PTM - CPLM Gene Name UniProt ID Type Position Code RFWD3; RNF201 Q6PCD5 Ubiquitination 402 K RFWD3; RNF201 Q6PCD5 Ubiquitination 583 K RFWD3; RNF201 Q6PCD5 Ubiquitination 766 K RFWD3; RNF201 Q6PCD5 Ubiquitination 321 K RFWD3; RNF201 Q6PCD5 Ubiquitination 433 K RFWD3; RNF201 Q6PCD5 Ubiquitination 658 K RFWD3; RNF201 Q6PCD5 Ubiquitination 697 K RFWD3; RNF201 Q6PCD5 Ubiquitination 389 K RFWD3; RNF201 Q6PCD5 Ubiquitination 772 K RFWD3; RNF201 Q6PCD5 Ubiquitination 364 K RFWD3; RNF201 Q6PCD5 Ubiquitination 440 K RFWD3; RNF201 Q6PCD5 Ubiquitination 370 K RFWD3; RNF201 Q6PCD5 Ubiquitination 498 K RFWD3; RNF201 Q6PCD5 Ubiquitination 435 K RFWD3; RNF201 Q6PCD5 Ubiquitination 359 K RFWD3; RNF201 Q6PCD5 Ubiquitination 488 K

PTM - dbPAF Gene Name UniProt ID Position Type Species RFWD3; RNF201 Q6PCD5 181 Y Homo sapiens(Human) RFWD3; RNF201 Q6PCD5 266 S Homo sapiens(Human) RFWD3; RNF201 Q6PCD5 423 S Homo sapiens(Human) RFWD3; RNF201 Q6PCD5 425 S Homo sapiens(Human) RFWD3; RNF201 Q6PCD5 427 S Homo sapiens(Human) RFWD3; RNF201 Q6PCD5 428 S Homo sapiens(Human) RFWD3; RNF201 Q6PCD5 46 S Homo sapiens(Human) RFWD3; RNF201 Q6PCD5 63 S Homo sapiens(Human) RFWD3; RNF201 Q6PCD5 661 T Homo sapiens(Human)

PTM - PhosSNP Gene Name dbSNP ID Gene Mutation AA Mutation Mutation Position Code Peptide Score Modification Type RFWD3; RNF201 rs7191921 GGC->GTC G->V 428 S VLSCSPSSQGQHKHK 428 Phosphorylation TypeIII-

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q6PCD5 K364-ac Acetylation RMKSSLLkEQMLRkQ Q6PCD5 K370-ac Acetylation LkEQMLRkQAELESA Q6PCD5 K488-m1 Methylation MLSTANMkSSQYIPM Q6PCD5 S46-p Phosphorylation VPADVVSsQGVPSIL Q6PCD5 S63-p Phosphorylation APAEVISsQATPPLL Q6PCD5 Y181-p Phosphorylation LRAPLDAyFQVSRTQ Q6PCD5 S266-p Phosphorylation KTLPKQPsPQKSEPL Q6PCD5 S423-p Phosphorylation GSQAWVLsCsPssQG Q6PCD5 S425-p Phosphorylation QAWVLsCsPssQGQH Q6PCD5 S427-p Phosphorylation WVLsCsPssQGQHKH Q6PCD5 S428-p Phosphorylation VLsCsPssQGQHKHK Q6PCD5 K488-sm Sumoylation MLSTANMkSSQYIPM Q6PCD5 K772-sm Sumoylation EkMVHIYkWE_____ Q6PCD5 K364-ub Ubiquitination RMKSSLLkEQMLRkQ Q6PCD5 K370-ub Ubiquitination LkEQMLRkQAELESA Q6PCD5 K389-ub Ubiquitination QLQVLTDkCTRLQRR Q6PCD5 K402-ub Ubiquitination RRVQDLQkLTSHQSQ Q6PCD5 K440-ub Ubiquitination KHKYHFQkTFTVSQA Q6PCD5 K488-ub Ubiquitination MLSTANMkSSQYIPM Q6PCD5 K498-ub Ubiquitination QYIPMHGkQIRGLAF Q6PCD5 K583-ub Ubiquitination VQELVAQkARCPLVS Q6PCD5 K658-ub Ubiquitination LVTYRPDkNHTTIRS Q6PCD5 K697-ub Ubiquitination FFGGPTCkLLTKNAI Q6PCD5 K766-ub Ubiquitination YLATLTEkMVHIYkW

PTM - dbPTM UniProt ID Position Code Type Resources References Q6PCD5 46 S Phosphorylation Swiss-Prot 1010711 20173098 Q6PCD5 63 S Phosphorylation Swiss-Prot 1010711 20173098 Q6PCD5 427 S Phosphorylation Swiss-Prot 1010711 17525332 Q6PCD5 428 S Phosphorylation Swiss-Prot 1010711 17525332 Q6PCD5 425 S Phosphorylation PhosphoELM.10011 18669648 Q6PCD5 427 S Phosphorylation PhosphoELM.10011 18669648;17525332 Q6PCD5 428 S Phosphorylation PhosphoELM.10011 17525332 Q6PCD5 364 K Ubiquitylation Phosphositeplus.1010730 21906983 Q6PCD5 389 K Ubiquitylation Phosphositeplus.1010730 21906983 Q6PCD5 402 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q6PCD5 583 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q6PCD5 766 K Ubiquitylation Phosphositeplus.1010730 21890473 Q6PCD5 266 S Phosphorylation Phosphositeplus.1010730 22115753 Q6PCD5 425 S Phosphorylation Phosphositeplus.1010730 19276368 Q6PCD5 427 S Phosphorylation Phosphositeplus.1010730 17525332;19276368 Q6PCD5 428 S Phosphorylation Phosphositeplus.1010730 17525332 Q6PCD5 46 S Phosphorylation Phosphositeplus.1010730 17478428 Q6PCD5 63 S Phosphorylation Phosphositeplus.1010730 17478428 Q6PCD5 425 S Phosphorylation HPRD 9.0 18669648,18077418 Q6PCD5 427 S Phosphorylation HPRD 9.0 17525332,18669648 Q6PCD5 428 S Phosphorylation HPRD 9.0 17525332,18077418 Q6PCD5 661 T Phosphorylation HPRD 9.0 17081983 Q6PCD5 661 T Phosphorylation SysPTM 1.1 17081983

PTM - HPRD Symbol Position Code Type References RFWD3 400 S Phosphorylation 18669648,18077418 RFWD3 402 S Phosphorylation 17525332,18669648 RFWD3 403 S Phosphorylation 17525332,18077418 RFWD3 425 S Phosphorylation 18669648,18077418 RFWD3 427 S Phosphorylation 17525332,18669648 RFWD3 428 S Phosphorylation 17525332,18077418 RFWD3 636 T Phosphorylation 17081983 RFWD3 661 T Phosphorylation 17081983

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q6PCD5 428 S 17525332 HTP Phosphorylation Q6PCD5 427 S 18669648 HTP Phosphorylation Q6PCD5 427 S 17525332 HTP Phosphorylation Q6PCD5 425 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q6PCD5 46 Phosphoserine; by ATM and ATR 20173098;28575657;28575658 Q6PCD5 63 Phosphoserine; by ATM and ATR 20173098;28575657;28575658

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 55159 120460 - K Ubiquitination 21987572 55159 120460 - K Ubiquitination 21963094 55159 120460 - K Ubiquitination 21139048 55159 120460 - K Ubiquitination 21890473 55159 120460 - K Ubiquitination 21906983 55159 120460 - K Ubiquitination 22505724 55159 120460 - K Ubiquitination 23000965 55159 120460 - K Ubiquitination 25147182

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID RFWD3 Homo sapiens (Human) 255 "255,LATLTEKMVHIYK" 255:21890473 RFWD3 Homo sapiens (Human) 766; 583; 402 "766,LATLTEKMVHIYK; 583,QELVAQKARCPLV; 402,RVQDLQKLTSHQS" 766:21890473; 583:21890473; 402:21890473 RFWD3 Homo sapiens (Human) 766; 583; 364; 402; 389 "766,LATLTEKMVHIYK; 583,QELVAQKARCPLV; 364,MKSSLLKEQMLRK; 402,RVQDLQKLTSHQS; 389,LQVLTDKCTRLQR" "766:21890473; 583:21890473,21906983; 364:21906983; 402:21890473,21906983; 389:21906983" RFWD3 Homo sapiens (Human) 766; 583; 402 "766,LATLTEKMVHIYK; 583,QELVAQKARCPLV; 402,RVQDLQKLTSHQS" 766:21890473; 583:21890473; 402:21890473