PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus PFDN1 RFWD3 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G HSP90B1 RFWD3 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G ATP6V0D1 RFWD3 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G RFWD3 PFDN2 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G CANX RFWD3 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G UBA1 RFWD3 25260751 intact exp G G G G G G G G G G G G G G G G G G CCT8 RFWD3 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G RFWD3 CCT7 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G RFWD3 PRIMPOL 24126761 intact exp G G G G G G G G G G G G G G G G G G CCT5 RFWD3 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G HSPD1 RFWD3 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G UBA52 RFWD3 20173098 dip exp G G G G G G G G G G G G G G G G G G RFWD3 LGR4 24639526 biogrid exp G G G G G G G G G G G G G G RFWD3 COA1 21504906 biogrid exp G G G G G G G G G G G G G G G G G G UBE2V1 RFWD3 25260751 intact exp UBE2E1 RFWD3 19549727 biogrid,intact exp G G G G G G G G G G G G G G G G G G CCT4 RFWD3 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G RFWD3 RNF41 26496610 biogrid,intact exp G G G G G G G G G G G G G RFWD3 MBIP 26186194 biogrid exp G G G G G G G G G G G G G G G G G G CCT3 RFWD3 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G XPO1 RFWD3 26673895 biogrid exp G G G G G G G G G G G G G G G G G G RPA1 RFWD3 24332808,21504906,24126761,21558276 biogrid,intact exp G G G G G G G G G G G G G G G G G G APP RFWD3 21832049 biogrid exp G G G G G G G G G G G G G G G G G G CEP170 RFWD3 26186194 biogrid exp G G G G G G G G G G G G G G G G G G DNAJB2 RFWD3 26186194 biogrid exp G G G G G G G G G G G G G G G G G G TCP1 RFWD3 26496610 biogrid,intact exp CCT2 RFWD3 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G RFWD3 HYOU1 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G CCT6A RFWD3 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G HSP90AB1 RFWD3 22939624 intact exp G G G G G G G G G G G G G G G G G G RFWD3 MBNL1 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G RFWD3 LYAR 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G RFWD3 UBE2W 19549727 biogrid,intact exp G G G G G G G G G G G G G G G G G G UBE2N RFWD3 19549727,25260751 biogrid,intact exp G G G G G G G G G G G G G G G G G G ELAVL1 RFWD3 19322201 biogrid exp G G G G G G G G G G G G G G G G G G RFWD3 MOV10 22658674 biogrid exp G G G G G G G G G G G G G G G RPA2 RFWD3 24332808,21504906,24126761,21558276 biogrid,intact exp G G G G G G G G G G G G G G G G G G HSP90AA1 RFWD3 22939624 biogrid exp G G G G G G G G G G G G G G G G G G UBE2D1 RFWD3 19549727,19690564 biogrid,intact exp G G G G G G G G G G G G G G G G G G RFWD3 GLG1 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G RPA3 RFWD3 24332808,21504906,24126761,21558276 biogrid,intact exp G G G G G G G G G G G G G G G G G G RFWD3 NXF1 22658674 biogrid exp G G G G G G G G G G G G G G G G G G RFWD3 UBE2D4 19549727,19690564, 23023127 biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G UBE2D2 RFWD3 19549727,19690564, 23023127 biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G MDM2 RFWD3 20173098, 23023127 biogrid,dip exp, pred G G G G G G G G G G G G G G G G G G UBE2D3 RFWD3 19549727,19690564, 23023127 biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G RFWD3 UBE2E3 19549727, 23023127 biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G TP53 RFWD3 20173098, 25402006, 23023127 biogrid,dip exp, pred G G G G G G G G G G G G G G G G G G RFWD3 DTX3L 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 TOPBP1 23023127 pred G G G G G G G G G G G G G G G G G G SOCS3 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G UBOX5 RFWD3 25402006 pred G G G G G G G G G G G G G G G G CNOT4 RFWD3 25402006 pred G G G G G G G G G G G G G G G G G G BRCA1 RFWD3 25402006, 23023127 pred G G G G ERCC8 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 SPC24 23023127 pred G G G RNF4 RFWD3 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 SIAH1 25402006 pred G G G G G G G G G G G G G G G G G G RFWD3 DTX2 25402006 pred G G G G G G G G G G G G G RFWD3 STUB1 25402006 pred G G G G G G G G G G G G G G G G G G RFWD3 DZIP3 25402006 pred G G G G G G G G G G G G G G G G G UBE2G2 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 SDF4 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 NUP37 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 RAD54B 23023127 pred G G G G G G G SEC13 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 UHRF1 23023127 pred G G G G G G G G G G G G MAD2L1BP RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 FZR1 23023127 pred G G G G G G G G G G G G G G G G G RFWD3 RAD54L 23023127 pred G G G G G G RNF43 RFWD3 25402006 pred G G G G G G G G G G G G RFWD3 RLIM 23023127 pred G G G G G G G G G G G G G G G G G G BOP1 RFWD3 23023127 pred G G G G G G G G G G G G G G RFWD3 RNF11 25402006 pred G G G G G G G G G G G G G G G G G G CHAF1B RFWD3 23023127 pred G G TTK RFWD3 23023127 pred G G G G G G G RFWD3 OTUB1 25402006 pred G G G G G G G G G G G G G G G G G G RFWD3 DTL 25402006 pred G G G G G G G G G PJA2 RFWD3 25402006 pred G G G G G G G G G G G G G G G G G G RFWD3 RBM38 23023127 pred G G G G G G G G G G G G G G G G G G UBE2S RFWD3 23023127 pred G G G G G G G G G G G G G G G G RFWD3 AMFR 25402006 pred G G G G G G G G G G G G G G G G G G FOXM1 RFWD3 23023127 pred G G G G RFWD3 TRIM39 25402006 pred RFWD3 GTSE1 25402006 pred G G G G G G G G G G G G G G G G G G CDK1 RFWD3 23023127 pred G G G G G G G G G G G G G DCAF12 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G BUB3 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G BIRC2 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 APBB2 23023127 pred G G G G G G G G G G G G G G G G G G RBBP7 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G DCAF8 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G CCNB1 RFWD3 23023127 pred G G G G G G G G G G G G G FBXO31 RFWD3 23023127 pred G G G G G G G G G G G G G G G G DCAF6 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 RNF111 25402006 pred G G G G G G G G G G G G G G G G G G RFWD3 ING4 23023127 pred G G G G G G G G G G G G G G G G G CDKN1B RFWD3 25402006 pred G G G G G G G G G G G G G G G G G G RFWD3 RNF125 25402006 pred G G G G G G G G G G G G G G G G G RFWD3 GNB4 23023127 pred G G G G G G G G G G G G G G G G G G TRIM21 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 CREBBP 25402006 pred G G G G G G G G G G G G G G G G G G GNGT1 RFWD3 23023127 pred G CD74 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G TP73 RFWD3 23023127 pred G G G RFWD3 RNF2 25402006 pred G MBD4 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 HJURP 25402006 pred G G G G G G G G G RPL24 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G UBE2L6 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G COL1A1 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G WDR5 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G GTF2H2 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 CBX8 23023127 pred BIRC5 RFWD3 23023127 pred G G G G G G G G BUB1B RFWD3 23023127 pred G G G G G G G G G G CDK2 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G PLK1 RFWD3 23023127 pred G G G G G G G G G G G RFWD3 USP17L2 23023127 pred CDC20 RFWD3 23023127 pred G G G G G G G G G NPHP1 RFWD3 23023127 pred G G G G G UBE2C RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 RNF26 25402006 pred G G G G G G G G G G G G G G G G G G RFWD3 AEN 23023127 pred G G G G G G G G G G G G G G ABL1 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 TRAF6 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 GAS2L3 23023127 pred G G G G G G G G G G G G G G G G BIRC3 RFWD3 25402006 pred G G G G G G G G G G G G G G G RFWD3 UBE2F 23023127 pred G G G G G G G G G G G G G G G G G G USP10 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 NUP43 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 RNF25 25402006 pred G CHEK2 RFWD3 23023127 pred G G G G G G G G G G UBE3A RFWD3 25402006 pred G G G G G G G G G G G G G G G G G G CDKN1A RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G UBE2G1 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 RNF126 25402006 pred G G G G G G G G G G G G G G G G G CDKN2B RFWD3 23023127 pred G G G G G G G G RFWD3 PSMG2 23023127 pred G G G G G G G G G G G G G G G G G G HRAS RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 CDT1 25402006 pred G G G G G G G G G PARP1 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 TRIM5 25402006 pred G G G G G G G G G G G G G G G G G RFWD3 FANCD2 23023127 pred G G G G G G G G G G G G RFWD3 TPX2 25402006 pred G G G G G G G G G G G G G G G WDHD1 RFWD3 23023127 pred G G G GNAI3 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G UBE2A RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 BARD1 25402006, 23023127 pred G G G G G G G G G G G DDB1 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 TOPORS 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G KNTC1 RFWD3 23023127 pred G G G G G G G G G G G G WWP2 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 RNF31 23023127 pred G G G G G G G G G G G RFWD3 UBE2T 25402006, 23023127 pred G G G G G G G THBD RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 BTRC 25402006 pred G G G G G G G G G G G G G G G G G G GNB2L1 RFWD3 23023127 pred ZWINT RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 PHLDA3 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 CHD8 25402006 pred G G G G G G G G G G G G G G G G G G XIAP RFWD3 25402006 pred G G G G G G G G G G G G G G G G G G NRAS RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G CENPE RFWD3 23023127 pred G G G NEDD4 RFWD3 25402006, 23023127 pred G G G G G G G G G G G G G G G G G RFWD3 TRAF7 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 CHFR 23023127 pred G G G G G G G G G G G G G G G G G G SP100 RFWD3 23023127 pred G G G G G G G G G G G G G G G G EP300 RFWD3 25402006 pred G G G G G G G G G G G G G G G G G G GNAT1 RFWD3 23023127 pred RFWD3 RAD18 23023127 pred G G G RFWD3 ANAPC11 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 RPS27L 23023127 pred G G G G G G G G G G G G G G G G G G NBN RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G SMARCA4 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G UBE2L3 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G CCNA2 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 MCM10 25402006 pred G G G G TGFB1 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 RNF5 25402006 pred G G G G G G G G G G G G G G G G G G UBE2B RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 DGCR8 23023127 pred TRIAP1 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 DDB2 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 MAD1L1 23023127 pred G G G G G G G G G G CENPF RFWD3 23023127 pred G G G G G G G G G G G G G RFWD3 ZNRF1 25402006 pred G G G G G G G G G G G G G G G G G G CKS2 RFWD3 23023127 pred G G G G G G G G G G G G G G G G GNAT2 RFWD3 23023127 pred DCAF10 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G GNB2 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G PDC RFWD3 23023127 pred WDR62 RFWD3 23023127 pred G G G G G G G G RFWD3 ZWILCH 23023127 pred G G G G G G G G G G G G G G G G G G RFWD3 DNMT3B 23023127 pred G G G G G G G G G G G G G G G NEK2 RFWD3 23023127 pred G G G G G G G IFI16 RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G MAD2L1 RFWD3 23023127 pred G G G G G G G G G G G G UBE2M RFWD3 23023127 pred G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q6PCD5 Q96FI0 two hybrid 19549727 direct interaction X 2 P15927 Q6PCD5 affinity chromatography technology 21504906 physical association X 2 P15927 Q6PCD5 affinity chromatography technology 21504906 physical association X 2 P15927 Q6PCD5 pull down 21504906 direct interaction X 2 P15927 Q6PCD5 affinity chromatography technology 24332808 physical association X 2 P15927 Q6PCD5 imaging technique 21558276 colocalization X 2 P15927 Q6PCD5 affinity chromatography technology 21558276 physical association X 2 P15927 Q6PCD5 pull down 21558276 direct interaction X 2 A0A024RA60 Q6PCD5 affinity chromatography technology 21504906 physical association X 2 A0A087WW00 Q6PCD5 two hybrid 19690564 direct interaction X 2 A0A087WW00 Q6PCD5 two hybrid 19549727 direct interaction X 2 A4D105 Q6PCD5 affinity chromatography technology 21504906 physical association X 2 A4D105 Q6PCD5 affinity chromatography technology 21504906 physical association X 2 A4D105 Q6PCD5 affinity chromatography technology 24332808 physical association X 2 A4D105 Q6PCD5 affinity chromatography technology 21558276 physical association X 2 A0A024R2K3 Q6PCD5 two hybrid 19549727 direct interaction X 2 P0CG48 Q6PCD5 affinity chromatography technology 22505724 physical association X 2 P0CG48 Q6PCD5 affinity chromatography technology 23000965 physical association X 2 P0CG48 Q6PCD5 affinity chromatography technology 25147182 physical association X 2 P0CG48 Q6PCD5 affinity chromatography technology 21987572 physical association X 2 P0CG48 Q6PCD5 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q6PCD5 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q6PCD5 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q6PCD5 affinity chromatography technology 21906983 physical association X 2 Q6PCD5 P05067-7 pull down 21832049 direct interaction X 2 Q6PCD5 P07900-2 affinity chromatography technology 22939624 physical association X 2 Q6PCD5 P62837 two hybrid 19690564 direct interaction X 2 Q6PCD5 A0A024RA90 two hybrid 19690564 direct interaction X 2 Q6PCD5 P62837 two hybrid 19549727 direct interaction X 2 Q6PCD5 A0A024RA90 two hybrid 19549727 direct interaction X 2 Q6PCD5 P04637-7 affinity chromatography technology 20173098 physical association X 2 Q6PCD5 P04637-7 pull down 20173098 direct interaction X 2 Q6PCD5 P04637-7 affinity chromatography technology 20173098 physical association X 2 P61077-3 Q6PCD5 two hybrid 19690564 direct interaction X 2 P61077-3 Q6PCD5 two hybrid 19549727 direct interaction X 2 P27694 Q6PCD5 affinity chromatography technology 21504906 physical association X 2 P27694 Q6PCD5 affinity chromatography technology 21504906 physical association X 2 P27694 Q6PCD5 affinity chromatography technology 21504906 physical association X 2 P27694 Q6PCD5 affinity chromatography technology 24332808 physical association X 2 P27694 Q6PCD5 affinity chromatography technology 21558276 physical association X 2 P27694 Q6PCD5 affinity chromatography technology 21558276 physical association X 2 P27694 Q6PCD5 pull down 21558276 direct interaction X 2 Q9BXB1 Q6PCD5 affinity chromatography technology 24639526 physical association X 2 Q969T4 Q6PCD5 two hybrid 19549727 direct interaction X 2 Q00987 Q6PCD5 pull down 20173098 direct interaction X 2 Q00987 Q6PCD5 affinity chromatography technology 20173098 physical association X 2 P61088 Q6PCD5 two hybrid 19549727 direct interaction X 2 Q6PCD5 anti bait coimmunoprecipitation 20173098 - C 3 Q6PCD5 anti bait coimmunoprecipitation 20173098 - C 3 Q6PCD5 pull down 20173098 - C 3 K7PPA8 Q6PCD5 pull down 20173098 direct interaction X 2 K7PPA8 Q6PCD5 anti bait coimmunoprecipitation 20173098 direct interaction X 2 K7PPA8 Q6PCD5 pull down 20173098 direct interaction X 2 K7PPA8 Q6PCD5 anti bait coimmunoprecipitation 20173098 direct interaction X 2 K7PPA8 Q6PCD5 anti bait coimmunoprecipitation 20173098 direct interaction X 2 Q6PCD5 P62987 comigration in sds page 20173098 direct interaction X 2 Q00987 Q6PCD5 pull down 20173098 direct interaction X 2 Q00987 Q6PCD5 anti bait coimmunoprecipitation 20173098 direct interaction X 2 Q00987 Q6PCD5 pull down 20173098 direct interaction X 2 Q00987 Q6PCD5 anti bait coimmunoprecipitation 20173098 direct interaction X 2 Q00987 Q6PCD5 anti tag coimmunoprecipitation 20173098 direct interaction X 2 Q00987 Q6PCD5 anti tag coimmunoprecipitation 20173098 direct interaction X 2 Q00987 Q6PCD5 pull down 20173098 direct interaction X 2 Q6PCD5 tandem affinity purification 24126761 association C 9 A0A024QZJ2 Q6PCD5 two hybrid array 19549727 physical association X 2 A0A024QZJ2 Q6PCD5 two hybrid array 19690564 physical association X 2 A0A024R2K3 Q6PCD5 two hybrid array 19549727 physical association X 2 Q96B02 Q6PCD5 two hybrid array 19549727 physical association X 2 Q6PCD5 tandem affinity purification 24126761 association C 16 Q6PCD5 tandem affinity purification 24126761 association C 16 Q6PCD5 tandem affinity purification 24126761 association C 16 Q6PCD5 ubiquitinase assay 25260751 ubiquitination reaction C 4 Q6PCD5 P62837 two hybrid array 19549727 physical association X 2 Q6PCD5 A0A024RA90 two hybrid array 19549727 physical association X 2 Q6PCD5 A0A024RA90 two hybrid array 19690564 physical association X 2 Q6PCD5 P62837 two hybrid array 19690564 physical association X 2 Q6PCD5 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2 A0A024RDH2 Q6PCD5 two hybrid array 19549727 physical association X 2 A0A024RDH2 Q6PCD5 two hybrid array 19690564 physical association X 2 Q969T4 Q6PCD5 two hybrid array 19549727 physical association X 2 Q81YX2 Q6PCD5 two hybrid pooling approach 20711500 physical association X 2 P61088 Q6PCD5 two hybrid array 19549727 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBE2E1 RFWD3 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101309|BIOGRID_124466 bait|bait prey|prey RPA3 RFWD3 MI:0004(affinity chromatography technology)|MI:0428(imaging technique)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21504906,21558276,24332808 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_218824|BIOGRID_146560|BIOGRID_308353|BIOGRID_218805 prey|prey|bait|prey bait|bait|prey|bait RFWD3 UBE2D4 MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0018(two hybrid) 19549727,19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(intact)|(biogrid)|(biogrid) UniProt_101460|UniProt_102508|BIOGRID_124465|BIOGRID_123518 prey|prey|prey|prey bait|bait|bait|bait RFWD3 UBE2E3 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124467|UniProt_101430 prey|prey bait|bait RFWD3 UBE2W MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101486|BIOGRID_124469 prey|prey bait|bait UBE2D2 RFWD3 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0397(two hybrid array) 19549727,19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(intact) UniProt_101034|BIOGRID_124166|BIOGRID_123451|UniProt_102439 bait|bait|bait|bait prey|prey|prey|prey RFWD3 COA1 MI:0004(affinity chromatography technology) 21504906 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_218812 bait prey RPA2 RFWD3 MI:0428(imaging technique)|MI:0004(affinity chromatography technology)|MI:0428(imaging technique)|MI:0004(affinity chromatography technology)|MI:0428(imaging technique)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21504906,21558276,24332808 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_146557|BIOGRID_218823|BIOGRID_146558|BIOGRID_218825|BIOGRID_146563|BIOGRID_218804|BIOGRID_308320 prey|prey|prey|prey|prey|prey|bait bait|bait|bait|bait|bait|bait|prey ELAVL1 RFWD3 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187501 bait prey HSP90AA1 RFWD3 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255416 bait prey UBE2D1 RFWD3 MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 19549727,19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(intact) UniProt_102412|BIOGRID_123423|BIOGRID_124464|UniProt_101239 bait|bait|bait|bait prey|prey|prey|prey UBE2D3 RFWD3 MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0018(two hybrid) 19549727,19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(intact)|(biogrid)|(biogrid) UniProt_101059|UniProt_102473|BIOGRID_124167|BIOGRID_123485 bait|bait|bait|bait prey|prey|prey|prey p53 RFWD3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20173098 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_146991|BIOGRID_146993|BIOGRID_146995 bait|prey|prey prey|bait|bait MDM2 RFWD3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20173098 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_146996|BIOGRID_146994 prey|prey bait|bait UBE2N RFWD3 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101388|BIOGRID_124468 bait|bait prey|prey HSP90AB1 RFWD3 MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_125076 prey bait APP RFWD3 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229389 prey bait RPA1 RFWD3 MI:0004(affinity chromatography technology)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21504906,21558276,24332808 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_218822|BIOGRID_146559|BIOGRID_146562|BIOGRID_146561|BIOGRID_308287|BIOGRID_218806|BIOGRID_218803 prey|prey|prey|bait|bait|prey|bait bait|bait|bait|prey|prey|bait|prey UBC RFWD3 MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473,21906983,21963094,21987572,22505724,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_181347|BIOGRID_163068|BIOGRID_166207|BIOGRID_224507|BIOGRID_173366|BIOGRID_267902|BIOGRID_172254 bait|bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality PFDN1 RFWD3 26496610,26496610 0007,0004 HT HSPD1 RFWD3 26496610,26496610 0007,0004 HT HSP90B1 RFWD3 26496610 0007 HT RPA2 RFWD3 24126761,21504906,26474068,21558276,21558276,21504906,21558276 0676,0004,0004,0004,0428,0096,0096 LC TCP1 RFWD3 26496610,26496610 0007,0004 HT DNAJB2 RFWD3 26186194 0004 HT RPA1 RFWD3 24126761,21504906,26474068,21558276,21558276 0676,0004,0004,0004,0096 LC CANX RFWD3 26496610,26496610 0007,0004 HT RPA3 RFWD3 24126761,21504906,21558276 0676,0004,0004 LC CCT6A RFWD3 26496610,26496610 0007,0004 HT CCT5 RFWD3 26496610 0007 HT CCT3 RFWD3 26496610 0007 HT CCT8 RFWD3 26496610,26496610 0007,0004 HT CCT4 RFWD3 26496610,26496610 0007,0004 HT ATP6V0D1 RFWD3 26496610,26496610 0007,0004 HT CCT2 RFWD3 26496610 0007 HT Q59H77 RFWD3 26496610 0004 HT CEP170 RFWD3 26186194 0004 HT RFWD3 GLG1 26496610,26496610 0007,0004 HT RFWD3 CCT7 26496610,26496610 0007,0004 HT RFWD3 RNF41 26496610,26496610 0007,0004 HT RFWD3 MBNL1 26496610,26496610 0007,0004 HT RFWD3 MBIP 26186194 0004 HT RFWD3 LYAR 26496610,26496610 0007,0004 HT RFWD3 PFDN2 26496610,26496610 0007,0004 HT RFWD3 HYOU1 26496610,26496610 0007,0004 HT RFWD3 HEL-S-69 26496610 0004 HT RFWD3 HEL-S-100N 26496610 0004 HT RFWD3 HEL-S-125M 26496610 0004 HT PFDN1 RFWD3 26496610,26496610 0007,0004 HT HSPD1 RFWD3 26496610,26496610 0007,0004 HT HSP90B1 RFWD3 26496610 0007 HT TCP1 RFWD3 26496610,26496610 0007,0004 HT DNAJB2 RFWD3 26186194 0004 HT CANX RFWD3 26496610,26496610 0007,0004 HT CCT6A RFWD3 26496610,26496610 0007,0004 HT CCT5 RFWD3 26496610 0007 HT CCT3 RFWD3 26496610 0007 HT CCT8 RFWD3 26496610,26496610 0007,0004 HT CCT4 RFWD3 26496610,26496610 0007,0004 HT ATP6V0D1 RFWD3 26496610,26496610 0007,0004 HT CCT2 RFWD3 26496610 0007 HT Q59H77 RFWD3 26496610 0004 HT CEP170 RFWD3 26186194 0004 HT RFWD3 GLG1 26496610,26496610 0007,0004 HT RFWD3 CCT7 26496610,26496610 0007,0004 HT RFWD3 RNF41 26496610,26496610 0007,0004 HT RFWD3 MBNL1 26496610,26496610 0007,0004 HT RFWD3 MBIP 26186194 0004 HT RFWD3 LYAR 26496610,26496610 0007,0004 HT RFWD3 PFDN2 26496610,26496610 0007,0004 HT RFWD3 HYOU1 26496610,26496610 0007,0004 HT RFWD3 HEL-S-69 26496610 0004 HT RFWD3 HEL-S-100N 26496610 0004 HT RFWD3 HEL-S-125M 26496610 0004 HT RPA2 RFWD3 24126761,21504906,26474068,21558276,21558276,21504906,21558276 0676,0004,0004,0004,0428,0096,0096 LC RPA1 RFWD3 24126761,21504906,26474068,21558276,21558276 0676,0004,0004,0004,0096 LC RPA3 RFWD3 24126761,21504906,21558276 0676,0004,0004 LC HSP90AB1 RFWD3 22939624 0729 HT UBC RFWD3 20173098 0808 LC UBA1 RFWD3 25260751 0997 LC UBE2D1 RFWD3 19690564,19549727,19549727,19690564 0397,0397,0018,0018 HT UBE2E1 RFWD3 19549727,19549727 0397,0018 HT UBE2D3 RFWD3 19690564,19549727,19549727,19690564 0397,0397,0018,0018 HT UBE2N RFWD3 19549727,19549727,25260751 0397,0018,0997 HT,LC UBE2D2 RFWD3 19690564,19549727,19549727,19690564 0397,0397,0018,0018 HT UBE2V1 RFWD3 25260751 0997 LC RFWD3 UBE2E3 19549727,19549727 0397,0018 HT RFWD3 UBE2W 19549727,19549727 0397,0018 HT RFWD3 UBE2D4 19690564,19549727,19549727,19690564 0397,0397,0018,0018 HT RFWD3 HEL-S-71 19549727 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q6PCD5 Q53QD7 RFWD3 DNAJB2 {ECO:0000312|HGNC:HGNC:5228} 0.126 Q6PCD5 Q5SW79 RFWD3 CEP170 0.126 26186194 Q9HCE1 Q6PCD5 MOV10 RFWD3 0.126 22658674 Q9NS73 Q6PCD5 MBIP RFWD3 0.126 26186194 Q9H4P4 Q6PCD5 RNF41 RFWD3 0.126 26496610 Q6PCD5 P25686 RFWD3 DNAJB2 0.126 26186194 Q6PCD5 P07900 RFWD3 HSP90AA1 0.126 22939624 Q6PCD5 P08238 RFWD3 HSP90AB1 0.126 22939624 Q6PCD5 Q6P5F9 RFWD3 XPO1 0.126 26673895 Q6PCD5 P62837 RFWD3 UBE2D2 0.554 19690564,19549727 Q6PCD5 E5RGS4 RFWD3 PFDN1 {ECO:0000313|ENSEMBL:ENSP00000428707} 0.126 26496610 Q6PCD5 P61421 RFWD3 ATP6V0D1 0.126 26496610 Q6PCD5 C9JP00 RFWD3 MBNL1 {ECO:0000313|ENSEMBL:ENSP00000420327} 0.126 26496610 Q6PCD5 O60925 RFWD3 PFDN1 0.126 26496610 Q6PCD5 P05067 RFWD3 APP 0.183 21832049 Q6PCD5 P22314 RFWD3 UBA1 0.033 25260751 Q6PCD5 P27824 RFWD3 CANX 0.126 26496610 Q6PCD5 P40227 RFWD3 CCT6A 0.126 26496610 Q6PCD5 P51965 RFWD3 UBE2E1 0.376 19549727 Q6PCD5 Q13404 RFWD3 UBE2V1 0.033 25260751 Q81YX2 Q6PCD5 Q81YX2 RFWD3 0.126 20711500 Q9NR56 Q6PCD5 MBNL1 RFWD3 0.126 26496610 Q9GZY4 Q6PCD5 COA1 RFWD3 0.21 21504906 Q9Y4L1 Q6PCD5 HYOU1 RFWD3 0.126 26496610 Q6PCD5 P04637 RFWD3 TP53 0.569 20173098 Q9Y2X8 Q6PCD5 UBE2D4 RFWD3 0.49 19690564,19549727 Q969T4 Q6PCD5 UBE2E3 RFWD3 0.286 19549727 Q96B02 Q6PCD5 UBE2W RFWD3 0.286 19549727 Q6PCD5 P15927 RFWD3 RPA2 0.82 26474068,21504906,24126761,21558276 Q9D952 Q6PCD5 EVPL RFWD3 0.236 26496610 Q6PCD5 P80315 RFWD3 CCT4 0.236 26496610 Q6PCD5 P42932 RFWD3 CCT8 0.236 26496610 Q6PCD5 P17987 RFWD3 TCP1 0.236 26496610 Q6PCD5 P10809 RFWD3 HSPD1 0.236 26496610 Q6PCD5 P14625 RFWD3 HSP90B1 0.236 26496610 Q6PCD5 P49368 RFWD3 CCT3 0.236 26496610 Q6PCD5 P50990 RFWD3 CCT8 0.236 26496610 Q6PCD5 P61088 RFWD3 UBE2N 0.396 19549727,25260751 Q6PCD5 P48643 RFWD3 CCT5 0.236 26496610 Q6PCD5 P61077 RFWD3 UBE2D3 0.554 19690564,19549727 Q6PCD5 P51668 RFWD3 UBE2D1 0.61 19690564,19549727 Q6PCD5 P50991 RFWD3 CCT4 0.236 26496610 Q6PCD5 P78371 RFWD3 CCT2 0.236 26496610 Q99832 Q6PCD5 CCT7 RFWD3 0.236 26496610 Q6PCD5 Q00987 RFWD3 MDM2 0.454 20173098 Q92896 Q6PCD5 GLG1 RFWD3 0.236 26496610 Q9UHV9 Q6PCD5 PFDN2 RFWD3 0.236 26496610 Q9NX58 Q6PCD5 LYAR RFWD3 0.236 26496610 Q6PCD5 P27694 RFWD3 RPA1 0.837 26474068,21504906,24332808,24126761,21558276 Q6PCD5 P35244 RFWD3 RPA3 0.454 21558276,24126761,21504906 Q96LW4 Q6PCD5 PRIMPOL RFWD3 0.126 24126761 Q9BXB1 Q6PCD5 LGR4 RFWD3 0.126 24639526 Q9UBU9 Q6PCD5 NXF1 RFWD3 0.126 22658674 Q6PCD5 Q15717 RFWD3 ELAVL1 0.126 19322201

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 XPO1 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database PFDN1 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database TP53 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database APP RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AA1 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database UBB RFWD3 MI:0362 inference MI:0461 interaction database UBC RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database HSPD1 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database HSP90B1 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database RPA2 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database TCP1 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database TAF1 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database UBA1 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database DNAJB2 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database RPA1 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database CANX RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database RPA3 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database CCT6A RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database CCT5 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database CCT3 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database CCT8 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database CCT4 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D1 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database UBE2E1 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database UBE2N RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database ATP6V0D1 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database RPS27A RFWD3 MI:0362 inference MI:0461 interaction database UBA52 RFWD3 MI:0362 inference MI:0461 interaction database CCT2 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database MDM2 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database UBE2V1 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database ELAVL1 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database CEP170 RFWD3 MI:0045 experimental interaction detection MI:0461 interaction database RFWD3 EVPL MI:0362 inference MI:0461 interaction database RFWD3 GLG1 MI:0045 experimental interaction detection MI:0461 interaction database RFWD3 UBE2E3 MI:0045 experimental interaction detection MI:0461 interaction database RFWD3 UBE2W MI:0045 experimental interaction detection MI:0461 interaction database RFWD3 PRIMPOL MI:0045 experimental interaction detection MI:0461 interaction database RFWD3 CCT7 MI:0045 experimental interaction detection MI:0461 interaction database RFWD3 LGR4 MI:0045 experimental interaction detection MI:0461 interaction database RFWD3 COA1 MI:0045 experimental interaction detection MI:0461 interaction database RFWD3 RNF41 MI:0045 experimental interaction detection MI:0461 interaction database RFWD3 MOV10 MI:0045 experimental interaction detection MI:0461 interaction database RFWD3 MBNL1 MI:0045 experimental interaction detection MI:0461 interaction database RFWD3 MBIP MI:0045 experimental interaction detection MI:0461 interaction database RFWD3 LYAR MI:0045 experimental interaction detection MI:0461 interaction database RFWD3 NXF1 MI:0045 experimental interaction detection MI:0461 interaction database RFWD3 PFDN2 MI:0045 experimental interaction detection MI:0461 interaction database RFWD3 UBE2D4 MI:0045 experimental interaction detection MI:0461 interaction database RFWD3 HYOU1 MI:0045 experimental interaction detection MI:0461 interaction database