Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change BLCA 15 72432366 72432366 + Missense_Mutation SNP G G C TCGA-GC-A3WC-01A-31D-A22Z-08 TCGA-GC-A3WC-10A-01D-A22Z-08 g.chr15:72432366G>C c.402G>C c.(400-402)gaG>gaC p.E134D BLCA 15 72432397 72432397 + Missense_Mutation SNP G G A TCGA-DK-AA6U-01A-11D-A391-08 TCGA-DK-AA6U-10A-01D-A394-08 g.chr15:72432397G>A c.433G>A c.(433-435)Gac>Aac p.D145N BRCA 15 72432133 72432133 + Missense_Mutation SNP G G A TCGA-E2-A1IN-01A-11D-A13L-09 TCGA-E2-A1IN-10A-01D-A188-09 g.chr15:72432133G>A c.169G>A c.(169-171)Gaa>Aaa p.E57K CESC 15 72432489 72432489 + Silent SNP T T C TCGA-FU-A3HY-01A-11D-A21Q-09 TCGA-FU-A3HY-10A-01D-A21Q-09 g.chr15:72432489T>C c.525T>C c.(523-525)tgT>tgC p.C175C COAD 15 72432223 72432223 + Frame_Shift_Del DEL T T - TCGA-CK-6746-01A-11D-1835-10 TCGA-CK-6746-10A-01D-1835-10 g.chr15:72432223delT c.259delT c.(259-261)tttfs p.F87fs COAD 15 72432223 72432223 + Frame_Shift_Del DEL T T - TCGA-CM-6674-01A-11D-1835-10 TCGA-CM-6674-10A-01D-1835-10 g.chr15:72432223delT c.259delT c.(259-261)tttfs p.F87fs COAD 15 72432307 72432307 + Frame_Shift_Del DEL T T - TCGA-A6-6781-01A-22D-1924-10 TCGA-A6-6781-10A-01D-1924-10 g.chr15:72432307delT c.343delT c.(343-345)tttfs p.F116fs COAD 15 72432440 72432440 + Missense_Mutation SNP A A C TCGA-A6-6780-01A-11D-1835-10 TCGA-A6-6780-10A-01D-1835-10 g.chr15:72432440A>C c.476A>C c.(475-477)aAc>aCc p.N159T COADREAD 15 72432223 72432223 + Frame_Shift_Del DEL T T - TCGA-CK-6746-01A-11D-1835-10 TCGA-CK-6746-10A-01D-1835-10 g.chr15:72432223delT c.259delT c.(259-261)tttfs p.F87fs COADREAD 15 72432223 72432223 + Frame_Shift_Del DEL T T - TCGA-CM-6674-01A-11D-1835-10 TCGA-CM-6674-10A-01D-1835-10 g.chr15:72432223delT c.259delT c.(259-261)tttfs p.F87fs COADREAD 15 72432307 72432307 + Frame_Shift_Del DEL T T - TCGA-A6-6781-01A-22D-1924-10 TCGA-A6-6781-10A-01D-1924-10 g.chr15:72432307delT c.343delT c.(343-345)tttfs p.F116fs COADREAD 15 72432440 72432440 + Missense_Mutation SNP A A C TCGA-A6-6780-01A-11D-1835-10 TCGA-A6-6780-10A-01D-1835-10 g.chr15:72432440A>C c.476A>C c.(475-477)aAc>aCc p.N159T DLBC 15 72432140 72432140 + Missense_Mutation SNP C C T TCGA-G8-6914-01A-11D-2210-10 TCGA-G8-6914-14A-01D-2210-10 g.chr15:72432140C>T c.176C>T c.(175-177)aCc>aTc p.T59I ESCA 15 72432295 72432295 + Missense_Mutation SNP G G C TCGA-L5-A8NQ-01A-11D-A36J-09 TCGA-L5-A8NQ-11A-11D-A36M-09 g.chr15:72432295G>C c.331G>C c.(331-333)Gat>Cat p.D111H ESCA 15 72432600 72432600 + Missense_Mutation SNP G G T TCGA-JY-A6FG-01A-11D-A33E-09 TCGA-JY-A6FG-10A-01D-A33H-09 g.chr15:72432600G>T c.636G>T c.(634-636)aaG>aaT p.K212N GBM 15 72432087 72432090 + Frame_Shift_Del DEL CAGT CAGT - TCGA-06-5412-01A-01D-1696-08 TCGA-06-5412-10A-01D-1696-08 g.chr15:72432087_72432090delCAGT c.123_126delCAGT c.(121-126)aacagtfs p.NS41fs GBM 15 72432114 72432114 + Silent SNP C C T TCGA-32-1986-01A-01D-1494-08 TCGA-32-1986-10A-01D-1494-08 g.chr15:72432114C>T c.150C>T c.(148-150)caC>caT p.H50H GBMLGG 15 72432087 72432090 + Frame_Shift_Del DEL CAGT CAGT - TCGA-06-5412-01A-01D-1696-08 TCGA-06-5412-10A-01D-1696-08 g.chr15:72432087_72432090delCAGT c.123_126delCAGT c.(121-126)aacagtfs p.NS41fs GBMLGG 15 72432114 72432114 + Silent SNP C C T TCGA-32-1986-01A-01D-1494-08 TCGA-32-1986-10A-01D-1494-08 g.chr15:72432114C>T c.150C>T c.(148-150)caC>caT p.H50H KIPAN 15 72432091 72432091 + Nonsense_Mutation SNP C C T TCGA-CW-5591-01A-01D-1534-10 TCGA-CW-5591-11A-01D-1535-10 g.chr15:72432091C>T c.127C>T c.(127-129)Cag>Tag p.Q43* KIPAN 15 72432093 72432093 + Missense_Mutation SNP G G C TCGA-CJ-4881-01A-01D-1373-10 TCGA-CJ-4881-11A-01D-1373-10 g.chr15:72432093G>C c.129G>C c.(127-129)caG>caC p.Q43H KIPAN 15 72432229 72432229 + Frame_Shift_Del DEL G G - TCGA-A4-8515-01A-11D-2396-08 TCGA-A4-8515-10A-01D-2396-08 g.chr15:72432229delG c.265delG c.(265-267)gccfs p.A89fs KIPAN 15 72432461 72432461 + Missense_Mutation SNP A A T TCGA-B9-A44B-01A-11D-A25F-10 TCGA-B9-A44B-10A-01D-A25F-10 g.chr15:72432461A>T c.497A>T c.(496-498)tAc>tTc p.Y166F KIRC 15 72432091 72432091 + Nonsense_Mutation SNP C C T TCGA-CW-5591-01A-01D-1534-10 TCGA-CW-5591-11A-01D-1535-10 g.chr15:72432091C>T c.127C>T c.(127-129)Cag>Tag p.Q43* KIRC 15 72432093 72432093 + Missense_Mutation SNP G G C TCGA-CJ-4881-01A-01D-1373-10 TCGA-CJ-4881-11A-01D-1373-10 g.chr15:72432093G>C c.129G>C c.(127-129)caG>caC p.Q43H KIRP 15 72432229 72432229 + Frame_Shift_Del DEL G G - TCGA-A4-8515-01A-11D-2396-08 TCGA-A4-8515-10A-01D-2396-08 g.chr15:72432229delG c.265delG c.(265-267)gccfs p.A89fs KIRP 15 72432461 72432461 + Missense_Mutation SNP A A T TCGA-B9-A44B-01A-11D-A25F-10 TCGA-B9-A44B-10A-01D-A25F-10 g.chr15:72432461A>T c.497A>T c.(496-498)tAc>tTc p.Y166F OV 15 72432489 72432489 + Nonsense_Mutation SNP T T A TCGA-13-0884-01B-01W-0494-09 TCGA-13-0884-10A-01W-0494-09 g.chr15:72432489T>A c.525T>A c.(523-525)tgT>tgA p.C175* PAAD 15 72432323 72432323 + Missense_Mutation SNP C C T TCGA-IB-7651-01A-11D-2154-08 TCGA-IB-7651-10A-01D-2154-08 g.chr15:72432323C>T c.359C>T c.(358-360)tCc>tTc p.S120F PAAD 15 72432577 72432577 + Missense_Mutation SNP C C A TCGA-IB-7651-01A-11D-2154-08 TCGA-IB-7651-10A-01D-2154-08 g.chr15:72432577C>A c.613C>A c.(613-615)Ctc>Atc p.L205I SKCM 15 72432043 72432043 + Missense_Mutation SNP C C T TCGA-FW-A3R5-06A-11D-A23B-08 TCGA-FW-A3R5-10A-01D-A23B-08 g.chr15:72432043C>T c.79C>T c.(79-81)Ctc>Ttc p.L27F SKCM 15 72432138 72432138 + Silent SNP C C T TCGA-FW-A3R5-06A-11D-A23B-08 TCGA-FW-A3R5-10A-01D-A23B-08 g.chr15:72432138C>T c.174C>T c.(172-174)gtC>gtT p.V58V SKCM 15 72432142 72432142 + Nonsense_Mutation SNP C C T TCGA-ER-A19P-06A-11D-A196-08 TCGA-ER-A19P-10A-01D-A198-08 g.chr15:72432142C>T c.178C>T c.(178-180)Cag>Tag p.Q60* SKCM 15 72432292 72432292 + Nonsense_Mutation SNP C C T TCGA-FW-A3R5-06A-11D-A23B-08 TCGA-FW-A3R5-10A-01D-A23B-08 g.chr15:72432292C>T c.328C>T c.(328-330)Caa>Taa p.Q110* SKCM 15 72432346 72432346 + Missense_Mutation SNP C C T TCGA-EE-A20C-06A-11D-A196-08 TCGA-EE-A20C-10A-01D-A198-08 g.chr15:72432346C>T c.382C>T c.(382-384)Cac>Tac p.H128Y SKCM 15 72432498 72432498 + Silent SNP C C T TCGA-EB-A5SG-06A-11D-A30X-08 TCGA-EB-A5SG-10A-01D-A30X-08 g.chr15:72432498C>T c.534C>T c.(532-534)ttC>ttT p.F178F

Mutation - ICGC Project Code Chromosome Chromosome Start Chromosome End Mutation Type Mutated from Allele Mutated to Allele Consequence Type AA Mutation CDS Mutation BLCA-CN 15 72432049 72432049 single base substitution G T missense_variant D29Y 85G>T BLCA-US 15 72432366 72432366 single base substitution G C downstream_gene_variant BLCA-US 15 72432366 72432366 single base substitution G C missense_variant E134D 402G>C BOCA-FR 15 72409146 72409146 single base substitution C A intron_variant BOCA-FR 15 72409146 72409146 single base substitution C A upstream_gene_variant BRCA-EU 15 72402163 72402163 single base substitution G A upstream_gene_variant BRCA-EU 15 72402948 72402948 single base substitution T C upstream_gene_variant BRCA-EU 15 72403416 72403416 single base substitution C T upstream_gene_variant BRCA-EU 15 72404459 72404459 single base substitution A G upstream_gene_variant BRCA-EU 15 72405833 72405833 single base substitution G C upstream_gene_variant BRCA-EU 15 72405845 72405845 single base substitution G C upstream_gene_variant BRCA-EU 15 72405864 72405864 single base substitution C T upstream_gene_variant BRCA-EU 15 72406195 72406195 single base substitution C T upstream_gene_variant BRCA-EU 15 72406347 72406347 deletion of <=200bp A - upstream_gene_variant BRCA-EU 15 72406780 72406780 single base substitution A G 5_prime_UTR_variant BRCA-EU 15 72406780 72406780 single base substitution A G upstream_gene_variant BRCA-EU 15 72407215 72407215 single base substitution A G intron_variant BRCA-EU 15 72407215 72407215 single base substitution A G upstream_gene_variant BRCA-EU 15 72407699 72407699 single base substitution A G intron_variant BRCA-EU 15 72407699 72407699 single base substitution A G upstream_gene_variant BRCA-EU 15 72408657 72408657 single base substitution G A intron_variant BRCA-EU 15 72408657 72408657 single base substitution G A upstream_gene_variant BRCA-EU 15 72409684 72409684 single base substitution C T intron_variant BRCA-EU 15 72409684 72409684 single base substitution C T upstream_gene_variant BRCA-EU 15 72410448 72410448 single base substitution C T intron_variant BRCA-EU 15 72410448 72410448 single base substitution C T upstream_gene_variant BRCA-EU 15 72411568 72411568 single base substitution G C intron_variant BRCA-EU 15 72414006 72414006 single base substitution C T intron_variant BRCA-EU 15 72414840 72414840 deletion of <=200bp A - intron_variant BRCA-EU 15 72414869 72414869 single base substitution T C intron_variant BRCA-EU 15 72414869 72414869 single base substitution T G intron_variant BRCA-EU 15 72415281 72415281 single base substitution G C intron_variant BRCA-EU 15 72416422 72416422 single base substitution G C intron_variant BRCA-EU 15 72416651 72416651 single base substitution T C intron_variant BRCA-EU 15 72416962 72416962 single base substitution G C intron_variant BRCA-EU 15 72417856 72417856 single base substitution G C intron_variant BRCA-EU 15 72418082 72418083 deletion of <=200bp GT - intron_variant BRCA-EU 15 72419762 72419762 single base substitution G C intron_variant BRCA-EU 15 72421069 72421069 single base substitution T C intron_variant BRCA-EU 15 72424258 72424258 single base substitution A T intron_variant BRCA-EU 15 72425593 72425593 single base substitution A T intron_variant BRCA-EU 15 72426705 72426705 single base substitution G A intron_variant BRCA-EU 15 72427369 72427369 single base substitution G C intron_variant BRCA-EU 15 72428697 72428697 single base substitution A C intron_variant BRCA-EU 15 72428976 72428976 single base substitution C T intron_variant BRCA-EU 15 72429197 72429197 single base substitution G A intron_variant BRCA-EU 15 72431260 72431260 single base substitution C T intron_variant BRCA-EU 15 72431602 72431602 single base substitution G C intron_variant BRCA-EU 15 72434776 72434776 single base substitution C T downstream_gene_variant BRCA-EU 15 72438107 72438107 single base substitution G A downstream_gene_variant BRCA-EU 15 72438119 72438119 single base substitution A G downstream_gene_variant BRCA-FR 15 72411568 72411568 single base substitution G C intron_variant BRCA-UK 15 72432109 72432109 single base substitution G C downstream_gene_variant BRCA-UK 15 72432109 72432109 single base substitution G C missense_variant D49H 145G>C BRCA-US 15 72432133 72432133 single base substitution G A downstream_gene_variant BRCA-US 15 72432133 72432133 single base substitution G A missense_variant E57K 169G>A CESC-US 15 72432489 72432489 single base substitution T C downstream_gene_variant CESC-US 15 72432489 72432489 single base substitution T C synonymous_variant C175C 525T>C CLLE-ES 15 72418060 72418060 single base substitution G A intron_variant CLLE-ES 15 72421556 72421556 single base substitution T G intron_variant COAD-US 15 72432223 72432223 deletion of <=200bp T - downstream_gene_variant COAD-US 15 72432223 72432223 deletion of <=200bp T - frameshift_variant F87 COAD-US 15 72432307 72432307 deletion of <=200bp T - downstream_gene_variant COAD-US 15 72432307 72432307 deletion of <=200bp T - frameshift_variant F115 COAD-US 15 72432440 72432440 single base substitution A C downstream_gene_variant COAD-US 15 72432440 72432440 single base substitution A C missense_variant N159T 476A>C EOPC-DE 15 72438033 72438033 single base substitution G A downstream_gene_variant ESAD-UK 15 72404570 72404570 deletion of <=200bp A - upstream_gene_variant ESAD-UK 15 72410700 72410700 single base substitution G T 5_prime_UTR_variant ESAD-UK 15 72410700 72410700 single base substitution G T intron_variant ESAD-UK 15 72412187 72412187 single base substitution G A intron_variant ESAD-UK 15 72417503 72417503 single base substitution T C intron_variant ESAD-UK 15 72417974 72417974 single base substitution A C intron_variant ESAD-UK 15 72418080 72418080 single base substitution T C intron_variant ESAD-UK 15 72418144 72418144 deletion of <=200bp T - intron_variant ESAD-UK 15 72418984 72418984 single base substitution C T intron_variant ESAD-UK 15 72419965 72419965 single base substitution A G intron_variant ESAD-UK 15 72420692 72420692 single base substitution A C intron_variant ESAD-UK 15 72421711 72421711 single base substitution T G intron_variant ESAD-UK 15 72421806 72421806 single base substitution C T intron_variant ESAD-UK 15 72423131 72423131 single base substitution C T intron_variant ESAD-UK 15 72423147 72423147 single base substitution G T intron_variant ESAD-UK 15 72433205 72433205 single base substitution G A 3_prime_UTR_variant ESAD-UK 15 72433205 72433205 single base substitution G A downstream_gene_variant ESAD-UK 15 72434456 72434456 single base substitution A C downstream_gene_variant ESAD-UK 15 72436966 72436966 single base substitution G A downstream_gene_variant ESAD-UK 15 72438107 72438107 single base substitution G A downstream_gene_variant ESCA-CN 15 72431908 72431908 single base substitution T C intron_variant GBM-US 15 72432087 72432090 deletion of <=200bp CAGT - downstream_gene_variant GBM-US 15 72432087 72432090 deletion of <=200bp CAGT - frameshift_variant NS41 GBM-US 15 72432114 72432114 single base substitution C T downstream_gene_variant GBM-US 15 72432114 72432114 single base substitution C T synonymous_variant H50H 150C>T KIRC-US 15 72432091 72432091 single base substitution C T downstream_gene_variant KIRC-US 15 72432091 72432091 single base substitution C T stop_gained Q43* 127C>T KIRC-US 15 72432093 72432093 single base substitution G C downstream_gene_variant KIRC-US 15 72432093 72432093 single base substitution G C missense_variant Q43H 129G>C KIRP-US 15 72432229 72432229 deletion of <=200bp G - downstream_gene_variant KIRP-US 15 72432229 72432229 deletion of <=200bp G - frameshift_variant A89 KIRP-US 15 72432461 72432461 single base substitution A T downstream_gene_variant KIRP-US 15 72432461 72432461 single base substitution A T missense_variant Y166F 497A>T LAML-KR 15 72414641 72414641 single base substitution A T intron_variant LAML-KR 15 72414737 72414737 single base substitution A G intron_variant LICA-FR 15 72406501 72406501 single base substitution T C upstream_gene_variant LICA-FR 15 72412581 72412581 single base substitution G A intron_variant LICA-FR 15 72417852 72417852 single base substitution G A intron_variant LICA-FR 15 72426057 72426057 single base substitution A G intron_variant LICA-FR 15 72433593 72433593 single base substitution A G downstream_gene_variant LINC-JP 15 72404397 72404397 single base substitution A G upstream_gene_variant LINC-JP 15 72414013 72414013 single base substitution G A intron_variant LINC-JP 15 72419118 72419118 single base substitution A G intron_variant LINC-JP 15 72426799 72426799 single base substitution A G intron_variant LINC-JP 15 72427299 72427299 single base substitution C A intron_variant LINC-JP 15 72428894 72428894 insertion of <=200bp - T intron_variant LINC-JP 15 72432077 72432077 single base substitution A G downstream_gene_variant LINC-JP 15 72432077 72432077 single base substitution A G missense_variant Y38C 113A>G LIRI-JP 15 72401717 72401717 single base substitution C A upstream_gene_variant LIRI-JP 15 72402460 72402460 single base substitution T C upstream_gene_variant LIRI-JP 15 72404173 72404173 single base substitution G C upstream_gene_variant LIRI-JP 15 72404526 72404526 single base substitution T C upstream_gene_variant LIRI-JP 15 72406222 72406222 single base substitution G A upstream_gene_variant LIRI-JP 15 72409036 72409036 single base substitution T A intron_variant LIRI-JP 15 72409036 72409036 single base substitution T A upstream_gene_variant LIRI-JP 15 72411814 72411814 single base substitution G C intron_variant LIRI-JP 15 72411871 72411871 single base substitution C T intron_variant LIRI-JP 15 72412270 72412270 single base substitution G T intron_variant LIRI-JP 15 72412642 72412642 single base substitution G A intron_variant LIRI-JP 15 72413189 72413189 single base substitution A G intron_variant LIRI-JP 15 72415069 72415069 single base substitution G A intron_variant LIRI-JP 15 72415346 72415346 single base substitution G A intron_variant LIRI-JP 15 72416636 72416636 single base substitution G A intron_variant LIRI-JP 15 72417275 72417275 single base substitution G A intron_variant LIRI-JP 15 72420880 72420880 single base substitution T C intron_variant LIRI-JP 15 72425343 72425343 single base substitution C G intron_variant LIRI-JP 15 72425417 72425417 single base substitution C T intron_variant LIRI-JP 15 72425750 72425750 single base substitution C T intron_variant LIRI-JP 15 72431661 72431661 single base substitution G T 5_prime_UTR_variant LIRI-JP 15 72431661 72431661 single base substitution G T intron_variant LIRI-JP 15 72434519 72434519 single base substitution G T downstream_gene_variant LIRI-JP 15 72435916 72435916 single base substitution A T downstream_gene_variant LIRI-JP 15 72436184 72436184 single base substitution T C downstream_gene_variant LIRI-JP 15 72436903 72436903 single base substitution G A downstream_gene_variant LIRI-JP 15 72437953 72437953 single base substitution C T downstream_gene_variant LUSC-KR 15 72402040 72402040 single base substitution G T upstream_gene_variant LUSC-KR 15 72403681 72403681 single base substitution T C upstream_gene_variant LUSC-KR 15 72407975 72407975 single base substitution C A intron_variant LUSC-KR 15 72407975 72407975 single base substitution C A upstream_gene_variant LUSC-KR 15 72409845 72409845 single base substitution T G intron_variant LUSC-KR 15 72409845 72409845 single base substitution T G upstream_gene_variant LUSC-KR 15 72413217 72413217 single base substitution G A intron_variant LUSC-KR 15 72414558 72414558 single base substitution A G intron_variant LUSC-KR 15 72414734 72414734 single base substitution T G intron_variant LUSC-KR 15 72414737 72414737 single base substitution A G intron_variant LUSC-KR 15 72418908 72418908 single base substitution G T intron_variant LUSC-KR 15 72433182 72433182 single base substitution C T 3_prime_UTR_variant LUSC-KR 15 72433182 72433182 single base substitution C T downstream_gene_variant LUSC-KR 15 72433341 72433341 single base substitution C G downstream_gene_variant MALY-DE 15 72406029 72406029 single base substitution T A upstream_gene_variant MALY-DE 15 72421989 72421989 single base substitution A C intron_variant MALY-DE 15 72427196 72427196 single base substitution T G intron_variant MALY-DE 15 72427775 72427776 deletion of <=200bp CT - intron_variant MELA-AU 15 72401786 72401786 single base substitution G A upstream_gene_variant MELA-AU 15 72401989 72401989 single base substitution G A upstream_gene_variant MELA-AU 15 72402230 72402230 single base substitution C T upstream_gene_variant MELA-AU 15 72402395 72402395 single base substitution G A upstream_gene_variant MELA-AU 15 72402458 72402458 single base substitution G A upstream_gene_variant MELA-AU 15 72402486 72402486 single base substitution G A upstream_gene_variant MELA-AU 15 72403158 72403158 single base substitution A G upstream_gene_variant MELA-AU 15 72404348 72404348 single base substitution T A upstream_gene_variant MELA-AU 15 72406251 72406251 single base substitution A G upstream_gene_variant MELA-AU 15 72406346 72406346 single base substitution G A upstream_gene_variant MELA-AU 15 72406727 72406727 single base substitution G A 5_prime_UTR_variant MELA-AU 15 72406727 72406727 single base substitution G A upstream_gene_variant MELA-AU 15 72406965 72406965 single base substitution G A intron_variant MELA-AU 15 72406965 72406965 single base substitution G A upstream_gene_variant MELA-AU 15 72407882 72407882 single base substitution G A intron_variant MELA-AU 15 72407882 72407882 single base substitution G A upstream_gene_variant MELA-AU 15 72408337 72408338 multiple base substitution (>=2bp and <=200bp) GG AT intron_variant MELA-AU 15 72408337 72408338 multiple base substitution (>=2bp and <=200bp) GG AT upstream_gene_variant MELA-AU 15 72409103 72409103 single base substitution C T intron_variant MELA-AU 15 72409103 72409103 single base substitution C T upstream_gene_variant MELA-AU 15 72409276 72409276 single base substitution G A 5_prime_UTR_variant MELA-AU 15 72409276 72409276 single base substitution G A intron_variant MELA-AU 15 72409276 72409276 single base substitution G A upstream_gene_variant MELA-AU 15 72409593 72409594 multiple base substitution (>=2bp and <=200bp) GG AA intron_variant MELA-AU 15 72409593 72409594 multiple base substitution (>=2bp and <=200bp) GG AA upstream_gene_variant MELA-AU 15 72410599 72410599 single base substitution C T intron_variant MELA-AU 15 72410599 72410599 single base substitution C T upstream_gene_variant MELA-AU 15 72410600 72410600 single base substitution C T intron_variant MELA-AU 15 72410600 72410600 single base substitution C T upstream_gene_variant MELA-AU 15 72410604 72410604 single base substitution C T intron_variant MELA-AU 15 72410604 72410604 single base substitution C T upstream_gene_variant MELA-AU 15 72412057 72412057 single base substitution C T intron_variant MELA-AU 15 72412193 72412193 single base substitution G A intron_variant MELA-AU 15 72412284 72412284 single base substitution C T intron_variant MELA-AU 15 72412928 72412928 single base substitution G A intron_variant MELA-AU 15 72413536 72413536 single base substitution G T intron_variant MELA-AU 15 72414103 72414103 single base substitution C T intron_variant MELA-AU 15 72414666 72414666 single base substitution T A intron_variant MELA-AU 15 72415079 72415080 multiple base substitution (>=2bp and <=200bp) GA AC intron_variant MELA-AU 15 72416743 72416743 single base substitution G A intron_variant MELA-AU 15 72417199 72417199 single base substitution G A intron_variant MELA-AU 15 72417924 72417924 single base substitution C T intron_variant MELA-AU 15 72418031 72418031 single base substitution C T intron_variant MELA-AU 15 72418203 72418203 single base substitution C T intron_variant MELA-AU 15 72418526 72418526 single base substitution C T intron_variant MELA-AU 15 72418889 72418889 single base substitution C T intron_variant MELA-AU 15 72419189 72419189 deletion of <=200bp T - intron_variant MELA-AU 15 72419246 72419246 single base substitution G T intron_variant MELA-AU 15 72419370 72419370 single base substitution C T intron_variant MELA-AU 15 72419507 72419507 single base substitution G A intron_variant MELA-AU 15 72421256 72421256 single base substitution G A intron_variant MELA-AU 15 72421580 72421580 single base substitution C T intron_variant MELA-AU 15 72421629 72421629 single base substitution G A intron_variant MELA-AU 15 72421794 72421794 single base substitution C T intron_variant MELA-AU 15 72422414 72422414 single base substitution C T intron_variant MELA-AU 15 72422445 72422445 single base substitution C T intron_variant MELA-AU 15 72422519 72422519 single base substitution G A intron_variant MELA-AU 15 72422801 72422801 single base substitution C T intron_variant MELA-AU 15 72422888 72422888 single base substitution A G intron_variant MELA-AU 15 72423161 72423161 single base substitution C T intron_variant MELA-AU 15 72423204 72423204 single base substitution G A intron_variant MELA-AU 15 72423642 72423642 single base substitution G A intron_variant MELA-AU 15 72423841 72423841 single base substitution T A intron_variant MELA-AU 15 72424044 72424044 single base substitution G A intron_variant MELA-AU 15 72424439 72424439 single base substitution C T intron_variant MELA-AU 15 72424485 72424485 single base substitution C T intron_variant MELA-AU 15 72424626 72424626 single base substitution C T intron_variant MELA-AU 15 72424642 72424642 single base substitution G A intron_variant MELA-AU 15 72424739 72424739 single base substitution T C intron_variant MELA-AU 15 72425310 72425310 single base substitution G A intron_variant MELA-AU 15 72425338 72425339 multiple base substitution (>=2bp and <=200bp) CC TT intron_variant MELA-AU 15 72425557 72425557 single base substitution C T intron_variant MELA-AU 15 72425641 72425641 single base substitution C T intron_variant MELA-AU 15 72425935 72425935 single base substitution G A intron_variant MELA-AU 15 72427121 72427121 single base substitution C T intron_variant MELA-AU 15 72427559 72427559 single base substitution C T intron_variant MELA-AU 15 72428138 72428138 single base substitution C T intron_variant MELA-AU 15 72428913 72428913 single base substitution C T intron_variant MELA-AU 15 72429056 72429056 single base substitution G A intron_variant MELA-AU 15 72429944 72429944 single base substitution C T intron_variant MELA-AU 15 72430093 72430093 single base substitution C T intron_variant MELA-AU 15 72430240 72430240 single base substitution G A intron_variant MELA-AU 15 72430269 72430269 single base substitution C G intron_variant MELA-AU 15 72430359 72430359 single base substitution C T intron_variant MELA-AU 15 72430437 72430437 single base substitution C T intron_variant MELA-AU 15 72430815 72430815 single base substitution C T intron_variant MELA-AU 15 72430875 72430875 single base substitution G A intron_variant MELA-AU 15 72430916 72430916 single base substitution C T intron_variant MELA-AU 15 72430949 72430949 single base substitution C T intron_variant MELA-AU 15 72431772 72431772 single base substitution C T 5_prime_UTR_variant MELA-AU 15 72431772 72431772 single base substitution C T intron_variant MELA-AU 15 72432011 72432011 single base substitution C T missense_variant S16L 47C>T MELA-AU 15 72432125 72432125 single base substitution T G downstream_gene_variant MELA-AU 15 72432125 72432125 single base substitution T G missense_variant I54S 161T>G MELA-AU 15 72432167 72432167 single base substitution C T downstream_gene_variant MELA-AU 15 72432167 72432167 single base substitution C T missense_variant P68L 203C>T MELA-AU 15 72432346 72432346 single base substitution C T downstream_gene_variant MELA-AU 15 72432346 72432346 single base substitution C T missense_variant H128Y 382C>T MELA-AU 15 72432427 72432427 single base substitution C T downstream_gene_variant MELA-AU 15 72432427 72432427 single base substitution C T missense_variant P155S 463C>T MELA-AU 15 72432876 72432876 single base substitution C T 3_prime_UTR_variant MELA-AU 15 72432876 72432876 single base substitution C T downstream_gene_variant MELA-AU 15 72432910 72432910 single base substitution C T 3_prime_UTR_variant MELA-AU 15 72432910 72432910 single base substitution C T downstream_gene_variant MELA-AU 15 72433130 72433130 single base substitution C T 3_prime_UTR_variant MELA-AU 15 72433130 72433130 single base substitution C T downstream_gene_variant MELA-AU 15 72433797 72433797 single base substitution C T downstream_gene_variant MELA-AU 15 72434168 72434168 single base substitution G A downstream_gene_variant MELA-AU 15 72435106 72435106 single base substitution C T downstream_gene_variant MELA-AU 15 72435116 72435116 single base substitution C T downstream_gene_variant MELA-AU 15 72435655 72435655 single base substitution C T downstream_gene_variant MELA-AU 15 72436106 72436106 single base substitution C T downstream_gene_variant MELA-AU 15 72436459 72436459 single base substitution G A downstream_gene_variant MELA-AU 15 72436560 72436560 single base substitution C T downstream_gene_variant MELA-AU 15 72436727 72436727 single base substitution G A downstream_gene_variant MELA-AU 15 72436810 72436810 single base substitution C T downstream_gene_variant MELA-AU 15 72436829 72436829 single base substitution C T downstream_gene_variant MELA-AU 15 72437197 72437198 multiple base substitution (>=2bp and <=200bp) TC GT downstream_gene_variant MELA-AU 15 72437230 72437230 single base substitution C T downstream_gene_variant MELA-AU 15 72437480 72437480 single base substitution C T downstream_gene_variant MELA-AU 15 72437484 72437484 single base substitution C T downstream_gene_variant MELA-AU 15 72438091 72438091 single base substitution G A downstream_gene_variant MELA-AU 15 72438182 72438182 single base substitution C T downstream_gene_variant ORCA-IN 15 72408735 72408735 single base substitution G C intron_variant ORCA-IN 15 72408735 72408735 single base substitution G C upstream_gene_variant ORCA-IN 15 72414717 72414717 single base substitution A G intron_variant OV-AU 15 72403261 72403261 single base substitution G A upstream_gene_variant OV-AU 15 72419183 72419183 single base substitution A T intron_variant OV-AU 15 72421969 72421969 single base substitution C G intron_variant OV-AU 15 72427063 72427063 single base substitution G C intron_variant OV-AU 15 72427863 72427863 single base substitution G C intron_variant OV-US 15 72432489 72432489 single base substitution T A downstream_gene_variant OV-US 15 72432489 72432489 single base substitution T A stop_gained C175* 525T>A PACA-AU 15 72403348 72403348 single base substitution A G upstream_gene_variant PACA-AU 15 72404219 72404219 single base substitution C G upstream_gene_variant PACA-AU 15 72404297 72404297 single base substitution G A upstream_gene_variant PACA-AU 15 72407641 72407641 single base substitution A T intron_variant PACA-AU 15 72407641 72407641 single base substitution A T upstream_gene_variant PACA-AU 15 72412006 72412006 single base substitution A G intron_variant PACA-AU 15 72414656 72414656 single base substitution A C intron_variant PACA-AU 15 72420697 72420697 single base substitution G A intron_variant PACA-AU 15 72435970 72435970 single base substitution A T downstream_gene_variant PACA-AU 15 72437295 72437295 single base substitution C G downstream_gene_variant PACA-AU 15 72438215 72438215 single base substitution C T downstream_gene_variant PACA-CA 15 72410423 72410423 single base substitution G A intron_variant PACA-CA 15 72410423 72410423 single base substitution G A upstream_gene_variant PACA-CA 15 72410424 72410424 single base substitution C T intron_variant PACA-CA 15 72410424 72410424 single base substitution C T upstream_gene_variant PACA-CA 15 72411940 72411940 single base substitution T A intron_variant PACA-CA 15 72415869 72415869 single base substitution A G intron_variant PACA-CA 15 72416327 72416327 single base substitution C T intron_variant PACA-CA 15 72420742 72420742 single base substitution A G intron_variant PACA-CA 15 72423687 72423687 single base substitution C A intron_variant PACA-CA 15 72425478 72425478 single base substitution C T intron_variant PACA-CA 15 72429473 72429473 single base substitution T C intron_variant PACA-CA 15 72436004 72436004 single base substitution A G downstream_gene_variant PACA-CA 15 72437714 72437714 insertion of <=200bp - T downstream_gene_variant PAEN-AU 15 72430030 72430030 single base substitution G T intron_variant PAEN-IT 15 72411885 72411885 single base substitution C T intron_variant PBCA-DE 15 72404573 72404573 single base substitution A T upstream_gene_variant PBCA-DE 15 72409512 72409512 single base substitution G A intron_variant PBCA-DE 15 72409512 72409512 single base substitution G A upstream_gene_variant PBCA-DE 15 72416032 72416032 single base substitution C G intron_variant PBCA-DE 15 72428133 72428133 single base substitution C T intron_variant PBCA-DE 15 72431052 72431052 single base substitution C T intron_variant PRAD-UK 15 72402912 72402912 single base substitution T G upstream_gene_variant PRAD-UK 15 72432694 72432694 single base substitution T C 3_prime_UTR_variant PRAD-UK 15 72432694 72432694 single base substitution T C downstream_gene_variant RECA-EU 15 72401731 72401731 single base substitution A C upstream_gene_variant RECA-EU 15 72406691 72406691 single base substitution C A 5_prime_UTR_variant RECA-EU 15 72406691 72406691 single base substitution C A upstream_gene_variant RECA-EU 15 72407739 72407739 single base substitution C T intron_variant RECA-EU 15 72407739 72407739 single base substitution C T upstream_gene_variant RECA-EU 15 72413608 72413608 single base substitution G C intron_variant RECA-EU 15 72413974 72413974 single base substitution T G intron_variant RECA-EU 15 72425204 72425204 single base substitution C T intron_variant RECA-EU 15 72426201 72426201 single base substitution T C intron_variant RECA-EU 15 72433400 72433400 single base substitution T G downstream_gene_variant SKCA-BR 15 72403979 72403980 deletion of <=200bp AT - upstream_gene_variant SKCA-BR 15 72407416 72407416 single base substitution G A intron_variant SKCA-BR 15 72407416 72407416 single base substitution G A upstream_gene_variant SKCA-BR 15 72410604 72410604 single base substitution C T intron_variant SKCA-BR 15 72410604 72410604 single base substitution C T upstream_gene_variant SKCA-BR 15 72410605 72410605 single base substitution C T intron_variant SKCA-BR 15 72410605 72410605 single base substitution C T upstream_gene_variant SKCA-BR 15 72423654 72423654 single base substitution C T intron_variant SKCA-BR 15 72425480 72425480 single base substitution C T intron_variant SKCA-BR 15 72427310 72427310 single base substitution A T intron_variant SKCA-BR 15 72428216 72428216 single base substitution C T intron_variant SKCA-BR 15 72430690 72430690 insertion of <=200bp - CT intron_variant SKCA-BR 15 72430971 72430971 single base substitution G A intron_variant SKCA-BR 15 72431772 72431772 single base substitution C T 5_prime_UTR_variant SKCA-BR 15 72431772 72431772 single base substitution C T intron_variant SKCA-BR 15 72432928 72432928 single base substitution C T 3_prime_UTR_variant SKCA-BR 15 72432928 72432928 single base substitution C T downstream_gene_variant SKCA-BR 15 72433512 72433512 single base substitution C T downstream_gene_variant SKCA-BR 15 72434086 72434086 single base substitution C T downstream_gene_variant SKCA-BR 15 72435967 72435967 single base substitution C T downstream_gene_variant SKCA-BR 15 72437016 72437016 single base substitution C T downstream_gene_variant SKCA-BR 15 72437305 72437305 single base substitution C T downstream_gene_variant SKCA-BR 15 72437937 72437937 single base substitution G T downstream_gene_variant SKCM-US 15 72432043 72432043 single base substitution C T missense_variant L27F 79C>T SKCM-US 15 72432138 72432138 single base substitution C T downstream_gene_variant SKCM-US 15 72432138 72432138 single base substitution C T synonymous_variant V58V 174C>T SKCM-US 15 72432292 72432292 single base substitution C T downstream_gene_variant SKCM-US 15 72432292 72432292 single base substitution C T stop_gained Q110* 328C>T SKCM-US 15 72432346 72432346 single base substitution C T downstream_gene_variant SKCM-US 15 72432346 72432346 single base substitution C T missense_variant H128Y 382C>T SKCM-US 15 72432498 72432498 single base substitution C T downstream_gene_variant SKCM-US 15 72432498 72432498 single base substitution C T synonymous_variant F178F 534C>T STAD-US 15 72432053 72432053 single base substitution A G missense_variant H30R 89A>G STAD-US 15 72432223 72432223 deletion of <=200bp T - downstream_gene_variant STAD-US 15 72432223 72432223 deletion of <=200bp T - frameshift_variant F87 UCEC-US 15 72432004 72432004 single base substitution C T missense_variant R14W 40C>T UCEC-US 15 72432105 72432105 single base substitution C T downstream_gene_variant UCEC-US 15 72432105 72432105 single base substitution C T synonymous_variant C47C 141C>T UCEC-US 15 72432336 72432336 single base substitution C T downstream_gene_variant UCEC-US 15 72432336 72432336 single base substitution C T synonymous_variant S124S 372C>T UCEC-US 15 72432394 72432394 single base substitution G T downstream_gene_variant UCEC-US 15 72432394 72432394 single base substitution G T stop_gained G144* 430G>T

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand 2492729 COSM5727097 c.379G>A p.V127I Substitution - Missense 15:72140002-72140002 + YULAN COSM1708351 c.430G>A p.G144R Substitution - Missense 15:72140053-72140053 + TCGA-FW-A3R5-06 COSM3887412 c.328C>T p.Q110* Substitution - Nonsense 15:72139951-72139951 + TCGA-AP-A0LM-01 COSM964568 c.40C>T p.R14W Substitution - Missense 15:72139663-72139663 + TCGA-32-1986-01 COSM3401903 c.150C>T p.H50H Substitution - coding silent 15:72139773-72139773 + E11 COSM1666361 c.208G>T p.E70* Substitution - Nonsense 15:72139831-72139831 + TCGA-AX-A05Z-01 COSM964570 c.141C>T p.C47C Substitution - coding silent 15:72139764-72139764 + TCGA-E2-A1IN-01 COSM1478333 c.169G>A p.E57K Substitution - Missense 15:72139792-72139792 + T2769 COSM1937142 c.10G>A p.V4I Substitution - Missense 15:72139633-72139633 + PD4119a COSM164256 c.145G>C p.D49H Substitution - Missense 15:72139768-72139768 + TCGA-AX-A060-01 COSM964574 c.430G>T p.G144* Substitution - Nonsense 15:72140053-72140053 + TCGA-BP-4770-01 COSM471024 c.614T>C p.L205P Substitution - Missense 15:72140237-72140237 + TCGA-A6-6781-01 COSM1374393 c.343delT p.H117fs*16 Deletion - Frameshift 15:72139966-72139966 + TCGA-CJ-4881-01 COSM3361513 c.129G>C p.Q43H Substitution - Missense 15:72139752-72139752 + PT35 COSM5913702 c.133C>T p.H45Y Substitution - Missense 15:72139756-72139756 + HCC75 COSM1608648 c.113A>G p.Y38C Substitution - Missense 15:72139736-72139736 + TCGA-FU-A3HY-01 COSM4838579 c.525T>C p.C175C Substitution - coding silent 15:72140148-72140148 + TCGA-B9-A44B-01 COSM3988108 c.497A>T p.Y166F Substitution - Missense 15:72140120-72140120 + TCGA-FW-A3R5-06 COSM3887410 c.79C>T p.L27F Substitution - Missense 15:72139702-72139702 + B59-3-Tumor COSM1749296 c.85G>T p.D29Y Substitution - Missense 15:72139708-72139708 + HT115 COSM1937144 c.334A>G p.K112E Substitution - Missense 15:72139957-72139957 + KM12 COSM1937150 c.596G>A p.R199K Substitution - Missense 15:72140219-72140219 + 79 COSM5012910 c.379G>C p.V127L Substitution - Missense 15:72140002-72140002 + HCT-15 COSM1678571 c.107T>C p.F36S Substitution - Missense 15:72139730-72139730 + SJHGG045_A COSM4970873 c.499G>A p.V167M Substitution - Missense 15:72140122-72140122 + TCGA-B5-A0JY-01 COSM964572 c.372C>T p.S124S Substitution - coding silent 15:72139995-72139995 + TCGA-EE-A20C-06 COSM3503673 c.382C>T p.H128Y Substitution - Missense 15:72140005-72140005 + TCGA-13-0884-01 COSM79279 c.525T>A p.C175* Substitution - Nonsense 15:72140148-72140148 + TCGA-A6-6780-01 COSM1374394 c.476A>C p.N159T Substitution - Missense 15:72140099-72140099 + 116 COSM5012909 c.18G>C p.L6F Substitution - Missense 15:72139641-72139641 + B59-3 COSM1749296 c.85G>T p.D29Y Substitution - Missense 15:72139708-72139708 + TCGA-BR-8361-01 COSM4056642 c.89A>G p.H30R Substitution - Missense 15:72139712-72139712 + TCGA-EB-A5SG-06 COSM3887413 c.534C>T p.F178F Substitution - coding silent 15:72140157-72140157 + TCGA-CM-6674-01 COSM1374392 c.259delT p.L88fs*1 Deletion - Frameshift 15:72139882-72139882 + TCGA-FW-A3R5-06 COSM3887411 c.174C>T p.V58V Substitution - coding silent 15:72139797-72139797 + 61 COSM5740389 c.308G>T p.W103L Substitution - Missense 15:72139931-72139931 + HCC75T COSM1608648 c.113A>G p.Y38C Substitution - Missense 15:72139736-72139736 + 1T COSM110107 c.47C>T p.S16L Substitution - Missense 15:72139670-72139670 + TCGA-CW-5591-01 COSM471023 c.127C>T p.Q43* Substitution - Nonsense 15:72139750-72139750 + ESCC_3 COSM5622555 c.429A>C p.K143N Substitution - Missense 15:72140052-72140052 + 278T COSM4386613 c.78G>T p.W26C Substitution - Missense 15:72139701-72139701 + HCT15 COSM1678571 c.107T>C p.F36S Substitution - Missense 15:72139730-72139730 + TCGA-GC-A3WC-01 COSM3794380 c.402G>C p.E134D Substitution - Missense 15:72140025-72140025 + D28 COSM5545758 c.281C>T p.S94F Substitution - Missense 15:72139904-72139904 +

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.512978;Hs.512989;Hs.513000;Hs.513002 15q23 608659 2387616|CGAP|BC031411|A/G|non-coding||1278|Candidate

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer CA AT Missense p.H50I c.148_149delinsAT 15 72432112 HNSC CAGT - Frameshift p.Q43Ffs*45 c.127_130delCAGT 15 72432087 GBM C T Missense p.H128Y c.382C>T 15 72432346 CM C T Nonsense p.Q43* c.127C>T 15 72432091 RCCC C T Nonsense p.Q60* c.178C>T 15 72432142 CM C T Synonymous p.H50H c.150C>T 15 72432114 GBM G A Missense p.E57K c.169G>A 15 72432133 BRCA G C Missense p.D49H c.145G>C 15 72432109 BRCA G C Missense p.Q43H c.129G>C 15 72432093 RCCC G T Nonsense p.G144* c.430G>T 15 72432394 UCEC T A Nonsense p.C175* c.525T>A 15 72432489 OV