PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q5VV17 A0A024QZU0 enzymatic study 23827681 direct interaction X 2 Q5VV17 affinity chromatography technology 19615732 physical association X 2 Q5VV17 Q14315 affinity chromatography technology 19615732 physical association X 2 Q5VV17 P0CG48 affinity chromatography technology 23000965 physical association X 2 Q5VV17 P0CG48 enzymatic study 23827681 direct interaction X 2 Q5VV17 P0CG48 affinity chromatography technology 25147182 physical association X 2 Q5VV17 Q60FE5 affinity chromatography technology 19615732 physical association X 2 Q5VV17 A0A024R7G8 affinity chromatography technology 19615732 physical association X 2 Q5VV17 P54727 affinity chromatography technology 19615732 physical association X 2 Q5VV17 P51784 affinity chromatography technology 19615732 physical association X 2 Q5VV17 P0CG48 affinity chromatography technology 21139048 physical association X 2 Q5VV17 Q5NI40 two hybrid pooling approach 20711500 physical association X 2 Q5VV17 Q8ZGJ9 two hybrid pooling approach 20711500 physical association X 2 Q5VV17 Q7CK47 two hybrid pooling approach 20711500 physical association X 2 Q5VV17 anti tag coimmunoprecipitation 19615732 physical association C 7

PPI - HINT Gene A Gene B PMID Method Quality LOC392787 OTUD1 19615732 0007 HT FLNB OTUD1 19615732,19615732 0004,0007 HT FLNA OTUD1 19615732,19615732 0004,0007 HT USP11 OTUD1 19615732,19615732 0004,0007 HT RAD23A OTUD1 19615732,19615732 0004,0007 HT RAD23B OTUD1 19615732,19615732 0004,0007 HT FLNC OTUD1 19615732,19615732 0004,0007 HT Q59H94 OTUD1 19615732 0004 HT LOC392787 OTUD1 19615732 0007 HT FLNB OTUD1 19615732,19615732 0004,0007 HT FLNA OTUD1 19615732,19615732 0004,0007 HT USP11 OTUD1 19615732,19615732 0004,0007 HT RAD23A OTUD1 19615732,19615732 0004,0007 HT RAD23B OTUD1 19615732,19615732 0004,0007 HT FLNC OTUD1 19615732,19615732 0004,0007 HT Q59H94 OTUD1 19615732 0004 HT UBC OTUD1 23827681 0415 LC RIPK1 OTUD1 23827681 0415 LC OTUD1 OTUD1 23827681 0114 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5VV17 Q5NI40 OTUD1 PPDK 0.126 20711500 Q5VV17 A4D1J9 OTUD1 LOC392787 0.126 19615732 Q5VV17 P0CG48 OTUD1 UBC 0.309 23827681 Q5VV17 Q13546 OTUD1 RIPK1 0.309 23827681 Q7CK47 Q5VV17 AHPC OTUD1 0.126 20711500 Q6P5F9 Q5VV17 XPO1 OTUD1 0.126 26673895 Q5VV17 O75369 OTUD1 FLNB 0.236 19615732 Q5VV17 P54727 OTUD1 RAD23B 0.236 19615732 Q5VV17 P21333 OTUD1 FLNA 0.236 19615732 Q5VV17 P54725 OTUD1 RAD23A 0.236 19615732 Q5VV17 Q14315 OTUD1 FLNC 0.236 19615732 Q5VV17 P51784 OTUD1 USP11 0.236 19615732 Q8ZGJ9 Q5VV17 RPIA2 OTUD1 0.126 20711500