01844-6 biochemical 22939629 colocalization X 2 Q8IYW5 O60264 affinity chromatography technology 23264744 physical association X 2 Q8IYW5 O60264 affinity chromatography technology 23264744 physical association X 2 Q8IYW5 Q14669 affinity chromatography technology 22884692 physical association X 2 Q8IYW5 Q15652-3 pull down 24240613 direct interaction X 2 Q8IYW5 Q15843 affinity chromatography technology 24634510 physical association X 2 Q8IYW5 Q8IYW5 enzymatic study 19203578 direct interaction X 2 Q8IYW5 P55854 affinity chromatography technology 25391492 physical association X 2 Q8IYW5 P60604-2 two hybrid 19690564 direct interaction X 2 Q8IYW5 Q12888 imaging technique 20016603 colocalization X 2 Q8IYW5 O95714 affinity chromatography technology 20023648 physical association X 2 Q8IYW5 Q12888 imaging technique 21552324 colocalization X 2 Q8IYW5 O75164 enzymatic study 22373579 direct interaction X 2 O95999 Q8IYW5 affinity chromatography technology 24732096 physical association X 2 Q8IYW5 P62987 pull down 22266820 direct interaction X 2 Q8IYW5 P62987 pull down 22266820 direct interaction X 2 Q15652 Q8IYW5 pull down 24240613 physical association X 2 Q8IYW5 Q13571 two hybrid 15231748 - X 2 Q8IYW5 Q13571 two hybrid 15231748 - X 2 Q8IYW5 Q9Y3C5 two hybrid 15231748 - X 2 Q8IYW5 Q9Y3C5 two hybrid 15231748 - X 2 A0A024RDL6 Q8IYW5 in vitro 16499958 - X 2 A0A024RDL6 Q8IYW5 in vitro 16499958 - X 2 Q8IYW5 pull down 21252943 association C 31 Q8IYW5 pull down 22884692 association C 3 Q8IYW5 Q13571 two hybrid 15231748 physical association X 2 Q8IYW5 Q9Y3C5 two hybrid 15231748 physical association X 2 Q8IYW5 P16104 confocal microscopy 19203578 colocalization X 2 Q8IYW5 P16104 confocal microscopy 19203578 colocalization X 2 Q8IYW5 P61088 anti bait coimmunoprecipitation 19203578 physical association X 2 Q8IYW5 P61088 anti bait coimmunoprecipitation 19203578 physical association X 2 Q8IYW5 P16104 confocal microscopy 19203578 colocalization X 2 Q8IYW5 A0A024RDU9 display technology 20195357 physical association X 2 Q8IYW5 P0CG47 pull down 16499958 direct interaction X 2 Q8IYW5 P60604 two hybrid array 19690564 physical association X 2 Q8IYW5 Q12888 confocal microscopy 22884692 colocalization X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B RNF168 RABGEF1 MI:0492(in vitro) 16499958 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_30448 - - RNF168 RABGEF1 MI:0492(in vitro) 16499958 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_30448 - - RNF168 POC1A MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_238373 bait prey SMARCA5 RNF168 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23264744 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_247585|BIOGRID_247584 bait|prey prey|bait JMJD1C RNF168 MI:0096(pull down) 24240613 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_297173 prey bait UBR5 RNF168 MI:0663(confocal microscopy)|MI:0004(affinity chromatography technology) 22884692 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_124720|BIOGRID_257100 prey|prey bait|bait UBC RNF168 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down) 18781797,21041483,21139048,21890473,21906983,21963094,22266820,22505724,22742833,22884692,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_169261|BIOGRID_178571|BIOGRID_194762|BIOGRID_223581|BIOGRID_174617|BIOGRID_162216|BIOGRID_265226|BIOGRID_269013|BIOGRID_257099|BIOGRID_145842|BIOGRID_193709 bait|bait|prey|bait|bait|bait|bait|bait|prey|prey|prey prey|prey|bait|prey|prey|prey|prey|prey|bait|bait|bait KIF5B RNF168 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241960 bait prey RNF168 TAF15 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_239240 prey bait TP53BP1 RNF168 MI:0663(confocal microscopy)|MI:0428(imaging technique)|MI:0428(imaging technique) 20016603,21552324,22884692 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization) (intact)|(biogrid)|(biogrid) UniProt_124719|BIOGRID_165202|BIOGRID_126123 neutral component|bait|bait neutral component|prey|prey RNF168 DDX1 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_236283 prey bait UBE2E1 RNF168 MI:0004(affinity chromatography technology) 22492721 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_225657 prey bait HIST2H2AA3 RNF168 MI:0096(pull down) 21041483 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_145844 prey bait HIST2H2BE RNF168 MI:0096(pull down) 21041483 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_145845 prey bait DCTN1 RNF168 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_240782 bait prey H2AFX RNF168 MI:0415(enzymatic study)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 19203578,19500350 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization) (biogrid)|(intact)|(intact)|(intact) BIOGRID_129201|UniProt_99149|UniProt_99151|UniProt_99150 prey|neutral component|neutral component|neutral component bait|neutral component|neutral component|neutral component UBB RNF168 MI:0004(affinity chromatography technology)|MI:0096(pull down) 16499958,22266820 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(intact) BIOGRID_192503|UniProt_84333 prey|prey bait|bait HERC2 RNF168 MI:0004(affinity chromatography technology) 20023648 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_148178 prey bait HIST2H2AC RNF168 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology) 19203578,21041483,22492721,22980979 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_126036|BIOGRID_126035|BIOGRID_145843|BIOGRID_252421|BIOGRID_190401 prey|prey|prey|prey|prey bait|bait|bait|bait|bait SUMO1 RNF168 MI:0004(affinity chromatography technology) 22508508 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_184784 bait prey KDM4A RNF168 MI:0004(affinity chromatography technology) 22373579 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_185360 prey bait LAPTM5 RNF168 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|-|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|(intact)|MI:0468(hprd)|(biogrid)|MI:0471(mint) MINT_61519|UniProt_79185|HPRD_2811|BIOGRID_259134|MINT_32671 bait|bait|-|bait|bait prey|prey|-|prey|prey SUMO2 RNF168 MI:0004(affinity chromatography technology) 21252943 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_183911 bait prey KDM1A RNF168 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24217620 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_293647|BIOGRID_293648 prey|bait bait|prey TRIP12 RNF168 MI:0663(confocal microscopy)|MI:0004(affinity chromatography technology) 22884692 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_124720|BIOGRID_257101 prey|prey bait|bait ECM29 RNF168 MI:0018(two hybrid) 20682791 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_199703 prey bait GTF2F2 RNF168 MI:0034(display technology) 20195357 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_104891 bait prey EWSR1 RNF168 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_240541 bait prey UBE2N RNF168 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 19203578,20725033,23255131 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(intact)|(intact) BIOGRID_248135|BIOGRID_142334|BIOGRID_223164|UniProt_99147|UniProt_99148 prey|prey|prey|bait|bait bait|bait|bait|prey|prey RNF168 RNF11 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association) (biogrid)|MI:0471(mint)|(intact)|MI:0468(hprd)|MI:0471(mint) BIOGRID_259427|MINT_31458|UniProt_78547|HPRD_37818|MINT_60223 prey|prey|prey|-|prey bait|bait|bait|-|bait UBE2G2 RNF168 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102569|BIOGRID_123580 bait|bait prey|prey UBE2D3 RNF168 MI:0415(enzymatic study)|MI:0004(affinity chromatography technology) 19500350,22373579 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_225743|BIOGRID_225639 prey|prey bait|bait

PPI - HINT Gene A Gene B PMID Method Quality PSMD11 RNF168 26496610,26496610 0007,0004 HT KDM1A RNF168 25999347,25999347,24217620 0004,0096,0004 LC UBB RNF168 16499958,22266820 0096,0004 LC UBC RNF168 22266820,22266820,26503038,21041483,22742833 0004,0096,0096,0096,0096 LC TBP RNF168 26496610,26496610 0007,0004 HT UBE2D3 RNF168 22373579,19500350 0096,0096 LC UBE2N RNF168 19203578,20725033 0006,0004 LC SUMO2 RNF168 26675234,26675234,21252943 0096,0004,0004 LC EWSR1 RNF168 22939629 0401 HT TP53BP1 RNF168 21552324,25999347,20016603,22884692 0428,0004,0428,0663 LC HIST2H2AC RNF168 21041483,19203578,19203578 0004,0004,0415 LC DKFZP686I0746 RNF168 22939629 0401 HT CCDC174 RNF168 26496610,26496610 0007,0004 HT SRCAP RNF168 26496610,26496610 0007,0004 HT RNF168 POC1A 22939629 0401 HT RNF168 FAM45A 26496610,26496610 0007,0004 HT RNF168 DDX1 22939629 0401 HT RNF168 TAF15 22939629 0401 HT RNF168 RPRD1B 26496610,26496610 0007,0004 HT RNF168 NUB1 26496610,26496610 0007,0004 HT RNF168 TACC3 26496610,26496610 0007,0004 HT RNF168 HEL-S-61 22939629 0401 HT RNF168 HEL-S-71 24732096,19203578,23255131,19203578,20725033 0004,0004,0004,0096,0004 LC PSMD11 RNF168 26496610,26496610 0007,0004 HT TBP RNF168 26496610,26496610 0007,0004 HT EWSR1 RNF168 22939629 0401 HT DKFZP686I0746 RNF168 22939629 0401 HT CCDC174 RNF168 26496610,26496610 0007,0004 HT SRCAP RNF168 26496610,26496610 0007,0004 HT RNF168 POC1A 22939629 0401 HT RNF168 FAM45A 26496610,26496610 0007,0004 HT RNF168 DDX1 22939629 0401 HT RNF168 TAF15 22939629 0401 HT RNF168 RPRD1B 26496610,26496610 0007,0004 HT RNF168 NUB1 26496610,26496610 0007,0004 HT RNF168 TACC3 26496610,26496610 0007,0004 HT RNF168 HEL-S-61 22939629 0401 HT KDM1A RNF168 25999347,25999347,24217620 0004,0096,0004 LC UBB RNF168 16499958,22266820 0096,0004 LC UBC RNF168 22266820,22266820,26503038,21041483,22742833 0004,0096,0096,0096,0096 LC UBE2D3 RNF168 22373579,19500350 0096,0096 LC UBE2N RNF168 19203578,20725033 0006,0004 LC SUMO2 RNF168 26675234,26675234,21252943 0096,0004,0004 LC TP53BP1 RNF168 21552324,25999347,20016603,22884692 0428,0004,0428,0663 LC HIST2H2AC RNF168 21041483,19203578,19203578 0004,0004,0415 LC RNF168 HEL-S-71 24732096,19203578,23255131,19203578,20725033 0004,0004,0004,0096,0004 LC KDM4A RNF168 22373579 0415 LC H2AFZ RNF168 26508657 0415 LC GTF2F2 RNF168 20195357 0034 LC H2AFX RNF168 19500350 0415 LC UBE2E1 RNF168 22492721,22492721 0096,0415 LC UBE2G2 RNF168 19690564,19690564 0397,0018 HT EWSR1 RNF168 22939629 0401 LC LAPTM5 RNF168 15231748 0018 HT HIST2H2AC RNF168 22492721,19203578,19203578,22980979 0415,0004,0415,0415 LC ECM29 RNF168 20682791 0018 LC DKFZP686I0746 RNF168 22939629 0401 LC RNF168 RNF168 19203578 0415 LC RNF168 POC1A 22939629 0401 LC RNF168 DDX1 22939629 0401 LC RNF168 TAF15 22939629 0401 LC RNF168 RNF11 15231748 0018 HT RNF168 HEL-S-61 22939629 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8IYW5 P55854 RNF168 SUMO3 0.21 26675234 Q8IYW5 P51668 RNF168 UBE2D1 0.183 26508657 Q8IYW5 Q12888 RNF168 TP53BP1 0.472 22884692,20016603,21552324,25999347 Q8IYW5 Q15652 RNF168 JMJD1C 0.309 24240613 Q8IYW5 Q16778 RNF168 HIST2H2BE 0.21 21041483 Q8IYW5 Q5VYK3 RNF168 ECM29 0.183 20682791 Q8IYW5 Q6FI13 RNF168 HIST2H2AA4 0.21 21041483 Q8IYW5 Q8IYW5 RNF168 RNF168 0.332 19203578 Q8NBT0 Q8IYW5 POC1A RNF168 0.081 22939629 Q8IYW5 P16403 RNF168 HIST1H1C 0.309 26503038 Q8IYW5 O95999 RNF168 BCL10 0.21 24732096 Q8IYW5 O75164 RNF168 KDM4A 0.309 22373579 Q8IYW5 O60264 RNF168 SMARCA5 0.376 23264744 Q8IYW5 P20226 RNF168 TBP 0.126 26496610 Q8IYW5 O95714 RNF168 HERC2 0.21 20023648 Q8IYW5 P16104 RNF168 H2AFX 0.472 19203578,19500350 Q8NCN4 Q8IYW5 RNF169 RNF168 0.21 21252943 Q8IYW5 P51965 RNF168 UBE2E1 0.309 22492721 Q8IYW5 P0C0S5 RNF168 H2AFZ 0.183 26508657 Q8IYW5 P60604 RNF168 UBE2G2 0.376 19690564 Q8IYW5 P0CG47 RNF168 UBB 0.309 16499958 Q8IYW5 P13984 RNF168 GTF2F2 0.126 20195357 Q9Y6A5 Q8IYW5 TACC3 RNF168 0.236 26496610 Q8IYW5 P61956 RNF168 SUMO2 0.454 26675234 Q8IYW5 Q6ZRS2 RNF168 SRCAP 0.236 26496610 Q8IYW5 Q14669 RNF168 TRIP12 0.376 22884692 Q8IYW5 Q6PII3 RNF168 CCDC174 0.236 26496610 Q9NQG5 Q8IYW5 RPRD1B RNF168 0.236 26496610 Q8TCE6 Q8IYW5 FAM45A RNF168 0.236 26496610 Q9Y5A7 Q8IYW5 NUB1 RNF168 0.236 26496610 Q8IYW5 P13196 RNF168 ALAS1 0.236 unassigned1304 Q8IYW5 O95071 RNF168 UBR5 0.376 22884692 Q9Y3C5 Q8IYW5 RNF11 RNF168 0.332 15231748 Q8IYW5 P61077 RNF168 UBE2D3 0.523 22373579,19500350 Q93009 Q8IYW5 USP7 RNF168 0.454 25894431 Q8IYW5 O00231 RNF168 PSMD11 0.236 26496610 Q8IYW5 O60341 RNF168 KDM1A 0.765 24217620,25999347 Q8IYW5 P61088 RNF168 UBE2N 0.832 20725033,19203578,23255131,24732096 Q8IYW5 P0CG48 RNF168 UBC 0.671 22742833,26503038,22266820 Q8IYW5 Q16777 RNF168 HIST2H2AC 0.794 22980979,19203578,22492721,21041483 Q92804 Q8IYW5 TAF15 RNF168 0.081 22939629 Q92499 Q8IYW5 DDX1 RNF168 0.081 22939629 Q8IYW5 P33176 RNF168 KIF5B 0.081 22939629 Q8IYW5 Q13571 RNF168 LAPTM5 0.332 15231748 Q8IYW5 Q14203 RNF168 DCTN1 0.081 22939629 Q8IYW5 Q01844 RNF168 EWSR1 0.081 22939629

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 PSMD11 RNF168 MI:0045 experimental interaction detection MI:0461 interaction database SMARCA5 RNF168 MI:0045 experimental interaction detection MI:0461 interaction database KDM1A RNF168 MI:0045 experimental interaction detection MI:0461 interaction database NBN RNF168 MI:0362 inference MI:1106 pathways database KDM4A RNF168 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RNF8 RNF168 MI:0362 inference MI:1106 pathways database KDM4B RNF168 MI:0362 inference MI:1106 pathways database UBR5 RNF168 MI:0045 experimental interaction detection MI:0461 interaction database HERC2 RNF168 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database BCL10 RNF168 MI:0045 experimental interaction detection MI:0461 interaction database CHEK2 RNF168 MI:0362 inference MI:1106 pathways database WHSC1 RNF168 MI:0362 inference MI:1106 pathways database H1F0 RNF168 MI:0362 inference MI:0461 interaction database H2AFZ RNF168 MI:0045 experimental interaction detection MI:0461 interaction database UBB RNF168 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database UBC RNF168 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database XRCC6 RNF168 MI:0362 inference MI:1106 pathways database XRCC5 RNF168 MI:0362 inference MI:1106 pathways database GTF2F2 RNF168 MI:0045 experimental interaction detection MI:0461 interaction database H2AFX RNF168 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database HIST1H1C RNF168 MI:0045 experimental interaction detection MI:0461 interaction database TBP RNF168 MI:0045 experimental interaction detection MI:0461 interaction database BRCA1 RNF168 MI:0362 inference MI:1106 pathways database BRCC3 RNF168 MI:0362 inference MI:1106 pathways database MRE11A RNF168 MI:0362 inference MI:1106 pathways database UBE2D1 RNF168 MI:0045 experimental interaction detection MI:0461 interaction database UBE2E1 RNF168 MI:0045 experimental interaction detection MI:0461 interaction database PPP5C RNF168 MI:0362 inference MI:1106 pathways database SUMO3 RNF168 MI:0045 experimental interaction detection MI:0461 interaction database UBE2G2 RNF168 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 RNF168 MI:0045 experimental interaction detection MI:0461 interaction database UBE2N RNF168 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SUMO2 RNF168 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database HIST1H4A RNF168 MI:0362 inference MI:1106 pathways database RPS27A RNF168 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database UBA52 RNF168 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database SUMO1 RNF168 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database UBE2I RNF168 MI:0362 inference MI:1106 pathways database RNF4 RNF168 MI:0362 inference MI:1106 pathways database TP53BP1 RNF168 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ATM RNF168 MI:0362 inference MI:1106 pathways database LAPTM5 RNF168 MI:0045 experimental interaction detection MI:0461 interaction database TRIP12 RNF168 MI:0045 experimental interaction detection MI:0461 interaction database MDC1 RNF168 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database JMJD1C RNF168 MI:0045 experimental interaction detection MI:0461 interaction database UBE2V2 RNF168 MI:0362 inference MI:1106 pathways database NEDD8 RNF168 MI:0045 experimental interaction detection MI:0461 interaction database HIST3H3 RNF168 MI:0362 inference MI:1106 pathways database HIST2H2AC RNF168 MI:0045 experimental interaction detection MI:0461 interaction database HIST2H2BE RNF168 MI:0045 experimental interaction detection MI:0461 interaction database RIF1 RNF168 MI:0362 inference MI:1106 pathways database ECM29 RNF168 MI:0045 experimental interaction detection MI:0461 interaction database HIST2H2AA3 RNF168 MI:0045 experimental interaction detection MI:0461 interaction database CCDC174 RNF168 MI:0045 experimental interaction detection MI:0461 interaction database FAM175A RNF168 MI:0362 inference MI:1106 pathways database SRCAP RNF168 MI:0045 experimental interaction detection MI:0461 interaction database PAXIP1 RNF168 MI:0362 inference MI:1106 pathways database HIST3H2A RNF168 MI:0362 inference MI:0461 interaction database RNF168 PIAS4 MI:0362 inference MI:1106 pathways database RNF168 RNF169 MI:0045 experimental interaction detection MI:0461 interaction database RNF168 FAM45A MI:0045 experimental interaction detection MI:0461 interaction database RNF168 H1FX MI:0362 inference MI:0461 interaction database RNF168 RAD50 MI:0362 inference MI:1106 pathways database RNF168 KAT5 MI:0362 inference MI:1106 pathways database RNF168 USP7 MI:0045 experimental interaction detection MI:0461 interaction database RNF168 UIMC1 MI:0362 inference MI:1106 pathways database RNF168 DCLRE1C MI:0362 inference MI:1106 pathways database RNF168 BARD1 MI:0362 inference MI:1106 pathways database RNF168 RPRD1B MI:0045 experimental interaction detection MI:0461 interaction database RNF168 BABAM1 MI:0362 inference MI:1106 pathways database RNF168 BRE MI:0362 inference MI:1106 pathways database RNF168 RNF11 MI:0045 experimental interaction detection MI:0461 interaction database RNF168 NUB1 MI:0045 experimental interaction detection MI:0461 interaction database RNF168 TACC3 MI:0045 experimental interaction detection MI:0461 interaction database