PTM - dbPAF Gene Name UniProt ID Position Type Species OTUD4; HIN1; KIAA1046 Q01804 1006 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 1011 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 1014 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 1023 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 1024 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 1031 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 1046 T Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 1047 Y Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 1049 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 1058 Y Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 1059 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 1085 Y Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 1087 Y Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 160 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 161 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 166 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 169 Y Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 190 T Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 199 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 202 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 204 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 208 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 284 Y Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 341 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 350 T Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 361 Y Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 368 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 385 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 399 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 401 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 412 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 414 T Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 416 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 434 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 437 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 439 Y Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 443 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 460 Y Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 474 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 503 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 541 Y Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 545 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 546 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 548 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 557 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 578 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 710 Y Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 720 Y Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 827 Y Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 893 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 900 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 905 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 907 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 908 T Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 940 S Homo sapiens(Human) OTUD4; HIN1; KIAA1046 Q01804 941 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q01804 K41-ac Acetylation LYRKLVAkDGSCLFR Q01804 K343-ac Acetylation SWNTVsGkkMKKPST Q01804 K344-ac Acetylation WNTVsGkkMKKPSTS Q01804 K1020-ac Acetylation DsRVQRPkEEssEDE Q01804 K266-m1 Methylation VEYEIWLkSKQAQQK Q01804 R380-m1 Methylation APSALPPrLQHPSGV Q01804 K1040-m1 Methylation ILRSGRSkQFYNQty Q01804 R1050-m1 Methylation YNQtyGsrkYkSDWG Q01804 K1051-m1 Methylation NQtyGsrkYkSDWGy Q01804 K1053-m1 Methylation tyGsrkYkSDWGysG Q01804 R1061-m2 Methylation SDWGysGrGGYQHVr Q01804 R1061-m1 Methylation SDWGysGrGGYQHVr Q01804 R1068-m1 Methylation rGGYQHVrSEESWKG Q01804 R1089-m1 Methylation DEGyQyHrNVRGRPF Q01804 S160-p Phosphorylation YPIKYKEssAMCQsL Q01804 S161-p Phosphorylation PIKYKEssAMCQsLL Q01804 S166-p Phosphorylation EssAMCQsLLyELLY Q01804 Y169-p Phosphorylation AMCQsLLyELLYEKV Q01804 T190-p Phosphorylation KIVMELDtLEVADED Q01804 S199-p Phosphorylation EVADEDNsEIsDsED Q01804 S202-p Phosphorylation DEDNsEIsDsEDDsC Q01804 S204-p Phosphorylation DNsEIsDsEDDsCKS Q01804 S208-p Phosphorylation IsDsEDDsCKSKTAA Q01804 Y284-p Phosphorylation SIAAGLQyEVGDKCQ Q01804 S341-p Phosphorylation PESWNTVsGkkMKKP Q01804 Y361-p Phosphorylation NFHSDVDyRGPKNPS Q01804 S399-p Phosphorylation FSSHSSGsQsQKFSS Q01804 S401-p Phosphorylation SHSSGsQsQKFSSEH Q01804 T414-p Phosphorylation EHKNLSRtPsQIIRK Q01804 S416-p Phosphorylation KNLSRtPsQIIRKPD Q01804 S434-p Phosphorylation VEDFDHTsREsNyFG Q01804 S437-p Phosphorylation FDHTsREsNyFGLsP Q01804 Y439-p Phosphorylation HTsREsNyFGLsPEE Q01804 S443-p Phosphorylation EsNyFGLsPEERREK Q01804 Y460-p Phosphorylation IEESRLLyEIQNRDE Q01804 S495-p Phosphorylation PCVQRKSsHVGDRKG Q01804 S503-p Phosphorylation HVGDRKGsRRRMDTE Q01804 S517-p Phosphorylation EERKDKDsIHGHSQL Q01804 Y541-p Phosphorylation ENITDDKyATVssPs Q01804 S545-p Phosphorylation DDKyATVssPsKSKK Q01804 S546-p Phosphorylation DKyATVssPsKSKKL Q01804 S548-p Phosphorylation yATVssPsKSKKLEC Q01804 S557-p Phosphorylation SKKLECPsPAEQKPA Q01804 Y710-p Phosphorylation FNLGVKAySCPMWAP Q01804 Y720-p Phosphorylation PMWAPHSyLYPLHQA Q01804 Y827-p Phosphorylation GQLLHADyEESLSGK Q01804 S893-p Phosphorylation EKGELDLsLENLDLs Q01804 S900-p Phosphorylation sLENLDLsKDCGsVs Q01804 S905-p Phosphorylation DLsKDCGsVstVDEF Q01804 S907-p Phosphorylation sKDCGsVstVDEFPE Q01804 T908-p Phosphorylation KDCGsVstVDEFPEA Q01804 S922-p Phosphorylation ARGEHVHsLPEASVS Q01804 S1006-p Phosphorylation KTAADVVsPGANsVD Q01804 S1011-p Phosphorylation VVsPGANsVDsRVQR Q01804 S1014-p Phosphorylation PGANsVDsRVQRPkE Q01804 S1023-p Phosphorylation VQRPkEEssEDENEV Q01804 S1024-p Phosphorylation QRPkEEssEDENEVs Q01804 S1031-p Phosphorylation sEDENEVsNILRSGR Q01804 T1046-p Phosphorylation SkQFYNQtyGsrkYk Q01804 Y1047-p Phosphorylation kQFYNQtyGsrkYkS Q01804 S1049-p Phosphorylation FYNQtyGsrkYkSDW Q01804 Y1058-p Phosphorylation kYkSDWGysGrGGYQ Q01804 S1059-p Phosphorylation YkSDWGysGrGGYQH Q01804 Y1085-p Phosphorylation SRSRDEGyQyHrNVR Q01804 Y1087-p Phosphorylation SRDEGyQyHrNVRGR Q01804 K330-ub Ubiquitination KHTSKNLkAPPPESW Q01804 K526-ub Ubiquitination HGHSQLDkRPEPSTL Q01804 K1040-ub Ubiquitination ILRSGRSkQFYNQty

PTM - dbPTM UniProt ID Position Code Type Resources References Q01804 1 M Acetylation Swiss-Prot 1010711 19413330 Q01804 438 Y Phosphorylation Swiss-Prot 1010711 15592455;17389395 Q01804 442 S Phosphorylation Swiss-Prot 1010711 18669648;19413330;19690332 Q01804 556 S Phosphorylation Swiss-Prot 1010711 19413330 Q01804 940 S Phosphorylation Swiss-Prot 1010711 16964243 Q01804 1005 S Phosphorylation Swiss-Prot 1010711 18669648;19413330;19690332 Q01804 1022 S Phosphorylation Swiss-Prot 1010711 17081983;18669648;19690332 Q01804 1023 S Phosphorylation Swiss-Prot 1010711 17081983;18669648;19690332 Q01804 1023 S Phosphorylation PhosphoELM.10011 17081983 Q01804 940 S Phosphorylation PhosphoELM.10011 16964243 Q01804 1023 S Phosphorylation PhosphoELM.10011 17081983 Q01804 329 K Ubiquitylation Phosphositeplus.1010730 21906983 Q01804 1005 S Phosphorylation Phosphositeplus.1010730 15302935;16964243;18669648;19664994;19664995;19690332;20058876;21406692 Q01804 1022 S Phosphorylation Phosphositeplus.1010730 14729942;15144186;18669648;19690332;20068231;20363803;21659604;22115753 Q01804 1023 S Phosphorylation Phosphositeplus.1010730 14729942;15144186;15302935;18669648;19664994;19690332;20068231;20363803;21406692;21659604;22115753 Q01804 1030 S Phosphorylation Phosphositeplus.1010730 20363803 Q01804 442 S Phosphorylation Phosphositeplus.1010730 18669648;19664994;19664995;19690332 Q01804 544 S Phosphorylation Phosphositeplus.1010730 20562096 Q01804 545 S Phosphorylation Phosphositeplus.1010730 19276368;20363803;20562096;20815410;21406692 Q01804 892 S Phosphorylation Phosphositeplus.1010730 19664994;20068231;21406692 Q01804 899 S Phosphorylation Phosphositeplus.1010730 20068231 Q01804 438 Y Phosphorylation Phosphositeplus.1010730 15592455;17016520;17389395;18083107;20007894;20562096 Q01804 459 Y Phosphorylation Phosphositeplus.1010730 14729942;15144186;20007894;21403953;21447384 Q01804 480 S Phosphorylation HPRD 9.0 18452278,20230923 Q01804 482 S Phosphorylation HPRD 9.0 20230923 Q01804 940 S Phosphorylation HPRD 9.0 15302935,18669648,19413330,19664995,19651622,19664994,18767875,16964243,20058876 Q01804 1023 S Phosphorylation SysPTM 1.1 17081983;18669648 Q01804 442 S Phosphorylation SysPTM 1.1 18669648 Q01804 1005 S Phosphorylation SysPTM 1.1 16964243;18669648 Q01804 1023 S Phosphorylation SysPTM 1.1 17081983;18669648

PTM - HPRD Symbol Position Code Type References OTUD4 302 S Phosphorylation 20068231 OTUD4 319 S Phosphorylation 20068231 OTUD4 373 Y Phosphorylation 15592455,17389395,17016520 OTUD4 377 S Phosphorylation 18669648,19413330,19664995,19664994,18767875 OTUD4 394 Y Phosphorylation 15144186 OTUD4 480 S Phosphorylation 18452278,20230923 OTUD4 482 S Phosphorylation 20230923 OTUD4 491 S Phosphorylation 19413330 OTUD4 827 S Phosphorylation 19651622,19664994,20068231 OTUD4 834 S Phosphorylation 19651622,20068231 OTUD4 940 S Phosphorylation 15302935,18669648,19413330,19664995,19651622,19664994,18767875,16964243,20058876 OTUD4 957 S Phosphorylation 15144186,18669648,19651622,18767875,18452278,20230923,20068231 OTUD4 958 S Phosphorylation 15144186,18669648,19651622,19664994,18767875,18452278,20230923,20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q01804 1023 S 17081983 HTP Phosphorylation Q01804 941 S 16964243 HTP Phosphorylation Q01804 1024 S 17081983 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q01804 1 N-acetylmethionine 22223895;22814378 Q01804 341 Phosphoserine 23186163 Q01804 443 Phosphoserine 18669648;19690332;23186163;24275569 Q01804 460 Phosphotyrosine 15144186 Q01804 546 Phosphoserine 23186163 Q01804 893 Phosphoserine 20068231;21406692;23186163 Q01804 900 Phosphoserine 20068231 Q01804 1006 Phosphoserine 16964243;18669648;19690332;21406692 Q01804 1014 Phosphoserine 23186163 Q01804 1023 Phosphoserine 18669648;19690332;20068231;23186163 Q01804 1024 Phosphoserine 18669648;19690332;20068231;23186163 Q01804 1049 Phosphoserine 23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type OTUD4 IPI00399254 S 1023 QRPKEEpSSEDENE phosphorylation OTUD4 IPI00399254 S 1024 RPKEESpSEDENEV phosphorylation OTUD4 IPI00399254 S 893 KGELDLpSLENLDL phosphorylation OTUD4 IPI00399254 S 900 LENLDLpSKDCGSV phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 54726 120112 - K Ubiquitination 22118674 54726 120112 - K Ubiquitination 21139048 54726 120112 - K Ubiquitination 21906983 54726 120112 - K Ubiquitination 23000965 54726 120112 - K Ubiquitination 24816145

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID OTUD4 Homo sapiens (Human) 330 "330,HTSKNLKAPPPES" 330:21906983 OTUD4 Homo sapiens (Human) 330 "330,HTSKNLKAPPPES" 330:21906983