PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus APP WDR88 21832049 biogrid exp P P P P P P P P P P P WDR88 NUDC 25036637 intact exp P P P P P P P P P P P P P P P P P P P P PDC WDR88 23023127 pred P P P P P P P P P P P P P P P P P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q6ZMY6 P05067-7 pull down 21832049 direct interaction X 2 Q6ZMY6 P0CG48 pull down 19850743 direct interaction X 2 Q6ZMY6 Q6KNA9 two hybrid pooling approach 20711500 physical association X 2 Q6ZMY6 Q81V26 two hybrid pooling approach 20711500 physical association X 2 Q6ZMY6 Q81KM0 two hybrid pooling approach 20711500 physical association X 2 Q6ZMY6 Q81U22 two hybrid pooling approach 20711500 physical association X 2 Q6ZMY6 Q81KV7 two hybrid pooling approach 20711500 physical association X 2 Q6ZMY6 P17778 two hybrid pooling approach 20711500 physical association X 2 Q6ZMY6 Q7CII9 two hybrid pooling approach 20711500 physical association X 2 Q6ZMY6 Q5NIQ5 two hybrid pooling approach 20711500 physical association X 2 Q6ZMY6 Q81YN3 two hybrid pooling approach 20711500 physical association X 2 Q6ZMY6 Q81LY0 two hybrid pooling approach 20711500 physical association X 2 Q6ZMY6 Q8CKD5 two hybrid pooling approach 20711500 physical association X 2 Q6ZMY6 Q7CIZ7 two hybrid pooling approach 20711500 physical association X 2 Q6ZMY6 Q7CG60 two hybrid pooling approach 20711500 physical association X 2 Q6ZMY6 Q9Y266 luminescence based mammalian interactome mapping 25036637 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality WDR88 NUDC 25036637 0729 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q6ZMY6 P05067 WDR88 APP 0.183 21832049 Q6ZMY6 Q5NIQ5 WDR88 Q5NIQ5 0.126 20711500 Q7CG60 Q6ZMY6 RSSA2 WDR88 0.126 20711500 Q7CII9 Q6ZMY6 PNTA WDR88 0.126 20711500 Q81KM0 Q6ZMY6 Q81KM0 WDR88 0.126 20711500 Q81KV7 Q6ZMY6 ARGG WDR88 0.126 20711500 Q81U22 Q6ZMY6 HEMH1 WDR88 0.126 20711500 Q81V26 Q6ZMY6 SPH WDR88 0.126 20711500 Q81YN3 Q6ZMY6 Q81YN3 WDR88 0.126 20711500 Q8CKD5 Q6ZMY6 Q8CKD5 WDR88 0.126 20711500 Q9Y266 Q6ZMY6 NUDC WDR88 0.126 25036637 Q7CIZ7 Q6ZMY6 APPA WDR88 0.126 20711500 Q81LY0 Q6ZMY6 Q81LY0 WDR88 0.126 20711500 Q6ZMY6 Q6KNA9 WDR88 METE 0.126 20711500 Q6ZMY6 P17778 WDR88 YOPM 0.126 20711500

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 APP WDR88 MI:0045 experimental interaction detection MI:0461 interaction database UBC WDR88 MI:0045 experimental interaction detection MI:0461 interaction database WDR88 NUDC MI:0045 experimental interaction detection MI:0461 interaction database