PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus OTUD4 LHX6 26186194 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP P GP GP G PRR5 OTUD4 17461779 innatedb,intact exp GP G G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G ATG12 OTUD4 17353931 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G KRT8 OTUD4 19615732 biogrid,intact exp GP G G G G G G G GP G GP GP GP G G GP G GP GP G GP GP GP G GP G GP G G FXR2 OTUD4 19615732 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G OTUD4 RPTN 19615732 biogrid exp G G OTUD4 RUNX1T1 17353931 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G OTUD4 OTUD4 19615732 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G OTUD4 REL 25416956 biogrid,intact exp GP G G G GP GP G G GP G GP G GP GP G GP GP GP GP G P GP GP G GP GP GP GP G OTUD4 MOG 19615732 biogrid,intact exp G G G G G GP G G GP G G G G G GP G G G GP G G G G G OTUD4 HSF2 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G GP G OTUD4 HRNR 19615732 intact exp P P P P P P P P P P P P P P P P P P P P KRT36 OTUD4 19615732 biogrid,intact exp P P P P OTUD4 KRT31 19615732 biogrid,intact exp G G G GP G P P P G P GP G P P GP G GP P G UBC OTUD4 23827681 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NPEPPS OTUD4 19615732 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP G G G GP GP G GP G G GP G GP GP G GP GP G OTUD4 CDK5RAP3 17353931 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G OTUD4 GPHN 19615732 biogrid,intact exp GP G G GP G G GP G GP GP G G G GP GP G GP G G G GP G GP G GP G G PRPF4 OTUD4 26496610 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G OTUD4 ILK 17353931 biogrid,intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PTBP3 OTUD4 22575643 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G OTUD4 TMBIM4 17353931 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G OAT OTUD4 19615732 biogrid,intact exp GP GP G G GP GP G GP G G GP GP GP G G GP GP G GP G G G GP GP GP G GP GP G OTUD4 AGO3 19167051 biogrid,intact exp G GP G G G GP G G G G GP G G G G G GP G G G G G GP G G G GP G G HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J OTUD4 26527279 biogrid exp P GP G GP P GP P P P P P P P P P P GP GP GP P GP P P CLEC3B OTUD4 17353931 biogrid,intact exp GALK1 OTUD4 19615732 biogrid,intact exp P P P P P P P GP P P P P P P P P P P P GP P P OTUD4 NAF1 26496610 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G KRT85 OTUD4 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G GRK5 OTUD4 22952844 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G OTUD4 BRF2 17353931 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G DNAJB1 OTUD4 19615732 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G GLA OTUD4 19615732 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP G G GP GP G GP G G GP GP G GP G GP GP G OTUD4 BAG5 19615732 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G STAT1 OTUD4 25416956 biogrid,intact exp G G G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP G G GP GP G GP G OTUD4 PARP11 19615732 biogrid exp G GP G G P G P GP P P P GP G P GP G P P GP P GP G GP GP TCF4 OTUD4 25416956 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G OTUD4 GAR1 26496610 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G OTUD4 MYCBP 19615732 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P XPO1 OTUD4 26673895 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RBFOX2 OTUD4 26186194 biogrid exp G GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G FMNL1 OTUD4 23182705 biogrid exp G G G GP G G GP GP G G G G G G G GP G OTUD4 WBP2NL 26186194 biogrid exp P P P G P P OTUD4 EXOSC8 25416956 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MYC OTUD4 21150319 i2d,intact exp GP GP G GP P G GP GP GP GP GP GP G GP P GP GP GP GP GP GP GP GP GP GP G OTUD4 FLNC 19615732 biogrid,intact exp G GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP G GP GP GP G GP GP G OTUD4 TUBA1A 19615732 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G OTUD4 KRT33B 19615732 biogrid,intact exp P P P OTUD4 NMD3 19615732 biogrid,intact exp G GP G G G GP G GP GP G GP G GP G G GP GP G G G G G GP G GP G G G G OTUD4 DSG1 19615732 biogrid,intact exp GP P P P GP P P P P P P P P OTUD4 BAP1 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G OTUD4 SCGB3A1 21836163 pred G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P25685 Q01804 affinity chromatography technology 19615732 physical association X 2 Q13418 Q01804 affinity chromatography technology 17353931 physical association X 2 Q71U36 Q01804 affinity chromatography technology 19615732 physical association X 2 Q6XPR3 Q01804 affinity chromatography technology 19615732 physical association X 2 Q9NR21-4 Q01804 affinity chromatography technology 19615732 physical association X 2 Q9HAW0 Q01804 affinity chromatography technology 17353931 physical association X 2 P51116 Q01804 affinity chromatography technology 19615732 physical association X 2 Q01804 Q04864 two hybrid 25416956 direct interaction X 2 Q01804 P05787 affinity chromatography technology 19615732 physical association X 2 Q01804 Q9UL15-2 affinity chromatography technology 19615732 physical association X 2 Q01804 B4E1P5 affinity chromatography technology 19167051 physical association X 2 Q01804 affinity chromatography technology 23182705 physical association X 2 O76013 Q01804 affinity chromatography technology 19615732 physical association X 2 P0CG48 Q01804 affinity chromatography technology 23000965 physical association X 2 P0CG48 Q01804 affinity chromatography technology 24816145 physical association X 2 P0CG48 Q01804 enzymatic study 23827681 direct interaction X 2 P0CG48 Q01804 affinity chromatography technology 22118674 physical association X 2 P0CG48 Q01804 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q01804 affinity chromatography technology 21906983 physical association X 2 P42224-2 Q01804 two hybrid 25416956 direct interaction X 2 P06280 Q01804 affinity chromatography technology 19615732 physical association X 2 P51570 Q01804 affinity chromatography technology 19615732 physical association X 2 O94817 Q01804 affinity chromatography technology 17353931 physical association X 2 Q01804 P15884-6 two hybrid 25416956 direct interaction X 2 Q01804 Q96B26 two hybrid 25416956 direct interaction X 2 Q01804 Q06455-4 affinity chromatography technology 17353931 physical association X 2 Q02413 Q01804 affinity chromatography technology 19615732 physical association X 2 Q01804 Q14315 affinity chromatography technology 19615732 physical association X 2 Q01804 Q15323 affinity chromatography technology 19615732 physical association X 2 Q01804 affinity chromatography technology 19615732 physical association X 2 Q01804 P04181 affinity chromatography technology 19615732 physical association X 2 Q01804 Q9NQX3 affinity chromatography technology 19615732 physical association X 2 Q01804 Q99417 affinity chromatography technology 19615732 physical association X 2 Q01804 Q96D46 affinity chromatography technology 19615732 physical association X 2 Q14525 Q01804 affinity chromatography technology 19615732 physical association X 2 P78386 Q01804 affinity chromatography technology 19615732 physical association X 2 P34947 Q01804 affinity chromatography technology 22952844 physical association X 2 A0A024R2Q7 Q01804 affinity chromatography technology 17353931 physical association X 2 P55786 Q01804 affinity chromatography technology 19615732 physical association X 2 Q06455 Q01804 anti bait coimmunoprecipitation 17353931 physical association X 2 Q01804 anti bait coimmunoprecipitation 22575643 association C 122 Q01804 anti tag coimmunoprecipitation 19167051 association C 42 Q13418 Q01804 anti bait coimmunoprecipitation 17353931 physical association X 2 A0A024R2C0 Q01804 two hybrid prey pooling approach 25416956 physical association X 2 A0A024R2C0 Q01804 two hybrid array 25416956 physical association X 2 A0A024R2C0 Q01804 validated two hybrid 25416956 physical association X 2 Q9HAW0 Q01804 anti bait coimmunoprecipitation 17353931 physical association X 2 Q01804 Q04864 two hybrid prey pooling approach 25416956 physical association X 2 Q01804 Q04864 two hybrid array 25416956 physical association X 2 Q01804 Q04864 validated two hybrid 25416956 physical association X 2 Q01804 anti tag coimmunoprecipitation 17461779 association C 12 Q7CJH7 Q01804 two hybrid pooling approach 20711500 physical association X 2 O94817 Q01804 anti bait coimmunoprecipitation 17353931 physical association X 2 Q96JB5 Q01804 anti bait coimmunoprecipitation 17353931 physical association X 2 Q01804 Q9HC24 anti bait coimmunoprecipitation 17353931 physical association X 2 Q01804 Q96B26 two hybrid prey pooling approach 25416956 physical association X 2 Q01804 Q96B26 two hybrid array 25416956 physical association X 2 Q01804 Q96B26 validated two hybrid 25416956 physical association X 2 P42224 Q01804 two hybrid prey pooling approach 25416956 physical association X 2 P42224 Q01804 two hybrid array 25416956 physical association X 2 P42224 Q01804 validated two hybrid 25416956 physical association X 2 A0A024R2Q7 Q01804 anti bait coimmunoprecipitation 17353931 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B GALK1 OTUD4 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119490|UniProt_100687 prey|prey bait|bait OAT OTUD4 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119626|UniProt_100687 prey|prey bait|bait OTUD4 KRT33B MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119556|UniProt_100687 bait|bait prey|prey OTUD4 RUNX1T1 MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_82351|UniProt_150373 prey|prey bait|bait OTUD4 FLNC MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119485|UniProt_100687 bait|bait prey|prey OTUD4 ILK MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_82181|UniProt_149033 prey|prey bait|bait CLEC3B OTUD4 MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_82543|UniProt_146382 bait|bait prey|prey UBC OTUD4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study) 21139048,21906983,22118674,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_267987|BIOGRID_172074|BIOGRID_181201|BIOGRID_160450 bait|bait|bait|bait prey|prey|prey|prey DNAJB1 OTUD4 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119522|UniProt_100687 prey|prey bait|bait OTUD4 BAG5 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120065|UniProt_100687 bait|bait prey|prey OTUD4 HDAC9 MI:0004(affinity chromatography technology) 22318606 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0799(additive genetic interaction defined by inequality) (biogrid) BIOGRID_193156 prey bait GLA OTUD4 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119496|UniProt_100687 prey|prey bait|bait OTUD4 MYCBP MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120383|UniProt_100687 bait|bait prey|prey ATG12 OTUD4 MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_150202|BIOGRID_81999 bait|bait prey|prey OTUD4 DSG1 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119448|UniProt_100687 bait|bait prey|prey OTUD4 CDK5RAP3 MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_150328 prey bait OTUD4 NMD3 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120432|UniProt_100687 bait|bait prey|prey KRT8 OTUD4 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119546|UniProt_100687 prey|prey bait|bait OTUD4 TUBA1A MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119874|UniProt_100687 bait|bait prey|prey FMNL1 OTUD4 MI:0004(affinity chromatography technology) 23182705 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_249441 bait prey GRK5 OTUD4 MI:0004(affinity chromatography technology) 22952844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_218391 bait prey OTUD4 PARP11 MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_120591 bait prey OTUD4 GPHN MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120148|UniProt_100687 bait|bait prey|prey OTUD4 MOG MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119589|UniProt_100687 bait|bait prey|prey OTUD4 EIF2C3 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19167051 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_145707|UniProt_98606 prey|prey bait|bait OTUD4 KRT31 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100687|BIOGRID_119553 bait|bait prey|prey KRT36 OTUD4 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119973|UniProt_100687 prey|prey bait|bait NPEPPS OTUD4 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120062|UniProt_100687 prey|prey bait|bait OTUD4 RPTN MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_120805 bait prey OTUD4 BRF2 MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_83726|UniProt_145125 prey|prey bait|bait OTUD4 TMBIM4 MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_148078 prey bait KRT85 OTUD4 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119562|UniProt_100687 prey|prey bait|bait FXR2 OTUD4 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120061|UniProt_100687 prey|prey bait|bait

PPI - HINT Gene A Gene B PMID Method Quality PRPF4 OTUD4 26496610,26496610 0007,0004 HT RBFOX2 OTUD4 26186194 0004 HT KRT36 OTUD4 19615732,19615732 0004,0007 HT ATG12 OTUD4 17353931,17353931 0006,0004 HT OAT OTUD4 19615732,19615732 0004,0007 HT CLEC3B OTUD4 17353931,17353931 0006,0004 HT KRT8 OTUD4 19615732,19615732 0004,0007 HT GLA OTUD4 19615732,19615732 0004,0007 HT DNAJB1 OTUD4 19615732,19615732 0004,0007 HT FXR2 OTUD4 19615732,19615732 0004,0007 HT GALK1 OTUD4 19615732,19615732 0004,0007 HT NPEPPS OTUD4 19615732,19615732 0004,0007 HT KRT85 OTUD4 19615732,19615732 0004,0007 HT OTUD4 DSG1 19615732,19615732 0004,0007 HT OTUD4 HSF2 26496610,26496610 0007,0004 HT OTUD4 RUNX1T1 17353931,17353931 0006,0004 HT OTUD4 ILK 17353931,17353931 0006,0004 HT OTUD4 FLNC 19615732,19615732 0004,0007 HT OTUD4 KRT33B 19615732,19615732 0004,0007 HT OTUD4 KRT31 19615732,19615732 0004,0007 HT OTUD4 MOG 19615732,19615732 0004,0007 HT OTUD4 Q59H94 19615732 0004 HT OTUD4 WBP2NL 26186194 0004 HT OTUD4 RPTN 19615732 0004 HT OTUD4 TUBA1A 19615732,19615732 0004,0007 HT OTUD4 Q7L4M3 19615732 0004 HT OTUD4 HRNR 19615732 0007 HT OTUD4 NMD3 19615732,19615732 0004,0007 HT OTUD4 NAF1 26496610,26496610 0007,0004 HT OTUD4 CDK5RAP3 17353931 0006 HT OTUD4 MYCBP 19615732,19615732 0004,0007 HT OTUD4 BRF2 17353931,17353931 0006,0004 HT OTUD4 TMBIM4 17353931 0006 HT OTUD4 GPHN 19615732,19615732 0004,0007 HT OTUD4 PARP11 19615732 0004 HT OTUD4 GAR1 26496610,26496610 0007,0004 HT OTUD4 BAG5 19615732,19615732 0004,0007 HT OTUD4 LHX6 26186194 0004 HT OTUD4 HEL-S-19 19615732 0004 HT OTUD4 HEL-S-28 17353931 0004 HT PRPF4 OTUD4 26496610,26496610 0007,0004 HT RBFOX2 OTUD4 26186194 0004 HT KRT36 OTUD4 19615732,19615732 0004,0007 HT ATG12 OTUD4 17353931,17353931 0006,0004 HT OAT OTUD4 19615732,19615732 0004,0007 HT CLEC3B OTUD4 17353931,17353931 0006,0004 HT KRT8 OTUD4 19615732,19615732 0004,0007 HT GLA OTUD4 19615732,19615732 0004,0007 HT DNAJB1 OTUD4 19615732,19615732 0004,0007 HT FXR2 OTUD4 19615732,19615732 0004,0007 HT GALK1 OTUD4 19615732,19615732 0004,0007 HT NPEPPS OTUD4 19615732,19615732 0004,0007 HT KRT85 OTUD4 19615732,19615732 0004,0007 HT OTUD4 DSG1 19615732,19615732 0004,0007 HT OTUD4 HSF2 26496610,26496610 0007,0004 HT OTUD4 RUNX1T1 17353931,17353931 0006,0004 HT OTUD4 ILK 17353931,17353931 0006,0004 HT OTUD4 FLNC 19615732,19615732 0004,0007 HT OTUD4 KRT33B 19615732,19615732 0004,0007 HT OTUD4 KRT31 19615732,19615732 0004,0007 HT OTUD4 MOG 19615732,19615732 0004,0007 HT OTUD4 Q59H94 19615732 0004 HT OTUD4 WBP2NL 26186194 0004 HT OTUD4 RPTN 19615732 0004 HT OTUD4 TUBA1A 19615732,19615732 0004,0007 HT OTUD4 Q7L4M3 19615732 0004 HT OTUD4 HRNR 19615732 0007 HT OTUD4 NMD3 19615732,19615732 0004,0007 HT OTUD4 NAF1 26496610,26496610 0007,0004 HT OTUD4 CDK5RAP3 17353931 0006 HT OTUD4 MYCBP 19615732,19615732 0004,0007 HT OTUD4 BRF2 17353931,17353931 0006,0004 HT OTUD4 TMBIM4 17353931 0006 HT OTUD4 GPHN 19615732,19615732 0004,0007 HT OTUD4 PARP11 19615732 0004 HT OTUD4 GAR1 26496610,26496610 0007,0004 HT OTUD4 BAG5 19615732,19615732 0004,0007 HT OTUD4 LHX6 26186194 0004 HT OTUD4 HEL-S-19 19615732 0004 HT OTUD4 HEL-S-28 17353931 0004 HT UBC OTUD4 25944111,23827681 0415,0415 LC TCF4 OTUD4 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT STAT1 OTUD4 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT OTUD4 REL 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT OTUD4 EXOSC8 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q01804 O43251 OTUD4 RBFOX2 0.126 26186194 Q6ICG8 Q01804 WBP2NL OTUD4 0.126 26186194 Q6NS38 Q01804 ALKBH2 OTUD4 0.21 25944111 Q6P5F9 Q01804 XPO1 OTUD4 0.126 26673895 Q01804 P01106 OTUD4 MYC 0.126 21150319 Q01804 O95466 OTUD4 FMNL1 0.126 23182705 Q01804 O95758 OTUD4 PTBP3 0.126 22575643 Q9NY12 Q01804 GAR1 OTUD4 0.236 26496610 Q96HR8 Q01804 NAF1 OTUD4 0.236 26496610 Q03933 Q01804 HSF2 OTUD4 0.236 26496610 Q01804 P78386 OTUD4 KRT85 0.236 19615732 Q01804 P55786 OTUD4 NPEPPS 0.236 19615732 Q01804 P05787 OTUD4 KRT8 0.236 19615732 Q01804 P04181 OTUD4 OAT 0.236 19615732 Q01804 O76013 OTUD4 KRT36 0.236 19615732 Q01804 P51570 OTUD4 GALK1 0.236 19615732 Q01804 P25685 OTUD4 DNAJB1 0.236 19615732 Q01804 P06280 OTUD4 GLA 0.236 19615732 Q01804 P0CG48 OTUD4 UBC 0.523 23827681,25944111 Q01804 P51116 OTUD4 FXR2 0.236 19615732 Q01804 P42224 OTUD4 STAT1 0.454 25416956 Q71U36 Q01804 TUBA1A OTUD4 0.236 19615732 Q14525 Q01804 KRT33B OTUD4 0.236 19615732 Q02413 Q01804 DSG1 OTUD4 0.236 19615732 Q14315 Q01804 FLNC OTUD4 0.236 19615732 Q49A26 Q01804 GLYR1 OTUD4 0.236 unassigned1304 Q15323 Q01804 KRT31 OTUD4 0.236 19615732 Q16653 Q01804 MOG OTUD4 0.236 19615732 Q9UL15 Q01804 BAG5 OTUD4 0.236 19615732 Q96D46 Q01804 NMD3 OTUD4 0.236 19615732 Q9NQX3 Q01804 GPHN OTUD4 0.236 19615732 Q99417 Q01804 MYCBP OTUD4 0.236 19615732 Q01804 O43172 OTUD4 PRPF4 0.236 26496610 Q04864 Q01804 REL OTUD4 0.454 25416956 Q93008 Q01804 USP9X OTUD4 0.376 25944111 Q93009 Q01804 USP7 OTUD4 0.569 25944111 Q96B26 Q01804 EXOSC8 OTUD4 0.583 25416956,unassigned1304 Q96JB5 Q01804 CDK5RAP3 OTUD4 0.236 17353931 Q9BSM1 Q01804 PCGF1 OTUD4 0.126 27505670 Q96Q83 Q01804 ALKBH3 OTUD4 0.569 25944111 Q9UPM6 Q01804 LHX6 OTUD4 0.126 26186194 Q01804 P34947 OTUD4 GRK5 0.126 22952844 Q01804 P85299 OTUD4 PRR5 0.126 17461779 Q13077 Q01804 TRAF1 OTUD4 0.21 25996949 Q01804 O94817 OTUD4 ATG12 0.332 17353931 Q01804 P05452 OTUD4 CLEC3B 0.332 17353931 Q01804 P15884 OTUD4 TCF4 0.454 25416956 Q06455 Q01804 RUNX1T1 OTUD4 0.332 17353931 Q13418 Q01804 ILK OTUD4 0.332 17353931 Q6XPR3 Q01804 RPTN OTUD4 0.126 19615732 Q7CJH7 Q01804 Q7CJH7 OTUD4 0.126 20711500 Q86YZ3 Q01804 HRNR OTUD4 0.126 19615732 Q9H9G7 Q01804 AGO3 OTUD4 0.332 19167051 Q9HAW0 Q01804 BRF2 OTUD4 0.332 17353931 Q9HC24 Q01804 TMBIM4 OTUD4 0.126 17353931 Q9NR21 Q01804 PARP11 OTUD4 0.126 19615732 Q01804 P68431 OTUD4 HIST1H3J 0.126 26527279

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 XPO1 OTUD4 MI:0045 experimental interaction detection MI:0461 interaction database PRPF4 OTUD4 MI:0045 experimental interaction detection MI:0461 interaction database RBFOX2 OTUD4 MI:0045 experimental interaction detection MI:0461 interaction database KRT36 OTUD4 MI:0045 experimental interaction detection MI:0461 interaction database ATG12 OTUD4 MI:0045 experimental interaction detection MI:0461 interaction database FMNL1 OTUD4 MI:0045 experimental interaction detection MI:0461 interaction database PTBP3 OTUD4 MI:0045 experimental interaction detection MI:0461 interaction database MYC OTUD4 MI:0045 experimental interaction detection MI:0461 interaction database OAT OTUD4 MI:0045 experimental interaction detection MI:0461 interaction database CLEC3B OTUD4 MI:0045 experimental interaction detection MI:0461 interaction database KRT8 OTUD4 MI:0045 experimental interaction detection MI:0461 interaction database GLA OTUD4 MI:0045 experimental interaction detection MI:0461 interaction database UBC OTUD4 MI:0045 experimental interaction detection MI:0461 interaction database TCF4 OTUD4 MI:0045 experimental interaction detection MI:0461 interaction database DNAJB1 OTUD4 MI:0045 experimental interaction detection MI:0461 interaction database GRK5 OTUD4 MI:0045 experimental interaction detection MI:0461 interaction database STAT1 OTUD4 MI:0045 experimental interaction detection MI:0461 interaction database FXR2 OTUD4 MI:0045 experimental interaction detection MI:0461 interaction database GALK1 OTUD4 MI:0045 experimental interaction detection MI:0461 interaction database NPEPPS OTUD4 MI:0045 experimental interaction detection MI:0461 interaction database HIST1H3A OTUD4 MI:0045 experimental interaction detection MI:0461 interaction database KRT85 OTUD4 MI:0045 experimental interaction detection MI:0461 interaction database PRR5 OTUD4 MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 DSG1 MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 HSF2 MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 REL MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 RUNX1T1 MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 TRAF1 MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 ILK MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 FLNC MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 KRT33B MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 KRT31 MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 MOG MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 WBP2NL MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 ALKBH2 MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 RPTN MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 TUBA1A MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 HRNR MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 BAP1 MI:0362 inference MI:0461 interaction database OTUD4 USP9X MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 USP7 MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 EXOSC8 MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 NMD3 MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 NAF1 MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 CDK5RAP3 MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 ALKBH3 MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 MYCBP MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 AGO3 MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 BRF2 MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 TMBIM4 MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 GPHN MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 PARP11 MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 GAR1 MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 BAG5 MI:0045 experimental interaction detection MI:0461 interaction database OTUD4 LHX6 MI:0045 experimental interaction detection MI:0461 interaction database