PTM - CPLM Gene Name UniProt ID Type Position Code IRF2BP1 Q8IU81 Ubiquitination 314 K IRF2BP1 Q8IU81 Ubiquitination 438 K IRF2BP1 Q8IU81 Ubiquitination 227 K IRF2BP1 Q8IU81 Ubiquitination 247 K IRF2BP1 Q8IU81 Ubiquitination 306 K IRF2BP1 Q8IU81 Ubiquitination 198 K IRF2BP1 Q8IU81 Ubiquitination 200 K

PTM - dbPAF Gene Name UniProt ID Position Type Species IRF2BP1 Q8IU81 118 S Homo sapiens(Human) IRF2BP1 Q8IU81 125 S Homo sapiens(Human) IRF2BP1 Q8IU81 130 Y Homo sapiens(Human) IRF2BP1 Q8IU81 186 S Homo sapiens(Human) IRF2BP1 Q8IU81 237 S Homo sapiens(Human) IRF2BP1 Q8IU81 268 Y Homo sapiens(Human) IRF2BP1 Q8IU81 371 S Homo sapiens(Human) IRF2BP1 Q8IU81 377 T Homo sapiens(Human) IRF2BP1 Q8IU81 384 S Homo sapiens(Human) IRF2BP1 Q8IU81 413 S Homo sapiens(Human) IRF2BP1 Q8IU81 416 T Homo sapiens(Human) IRF2BP1 Q8IU81 421 S Homo sapiens(Human) IRF2BP1 Q8IU81 436 S Homo sapiens(Human) IRF2BP1 Q8IU81 453 S Homo sapiens(Human) IRF2BP1 Q8IU81 457 S Homo sapiens(Human) IRF2BP1 Q8IU81 459 T Homo sapiens(Human) IRF2BP1 Q8IU81 478 S Homo sapiens(Human) IRF2BP1 Q8IU81 480 T Homo sapiens(Human) IRF2BP1 Q8IU81 487 S Homo sapiens(Human) IRF2BP1 Q8IU81 491 S Homo sapiens(Human) IRF2BP1 Q8IU81 493 T Homo sapiens(Human) IRF2BP1 Q8IU81 496 T Homo sapiens(Human) IRF2BP1 Q8IU81 66 S Homo sapiens(Human)

PTM - PhosSNP Gene Name dbSNP ID Gene Mutation AA Mutation Mutation Position Code Peptide Score Modification Type IRF2BP1 rs60158447 GCT->GGT A->G 421 S AETPGVPSPIAALKN 421 Phosphorylation TypeIII-

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q8IU81 R120-m1 Methylation DRATSSGrLPLPsPA Q8IU81 R177-m1 Methylation AVSGLGSrGLTLAPG Q8IU81 R189-m1 Methylation APGLsPArPLFGsDF Q8IU81 R245-m1 Methylation ACAPFNVrFKKDHGL Q8IU81 S58-p Phosphorylation AARQLKRsHVLPEGR Q8IU81 S66-p Phosphorylation HVLPEGRsPGPPALK Q8IU81 S125-p Phosphorylation SGrLPLPsPALEyTL Q8IU81 Y130-p Phosphorylation LPsPALEyTLGSRLA Q8IU81 S186-p Phosphorylation LTLAPGLsPArPLFG Q8IU81 S194-p Phosphorylation PArPLFGsDFEKEKQ Q8IU81 S237-p Phosphorylation REQLLALsACAPFNV Q8IU81 Y268-p Phosphorylation ATARPPGyEFELKLF Q8IU81 S371-p Phosphorylation GPPPRAPsRNLAPtP Q8IU81 T377-p Phosphorylation PsRNLAPtPRRRkAs Q8IU81 S384-p Phosphorylation tPRRRkAsPEPEGEA Q8IU81 S413-p Phosphorylation VAPGGPYsAEtPGVP Q8IU81 T416-p Phosphorylation GGPYsAEtPGVPsPI Q8IU81 S421-p Phosphorylation AEtPGVPsPIAALKN Q8IU81 S436-p Phosphorylation VAEALGHsPkDPGGG Q8IU81 S453-p Phosphorylation PVRAGGAsPAAsSTA Q8IU81 S457-p Phosphorylation GGAsPAAsSTAQPPT Q8IU81 S478-p Phosphorylation RNGEAEVsPTAGAEA Q8IU81 K314-sm Sumoylation ALASSGFkYLEYERR Q8IU81 K382-sm Sumoylation APtPRRRkAsPEPEG Q8IU81 K306-ub Ubiquitination DALREPGkALASSGF Q8IU81 K314-ub Ubiquitination ALASSGFkYLEYERR Q8IU81 K438-ub Ubiquitination EALGHsPkDPGGGGG

PTM - dbPTM UniProt ID Position Code Type Resources References Q8IU81 2 A Acetylation Swiss-Prot 1010711 19413330 Q8IU81 66 S Phosphorylation Swiss-Prot 1010711 18669648 Q8IU81 125 S Phosphorylation Swiss-Prot 1010711 18220336;19690332 Q8IU81 186 S Phosphorylation Swiss-Prot 1010711 18669648 Q8IU81 421 S Phosphorylation Swiss-Prot 1010711 17081983;18669648 Q8IU81 436 S Phosphorylation Swiss-Prot 1010711 17081983;18669648;19690332 Q8IU81 453 S Phosphorylation Swiss-Prot 1010711 17081983;18220336;18669648 Q8IU81 457 S Phosphorylation Swiss-Prot 1010711 18669648 Q8IU81 314 K Ubiquitylation Phosphositeplus.1010730 21890473 Q8IU81 438 K Ubiquitylation Phosphositeplus.1010730 21890473 Q8IU81 125 S Phosphorylation Phosphositeplus.1010730 18220336;19690332 Q8IU81 186 S Phosphorylation Phosphositeplus.1010730 18669648;20068231;22115753 Q8IU81 384 S Phosphorylation Phosphositeplus.1010730 20068231;20363803;20562096;21406692;21659604;22115753 Q8IU81 421 S Phosphorylation Phosphositeplus.1010730 18669648;19362540;20068231;22115753 Q8IU81 436 S Phosphorylation Phosphositeplus.1010730 17081983;18669648;19276368;19362540;19690332;20068231;20363803;20393185;21406692;21659604;22115753 Q8IU81 453 S Phosphorylation Phosphositeplus.1010730 18220336;18669648;19276368;19664995;20068231;20363803;20393185;21406692;21659604;22115753 Q8IU81 457 S Phosphorylation Phosphositeplus.1010730 18669648 Q8IU81 66 S Phosphorylation Phosphositeplus.1010730 18669648;20068231;20363803;21406692;22115753 Q8IU81 130 Y Phosphorylation Phosphositeplus.1010730 20562096 Q8IU81 268 Y Phosphorylation Phosphositeplus.1010730 17360941 Q8IU81 66 S Phosphorylation HPRD 9.0 18669648,20068231 Q8IU81 186 S Phosphorylation HPRD 9.0 18669648,20068231 Q8IU81 384 S Phosphorylation HPRD 9.0 19651622,18212344,20068231 Q8IU81 421 S Phosphorylation HPRD 9.0 17081983,18669648,20068231 Q8IU81 436 S Phosphorylation HPRD 9.0 17081983,18669648,19651622,18452278,20068231 Q8IU81 453 S Phosphorylation HPRD 9.0 17081983,18669648,19664995,19651622,18452278,20068231 Q8IU81 457 S Phosphorylation HPRD 9.0 18669648 Q8IU81 491 S Phosphorylation HPRD 9.0 20068231 Q8IU81 493 T Phosphorylation HPRD 9.0 20068231 Q8IU81 66 S Phosphorylation SysPTM 1.1 18669648 Q8IU81 186 S Phosphorylation SysPTM 1.1 18669648 Q8IU81 384 S Phosphorylation SysPTM 1.1 18212344 Q8IU81 421 S Phosphorylation SysPTM 1.1 18669648;17081983 Q8IU81 436 S Phosphorylation SysPTM 1.1 18669648;17081983 Q8IU81 453 S Phosphorylation SysPTM 1.1 18669648;17081983 Q8IU81 457 S Phosphorylation SysPTM 1.1 18669648

PTM - HPRD Symbol Position Code Type References IRF2BP1 186 S Phosphorylation 18669648,20068231 IRF2BP1 384 S Phosphorylation 19651622,18212344,20068231 IRF2BP1 421 S Phosphorylation 17081983,18669648,20068231 IRF2BP1 436 S Phosphorylation 17081983,18669648,19651622,18452278,20068231 IRF2BP1 453 S Phosphorylation 17081983,18669648,19664995,19651622,18452278,20068231 IRF2BP1 457 S Phosphorylation 18669648 IRF2BP1 491 S Phosphorylation 20068231 IRF2BP1 493 T Phosphorylation 20068231 IRF2BP1 66 S Phosphorylation 18669648,20068231

PTM - UniProt UniProt ID Position Type PMIDs Q8IU81 66 Phosphoserine 20068231;23186163;24275569 Q8IU81 125 Phosphoserine 18220336;23186163 Q8IU81 177 Omega-N-methylarginine 24129315 Q8IU81 186 Phosphoserine 18669648 Q8IU81 371 Phosphoserine 23186163 Q8IU81 384 Phosphoserine 20068231 Q8IU81 421 Phosphoserine 18669648;20068231;23186163;24275569 Q8IU81 436 Phosphoserine 17081983;19690332;20068231;21406692;23186163;24275569 Q8IU81 453 Phosphoserine 18220336;18669648;20068231;21406692;23186163;24275569 Q8IU81 457 Phosphoserine 18669648

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type IRF2BP1 IPI00645608 S 186 TLAPGLpSPARPLF phosphorylation IRF2BP1 IPI00645608 S 421 ETPGVPpSPIAALK phosphorylation IRF2BP1 IPI00645608 S 436 AEALGHpSPKDPGG phosphorylation IRF2BP1 IPI00645608 S 453 VRAGGApSPAASST phosphorylation IRF2BP1 IPI00645608 S 66 VLPEGRpSPGPPAL phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 26145 117576 - K Sumoylation 21693764 26145 117576 - K Ubiquitination 21139048 26145 117576 - K Ubiquitination 21890473 26145 117576 - K Sumoylation 19471022 26145 117576 - K Sumoylation 21252943 26145 117576 - K Ubiquitination 22505724 26145 117576 - K Sumoylation 24654937 26145 117576 - K Ubiquitination 24816145 26145 117576 - K Sumoylation 25027693

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID IRF2BP1 Homo sapiens (Human) 314; 438 "314,LASSGFKYLEYER; 438,ALGHSPKDPGGGG" 314:21890473; 438:21890473 IRF2BP1 Homo sapiens (Human) 314; 438 "314,LASSGFKYLEYER; 438,ALGHSPKDPGGGG" 314:21890473; 438:21890473