PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus COPS2 LRR1 19295130,26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G LRR1 BTBD1 25011449 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G COPS5 LRR1 19295130,19615732,21145461 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB38 LRR1 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G LRR1 COPS7A 19295130,26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G RAB5C LRR1 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G LRR1 SUGT1 25036637 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G LRR1 PNMA2 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G LRR1 COPS7B 19295130 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRIP13 LRR1 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G COPS6 LRR1 19295130,26186194,19615732,21145461 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G RFWD2 LRR1 19295130 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G LRR1 COPS4 19295130 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G LRR1 RAPGEF2 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G LRR1 COPS3 19295130,26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G MTUS2 LRR1 25416956 biogrid,intact exp G G G G G G G G G G LRR1 COPS8 19295130 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G PTPN14 LRR1 22948661 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G TCEB2 LRR1 19295130,15601820, 25402006 innatedb,biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G RBX1 LRR1 19295130,15601820, 25402006 innatedb,biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL3 LRR1 21145461,25011449, 25402006 innatedb,biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G TCEB1 LRR1 19295130,15601820, 25402006 innatedb,biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL2 LRR1 19295130,15601820,21145461, 25402006 innatedb,biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G TNFRSF9 LRR1 11804328, 21836163 hprd,biogrid exp, pred G G G G G G G G G G G G G G G G G G CUL5 LRR1 21145461, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL4B LRR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO31 LRR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G CDC34 LRR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G LRR1 RAB40C 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G MED8 LRR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW8 LRR1 25402006 pred CUL4A LRR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G SPSB1 LRR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G SPSB4 LRR1 25402006 pred G SKP1 LRR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G DCUN1D1 LRR1 25402006 pred G G G G G G G G G G G G G G G CUL1 LRR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS4 LRR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G LRRC41 LRR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS2 LRR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS5 LRR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G FAF2 LRR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G VHL LRR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS3 LRR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G LRR1 SPSB2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G NEDD8 LRR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL7 LRR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G CAND1 LRR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO18 LRR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G LRR1 FEM1B 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBXN7 LRR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q96L50 anti tag coimmunoprecipitation 15601820 association C 7 Q96L50 Q15645 two hybrid prey pooling approach 25416956 physical association X 2 Q96L50 Q5JR59 two hybrid prey pooling approach 25416956 physical association X 2 Q96L50 Q15645 two hybrid array 25416956 physical association X 2 Q96L50 Q5JR59 two hybrid array 25416956 physical association X 2 Q96L50 Q15645 validated two hybrid 25416956 physical association X 2 Q96L50 Q5JR59 validated two hybrid 25416956 physical association X 2 Q96L50 anti tag coimmunoprecipitation 19615732 physical association C 35 Q96L50 anti tag coimmunoprecipitation 15601820 association C 5 Q96L50 anti tag coimmunoprecipitation 15601820 association C 5 Q96L50 anti tag coimmunoprecipitation 19615732 physical association C 55 Q96L50 Q9UL42 two hybrid prey pooling approach 25416956 physical association X 2 Q96L50 Q9UL42 two hybrid array 25416956 physical association X 2 Q96L50 Q9UL42 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B LRR1 COPS7B MI:0004(affinity chromatography technology) 19295130 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_221623 bait prey PTPN14 LRR1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22948661 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_208818|BIOGRID_208853 bait|bait prey|prey COPS2 LRR1 MI:0004(affinity chromatography technology) 19295130 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_221617 prey bait COPS6 LRR1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19295130,19615732,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(intact) BIOGRID_120799|BIOGRID_221621|BIOGRID_205716|UniProt_100633 bait|prey|bait|bait prey|bait|prey|prey CUL2 LRR1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15601820,19295130,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) UniProt_164462|UniProt_80345|UniProt_164451|UniProt_80334|UniProt_164450|UniProt_80333|BIOGRID_250368|BIOGRID_250372|BIOGRID_250363|BIOGRID_203921|BIOGRID_221626 prey|prey|prey|prey|bait|bait|prey|prey|bait|bait|prey bait|bait|bait|bait|prey|prey|bait|bait|prey|prey|bait TCEB1 LRR1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15601820,19295130 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(biogrid)|(biogrid)|(biogrid) UniProt_164462|UniProt_164451|UniProt_80345|UniProt_80334|BIOGRID_250375|BIOGRID_250371|BIOGRID_221628 prey|prey|prey|prey|prey|prey|prey bait|bait|bait|bait|bait|bait|bait TCEB2 LRR1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15601820,19295130 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(biogrid)|(biogrid)|(biogrid) UniProt_164462|UniProt_164451|UniProt_80345|UniProt_80334|BIOGRID_250374|BIOGRID_250370|BIOGRID_221627 prey|prey|prey|prey|prey|prey|prey bait|bait|bait|bait|bait|bait|bait LRR1 COPS8 MI:0004(affinity chromatography technology) 19295130 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_221624 bait prey CUL5 LRR1 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_203557 bait prey COPS5 LRR1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19295130,19615732,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(intact) BIOGRID_120798|BIOGRID_221620|BIOGRID_205429|UniProt_100632 bait|prey|bait|bait prey|bait|prey|prey LRR1 COPS7A MI:0004(affinity chromatography technology) 19295130 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_221622 bait prey RFWD2 LRR1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19295130 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_221616|BIOGRID_221729 prey|bait bait|prey LRR1 COPS3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19295130 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_221618|BIOGRID_221744 bait|prey prey|bait LRR1 COPS4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19295130 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_221619|BIOGRID_221766 bait|prey prey|bait UBC LRR1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21906983,21963094,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_178851|BIOGRID_166321|BIOGRID_169546|BIOGRID_269037|BIOGRID_180047 bait|bait|bait|bait|bait prey|prey|prey|prey|prey TNFRSF9 LRR1 MI:0018(two hybrid)|MI:0492(in vitro)|MI:0018(two hybrid) 11804328 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0407(direct interaction) (biogrid)|MI:0468(hprd)|(biogrid) BIOGRID_226864|HPRD_10541|BIOGRID_212481 bait|-|bait prey|-|prey RBX1 LRR1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15601820,19295130 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(biogrid)|(biogrid)|(biogrid) UniProt_164462|UniProt_80345|UniProt_164451|UniProt_80334|BIOGRID_250369|BIOGRID_250373|BIOGRID_221625 prey|prey|prey|prey|prey|prey|prey bait|bait|bait|bait|bait|bait|bait

PPI - HINT Gene A Gene B PMID Method Quality RAB5C LRR1 26496610,26496610 0007,0004 HT RBX1 LRR1 15601820,15601820,19295130 0004,0007,0004 LC CUL2 LRR1 15601820,21145461,19295130,15601820 0004,0004,0004,0007 LC,HT TCEB1 LRR1 15601820,15601820,19295130 0004,0007,0004 LC TCEB2 LRR1 15601820,15601820,19295130 0004,0007,0004 LC Q59EL2 LRR1 26186194,19295130 0004,0004 HT,LC COPS6 LRR1 19615732,21145461,26186194,19295130,19615732 0004,0004,0004,0004,0007 HT,LC COPS5 LRR1 19615732,21145461,19615732,19295130 0004,0004,0007,0004 HT,LC CUL5 LRR1 21145461 0004 HT LRR1 Q9H6F0 26186194 0004 HT LRR1 COPS7A 26496610,19295130,26496610 0007,0004,0004 HT,LC LRR1 COPS3 26186194,19295130 0004,0004 HT,LC LRR1 RAPGEF2 26496610,26496610 0007,0004 HT RAB5C LRR1 26496610,26496610 0007,0004 HT CUL2 LRR1 21145461 0004 HT Q59EL2 LRR1 26186194 0004 HT COPS6 LRR1 19615732,21145461,26186194,19615732 0004,0004,0004,0007 HT COPS5 LRR1 19615732,21145461,19615732 0004,0004,0007 HT CUL5 LRR1 21145461 0004 HT LRR1 Q9H6F0 26186194 0004 HT LRR1 COPS7A 26496610,26496610 0007,0004 HT LRR1 COPS3 26186194 0004 HT LRR1 RAPGEF2 26496610,26496610 0007,0004 HT RBX1 LRR1 15601820,15601820,19295130 0004,0007,0004 LC CUL2 LRR1 15601820,19295130,15601820 0004,0004,0007 LC TCEB1 LRR1 15601820,15601820,19295130 0004,0007,0004 LC TCEB2 LRR1 15601820,15601820,19295130 0004,0007,0004 LC Q59EL2 LRR1 19295130 0004 LC COPS6 LRR1 19295130 0004 LC COPS5 LRR1 19295130 0004 LC LRR1 COPS7A 19295130 0004 LC LRR1 COPS3 19295130 0004 LC B4DYC6 LRR1 25036637 0729 HT TNFRSF9 LRR1 11804328,11804328 0096,0018 LC TRIP13 LRR1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT MTUS2 LRR1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT LRR1 PNMA2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q96L50 Q8NAP3 LRR1 ZBTB38 0.126 26186194 Q9H0C5 Q96L50 BTBD1 LRR1 0.21 25011449 Q9Y4G8 Q96L50 RAPGEF2 LRR1 0.236 26496610 Q9UL42 Q96L50 PNMA2 LRR1 0.454 25416956 Q96L50 Q15645 LRR1 TRIP13 0.454 25416956 Q96L50 Q16877 LRR1 PFKFB4 0.236 unassigned1304 Q96L50 Q07011 LRR1 TNFRSF9 0.523 11804328 Q96L50 P51148 LRR1 RAB5C 0.236 26496610 Q96L50 Q13617 LRR1 CUL2 0.554 21145461,15601820,19295130 Q96L50 P62877 LRR1 RBX1 0.332 15601820,19295130 Q96L50 Q15370 LRR1 TCEB2 0.332 15601820,19295130 Q96L50 Q15369 LRR1 TCEB1 0.332 15601820,19295130 Q96L50 Q93034 LRR1 CUL5 0.126 21145461 Q96L50 B4DYC6 LRR1 B4DYC6 0.126 25036637 Q96L50 P61201 LRR1 COPS2 0.236 19295130,26186194 Q96L50 Q5JR59 LRR1 MTUS2 0.454 25416956 Q96L50 Q7L5N1 LRR1 COPS6 0.49 21145461,26186194,19615732,19295130 Q96L50 Q86500 LRR1 Q86500 0.126 24955142 Q96L50 Q8NHY2 LRR1 RFWD2 0.236 19295130 Q96L50 Q92905 LRR1 COPS5 0.416 21145461,19615732,19295130 Q99627 Q96L50 COPS8 LRR1 0.126 19295130 Q9BT78 Q96L50 COPS4 LRR1 0.236 19295130 Q9H9Q2 Q96L50 COPS7B LRR1 0.126 19295130 Q9UBW8 Q96L50 COPS7A LRR1 0.332 26496610,19295130 Q9UNS2 Q96L50 COPS3 LRR1 0.332 19295130,26186194 Q96L50 Q13618 LRR1 CUL3 0.21 25011449 Q96L50 Q3THE2 LRR1 MYL12B 0.126 26496610

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MYL12B LRR1 MI:0362 inference MI:0461 interaction database HSP90AA1 LRR1 MI:0362 inference MI:0461 interaction database HSP90AB1 LRR1 MI:0362 inference MI:0461 interaction database UBC LRR1 MI:0045 experimental interaction detection MI:0461 interaction database MYL12A LRR1 MI:0362 inference MI:0461 interaction database RAB5C LRR1 MI:0045 experimental interaction detection MI:0461 interaction database COPS2 LRR1 MI:0045 experimental interaction detection MI:0461 interaction database SEC61A1 LRR1 MI:0362 inference MI:0461 interaction database RBX1 LRR1 MI:0045 experimental interaction detection MI:0461 interaction database RAD51 LRR1 MI:0362 inference MI:0461 interaction database TNFRSF9 LRR1 MI:0045 experimental interaction detection MI:0461 interaction database GPS1 LRR1 MI:0362 inference MI:0461 interaction database CUL2 LRR1 MI:0045 experimental interaction detection MI:0461 interaction database CUL3 LRR1 MI:0045 experimental interaction detection MI:0461 interaction database TCEB1 LRR1 MI:0045 experimental interaction detection MI:0461 interaction database TCEB2 LRR1 MI:0045 experimental interaction detection MI:0461 interaction database TRIP13 LRR1 MI:0045 experimental interaction detection MI:0461 interaction database PTPN14 LRR1 MI:0045 experimental interaction detection MI:0461 interaction database MTUS2 LRR1 MI:0045 experimental interaction detection MI:0461 interaction database TUBA1A LRR1 MI:0362 inference MI:0461 interaction database COPS6 LRR1 MI:0045 experimental interaction detection MI:0461 interaction database WDFY3 LRR1 MI:0362 inference MI:0461 interaction database ZBTB38 LRR1 MI:0045 experimental interaction detection MI:0461 interaction database RFWD2 LRR1 MI:0045 experimental interaction detection MI:0461 interaction database COPS5 LRR1 MI:0045 experimental interaction detection MI:0461 interaction database CUL5 LRR1 MI:0045 experimental interaction detection MI:0461 interaction database LRR1 COPS8 MI:0045 experimental interaction detection MI:0461 interaction database LRR1 COPS4 MI:0045 experimental interaction detection MI:0461 interaction database LRR1 BTBD1 MI:0045 experimental interaction detection MI:0461 interaction database LRR1 COPS7B MI:0045 experimental interaction detection MI:0461 interaction database LRR1 PATZ1 MI:0362 inference MI:0461 interaction database LRR1 COPS7A MI:0045 experimental interaction detection MI:0461 interaction database LRR1 PNMA2 MI:0045 experimental interaction detection MI:0461 interaction database LRR1 COPS3 MI:0045 experimental interaction detection MI:0461 interaction database LRR1 SUGT1 MI:0362 inference MI:0461 interaction database LRR1 RAPGEF2 MI:0045 experimental interaction detection MI:0461 interaction database