PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SENP8 AKIP1 16998474 biogrid exp G G G G G G G G G G G G SENP8 USP28 22626734 biogrid exp P P G P GP G GP P G GP P P P P P GP P G P GP P GP GP P P GP RPS14 SENP8 23246961 biogrid exp P P G P GP G GP P G GP P P P P P GP P G P GP P GP GP P P GP SENP8 SMURF1 24821572 biogrid exp P G P GP G G P G GP P P GP G P G G G P GP SENP8 SENP8 i2d exp P P G P GP G GP P G GP P P P P P GP P G P GP P GP GP P P GP PLA2G2A SENP8 22118674 biogrid exp P P P P G GP P P P P GP P P GP GP GP P GP SENP8 USP21 22626734 biogrid exp P P G GP G GP P G GP P P P P G P G P GP P G GP P GP RPL11 SENP8 18274552 mint,intact exp P P G P GP G G P G G P P P P P G P G P GP P GP GP P P GP NEDD8 SENP8 15567417,15775960,19328766,12759363, 21836163, 16082366 hprd,biogrid,i2d,intact exp, ortho, pred P P G P GP G GP P G GP P P P P P GP P G P GP P GP GP P P GP CUL4A SENP8 20190741, 21836163 biogrid exp, pred G G G G G G G G G G G G GPS1 SENP8 23408908, 21836163 biogrid exp, pred G G G G G G G G G G G G CUL2 SENP8 12730221, 21836163 biogrid exp, pred P P G GP G G P G GP P P P P GP P G P GP P G G P GP COPS2 SENP8 23408908, 21836163 biogrid exp, pred P P G GP G GP P G GP P P P P P GP P G P GP P GP GP P P GP SENP8 USP15 22626734, 21836163 biogrid exp, pred P G P GP G G P G GP P P P P P GP P G P GP P GP GP P P GP CUL1 SENP8 23408908,20190741, 21836163 biogrid exp, pred P G GP G GP P G GP P P P P GP P G P GP P GP GP P P GP NAE1 SENP8 25402006 pred P P G P GP G GP P G GP P P P P P GP P G P GP P GP GP P P GP UBE2M SENP8 25402006 pred P P G P GP G GP P G GP P P P P GP P G P G P GP GP P P GP TCEB2 SENP8 21836163 pred G G G G G G G G G G G G FBXW7 SENP8 21836163 pred P P G P GP G GP P G GP P P P P P G P G P GP P GP GP P P GP COPS6 SENP8 21836163 pred P P G P GP G GP P G GP P P P P GP P G P GP P G GP P P GP CAND1 SENP8 21836163 pred P G G G G P G GP P P GP G G P GP GP GP SENP8 COPS8 21836163 pred G GP G GP G G P P G G G G G GP CSN1S1 SENP8 21836163 pred SENP8 DTL 21836163 pred P P P P P P P P GP P P P P G GP FBXL20 SENP8 21836163 pred P P G P G G G P G GP P P P P G P G P GP P G GP P P GP SF3B3 SENP8 21836163 pred P P G P GP G GP P G GP P P P P P GP P G P GP P GP GP P P GP CUL4B SENP8 21836163 pred P P G P GP G GP P G GP P P P P G P G P GP P GP GP P P GP SENP8 RCHY1 21836163 pred P G GP G GP P G GP P P P G P G G P G GP P G UBA3 SENP8 25402006 pred P P G P GP G GP P G GP P P P P P GP P G P GP P GP GP P P GP SENP8 NUB1 25402006 pred P P G P G G GP P G GP P P P P GP P G P GP GP GP P P GP FBXO18 SENP8 21836163 pred P P G P GP G GP P G GP P P P P P G P G P GP P GP GP P P GP PYDC1 SENP8 21836163 pred G SENP8 EIF3K 21836163 pred P P G P GP G G P G GP P P P P P GP P G P GP P GP GP P P GP FBXO11 SENP8 21836163 pred G GP G G G G P P P P G G P G G GP G RBX1 SENP8 21836163 pred G GP G GP G G P P G P G P GP G G GP UCHL3 SENP8 25402006 pred P P G P GP G GP P G GP P P P P P G P G P GP P GP GP P P GP SENP8 TOLLIP 21836163 pred P P G P GP G GP P G GP P P P P P GP P G P GP P GP GP P GP SENP8 FBXW11 21836163 pred G G G G G G G G G G G G MLF1 SENP8 21836163 pred P P G P GP G GP P G GP P P P P GP P G P GP P G GP P P GP SKP2 SENP8 21836163 pred P P G P GP G GP P G G P P P P P G P G P G GP GP P P GP UBE2D1 SENP8 21836163 pred P G P GP G G P G GP P P P P GP P G P GP GP G P P GP SENP8 COPS3 21836163 pred P P G P GP G GP P G GP P P P P P GP P G P GP P GP GP P P GP SENP8 BRD8 21836163 pred P P P P P P P P P P P P P P P P P P P GP PMF1 SENP8 21836163 pred P G GP G GP P G GP P P G G GP G G P GP STAMBP SENP8 21836163 pred P P G P GP G GP P G GP P P P P P GP P G P GP P GP GP P P GP SENP8 SAP130 21836163 pred G G G G G G G G G G G G EIF3E SENP8 21836163 pred P P G P GP G GP P G GP P P P P P GP P G P GP P G GP P P GP FBXO31 SENP8 21836163 pred P P G P GP G GP P G GP P P P P G P G P GP P GP GP P P GP COPS5 SENP8 21836163 pred P P G P GP G GP P G GP P P P P P GP P G P GP P GP GP P P GP SENP8 NLK 21836163 pred P P G P GP G G P G G P G G P GP G G GP SENP8 UBQLN2 21836163 pred P P G P GP G GP P G GP P P P P P GP P G P GP P GP GP P P GP UBE2D2 SENP8 21836163 pred P G P GP G G P G GP P P P P GP P G P GP GP G P P GP GPR1 SENP8 21836163 pred P P G P GP G GP P G GP P P P P P G P G P P P GP GP P P P SENP8 GCM1 21836163 pred P P P P P SENP8 BTRC 21836163 pred P P G P GP G GP P G GP P P P P P GP P G P GP P GP GP P GP ABCA5 SENP8 21836163 pred P P G P GP G GP P G GP P P P P P GP P G P GP P GP GP P P GP SENP8 FBXO7 21836163 pred P P G P GP G GP P G GP P P P P P GP P G P GP P GP GP P GP UBE3C SENP8 21836163 pred P G P GP G GP P G GP P P P P G P G P GP P GP GP P P GP TCEB3 SENP8 21836163 pred P P G P GP G GP P G GP P P P P P G P G P GP P GP GP P GP

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q96LD8 Q15843 - 15567417 - X 2 Q96LD8 Q15843 in vitro 15567417 - X 2 Q96LD8 Q15843 in vitro 15567417 - X 2 Q96LD8 Q15843 x-ray crystallography 15567417 direct interaction X 2 Q96LD8 P62913 enzymatic study 18274552 deneddylation reaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B GPS1 SENP8 MI:0415(enzymatic study)|MI:0415(enzymatic study) 23408908 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_251384|BIOGRID_251383 prey|bait bait|prey PLA2G2A SENP8 MI:0415(enzymatic study) 22118674 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_160293 prey bait RPS14 SENP8 MI:0004(affinity chromatography technology) 23246961 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_246823 prey bait COPS2 SENP8 MI:0415(enzymatic study)|MI:0415(enzymatic study) 23408908 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_251382|BIOGRID_251381 bait|bait prey|prey CUL2 SENP8 MI:0415(enzymatic study) 12730221 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_201295 prey bait SENP8 PINK1 MI:0004(affinity chromatography technology) 22388932 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_227361 bait prey CUL1 SENP8 MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0415(enzymatic study) 20190741,23408908 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_219296|BIOGRID_251378|BIOGRID_219294|BIOGRID_219290 prey|prey|bait|prey bait|bait|prey|bait NEDD8 SENP8 MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0492(in vitro)|MI:0114(x-ray crystallography)|MI:0096(pull down)|MI:0114(x-ray crystallography)|MI:0415(enzymatic study)|MI:0096(pull down) 12759363,15567417,15775960,17440617,19328766 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0407(direct interaction)|-|MI:0914(association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid) BIOGRID_199097|BIOGRID_199098|HPRD_32573|BIOGRID_208472|BIOGRID_185961|UniProt_80247|BIOGRID_199242|BIOGRID_133819 prey|prey|-|prey|bait|neutral component|prey|prey bait|bait|-|bait|prey|neutral component|bait|bait PARK2 SENP8 MI:0004(affinity chromatography technology) 22388932 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_227360 prey bait SENP8 USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223083 prey bait E2F1 SENP8 MI:0004(affinity chromatography technology) 23001041 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_218322 prey bait UBB SENP8 MI:0096(pull down) 17440617 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_185960 bait prey SENP8 USP28 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223126 prey bait RPL11 SENP8 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 18274552 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0569(deneddylation reaction)|MI:0569(deneddylation reaction)|MI:0569(deneddylation reaction) MI:0471(mint)|MI:0471(mint)|(intact) MINT_64943|MINT_35892|UniProt_96276 neutral component|neutral component|neutral component neutral component|neutral component|neutral component NRF1 SENP8 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_295246 bait prey SENP8 AKIP1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16998474 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_129137|BIOGRID_129138|BIOGRID_129136 bait|prey|bait prey|bait|prey SENP8 USP15 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223101 prey bait CUL4A SENP8 MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0415(enzymatic study) 20190741 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_219297|BIOGRID_219295|BIOGRID_219291 prey|bait|prey bait|prey|bait

PPI - HINT Gene A Gene B PMID Method Quality NEDD8 SENP8 12759363,17440617 0096,0096 LC NEDD8 SENP8 12759363,17440617 0096,0096 LC PLA2G2A SENP8 22118674 0415 LC RPL11 SENP8 18274552 0415 LC GPS1 SENP8 23408908 0047 LC CUL1 SENP8 20190741,20190741,23408908 0415,0004,0415 LC CUL2 SENP8 12730221 0415 LC CUL4A SENP8 20190741,20190741 0415,0004 LC NEDD8 SENP8 19328766,15567417,15775960,15775960 0415,0114,0114,0415 LC Q59EL2 SENP8 23408908,23408908 0047,0004 LC SENP8 SENP8 15775960 0114 LC SENP8 USP28 22626734 0415 HT SENP8 SMURF1 24821572 0415 LC SENP8 USP21 22626734 0415 HT SENP8 USP15 22626734 0415 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NQ31 Q96LD8 AKIP1 SENP8 0.569 16998474 Q9Y4E8 Q96LD8 USP15 SENP8 0.183 22626734 Q96LD8 P61201 SENP8 COPS2 0.454 23408908 Q96LD8 Q15843 SENP8 NEDD8 0.891 15775960,15567417,19328766,12759363 Q96LD8 P14555 SENP8 PLA2G2A 0.309 22118674 Q96LD8 P62263 SENP8 RPS14 0.21 23246961 Q96LD8 P62913 SENP8 RPL11 0.033 18274552 Q96LD8 Q13098 SENP8 GPS1 0.523 23408908 Q96LD8 Q13617 SENP8 CUL2 0.309 12730221 Q9HCE7 Q96LD8 SMURF1 SENP8 0.309 24821572 Q96RU2 Q96LD8 USP28 SENP8 0.183 22626734 Q9UK80 Q96LD8 USP21 SENP8 0.183 22626734 Q96LD8 Q13616 SENP8 CUL1 0.702 23408908,20190741 Q96LD8 Q13619 SENP8 CUL4A 0.569 20190741

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 UBB SENP8 MI:0045 experimental interaction detection MI:0461 interaction database PLA2G2A SENP8 MI:0045 experimental interaction detection MI:0461 interaction database UCHL3 SENP8 MI:0362 inference MI:1106 pathways database COPS2 SENP8 MI:0045 experimental interaction detection MI:0461 interaction database RPS14 SENP8 MI:0045 experimental interaction detection MI:0461 interaction database RPL11 SENP8 MI:0045 experimental interaction detection MI:0461 interaction database GPS1 SENP8 MI:0045 experimental interaction detection MI:0461 interaction database CUL1 SENP8 MI:0045 experimental interaction detection MI:0461 interaction database CUL2 SENP8 MI:0045 experimental interaction detection MI:0461 interaction database CUL4A SENP8 MI:0045 experimental interaction detection MI:0461 interaction database NEDD8 SENP8 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SENP8 USP28 MI:0045 experimental interaction detection MI:0461 interaction database SENP8 SMURF1 MI:0045 experimental interaction detection MI:0461 interaction database SENP8 AKIP1 MI:0045 experimental interaction detection MI:0461 interaction database SENP8 USP21 MI:0045 experimental interaction detection MI:0461 interaction database SENP8 USP15 MI:0045 experimental interaction detection MI:0461 interaction database