PTM - CPLM Gene Name UniProt ID Type Position Code RNF168 Q8IYW5 Ubiquitination 232 K RNF168 Q8IYW5 Ubiquitination 455 K RNF168 Q8IYW5 Ubiquitination 399 K RNF168 Q8IYW5 Ubiquitination 227 K RNF168 Q8IYW5 Ubiquitination 341 K RNF168 Q8IYW5 Ubiquitination 548 K RNF168 Q8IYW5 Ubiquitination 528 K RNF168 Q8IYW5 Ubiquitination 173 K RNF168 Q8IYW5 Ubiquitination 485 K RNF168 Q8IYW5 Ubiquitination 254 K RNF168 Q8IYW5 Ubiquitination 334 K RNF168 Q8IYW5 Ubiquitination 459 K RNF168 Q8IYW5 Ubiquitination 126 K RNF168 Q8IYW5 Ubiquitination 441 K RNF168 Q8IYW5 Ubiquitination 181 K RNF168 Q8IYW5 Ubiquitination 389 K RNF168 Q8IYW5 Ubiquitination 203 K RNF168 Q8IYW5 Ubiquitination 158 K RNF168 Q8IYW5 Ubiquitination 112 K RNF168 Q8IYW5 Ubiquitination 406 K RNF168 Q8IYW5 Ubiquitination 468 K RNF168 Q8IYW5 Ubiquitination 524 K RNF168 Q8IYW5 Ubiquitination 409 K RNF168 Q8IYW5 Ubiquitination 560 K RNF168 Q8IYW5 Ubiquitination 383 K RNF168 Q8IYW5 Ubiquitination 387 K

PTM - dbPAF Gene Name UniProt ID Position Type Species RNF168 Q8IYW5 104 Y Homo sapiens(Human) RNF168 Q8IYW5 134 S Homo sapiens(Human) RNF168 Q8IYW5 183 S Homo sapiens(Human) RNF168 Q8IYW5 195 S Homo sapiens(Human) RNF168 Q8IYW5 197 S Homo sapiens(Human) RNF168 Q8IYW5 208 T Homo sapiens(Human) RNF168 Q8IYW5 230 T Homo sapiens(Human) RNF168 Q8IYW5 237 S Homo sapiens(Human) RNF168 Q8IYW5 251 S Homo sapiens(Human) RNF168 Q8IYW5 278 S Homo sapiens(Human) RNF168 Q8IYW5 393 S Homo sapiens(Human) RNF168 Q8IYW5 394 S Homo sapiens(Human) RNF168 Q8IYW5 404 S Homo sapiens(Human) RNF168 Q8IYW5 411 S Homo sapiens(Human) RNF168 Q8IYW5 414 S Homo sapiens(Human) RNF168 Q8IYW5 415 S Homo sapiens(Human) RNF168 Q8IYW5 421 T Homo sapiens(Human) RNF168 Q8IYW5 426 T Homo sapiens(Human) RNF168 Q8IYW5 470 S Homo sapiens(Human) RNF168 Q8IYW5 481 S Homo sapiens(Human) RNF168 Q8IYW5 509 T Homo sapiens(Human) RNF168 Q8IYW5 558 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q8IYW5 S59-p Phosphorylation PFCRRRVsSWTRYHT Q8IYW5 S70-p Phosphorylation RYHTRRNsLVNVELW Q8IYW5 Y104-p Phosphorylation SEEVADDyQPVRLLS Q8IYW5 S134-p Phosphorylation VAAERRAsEEEENKA Q8IYW5 S183-p Phosphorylation EELARKLsIDINNFC Q8IYW5 T208-p Phosphorylation SRkSDPVtPkSEKKS Q8IYW5 T230-p Phosphorylation GDIQkYLtPkSQFGs Q8IYW5 S237-p Phosphorylation tPkSQFGsASHSEAV Q8IYW5 S251-p Phosphorylation VQEVRKDsVSkDIDS Q8IYW5 S329-p Phosphorylation GKELCVLsHERPkTR Q8IYW5 S394-p Phosphorylation KRkNQESsFEAVkDP Q8IYW5 S404-p Phosphorylation AVkDPCFsAkRRkVs Q8IYW5 S411-p Phosphorylation sAkRRkVsPEssPDQ Q8IYW5 S414-p Phosphorylation RRkVsPEssPDQEEt Q8IYW5 S415-p Phosphorylation RkVsPEssPDQEEtE Q8IYW5 T421-p Phosphorylation ssPDQEEtEINFtQk Q8IYW5 T426-p Phosphorylation EEtEINFtQkLIDLE Q8IYW5 S470-p Phosphorylation VPNRQkGsPDEYHLR Q8IYW5 T479-p Phosphorylation DEYHLRAtSsPPDkV Q8IYW5 S481-p Phosphorylation YHLRAtSsPPDkVLN Q8IYW5 S530-p Phosphorylation LKMQLkQsVNRRKMP Q8IYW5 S558-p Phosphorylation HSLQPSIsQkSVFQM Q8IYW5 K210-sm Sumoylation kSDPVtPkSEKKSKN Q8IYW5 K468-sm Sumoylation QMVPNRQkGsPDEYH Q8IYW5 K112-ub Ubiquitination QPVRLLSkPGELRRE Q8IYW5 K158-ub Ubiquitination AEEEEEEkRQAEKRR Q8IYW5 K203-ub Ubiquitination ASPLNSRkSDPVtPk Q8IYW5 K227-ub Ubiquitination RNTGDIQkYLtPkSQ Q8IYW5 K232-ub Ubiquitination IQkYLtPkSQFGsAS Q8IYW5 K254-ub Ubiquitination VRKDsVSkDIDSSDR Q8IYW5 K334-ub Ubiquitination VLsHERPkTRVPYSk Q8IYW5 K341-ub Ubiquitination kTRVPYSkETAVMPC Q8IYW5 K389-ub Ubiquitination SKEISKRkNQESsFE Q8IYW5 K399-ub Ubiquitination ESsFEAVkDPCFsAk Q8IYW5 K406-ub Ubiquitination kDPCFsAkRRkVsPE Q8IYW5 K409-ub Ubiquitination CFsAkRRkVsPEssP Q8IYW5 K428-ub Ubiquitination tEINFtQkLIDLEHL Q8IYW5 K455-ub Ubiquitination LLALQLQkEVDkEQM Q8IYW5 K459-ub Ubiquitination QLQkEVDkEQMVPNR Q8IYW5 K468-ub Ubiquitination QMVPNRQkGsPDEYH Q8IYW5 K485-ub Ubiquitination AtSsPPDkVLNGQRK Q8IYW5 K528-ub Ubiquitination VSLKMQLkQsVNRRK Q8IYW5 K548-ub Ubiquitination RDHCKVSkSAHSLQP Q8IYW5 K560-ub Ubiquitination LQPSIsQkSVFQMFQ

PTM - dbPTM UniProt ID Position Code Type Resources References Q8IYW5 411 S Phosphorylation Swiss-Prot 1010711 18669648;19690332 Q8IYW5 414 S Phosphorylation Swiss-Prot 1010711 18669648;19690332 Q8IYW5 415 S Phosphorylation Swiss-Prot 1010711 18669648;19690332 Q8IYW5 421 T Phosphorylation Swiss-Prot 1010711 18669648 Q8IYW5 411 S Phosphorylation PhosphoELM.10011 18669648 Q8IYW5 414 S Phosphorylation PhosphoELM.10011 18669648 Q8IYW5 415 S Phosphorylation PhosphoELM.10011 18669648 Q8IYW5 421 T Phosphorylation PhosphoELM.10011 18669648 Q8IYW5 227 K Ubiquitylation Phosphositeplus.1010730 21906983 Q8IYW5 232 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q8IYW5 409 K Ubiquitylation Phosphositeplus.1010730 21906983 Q8IYW5 455 K Ubiquitylation Phosphositeplus.1010730 21890473 Q8IYW5 468 K Ubiquitylation Phosphositeplus.1010730 21906983 Q8IYW5 411 S Phosphorylation Phosphositeplus.1010730 18669648;19690332 Q8IYW5 414 S Phosphorylation Phosphositeplus.1010730 18669648;19690332 Q8IYW5 415 S Phosphorylation Phosphositeplus.1010730 18669648;19690332 Q8IYW5 421 T Phosphorylation Phosphositeplus.1010730 18669648 Q8IYW5 411 S Phosphorylation HPRD 9.0 18669648 Q8IYW5 414 S Phosphorylation HPRD 9.0 18669648 Q8IYW5 415 S Phosphorylation HPRD 9.0 18669648 Q8IYW5 421 T Phosphorylation HPRD 9.0 18669648 Q8IYW5 411 S Phosphorylation SysPTM 1.1 18669648 Q8IYW5 414 S Phosphorylation SysPTM 1.1 18669648 Q8IYW5 415 S Phosphorylation SysPTM 1.1 18669648 Q8IYW5 421 T Phosphorylation SysPTM 1.1 18669648

PTM - HPRD Symbol Position Code Type References RNF168 411 S Phosphorylation 18669648 RNF168 414 S Phosphorylation 18669648 RNF168 415 S Phosphorylation 18669648 RNF168 421 T Phosphorylation 18669648

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q8IYW5 414 S 18669648 HTP Phosphorylation Q8IYW5 421 T 18669648 HTP Phosphorylation Q8IYW5 411 S 18669648 HTP Phosphorylation Q8IYW5 415 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q8IYW5 134 Phosphoserine 23186163 Q8IYW5 411 Phosphoserine 18669648;19690332;23186163 Q8IYW5 414 Phosphoserine 18669648;19690332 Q8IYW5 415 Phosphoserine 18669648;19690332 Q8IYW5 470 Phosphoserine 23186163

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 165918 127922 - K Ubiquitination 18781797 165918 127922 - K Ubiquitination 21139048 165918 127922 - K Ubiquitination 21890473 165918 127922 - K Ubiquitination 21906983 165918 127922 - K Sumoylation 21252943 165918 127922 - K Sumoylation 22508508 165918 127922 - K Ubiquitination 22505724 165918 127922 - K Ubiquitination 22884692 165918 127922 - K Ubiquitination 21963094 165918 127922 - K Ubiquitination 23000965 165918 127922 - K Ubiquitination 24634510 165918 127922 - K Neddylation 24634510 165918 127922 - K Ubiquitination 24816145 165918 127922 - K Sumoylation 25391492 165918 127922 - K Ubiquitination 22266820

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID RNF168 Homo sapiens (Human) 409; 232; 455; 468; 227 "409,FSAKRRKVSPESS; 232,QKYLTPKSQFGSA; 455,LALQLQKEVDKEQ; 468,MVPNRQKGSPDEY; 227,NTGDIQKYLTPKS" "409:21906983; 232:21890473,21906983; 455:21890473; 468:21906983; 227:21906983"