PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RHOBTB3 RAB9B 19490898 intact exp P P G GP G G GP G P G G GP GP GP G GP G G G G GP G RHOBTB3 RHOBTB2 18835386 biogrid exp P G G G G P G GP G P G G P HGS RHOBTB3 19019082 biogrid exp GP GP G G GP GP G G GP G G G GP G G G GP GP GP G GP GP G G G G G GP G BHLHE40 RHOBTB3 25416956 biogrid,intact exp G GP G G G GP G G GP G G G G G G G GP G GP G GP GP G G G G G GP G RHOBTB3 RABGGTB 26186194 biogrid exp GP GP G G GP GP G G GP G G G GP G G G GP GP GP G GP GP G G G G G GP G RHOBTB3 KIR2DS2 26186194 biogrid exp G RHOBTB3 RBX1 24145166 biogrid exp G G G G G GP G G G G G G GP G G G GP G GP G GP GP G G G G G GP G RHOBTB3 RBPMS 25416956 biogrid,intact exp GP GP G G G G G G GP G G G GP G G G G GP G G G GP G G G G G GP G RHOBTB3 RAB9A 19490898 biogrid exp GP GP G G GP GP G G GP G G G GP G G G GP GP GP G GP GP G G G G G GP G RHOBTB3 RHOBTB3 18835386 biogrid exp GP GP G G GP GP G G GP G G G GP G G G GP GP GP G GP GP G G G G G GP G PLIN3 RHOBTB3 19490898 biogrid,intact exp GP GP G G GP GP G G GP G G G GP G G G GP GP GP G GP GP G G G G G GP G RHOBTB3 HTR7 22245496 biogrid exp P P P P P P P P P G P P GP RHOBTB3 UBXN11 25416956 biogrid,intact exp G GP G G G GP G G P G G G GP G G G GP GP GP G GP GP G G G G G GP G ISLR RHOBTB3 26186194 biogrid exp G GP G G G GP G G GP G G G G G G G GP GP P G GP GP G G G G G GP G RHOBTB3 FAS 26186194 biogrid exp GP GP G G G GP G G GP G G GP G G G GP G GP G GP GP G G G G G GP G RHOBTB3 CCNE1 24145166 biogrid exp P GP G G GP GP G G GP G P G G GP P P GP P G G G GP RHOBTB3 CCNB1 24145166 biogrid exp P G G GP G G G GP G G G G G G G GP G G G GP RHOBTB3 NTRK1 25921289 biogrid exp P P P G P P P P P P P RHOBTB3 NRG1 26186194 biogrid exp G GP GP G G G G G GP G G G P G G G RHOBTB3 CUL3 18835386,24145166,21145461 biogrid exp GP GP G G GP GP G G GP G G G GP G G G GP GP GP G GP GP G G G G G GP G RHOBTB3 LRRC41 ortho G G G G GP G G G GP G G G GP G G G G G GP G GP G G G G G G GP G RHOBTB3 ZBTB16 23023127 pred G GP G G G GP G G GP G G G GP G G G GP G GP G G GP G G G G G GP G RHOBTB3 TNFAIP1 16082366 pred G G G G G G G G GP G G G G G G G G G GP G G G G G G G G G G RHOBTB3 BCL6 23023127 pred G G G G GP G G G G G G G G G G G G G G G GP G G G G G G G G RHOBTB3 RERE 16082366 pred GP GP G G GP GP G G GP G G G GP G G G GP G GP G GP GP G G G G G GP G RHOBTB3 SQSTM1 23023127 pred GP GP G G GP G G G GP G G G GP G G G G GP GP G GP GP G G G G G GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O14503 O94955 two hybrid 25416956 direct interaction X 2 O94955 affinity chromatography technology 22709582 physical association X 2 O94955 Q9BYZ6-3 affinity chromatography technology 18835386 physical association X 2 O94955 Q9BYZ6-3 two hybrid 18835386 direct interaction X 2 O94955 Q9BYZ6-3 affinity chromatography technology 18835386 physical association X 2 O94955 affinity chromatography technology 22709582 physical association X 2 O94955 B4E3T4 two hybrid 25416956 direct interaction X 2 O94955 Q5T124-3 two hybrid 25416956 direct interaction X 2 O94955 O14964 pull down 19019082 direct interaction X 2 O94955 P34969-3 affinity chromatography technology 22245496 physical association X 2 O94955 P34969-3 affinity chromatography technology 22245496 physical association X 2 O94955 A0A024R475 affinity chromatography technology 21145461 physical association X 2 O94955 A0A024R475 affinity chromatography technology 18835386 physical association X 2 O94955 A0A024R475 affinity chromatography technology 18835386 physical association X 2 O94955 O94955 affinity chromatography technology 18835386 physical association X 2 O94955 O94955 two hybrid 18835386 direct interaction X 2 O94955 A0A024RBV5 two hybrid 19490898 direct interaction X 2 O94955 A0A024RBV5 pull down 19490898 direct interaction X 2 O94955 O60664 biochemical 19490898 association X 2 O94955 P14635 affinity chromatography technology 24145166 physical association X 2 O94955 A0A024R475 affinity chromatography technology 24145166 physical association X 2 O94955 P62877 affinity chromatography technology 24145166 physical association X 2 O94955 P78396-2 affinity chromatography technology 24145166 physical association X 2 O94955 A0A024R475 pull down 24145166 direct interaction X 2 O94955 P62877 pull down 24145166 direct interaction X 2 O94955 A0A024R475 affinity chromatography technology 24145166 physical association X 2 P24864 O94955 affinity chromatography technology 24145166 physical association X 2 P24864 O94955 affinity chromatography technology 24145166 physical association X 2 P24864 O94955 enzymatic study 24145166 direct interaction X 2 P0CG48 O94955 affinity chromatography technology 18835386 physical association X 2 P0CG48 O94955 affinity chromatography technology 21963094 physical association X 2 P0CG48 O94955 affinity chromatography technology 23000965 physical association X 2 P0CG48 O94955 affinity chromatography technology 21987572 physical association X 2 P0CG48 O94955 affinity chromatography technology 21139048 physical association X 2 P0CG48 O94955 affinity chromatography technology 21890473 physical association X 2 P0CG48 O94955 affinity chromatography technology 21906983 physical association X 2 O14503 O94955 two hybrid prey pooling approach 25416956 physical association X 2 O14503 O94955 two hybrid array 25416956 physical association X 2 O14503 O94955 validated two hybrid 25416956 physical association X 2 O94955 Q5T124 two hybrid prey pooling approach 25416956 physical association X 2 O94955 Q5T124 two hybrid array 25416956 physical association X 2 O94955 Q5T124 validated two hybrid 25416956 physical association X 2 P24408 O94955 two hybrid 19490898 physical association X 2 P24408 O94955 two hybrid 19490898 physical association X 2 P24408 O94955 pull down 19490898 direct interaction X 2 P24408 O94955 two hybrid 19490898 physical association X 2 P24408 O94955 two hybrid 19490898 physical association X 2 O94955 O60664 cross-linking study 19490898 physical association X 2 O94955 Q9NP90 two hybrid 19490898 physical association X 2 Q93062 O94955 two hybrid prey pooling approach 25416956 physical association X 2 Q93062 O94955 two hybrid array 25416956 physical association X 2 Q93062 O94955 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B RHOBTB3 CCNB1 MI:0004(affinity chromatography technology) 24145166 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_294502 prey bait RHOBTB3 CCNA1 MI:0004(affinity chromatography technology) 24145166 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_294506 bait prey RHOBTB3 RAB9B MI:0018(two hybrid) 19490898 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_101649 unspecified role unspecified role PLIN3 RHOBTB3 MI:0018(two hybrid)|MI:0018(two hybrid) 19490898 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association) (intact)|(biogrid) UniProt_101655|BIOGRID_214859 neutral component|prey neutral component|bait RHOBTB3 UBC MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18835386,21139048,21890473,21906983,21963094,21987572,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_264363|BIOGRID_268034|BIOGRID_168006|BIOGRID_209243|BIOGRID_163787|BIOGRID_175219|BIOGRID_177432 prey|prey|prey|bait|prey|prey|prey bait|bait|bait|prey|bait|bait|bait RHOBTB3 HTR7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22245496 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_197174|BIOGRID_197173 prey|bait bait|prey RHOBTB3 CCNE1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24145166 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_294503|BIOGRID_294501|BIOGRID_294507 bait|prey|bait prey|bait|prey HGS RHOBTB3 MI:0096(pull down) 19019082 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_116273 bait prey RHOBTB3 CUL3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18835386,21145461,24145166 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_209209|BIOGRID_294512|BIOGRID_294504|BIOGRID_201874|BIOGRID_294509|BIOGRID_209217 bait|prey|bait|prey|bait|prey prey|bait|prey|bait|prey|bait RHOBTB3 RAB9A MI:0018(two hybrid)|MI:0018(two hybrid) 19490898 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_214857|BIOGRID_214858 prey|bait bait|prey RHOBTB3 RHOBTB2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18835386 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_209228|BIOGRID_209235|BIOGRID_209240 prey|prey|bait bait|bait|prey RHOBTB3 RBX1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24145166 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_294505|BIOGRID_294510 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality ISLR RHOBTB3 26186194 0004 HT RHOBTB3 RHOBTB3 26215701,18835386,18835386 0004,0004,0018 LC RHOBTB3 KIR2DS2 26186194 0004 HT RHOBTB3 RABGGTB 26186194 0004 HT RHOBTB3 NRG1 26186194 0004 HT RHOBTB3 CUL3 24145166,21145461,24145166,18835386 0096,0004,0004,0004 LC,HT RHOBTB3 Q59FU8 26186194 0004 HT ISLR RHOBTB3 26186194 0004 HT RHOBTB3 KIR2DS2 26186194 0004 HT RHOBTB3 RABGGTB 26186194 0004 HT RHOBTB3 NRG1 26186194 0004 HT RHOBTB3 CUL3 21145461 0004 HT RHOBTB3 Q59FU8 26186194 0004 HT RHOBTB3 RHOBTB3 26215701,18835386,18835386 0004,0004,0018 LC RHOBTB3 CUL3 24145166,24145166,18835386 0096,0004,0004 LC BHLHE40 RHOBTB3 25416956,25416956,25416956 1112,0397,1356 HT PLIN3 RHOBTB3 19490898,19490898 0401,0030 LC RHOBTB3 RHOBTB3 18835386,18835386 0004,0018 LC RHOBTB3 CCNE1 24145166,24145166 0415,0004 LC RHOBTB3 VHL 26215701,26215701,26215701 0004,0018,0096 LC RHOBTB3 RAB9A 19490898,19490898 0018,0096 LC RHOBTB3 UBXN11 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT RHOBTB3 BHLHB2 25416956 0018 HT RHOBTB3 RBPMS 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT RHOBTB3 RHOBTB2 18835386,18835386 0004,0018 LC RHOBTB3 RAB9B 19490898 0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID O94955 O14964 RHOBTB3 HGS 0.309 19019082 P53611 O94955 RABGGTB RHOBTB3 0.126 26186194 Q8K1C9 O94955 LRRC41 RHOBTB3 0.376 22709582 P24864 O94955 CCNE1 RHOBTB3 0.569 24145166 P25445 O94955 FAS RHOBTB3 0.126 26186194 Q9NP90 O94955 RAB9B RHOBTB3 0.309 19490898 Q9GZT9 O94955 EGLN1 RHOBTB3 0.376 26215701 P07900 O94955 HSP90AA1 RHOBTB3 0.21 26215701 O94955 O14503 RHOBTB3 BHLHE40 0.583 25416956,unassigned1304 P40337 O94955 VHL RHOBTB3 0.623 26215701 Q16665 O94955 HIF1A RHOBTB3 0.21 26215701 Q5T124 O94955 UBXN11 RHOBTB3 0.454 25416956 Q9BYZ6 O94955 RHOBTB2 RHOBTB3 0.569 18835386 P04629 O94955 NTRK1 RHOBTB3 0.126 25921289 Q8IYA8 O94955 CCDC36 RHOBTB3 0.236 unassigned1304 Q96SF7 O94955 TBX15 RHOBTB3 0.236 unassigned1304 Q96JM7 O94955 L3MBTL3 RHOBTB3 0.236 unassigned1304 Q49A26 O94955 GLYR1 RHOBTB3 0.236 unassigned1304 Q5JST6 O94955 EFHC2 RHOBTB3 0.236 unassigned1304 P24408 O94955 RAB9A RHOBTB3 0.772 19490898 O94955 O60664 RHOBTB3 PLIN3 0.376 19490898 P62877 O94955 RBX1 RHOBTB3 0.454 24145166 Q9UGI0 O94955 ZRANB1 RHOBTB3 0.236 unassigned1304 Q9UPG8 O94955 PLAGL2 RHOBTB3 0.236 unassigned1304 Q70EL1 O94955 USP54 RHOBTB3 0.236 unassigned1304 O94955 O94955 RHOBTB3 RHOBTB3 0.61 18835386,26215701 Q13618 O94955 CUL3 RHOBTB3 0.765 18835386,24145166,21145461 Q93062 O94955 RBPMS RHOBTB3 0.454 25416956 Q9UGP4 O94955 LIMD1 RHOBTB3 0.376 26215701 P34969 O94955 HTR7 RHOBTB3 0.376 22245496 P43631 O94955 KIR2DS2 RHOBTB3 0.126 26186194 P14635 O94955 CCNB1 RHOBTB3 0.21 24145166 P51151 O94955 RAB9A RHOBTB3 0.523 19490898 Q02297 O94955 NRG1 RHOBTB3 0.126 26186194 O94955 O14498 RHOBTB3 ISLR 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 ISLR RHOBTB3 MI:0045 experimental interaction detection MI:0461 interaction database BHLHE40 RHOBTB3 MI:0045 experimental interaction detection MI:0461 interaction database HGS RHOBTB3 MI:0045 experimental interaction detection MI:0461 interaction database PLIN3 RHOBTB3 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RHOBTB3 NTRK1 MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB3 HSP90AA1 MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB3 UBC MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB3 IGF2R MI:0362 inference MI:1106 pathways database RHOBTB3 CCNB1 MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB3 M6PR MI:0362 inference MI:1106 pathways database RHOBTB3 CCNE1 MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB3 FAS MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB3 HTR7 MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB3 VHL MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB3 KIR2DS2 MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB3 RAB9A MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RHOBTB3 RABGGTB MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB3 RBX1 MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB3 CCNA1 MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB3 NRG1 MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB3 CUL3 MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB3 LRRC41 MI:0362 inference MI:0461 interaction database RHOBTB3 VAMP3 MI:0362 inference MI:1106 pathways database RHOBTB3 HIF1A MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB3 UBXN11 MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB3 RABEPK MI:0362 inference MI:1106 pathways database RHOBTB3 RBPMS MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB3 RHOBTB2 MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB3 EGLN1 MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB3 EGLN3 MI:0362 inference MI:0461 interaction database RHOBTB3 RAB9B MI:0045 experimental interaction detection MI:0461 interaction database RHOBTB3 LIMD1 MI:0045 experimental interaction detection MI:0461 interaction database