Mutation - ICGC Project Code Chromosome Chromosome Start Chromosome End Mutation Type Mutated from Allele Mutated to Allele Consequence Type AA Mutation CDS Mutation BRCA-EU 10 23725638 23725638 single base substitution C T upstream_gene_variant BRCA-EU 10 23726034 23726034 single base substitution C A upstream_gene_variant BRCA-EU 10 23726171 23726171 insertion of <=200bp - G upstream_gene_variant BRCA-EU 10 23726474 23726474 single base substitution C A upstream_gene_variant BRCA-EU 10 23732575 23732575 single base substitution G C downstream_gene_variant BRCA-EU 10 23732935 23732935 single base substitution G C downstream_gene_variant BRCA-EU 10 23733330 23733330 single base substitution T C downstream_gene_variant BRCA-EU 10 23734298 23734298 single base substitution G C downstream_gene_variant BRCA-EU 10 23735355 23735355 insertion of <=200bp - A downstream_gene_variant BRCA-FR 10 23723816 23723816 single base substitution A C upstream_gene_variant BRCA-FR 10 23725638 23725638 single base substitution C T upstream_gene_variant BRCA-KR 10 23729031 23729031 single base substitution G A synonymous_variant G215G 645G>A BRCA-US 10 23729805 23729805 single base substitution G T missense_variant M473I 1419G>T CESC-US 10 23729371 23729371 single base substitution G A missense_variant V329M 985G>A CLLE-ES 10 23729521 23729521 single base substitution C T missense_variant P379S 1135C>T COAD-US 10 23730165 23730165 insertion of <=200bp - T 3_prime_UTR_variant COAD-US 10 23730996 23730996 deletion of <=200bp T - 3_prime_UTR_variant COCA-CN 10 23723605 23723605 single base substitution A T upstream_gene_variant COCA-CN 10 23723642 23723642 single base substitution C T upstream_gene_variant COCA-CN 10 23728830 23728830 single base substitution G C synonymous_variant L148L 444G>C COCA-CN 10 23729423 23729423 single base substitution A G missense_variant Y346C 1037A>G COCA-CN 10 23729756 23729756 single base substitution A C missense_variant K457T 1370A>C COCA-CN 10 23733673 23733673 single base substitution A G downstream_gene_variant COCA-CN 10 23735581 23735581 single base substitution T C downstream_gene_variant ESAD-UK 10 23723245 23723245 single base substitution C A upstream_gene_variant ESAD-UK 10 23725228 23725228 insertion of <=200bp - T upstream_gene_variant ESAD-UK 10 23725315 23725315 single base substitution T C upstream_gene_variant ESAD-UK 10 23726652 23726652 single base substitution C G upstream_gene_variant ESAD-UK 10 23727203 23727203 single base substitution C T upstream_gene_variant ESAD-UK 10 23732058 23732058 single base substitution C A downstream_gene_variant ESAD-UK 10 23733628 23733628 single base substitution C A downstream_gene_variant ESAD-UK 10 23733948 23733948 single base substitution G A downstream_gene_variant ESAD-UK 10 23735304 23735304 single base substitution G A downstream_gene_variant LICA-FR 10 23732737 23732737 single base substitution T A downstream_gene_variant LINC-JP 10 23728279 23728279 single base substitution G A 5_prime_UTR_variant LINC-JP 10 23728335 23728335 single base substitution C T 5_prime_UTR_variant LIRI-JP 10 23723477 23723477 single base substitution T C upstream_gene_variant LIRI-JP 10 23723734 23723734 single base substitution C T upstream_gene_variant LIRI-JP 10 23724276 23724276 single base substitution A C upstream_gene_variant LIRI-JP 10 23725081 23725081 single base substitution G A upstream_gene_variant LIRI-JP 10 23730941 23730941 single base substitution C G 3_prime_UTR_variant LIRI-JP 10 23731986 23731986 single base substitution G C downstream_gene_variant LIRI-JP 10 23735578 23735578 single base substitution A T downstream_gene_variant LIRI-JP 10 23735579 23735579 single base substitution T G downstream_gene_variant LIRI-JP 10 23736130 23736130 single base substitution T C downstream_gene_variant LUSC-KR 10 23730778 23730778 single base substitution C T 3_prime_UTR_variant LUSC-KR 10 23731224 23731224 single base substitution C T 3_prime_UTR_variant LUSC-KR 10 23731256 23731256 single base substitution C A 3_prime_UTR_variant LUSC-KR 10 23732710 23732710 single base substitution A T downstream_gene_variant LUSC-KR 10 23735786 23735786 single base substitution C A downstream_gene_variant MELA-AU 10 23723746 23723746 single base substitution C T upstream_gene_variant MELA-AU 10 23724005 23724005 single base substitution C T upstream_gene_variant MELA-AU 10 23724398 23724398 single base substitution G A upstream_gene_variant MELA-AU 10 23724585 23724585 single base substitution A T upstream_gene_variant MELA-AU 10 23724954 23724954 single base substitution C T upstream_gene_variant MELA-AU 10 23725514 23725514 single base substitution C T upstream_gene_variant MELA-AU 10 23726674 23726674 single base substitution G A upstream_gene_variant MELA-AU 10 23726793 23726793 single base substitution G A upstream_gene_variant MELA-AU 10 23728338 23728338 single base substitution C G 5_prime_UTR_variant MELA-AU 10 23729634 23729634 single base substitution T C synonymous_variant D416D 1248T>C MELA-AU 10 23729636 23729636 single base substitution C A missense_variant S417Y 1250C>A MELA-AU 10 23729831 23729831 single base substitution G A stop_retained_variant *482* 1445G>A MELA-AU 10 23731184 23731184 single base substitution T A 3_prime_UTR_variant MELA-AU 10 23731617 23731618 multiple base substitution (>=2bp and <=200bp) CC TT downstream_gene_variant MELA-AU 10 23732136 23732136 single base substitution T A downstream_gene_variant MELA-AU 10 23734374 23734374 single base substitution T G downstream_gene_variant MELA-AU 10 23734436 23734436 single base substitution G A downstream_gene_variant MELA-AU 10 23734773 23734773 single base substitution A G downstream_gene_variant MELA-AU 10 23734888 23734888 single base substitution C T downstream_gene_variant MELA-AU 10 23734970 23734970 single base substitution G A downstream_gene_variant MELA-AU 10 23734990 23734990 single base substitution C T downstream_gene_variant MELA-AU 10 23735969 23735969 single base substitution C T downstream_gene_variant OV-AU 10 23725053 23725053 single base substitution G A upstream_gene_variant OV-AU 10 23729097 23729097 single base substitution G A stop_gained W237* 711G>A OV-AU 10 23732604 23732604 single base substitution T A downstream_gene_variant PACA-AU 10 23726954 23726954 single base substitution A C upstream_gene_variant PACA-AU 10 23728702 23728702 single base substitution C T missense_variant P106S 316C>T PACA-CA 10 23724024 23724024 single base substitution G T upstream_gene_variant PACA-CA 10 23725026 23725026 deletion of <=200bp T - upstream_gene_variant PACA-CA 10 23725227 23725227 insertion of <=200bp - T upstream_gene_variant PACA-CA 10 23726204 23726204 single base substitution T C upstream_gene_variant PACA-CA 10 23729711 23729711 single base substitution A G missense_variant N442S 1325A>G PACA-CA 10 23730616 23730616 single base substitution T C 3_prime_UTR_variant PACA-CA 10 23733353 23733353 deletion of <=200bp T - downstream_gene_variant PACA-CA 10 23733741 23733741 single base substitution C T downstream_gene_variant PAEN-AU 10 23732948 23732948 single base substitution C T downstream_gene_variant PRAD-UK 10 23723276 23723276 single base substitution G A upstream_gene_variant READ-US 10 23729812 23729812 single base substitution G T stop_gained E476* 1426G>T RECA-EU 10 23732144 23732144 single base substitution C G downstream_gene_variant SKCA-BR 10 23728311 23728311 single base substitution T C 5_prime_UTR_variant SKCA-BR 10 23729089 23729089 single base substitution A G missense_variant R235G 703A>G SKCA-BR 10 23729130 23729130 single base substitution T G synonymous_variant G248G 744T>G SKCA-BR 10 23732330 23732330 single base substitution C T downstream_gene_variant

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand ESCC_13 COSM5625042 c.255C>T p.A85A Substitution - coding silent 10:23439712-23439712 + 039T COSM1728776 c.1028C>T p.T343M Substitution - Missense 10:23440485-23440485 + PCSI_0224_Pa_P_526 COSM3786664 c.1325A>G p.N442S Substitution - Missense 10:23440782-23440782 + WSU-HN30 COSM4597593 c.976A>T p.S326C Substitution - Missense 10:23440433-23440433 + PTC-88C COSM4144603 c.32A>C p.Y11S Substitution - Missense 10:23439489-23439489 + TCGA-B6-A0IJ-01 COSM427397 c.1419G>T p.M473I Substitution - Missense 10:23440876-23440876 + UPCI:SCC090 COSM4597593 c.976A>T p.S326C Substitution - Missense 10:23440433-23440433 + 159-01-1TD COSM145739 c.1135C>T p.P379S Substitution - Missense 10:23440592-23440592 + 12_tFL COSM4170289 c.1264A>C p.I422L Substitution - Missense 10:23440721-23440721 + PTC-515C COSM4144605 c.788C>T p.P263L Substitution - Missense 10:23440245-23440245 + HT55 COSM2133359 c.1018A>T p.R340W Substitution - Missense 10:23440475-23440475 + PDA_074 COSM4597593 c.976A>T p.S326C Substitution - Missense 10:23440433-23440433 + YUKAT COSM5370467 c.1238G>A p.G413D Substitution - Missense 10:23440695-23440695 + CSCC-27-T COSM4556031 c.676G>A p.E226K Substitution - Missense 10:23440133-23440133 + 86788 COSM96098 c.987G>A p.V329V Substitution - coding silent 10:23440444-23440444 + AOCS-164-1-7 COSM4422210 c.711G>A p.W237* Substitution - Nonsense 10:23440168-23440168 + sysucc-882T COSM5446852 c.444G>C p.L148L Substitution - coding silent 10:23439901-23439901 + 8066497 COSM3769095 c.316C>T p.P106S Substitution - Missense 10:23439773-23439773 + PTC-77C COSM4144604 c.84C>T p.A28A Substitution - coding silent 10:23439541-23439541 + 87969 COSM94891 c.1333T>A p.Y445N Substitution - Missense 10:23440790-23440790 + TCGA-F5-6814-01 COSM3414917 c.1426G>T p.E476* Substitution - Nonsense 10:23440883-23440883 + 159 COSM145739 c.1135C>T p.P379S Substitution - Missense 10:23440592-23440592 + UD-SCC-2 COSM4597593 c.976A>T p.S326C Substitution - Missense 10:23440433-23440433 + 029T COSM1728196 c.959G>A p.C320Y Substitution - Missense 10:23440416-23440416 + pfg068T COSM4751254 c.914G>A p.R305Q Substitution - Missense 10:23440371-23440371 + ML_30_T_01 COSM5038198 c.703A>G p.R235G Substitution - Missense 10:23440160-23440160 + 587376 COSM1218998 c.866A>C p.K289T Substitution - Missense 10:23440323-23440323 + CSCC-11-T COSM4458001 c.1068C>T p.P356P Substitution - coding silent 10:23440525-23440525 + SJOS001107_M1 COSM5023195 c.1338C>A p.D446E Substitution - Missense 10:23440795-23440795 + KPOPBR-60-T COSM5963704 c.645G>A p.G215G Substitution - coding silent 10:23440102-23440102 + SJOS001107_M2 COSM5023195 c.1338C>A p.D446E Substitution - Missense 10:23440795-23440795 + Br03X COSM54367 c.1020G>A p.R340R Substitution - coding silent 10:23440477-23440477 + TCGA-DG-A2KM-01 COSM4851747 c.985G>A p.V329M Substitution - Missense 10:23440442-23440442 +

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.499042 10p12.2 612022

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer G A Synonymous p.R340R c.1020G>A 10 23729406 GBM G T Missense p.M473I c.1419G>T 10 23729805 BRCA