PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus NTRK1 IRF2BP1 25921289 biogrid exp P P P G P P P P P P P P P P P P P P IRF2 IRF2BP1 21903422,12799427 innatedb,hprd,biogrid,intact,bci exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TGIF1 IRF2BP1 18511908 hprd exp GP G G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G IRF2BP1 PCBD2 20211142 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SMAD1 IRF2BP1 15231748 biogrid,i2d,mint,intact exp G G G G G G G G GP G G G G G G G G G G G G G G G G G G GP G FOSL2 IRF2BP1 26186194 biogrid exp GP GP G G GP GP G G GP GP G GP GP G GP GP G G G GP GP GP G GP G GP G ARHGAP1 IRF2BP1 26344197 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G VGLL4 IRF2BP1 26186194 biogrid exp GP GP G G G GP G G GP G GP G G GP G GP GP GP GP G GP GP GP G GP GP GP GP G IRF2BP1 KDM3A 26344197 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G OBSL1 IRF2BP1 24711643 biogrid exp GP GP G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G IRF2BP1 FARSA 26344197 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TATDN1 IRF2BP1 26344197 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SOX2 IRF2BP1 23667531 biogrid exp P P G P GP G GP G P P GP P GP GP P G P GP P GP P GP GP G IRF2BP1 JDP2 18671972 innatedb,biogrid,mint,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G IRF2BP1 CCNL2 26186194 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G IRF2BP1 SH3KBP1 19531213 biogrid exp G G G G GP GP G G G G G G G GP G G GP G G G GP G G G G GP G G G QPRT IRF2BP1 26186194 biogrid exp GP GP G G G GP G G G G GP GP GP GP G GP GP G G G GP GP G G GP GP GP GP G HIP1R IRF2BP1 26344197 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G ATF2 IRF2BP1 18671972 innatedb,biogrid,mint,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G IRF9 IRF2BP1 12799427 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SUMO3 IRF2BP1 ortho GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G YWHAE IRF2BP1 ortho GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G IRF2BP2 IRF2BP1 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G JUND IRF2BP1 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G IRF2BP1 BRD7 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G IFNB1 IRF2BP1 25402006 pred P P P P P P P P P P P P P P P P P P P P P EP300 IRF2BP1 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ATF7 IRF2BP1 25402006 pred GP G G G GP G G G G G G G G GP G G G G G G G G G G G G G GP G JUNB IRF2BP1 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TAP1 IRF2BP1 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G IRF1 IRF2BP1 25402006 pred GP GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP G GP GP GP G GP GP G CIITA IRF2BP1 25402006 pred GP GP G G G P G G GP GP G GP GP G GP GP G G G P GP P GP GP GP G G MAPK9 IRF2BP1 25402006 pred G GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PGR IRF2BP1 25402006 pred GP G P G G G G G G G P GP P G P G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8IU81 affinity chromatography technology 19531213 physical association X 2 Q8IU81 P48431 affinity chromatography technology 23667531 physical association X 2 Q8IU81 A0A024R3Z2 affinity chromatography technology 24654937 physical association X 2 Q8IU81 P61956-2 affinity chromatography technology 25027693 physical association X 2 Q8IU81 Q8WYK2-2 affinity chromatography technology 18671972 physical association X 2 Q8IU81 Q8WYK2-2 affinity chromatography technology 18671972 physical association X 2 Q8IU81 Q8WYK2-2 pull down 18671972 direct interaction X 2 Q8IU81 P15336 pull down 18671972 direct interaction X 2 Q8IU81 Q9H0N5 two hybrid 20211142 direct interaction X 2 Q8IU81 P61956-2 affinity chromatography technology 21693764 physical association X 2 Q8IU81 P61956-2 affinity chromatography technology 19471022 physical association X 2 Q8IU81 P61956-2 affinity chromatography technology 21252943 physical association X 2 Q8IU81 Q00978 two hybrid 12799427 direct interaction X 2 Q8IU81 P14316 two hybrid 12799427 direct interaction X 2 Q8IU81 P14316 two hybrid 12799427 direct interaction X 2 Q8IU81 P14316 affinity chromatography technology 12799427 physical association X 2 Q8IU81 P0CG48 affinity chromatography technology 22505724 physical association X 2 Q8IU81 Q15797 two hybrid 15231748 direct interaction X 2 Q8IU81 P0CG48 affinity chromatography technology 24816145 physical association X 2 Q8IU81 affinity chromatography technology 24711643 physical association X 2 Q8IU81 P14316 affinity chromatography technology 21903422 physical association X 2 Q8IU81 P0CG48 affinity chromatography technology 21139048 physical association X 2 Q8IU81 P0CG48 affinity chromatography technology 21890473 physical association X 2 Q8IU81 P14316 two hybrid 12799427 - X 2 Q8IU81 P14316 in vivo 12799427 - X 2 Q8IU81 P14316 in vitro 12799427 - X 2 Q8IU81 Q15583-4 two hybrid 18511908 - X 2 Q8IU81 Q15583-4 in vivo 18511908 - X 2 Q8IU81 Q15583-4 two hybrid 18511908 - X 2 Q8IU81 Q15583-4 in vivo 18511908 - X 2 Q8IU81 P14316 in vitro 12799427 - X 2 Q8IU81 P14316 two hybrid 12799427 - X 2 Q8IU81 P14316 in vivo 12799427 - X 2 Q8IU81 anti tag coimmunoprecipitation 18671972 association C 5 Q8IU81 anti tag coimmunoprecipitation 21903422 association C 12 Q8IU81 P15336 pull down 18671972 physical association X 2 Q8IU81 anti tag coimmunoprecipitation 18671972 association C 10 Q8IU81 Q15797 two hybrid 15231748 physical association X 2 Q8IU81 A0A024R6D7 pull down 18671972 physical association X 2 Q8IU81 A0A024R6D7 anti bait coimmunoprecipitation 18671972 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B IRF9 IRF2BP1 MI:0018(two hybrid) 12799427 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_213521 bait prey ATF2 IRF2BP1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 18671972 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|MI:0471(mint)|(biogrid)|MI:0471(mint) UniProt_97923|MINT_37893|BIOGRID_116587|MINT_67076 bait|bait|bait|bait prey|prey|prey|prey IRF2 IRF2BP1 MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 12799427,21903422 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|-|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0914(association)|MI:0914(association) (biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|(biogrid)|(intact)|(intact) BIOGRID_155543|BIOGRID_213527|HPRD_36460|BIOGRID_213524|BIOGRID_213522|UniProt_172502|UniProt_115760 bait|bait|-|prey|bait|bait|bait prey|prey|-|bait|prey|prey|prey UBC IRF2BP1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473,22505724 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_172565|BIOGRID_173991|BIOGRID_223870 bait|bait|bait prey|prey|prey TGIF1 IRF2BP1 MI:0493(in vivo) 18511908 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_33278 - - IRF2BP1 PCBD2 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128898 bait prey IRF2BP1 JDP2 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 18671972 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association) MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|(biogrid)|MI:0471(mint)|(biogrid)|MI:0471(mint)|(biogrid)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint) MINT_67074|UniProt_97921|MINT_37892|UniProt_97922|BIOGRID_116581|MINT_37891|BIOGRID_116586|MINT_67075|BIOGRID_116585|MINT_37887|MINT_67070|UniProt_97919|UniProt_97918|MINT_37886|MINT_67069 bait|bait|prey|prey|prey|bait|prey|prey|bait|prey|prey|prey|prey|prey|prey prey|prey|bait|bait|bait|prey|bait|bait|prey|bait|bait|bait|bait|bait|bait IRF2BP1 SH3KBP1 MI:0004(affinity chromatography technology) 19531213 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_191202 prey bait SMAD1 IRF2BP1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(biogrid)|(intact) MINT_32509|MINT_61357|BIOGRID_259239|UniProt_79030 bait|bait|bait|bait prey|prey|prey|prey SUMO2 IRF2BP1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19471022,21252943,21693764 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_183109|BIOGRID_183808|BIOGRID_165687 bait|bait|bait prey|prey|prey SOX2 IRF2BP1 MI:0004(affinity chromatography technology) 23667531 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_275036 bait prey

PPI - HINT Gene A Gene B PMID Method Quality HIP1R IRF2BP1 26344197 0401 HT IRF2 IRF2BP1 21903422,12799427,12799427,21903422 0007,0018,0004,0004 LC FOSL2 IRF2BP1 26186194 0004 HT ARHGAP1 IRF2BP1 26344197 0401 HT VGLL4 IRF2BP1 26186194 0004 HT TATDN1 IRF2BP1 26344197 0401 HT IRF2BP1 CCNL2 26186194 0004 HT IRF2BP1 FARSA 26344197 0401 HT IRF2BP1 KDM3A 26344197 0401 HT IRF2BP1 HEL-S-90N 26186194 0004 HT HIP1R IRF2BP1 26344197 0401 HT FOSL2 IRF2BP1 26186194 0004 HT ARHGAP1 IRF2BP1 26344197 0401 HT VGLL4 IRF2BP1 26186194 0004 HT TATDN1 IRF2BP1 26344197 0401 HT IRF2BP1 CCNL2 26186194 0004 HT IRF2BP1 FARSA 26344197 0401 HT IRF2BP1 KDM3A 26344197 0401 HT IRF2BP1 HEL-S-90N 26186194 0004 HT IRF2 IRF2BP1 21903422,12799427,12799427,21903422 0007,0018,0004,0004 LC HIP1R IRF2BP1 26344197 0401 LC IRF2 IRF2BP1 12799427,12799427 0018,0004 LC IRF9 IRF2BP1 12799427 0018 LC ARHGAP1 IRF2BP1 26344197 0401 LC TGIF1 IRF2BP1 18511908 0018 LC SMAD1 IRF2BP1 15231748 0018 HT TATDN1 IRF2BP1 26344197 0401 LC IRF2BP1 PCBD2 20211142 0018 HT IRF2BP1 FARSA 26344197 0401 LC IRF2BP1 KDM3A 26344197 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8IU81 Q5VWT5 IRF2BP1 C1ORF168 0.126 unassigned1312 Q8IU81 Q15813 IRF2BP1 TBCE 0.126 unassigned1312 Q8IU81 Q07960 IRF2BP1 ARHGAP1 0.081 26344197 Q8IU81 P58340 IRF2BP1 MLF1 0.126 unassigned1312 Q8IU81 P30419 IRF2BP1 NMT1 0.126 unassigned1312 Q8IU81 P14316 IRF2BP1 IRF2 0.712 12799427,21903422 Q8IU81 O75165 IRF2BP1 DNAJC13 0.126 unassigned1312 Q8IU81 Q3B7T1 IRF2BP1 EDRF1 0.126 unassigned1312 Q9Y285 Q8IU81 FARSA IRF2BP1 0.081 26344197 Q9H0N5 Q8IU81 PCBD2 IRF2BP1 0.183 20211142 Q9NR56 Q8IU81 MBNL1 IRF2BP1 0.126 unassigned1312 Q8IU81 O75147 IRF2BP1 OBSL1 0.126 24711643 Q8IU81 P04629 IRF2BP1 NTRK1 0.126 25921289 Q8IU81 Q15797 IRF2BP1 SMAD1 0.332 15231748 Q8WYK2 Q8IU81 JDP2 IRF2BP1 0.787 18671972 Q96B97 Q8IU81 SH3KBP1 IRF2BP1 0.126 19531213 Q96S94 Q8IU81 CCNL2 IRF2BP1 0.126 26186194 Q8IU81 P48431 IRF2BP1 SOX2 0.126 23667531 Q8IU81 Q14135 IRF2BP1 VGLL4 0.126 26186194 Q8IU81 Q00978 IRF2BP1 IRF9 0.309 12799427 Q8IU81 Q15274 IRF2BP1 QPRT 0.126 26186194 Q8IU81 Q13469 IRF2BP1 NFATC2 0.126 27637333 Q8IU81 P15336 IRF2BP1 ATF2 0.454 18671972 Q8IU81 P15408 IRF2BP1 FOSL2 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 OBSL1 IRF2BP1 MI:0045 experimental interaction detection MI:0461 interaction database NTRK1 IRF2BP1 MI:0045 experimental interaction detection MI:0461 interaction database UBC IRF2BP1 MI:0045 experimental interaction detection MI:0461 interaction database IRF2 IRF2BP1 MI:0045 experimental interaction detection MI:0461 interaction database ATF2 IRF2BP1 MI:0045 experimental interaction detection MI:0461 interaction database FOSL2 IRF2BP1 MI:0045 experimental interaction detection MI:0461 interaction database SOX2 IRF2BP1 MI:0045 experimental interaction detection MI:0461 interaction database SUMO3 IRF2BP1 MI:0362 inference MI:0461 interaction database SUMO2 IRF2BP1 MI:0045 experimental interaction detection MI:0461 interaction database SUMO1 IRF2BP1 MI:0045 experimental interaction detection MI:0461 interaction database IRF9 IRF2BP1 MI:0045 experimental interaction detection MI:0461 interaction database RAB33A IRF2BP1 MI:0362 inference MI:0461 interaction database VGLL4 IRF2BP1 MI:0045 experimental interaction detection MI:0461 interaction database QPRT IRF2BP1 MI:0045 experimental interaction detection MI:0461 interaction database TGIF1 IRF2BP1 MI:0362 inference MI:1106 pathways database SMAD1 IRF2BP1 MI:0045 experimental interaction detection MI:0461 interaction database SUMO4 IRF2BP1 MI:0362 inference MI:0461 interaction database IRF2BP1 JDP2 MI:0045 experimental interaction detection MI:0461 interaction database IRF2BP1 SH3KBP1 MI:0045 experimental interaction detection MI:0461 interaction database IRF2BP1 CCNL2 MI:0045 experimental interaction detection MI:0461 interaction database IRF2BP1 PCBD2 MI:0045 experimental interaction detection MI:0461 interaction database