PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus XIAP TRIM8 22493164 biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G G GP GP G GP G GP GP G RCHY1 TRIM8 22493164 biogrid,intact exp G GP G G G GP G GP GP G GP G GP G G GP GP G GP G G G GP G GP G GP G G TP53 TRIM8 22262183 biogrid exp G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G USP2 TRIM8 23105109 biogrid exp GP G P GP G GP P G GP GP GP GP P GP GP GP G GP P GP GP GP P P GP G TRIM8 TRIM9 22493164 biogrid,intact exp G G G G G G G G G G G UBE2V1 TRIM8 19549727 biogrid,intact exp TRIM24 TRIM8 22493164 biogrid,intact exp G G G G G G G G GP G G G GP GP G GP G GP G G GP GP GP GP GP G GP GP G SIAH1 TRIM8 22493164 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2D3 TRIM8 19549727 biogrid,intact exp GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G UBE2L6 TRIM8 19549727 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G USP7 TRIM8 21988832,23105109 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PCGF5 TRIM8 22493164 biogrid,intact exp GP G G G G GP G G G G GP G G G G GP GP G G G G G G GP GP G GP GP G BRAP TRIM8 22493164 biogrid,intact exp P P G GP P GP P P P P P G GP P P G GP P GP GP GP P P GP UBE2D2 TRIM8 19549727,22084099 biogrid,intact exp GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G TRIM8 NOD2 22829933 intact exp P G GP P P P GP P P P P P P P P P GP P TRIM8 MSL2 22493164 biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G GP GP G GP GP G TRIM47 TRIM8 22493164 biogrid,intact exp GP P G P GP G GP GP G GP GP GP GP G GP GP G GP P GP GP GP GP GP G ELAVL1 TRIM8 19322201 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G RNF111 TRIM8 22493164 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM25 TRIM8 22493164 biogrid,intact exp G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G TRIM8 TRIM15 22493164 biogrid,intact exp P P G GP GP G P GP GP GP P P G GP GP G GP G GP GP P GP GP GP P G TRIM8 TRIM15 22493164 biogrid,intact exp P P G GP GP G P GP GP GP P P G GP GP G GP G GP GP P GP GP GP P G CBL TRIM8 22493164 biogrid,intact exp G GP G G GP GP G G GP G GP G GP GP G G GP GP G G G G G G G GP G GP G TRIM21 TRIM8 22493164 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G OTUB2 TRIM8 23105109 biogrid exp P P P P P P P P GP TNFAIP3 TRIM8 23105109 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G TRAF5 TRIM8 22493164 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G TRIM8 UBE2D4 19549727 biogrid,intact exp GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G RNF138 TRIM8 22493164 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G TRIM8 RNF7 22493164 biogrid,intact exp GP GP G G GP GP G G GP G GP GP G GP G GP GP G GP G GP GP G G GP GP GP GP G TRIM8 RC3H2 22493164 biogrid,intact exp GP G G G G GP G GP GP G GP GP G G G GP GP G GP G G G GP G GP G GP GP G UBE2D1 TRIM8 19549727 biogrid,intact exp GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G TRIM43 TRIM8 22493164 biogrid,intact exp P P P P P P P P P P P P P P P P P P MKRN3 TRIM8 22493164 biogrid,intact exp P P P P P P P P P P P P P P P P P P P TRIM8 PIAS3 20516148 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF113A TRIM8 22493164 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM8 USP21 23105109 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G RNF141 TRIM8 22493164 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM27 TRIM8 22829933 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM8 RAD18 22493164 biogrid,intact exp P P P P GP P P G P P GP P UHRF2 TRIM8 22493164 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ITSN1 TRIM8 22558309 biogrid exp G GP G G G GP G GP GP G GP GP GP GP G GP GP G G G GP G GP GP GP G GP GP G UBE2W TRIM8 19549727 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USP39 TRIM8 23105109 biogrid exp G G G G G G G G G G G G G G G G G G G G G G CCNH TRIM8 21988832 biogrid,intact exp G GP G G G GP G G GP G GP GP G G G GP GP G GP G G GP G G GP G GP GP G TRIM8 RNF41 22493164 biogrid,intact exp GP GP G G G GP G GP GP G GP P G G GP GP P P G P G P GP GP GP GP P TRIM8 RNF181 22493164 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G MAP3K7 TRIM8 22084099 biogrid exp GP GP G G G GP G G GP G G GP GP G G G GP G GP G GP GP G G G G GP GP G HSP90AB1 TRIM8 21689689 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM8 TRIM8 22829933,22493164,11331580 hprd,biogrid,intact exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS1 TRIM8 12163497, 25402006, 21836163 hprd exp, ortho, pred GP GP P P GP GP GP GP GP GP G GP P GP GP G GP P GP P GP GP GP GP G TRIM8 TRIM39 22493164, 16082366 biogrid,intact exp, pred P P P P P P P P P P P P P TRIM8 TRIM2 22493164, 16082366 biogrid,intact exp, pred GP G G GP G G GP G G G G G G G GP G G G G G G G G G G ARHGEF1 TRIM8 25402006 ortho, pred GP G G G GP G G G GP G GP G GP GP G GP G GP G G GP G GP G GP GP GP G G TRIM38 TRIM8 16082366 pred GP GP G GP P G GP GP GP GP GP GP G GP GP GP GP GP GP GP GP GP GP GP P G TRIM8 TRIM17 16082366 pred P P P P P P P P P P P P P P P P P P GP

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P21580 Q9BZR9 two hybrid 23105109 direct interaction X 2 Q93009 Q9BZR9 two hybrid 23105109 direct interaction X 2 Q93009 Q9BZR9 two hybrid 21988832 direct interaction X 2 Q9BZR9 P62837 pull down 22084099 direct interaction X 2 Q9BZR9 O75604-2 two hybrid 23105109 direct interaction X 2 Q9BZR9 Q9UK80 two hybrid 23105109 direct interaction X 2 Q9BZR9 Q96PM5-2 two hybrid 22493164 direct interaction X 2 Q9BZR9 Q9HBD1-6 two hybrid 22493164 direct interaction X 2 Q9BZR9 Q96PU4 two hybrid 22493164 direct interaction X 2 Q9BZR9 Q96BQ3 two hybrid 22493164 direct interaction X 2 Q9BZR9 Q9BZR9 two hybrid 22493164 direct interaction X 2 Q9BZR9 Q9P0P0 two hybrid 22493164 direct interaction X 2 Q9BZR9 A0A024R5T5 two hybrid 22493164 direct interaction X 2 Q9BZR9 O15164 two hybrid 22493164 direct interaction X 2 Q9BZR9 Q9UBF6-2 two hybrid 22493164 direct interaction X 2 Q9BZR9 two hybrid 22493164 direct interaction X 2 Q9BZR9 A0A024RB33 two hybrid 22493164 direct interaction X 2 Q9BZR9 A0A024RCP5 two hybrid 22493164 direct interaction X 2 Q9BZR9 two hybrid 21988832 direct interaction X 2 Q9BZR9 Q9BZR9 two hybrid 11331580 direct interaction X 2 Q9BZR9 P62837 two hybrid 19549727 direct interaction X 2 Q9BZR9 P61077-3 two hybrid 19549727 direct interaction X 2 Q9BZR9 A0A024RA90 two hybrid 19549727 direct interaction X 2 Q9BZR9 Q13404 two hybrid 19549727 direct interaction X 2 Q9BZR9 Q96FI0 two hybrid 19549727 direct interaction X 2 Q9BZR9 Q9Y6X2 affinity chromatography technology 20516148 physical association X 2 Q8IUQ4 Q9BZR9 two hybrid 22493164 direct interaction X 2 Q8WVD5 Q9BZR9 two hybrid 22493164 direct interaction X 2 P98170 Q9BZR9 two hybrid 22493164 direct interaction X 2 O15541 Q9BZR9 two hybrid 22493164 direct interaction X 2 Q5SRL0 Q9BZR9 two hybrid 22493164 direct interaction X 2 Q8WVD3-2 Q9BZR9 two hybrid 22493164 direct interaction X 2 Q13064 Q9BZR9 two hybrid 22493164 direct interaction X 2 Q96DC9 Q9BZR9 two hybrid 23105109 direct interaction X 2 Q9NS91 Q9BZR9 two hybrid 22493164 direct interaction X 2 P19474 Q9BZR9 two hybrid 22493164 direct interaction X 2 Q9BZR9 O43318-4 affinity chromatography technology 22084099 physical association X 2 Q9BZR9 O43318-4 enzymatic study 22084099 direct interaction X 2 Q9BZR9 A0A024RD80 pull down 21689689 direct interaction X 2 Q9BZR9 A0A024RD80 affinity chromatography technology 21689689 physical association X 2 Q9BZR9 P04637-7 affinity chromatography technology 22262183 physical association X 2 Q9BZR9 Q9HCI7-2 two hybrid 22493164 direct interaction X 2 Q9BZR9 P22681 two hybrid 22493164 direct interaction X 2 Q9BZR9 Q7Z569 two hybrid 22493164 direct interaction X 2 Q9BZR9 Q9C040 two hybrid 22493164 direct interaction X 2 Q9BZR9 Q86SE9 two hybrid 22493164 direct interaction X 2 Q9BZR9 O00463 two hybrid 22493164 direct interaction X 2 Q9BZR9 A0A087WW00 two hybrid 19549727 direct interaction X 2 Q9BZR9 O14933-2 two hybrid 19549727 direct interaction X 2 Q9BZR9 Q6PD56 two hybrid 22558309 direct interaction X 2 Q14258 Q9BZR9 two hybrid 22493164 direct interaction X 2 Q96LD4 Q9BZR9 two hybrid 22493164 direct interaction X 2 Q53GS9 Q9BZR9 two hybrid 23105109 direct interaction X 2 Q9BZR9 O15524 in vivo 12163497 - X 2 Q9BZR9 O15524 in vivo 12163497 - X 2 Q9BZR9 Q9BZR9 in vivo 11331580 - X 2 Q9BZR9 Q9BZR9 two hybrid 11331580 - X 2 Q9BZR9 Q9BZR9 in vitro 11331580 - X 2 Q9BZR9 P62837 two hybrid array 19549727 physical association X 2 Q9BZR9 Q13404 two hybrid array 19549727 physical association X 2 Q9BZR9 A0A024RA90 two hybrid array 19549727 physical association X 2 Q9BZR9 Q9BZR9 two hybrid array 22493164 physical association X 2 Q9BZR9 O15164 two hybrid array 22493164 physical association X 2 Q9BZR9 Q9P0P0 two hybrid array 22493164 physical association X 2 Q9BZR9 A0A024RB33 two hybrid array 22493164 physical association X 2 Q9BZR9 A0A024RCP5 two hybrid array 22493164 physical association X 2 Q9BZR9 Q96PU4 two hybrid array 22493164 physical association X 2 Q9BZR9 Q96BQ3 two hybrid array 22493164 physical association X 2 Q9BZR9 Q9BZR9 anti tag coimmunoprecipitation 22493164 physical association X 2 Q9BZR9 Q9BZR9 two hybrid 22829933 physical association X 2 Q8IUQ4 Q9BZR9 two hybrid array 22493164 physical association X 2 A0A024QZJ2 Q9BZR9 two hybrid array 19549727 physical association X 2 Q9UBF6 Q9BZR9 two hybrid array 22493164 physical association X 2 Q8WVD5 Q9BZR9 two hybrid array 22493164 physical association X 2 P98170 Q9BZR9 two hybrid array 22493164 physical association X 2 O15541 Q9BZR9 two hybrid array 22493164 physical association X 2 Q96PM5 Q9BZR9 two hybrid array 22493164 physical association X 2 A0A024R899 Q9BZR9 two hybrid array 22493164 physical association X 2 Q5SRL0 Q9BZR9 two hybrid array 22493164 physical association X 2 Q13064 Q9BZR9 two hybrid array 22493164 physical association X 2 Q8WVD3 Q9BZR9 two hybrid array 22493164 physical association X 2 O14933 Q9BZR9 two hybrid array 19549727 physical association X 2 Q96B02 Q9BZR9 two hybrid array 19549727 physical association X 2 Q9NS91 Q9BZR9 two hybrid array 22493164 physical association X 2 P19474 Q9BZR9 two hybrid array 22493164 physical association X 2 Q9BZR9 A0A024RDH2 two hybrid array 19549727 physical association X 2 Q9BZR9 P22681 two hybrid array 22493164 physical association X 2 Q9BZR9 Q7Z569 two hybrid array 22493164 physical association X 2 Q9BZR9 Q9HCI7 two hybrid array 22493164 physical association X 2 Q9BZR9 O00463 two hybrid array 22493164 physical association X 2 Q9BZR9 Q9C040 two hybrid array 22493164 physical association X 2 Q9BZR9 Q86SE9 two hybrid array 22493164 physical association X 2 Q9BZR9 Q9C026 two hybrid array 22493164 physical association X 2 Q9BZR9 Q9HC29 two hybrid 22829933 physical association X 2 Q9BZR9 P14373 two hybrid 22829933 physical association X 2 Q14258 Q9BZR9 two hybrid array 22493164 physical association X 2 Q96LD4 Q9BZR9 two hybrid array 22493164 physical association X 2 Q6ZNA4 Q9BZR9 two hybrid array 22493164 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B TRIM8 RNF7 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122585|BIOGRID_284136 bait|bait prey|prey MKRN3 TRIM8 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284082|UniProt_122444 prey|prey bait|bait UBE2D3 TRIM8 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124102|UniProt_101064 bait|bait prey|prey CCNH TRIM8 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_286545|UniProt_119337 bait|unspecified role prey|unspecified role UHRF2 TRIM8 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284030|UniProt_122589 prey|prey bait|bait TRIM8 USP21 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248216 prey bait HSP90AB1 TRIM8 MI:0096(pull down)|MI:0096(pull down) 21689689 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_211960|BIOGRID_211959 prey|prey bait|bait RNF113A TRIM8 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_283968|UniProt_122584 prey|prey bait|bait TRIM21 TRIM8 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122495|BIOGRID_284162 prey|bait bait|prey UBE2V1 TRIM8 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124104|UniProt_101121 bait|bait prey|prey ITSN1 TRIM8 MI:0018(two hybrid) 22558309 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_185843 bait prey USP39 TRIM8 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248231 bait prey PCGF5 TRIM8 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122591|BIOGRID_284106 prey|bait bait|prey USP2 TRIM8 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248172 bait prey TRIM8 RAD18 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284074|UniProt_122572 prey|bait bait|prey TRIM43 TRIM8 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284034|UniProt_122609 bait|bait prey|prey SIAH1 TRIM8 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284009|UniProt_122491 bait|prey prey|bait MAP3K7 TRIM8 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22084099 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_209460|BIOGRID_209458 prey|bait bait|prey TRIM47 TRIM8 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_283969|UniProt_122602 bait|prey prey|bait TRIM8 PIAS3 MI:0004(affinity chromatography technology) 20516148 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_161332 bait prey TRIM8 RNF181 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284073|UniProt_122550 prey|bait bait|prey UBE2W TRIM8 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124105|UniProt_101174 bait|bait prey|prey TNFAIP3 TRIM8 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248262 bait prey TRIM8 UBE2D4 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124103|UniProt_101158 prey|prey bait|bait TRIM8 TRIM39 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122588|BIOGRID_284163 bait|bait prey|prey TRIM8 MSL2 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122565|BIOGRID_283970 bait|prey prey|bait TRIM8 RC3H2 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_283967|UniProt_122561 prey|bait bait|prey TRIM24 TRIM8 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122512|BIOGRID_284086 prey|bait bait|prey CBL TRIM8 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284010|UniProt_122466 bait|prey prey|bait TRIM8 RNF41 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284154|UniProt_122586 bait|bait prey|prey TRAF5 TRIM8 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122583|BIOGRID_284128 prey|prey bait|bait RNF111 TRIM8 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122422|BIOGRID_284085 prey|prey bait|bait TRIM9 TRIM8 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284152|UniProt_122605 bait|prey prey|bait UBE2D1 TRIM8 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101013|BIOGRID_124100 bait|bait prey|prey XIAP TRIM8 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284029|UniProt_122459 bait|prey prey|bait OTUB2 TRIM8 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248247 bait prey USP7 TRIM8 MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832,23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_248194|BIOGRID_285859|UniProt_119946 bait|prey|unspecified role prey|bait|unspecified role RCHY1 TRIM8 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122543|BIOGRID_283966 prey|bait bait|prey BRAP TRIM8 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122507|BIOGRID_284056 prey|bait bait|prey TRIM25 TRIM8 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122502|BIOGRID_284055 prey|bait bait|prey TRIM15 TRIM8 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_283973|UniProt_122446 bait|prey prey|bait TRIM15 TRIM8 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_283973|UniProt_122446 bait|prey prey|bait RNF138 TRIM8 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122551|BIOGRID_283991 prey|bait bait|prey TRIM2 TRIM8 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284057|UniProt_122587 prey|prey bait|bait ELAVL1 TRIM8 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187038 bait prey RNF141 TRIM8 MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_122544 prey bait UBE2D2 TRIM8 MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid) 19549727,22084099 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_124101|BIOGRID_226019|UniProt_101039 bait|prey|bait prey|bait|prey UBE2L6 TRIM8 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101421|BIOGRID_124353 bait|bait prey|prey SOCS1 TRIM8 MI:0493(in vivo) 12163497 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_12535 - -

PPI - HINT Gene A Gene B PMID Method Quality TRAF5 TRIM8 22493164,22493164 0018,0397 HT UBE2L6 TRIM8 19549727,19549727 0397,0018 HT TRIM24 TRIM8 22493164,22493164 0018,0397 HT RNF113A TRIM8 22493164,22493164 0018,0397 HT MAP3K7 TRIM8 22084099,22084099 0415,0004 LC USP2 TRIM8 23105109 0018 LC TRIM27 TRIM8 22829933 0018 LC TRIM21 TRIM8 22493164,22493164 0018,0397 HT TNFAIP3 TRIM8 23105109 0018 LC CBL TRIM8 22493164,22493164 0018,0397 HT UBE2D1 TRIM8 19549727,19549727 0397,0018 HT CCNH TRIM8 21988832 0018 HT UBE2D3 TRIM8 19549727,19549727 0397,0018 HT UBE2D2 TRIM8 19549727,19549727 0397,0018 HT XIAP TRIM8 22493164,22493164 0018,0397 HT MKRN3 TRIM8 22493164,22493164 0018,0397 HT UBE2V1 TRIM8 19549727,19549727 0397,0018 HT TRIM25 TRIM8 22493164,22493164 0018,0397 HT ITSN1 TRIM8 22558309 0018 HT USP39 TRIM8 23105109 0018 LC RNF111 TRIM8 22493164,22493164 0018,0397 HT BRAP TRIM8 22493164,22493164 0018,0397 HT PCGF5 TRIM8 22493164,22493164 0018,0397 HT SIAH1 TRIM8 22493164,22493164 0018,0397 HT RNF138 TRIM8 22493164,22493164 0018,0397 HT RNF141 TRIM8 22493164,22493164 0018,0397 HT USP7 TRIM8 23105109,21988832 0018,0018 LC,HT UBE2W TRIM8 19549727,19549727 0397,0018 HT TRIM43 TRIM8 22493164,22493164 0018,0397 HT OTUB2 TRIM8 23105109 0018 LC TRIM47 TRIM8 22493164,22493164 0018,0397 HT RCHY1 TRIM8 22493164,22493164 0018,0397 HT UHRF2 TRIM8 22493164,22493164 0018,0397 HT TRIM8 TRIM8 22493164,22829933,22493164,11331580,22493164 0018,0018,0007,0018,0397 HT,LC TRIM8 TRIM15 22493164,22493164 0018,0397 HT TRIM8 TRIM9 22493164,22493164 0018,0397 HT TRIM8 TRIM2 22493164,22493164 0018,0397 HT TRIM8 RNF41 22493164,22493164 0018,0397 HT TRIM8 RC3H2 22493164,22493164 0018,0397 HT TRIM8 NOD2 22829933 0018 LC TRIM8 MSL2 22493164,22493164 0018,0397 HT TRIM8 TRIM39 22493164,22493164 0018,0397 HT TRIM8 RAD18 22493164,22493164 0018,0397 HT TRIM8 RNF181 22493164,22493164 0018,0397 HT TRIM8 MAGEC2 25590999 0018 LC TRIM8 RNF7 22493164,22493164 0018,0397 HT TRIM8 USP21 23105109 0018 LC TRIM8 UBE2D4 19549727,19549727 0397,0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9BZR9 Q53GS9 TRIM8 USP39 0.183 23105109 Q9BZR9 Q5NGF9 TRIM8 Q5NGF9 0.126 20711500 Q9HC29 Q9BZR9 NOD2 TRIM8 0.309 22829933 Q9BZR9 O75604 TRIM8 USP2 0.183 23105109 Q9BZR9 Q81MN9 TRIM8 PPK 0.126 20711500 Q9BZR9 Q81V76 TRIM8 Q81V76 0.126 20711500 Q9BZR9 P14373 TRIM8 TRIM27 0.309 22829933 Q9BZR9 P04637 TRIM8 TP53 0.21 22262183 Q9H5Z6 Q9BZR9 FAM124B TRIM8 0.236 unassigned1304 Q9HCI7 Q9BZR9 MSL2 TRIM8 0.286 22493164 Q9BZR9 Q8N3F0 TRIM8 MTURN 0.236 unassigned1304 Q9BZR9 Q8NEC5 TRIM8 CATSPER1 0.236 unassigned1304 Q9BZR9 Q8NFP7 TRIM8 NUDT10 0.236 unassigned1304 Q9BZR9 Q8TBB1 TRIM8 LNX1 0.236 unassigned1304 Q9BZR9 Q96PM5 TRIM8 RCHY1 0.286 22493164 Q9BZR9 Q96GG9 TRIM8 DCUN1D1 0.236 unassigned1304 Q9BZR9 Q96KP6 TRIM8 TNIP3 0.236 unassigned1304 Q9BZR9 Q96LD4 TRIM8 TRIM47 0.286 22493164 Q9BZR9 Q17RB8 TRIM8 LONRF1 0.236 unassigned1304 Q9BZR9 O00463 TRIM8 TRAF5 0.286 22493164 Q9BZR9 Q6ZNA4 TRIM8 RNF111 0.286 22493164 Q9BZR9 P08238 TRIM8 HSP90AB1 0.454 21689689 Q9H4P4 Q9BZR9 RNF41 TRIM8 0.286 22493164 Q9C040 Q9BZR9 TRIM2 TRIM8 0.286 22493164 Q9C019 Q9BZR9 TRIM15 TRIM8 0.286 22493164 Q9C019 Q9BZR9 TRIM15 TRIM8 0.286 22493164 Q9BZR9 P19474 TRIM8 TRIM21 0.286 22493164 Q9BZR9 Q63HR2 TRIM8 TENC1 0.236 unassigned1304 Q9BZR9 P98170 TRIM8 XIAP 0.286 22493164 Q9BZR9 P45974 TRIM8 USP5 0.236 unassigned1304 Q9BZR9 Q5VVQ6 TRIM8 YOD1 0.236 unassigned1304 Q9BZR9 O94888 TRIM8 UBXN7 0.236 unassigned1304 Q9BZR9 P49639 TRIM8 HOXA1 0.236 unassigned1304 Q9BZR9 O14787 TRIM8 TNPO2 0.236 unassigned1304 Q9BZR9 O14964 TRIM8 HGS 0.236 unassigned1304 Q9BZR9 P54725 TRIM8 RAD23A 0.236 unassigned1304 Q9BZR9 P57075 TRIM8 UBASH3A 0.236 unassigned1304 Q9BZR9 Q96DC9 TRIM8 OTUB2 0.376 unassigned1304,23105109 Q9BZR9 Q9BZR9 TRIM8 TRIM8 0.748 11331580,22829933,22493164 Q9BZR9 Q8WVD3 TRIM8 RNF138 0.286 22493164 Q9BZR9 Q8WVD5 TRIM8 RNF141 0.286 22493164 Q9BZR9 Q96BQ3 TRIM8 TRIM43 0.286 22493164 Q9BZR9 Q96PU4 TRIM8 UHRF2 0.286 22493164 Q9BZR9 O14933 TRIM8 UBE2L6 0.454 19549727,unassigned1304 Q9BZR9 O15164 TRIM8 TRIM24 0.286 22493164 Q9BZR9 O15541 TRIM8 RNF113A 0.286 22493164 Q9BZR9 O43318 TRIM8 MAP3K7 0.454 22084099 Q9BZR9 P22681 TRIM8 CBL 0.286 22493164 Q9BZR9 P51668 TRIM8 UBE2D1 0.454 19549727,unassigned1304 Q9BZR9 P51946 TRIM8 CCNH 0.332 21988832 Q9BZR9 P61077 TRIM8 UBE2D3 0.286 19549727 Q9BZR9 P62837 TRIM8 UBE2D2 0.286 19549727 Q9BZR9 Q13064 TRIM8 MKRN3 0.286 22493164 Q9BZR9 Q13404 TRIM8 UBE2V1 0.286 19549727 Q9BZR9 Q14258 TRIM8 TRIM25 0.286 22493164 Q9BZR9 Q7Z569 TRIM8 BRAP 0.286 22493164 Q9BZR9 Q81NR7 TRIM8 Q81NR7 0.126 20711500 Q9BZR9 Q81T57 TRIM8 Q81T57 0.126 20711500 Q9BZR9 Q86SE9 TRIM8 PCGF5 0.286 22493164 Q9BZR9 Q8IUQ4 TRIM8 SIAH1 0.286 22493164 Q9BZR9 Q93009 TRIM8 USP7 0.454 23105109,21988832 Q9BZR9 Q96B02 TRIM8 UBE2W 0.376 19549727 Q9C026 Q9BZR9 TRIM9 TRIM8 0.286 22493164 Q9HBD1 Q9BZR9 RC3H2 TRIM8 0.286 22493164 Q9HCM9 Q9BZR9 TRIM39 TRIM8 0.286 22493164 Q9NS91 Q9BZR9 RAD18 TRIM8 0.286 22493164 Q9P0P0 Q9BZR9 RNF181 TRIM8 0.286 22493164 Q9UBF6 Q9BZR9 RNF7 TRIM8 0.286 22493164 Q9Y2X8 Q9BZR9 UBE2D4 TRIM8 0.523 19549727,unassigned1304 Q9Y6X2 Q9BZR9 PIAS3 TRIM8 0.21 20516148 Q9UBF1 Q9BZR9 MAGEC2 TRIM8 0.309 25590999 Q9UK80 Q9BZR9 USP21 TRIM8 0.183 23105109 Q9BZR9 C5E527 TRIM8 PB2 {ECO:0000256|RULEBASE:RU361246, ECO:0000313|EMBL:ACQ84476.1} 0.126 unassigned1333 Q9BZR9 P43355 TRIM8 MAGEA1 0.21 25590999 Q9BZR9 Q15717 TRIM8 ELAVL1 0.126 19322201 Q9BZR9 Q15811 TRIM8 ITSN1 0.183 22558309 Q9BZR9 P21580 TRIM8 TNFAIP3 0.183 23105109

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 TRAF5 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database UBE2L6 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database TRIM24 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database SOCS1 TRIM8 MI:0362 inference MI:0461 interaction database RNF113A TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database MAP3K7 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database USP2 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database TP53 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database TRIM27 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database TNFAIP3 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database CBL TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database MAGEA1 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D1 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database CCNH TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database XIAP TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database MKRN3 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database UBE2V1 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database TRIM25 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database ELAVL1 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database ITSN1 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database USP39 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database RNF111 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database BRAP TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database PCGF5 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database SIAH1 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database RNF138 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database RNF141 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database ARHGEF1 TRIM8 MI:0362 inference MI:0461 interaction database USP7 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database UBE2W TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database TRIM43 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database OTUB2 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database TRIM47 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database RCHY1 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database UHRF2 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database TRIM8 TRIM15 MI:0045 experimental interaction detection MI:0461 interaction database TRIM8 TRIM9 MI:0045 experimental interaction detection MI:0461 interaction database TRIM8 TRIM2 MI:0045 experimental interaction detection MI:0461 interaction database TRIM8 RNF41 MI:0045 experimental interaction detection MI:0461 interaction database TRIM8 RC3H2 MI:0045 experimental interaction detection MI:0461 interaction database TRIM8 NOD2 MI:0045 experimental interaction detection MI:0461 interaction database TRIM8 MSL2 MI:0045 experimental interaction detection MI:0461 interaction database TRIM8 TRIM39 MI:0045 experimental interaction detection MI:0461 interaction database TRIM8 RAD18 MI:0045 experimental interaction detection MI:0461 interaction database TRIM8 RNF181 MI:0045 experimental interaction detection MI:0461 interaction database TRIM8 MAGEC2 MI:0045 experimental interaction detection MI:0461 interaction database TRIM8 RNF7 MI:0045 experimental interaction detection MI:0461 interaction database TRIM8 USP21 MI:0045 experimental interaction detection MI:0461 interaction database TRIM8 UBE2D4 MI:0045 experimental interaction detection MI:0461 interaction database TRIM8 PIAS3 MI:0045 experimental interaction detection MI:0461 interaction database