PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus EIF2S2 RNF26 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G RAB6A RNF26 26186194 biogrid exp GP GP G G G GP G G GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G RNF26 UBE2D4 19549727 biogrid,intact exp GP G G G GP GP G G GP G GP GP GP GP G G GP G GP G GP GP G G G GP GP GP G ZMPSTE24 RNF26 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G G GP G GP GP G EEF1A2 RNF26 26186194 biogrid exp G G GP G GP G G P P G G GP GP G P GP G G G GP G G PSME1 RNF26 26186194 biogrid exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G CYB5R3 RNF26 26186194 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G ZNF143 RNF26 26186194 biogrid exp G GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP G G GP GP GP GP G UBE2E1 RNF26 19549727 biogrid,intact exp GP GP G G G GP G G GP G GP G G GP G GP GP G G G GP G G G GP G GP GP G UBE2Q1 RNF26 19690564 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2D3 RNF26 19549727,19690564 biogrid,intact exp GP G G G GP GP G G GP G GP GP GP GP G G GP G GP G GP GP G G G GP GP GP G UBE2W RNF26 19549727,19690564 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G UBE2D1 RNF26 19549727 biogrid,intact exp GP G G G GP GP G G GP G GP GP GP GP G G GP G GP G GP GP G G G GP GP GP G RNF26 CUEDC2 26186194 biogrid exp G G G G GP GP G G G G GP G GP G G GP GP G G G G G G G GP G G G G ARF5 RNF26 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2D2 RNF26 19549727,19690564 biogrid,intact exp GP G G G GP GP G G GP G GP GP GP GP G G GP G GP G GP GP G G G GP GP GP G ETF1 RNF26 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G G GP G GP GP G STOM RNF26 26186194 biogrid exp G G G G GP GP G G GP G GP GP GP G G GP GP G G G GP G G G GP GP G GP G RNF26 RAB1B 26186194 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G RBM26 RNF26 26186194 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G RAB2A RNF26 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G UBE2U RNF26 19690564 biogrid,intact exp P P P P P P P P P P P P P P P P P GP UBE2G2 RNF26 19690564 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G NEDD4 RNF26 25402006 pred GP GP G GP P G GP GP GP G GP GP G GP GP G GP G GP GP G G GP GP GP P G ZNRF1 RNF26 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G RNF4 RNF26 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP G G G GP GP G G G G GP GP G RNF26 AMFR 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G RNF43 RNF26 25402006 pred P GP P P P GP GP G P P G GP P G GP G GP GP G GP P GP GP G RNF111 RNF26 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G RNF26 RNF11 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G XIAP RNF26 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G G GP G G GP G GP GP G OTUB1 RNF26 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G RNF26 TRAF6 25402006 pred GP GP G G GP G G GP GP G GP GP GP G G GP G G G G GP GP G G GP GP GP GP G RNF126 RNF26 25402006 pred GP G G G GP GP G G GP G GP G GP GP G GP GP G P G GP GP G G GP GP GP GP G RFWD3 RNF26 25402006 pred G G G G G G G G G G G G G G G G G G PJA2 RNF26 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G RNF25 RNF26 25402006 pred P G P P P P P P P P P P P P GP P P RNF125 RNF26 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP G G GP GP GP P G DTX3L RNF26 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP G G G GP GP GP GP G SIAH1 RNF26 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G DZIP3 RNF26 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G P GP G G GP G GP GP G CNOT4 RNF26 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9BY78 A0A024RA90 two hybrid 19549727 direct interaction X 2 Q9BY78 Q96FI0 two hybrid 19549727 direct interaction X 2 Q9BY78 two hybrid 19690564 direct interaction X 2 Q9BY78 Q96FI0 two hybrid 19690564 direct interaction X 2 Q7Z7E8 Q9BY78 two hybrid 19690564 direct interaction X 2 Q9BY78 A0A087WW00 two hybrid 19549727 direct interaction X 2 Q9BY78 P62837 two hybrid 19549727 direct interaction X 2 Q9BY78 P61077-3 two hybrid 19549727 direct interaction X 2 Q9BY78 A0A024R2K3 two hybrid 19549727 direct interaction X 2 Q9BY78 P62837 two hybrid 19690564 direct interaction X 2 Q9BY78 P61077-3 two hybrid 19690564 direct interaction X 2 Q9BY78 P60604-2 two hybrid 19690564 direct interaction X 2 Q9BY78 A0A024RA90 two hybrid 19549727 physical association X 2 P60604 Q9BY78 two hybrid array 19690564 physical association X 2 Q7Z7E8 Q9BY78 two hybrid array 19690564 physical association X 2 Q96B02 Q9BY78 two hybrid 19549727 physical association X 2 Q96B02 Q9BY78 two hybrid array 19690564 physical association X 2 Q9BY78 P62837 two hybrid 19549727 physical association X 2 Q9BY78 A0A024RDH2 two hybrid 19549727 physical association X 2 Q9BY78 A0A024R2K3 two hybrid 19549727 physical association X 2 Q9BY78 P62837 two hybrid array 19690564 physical association X 2 Q9BY78 A0A024RDH2 two hybrid array 19690564 physical association X 2 Q9BY78 Q5VVX9 two hybrid array 19690564 physical association X 2 A0A024QZJ2 Q9BY78 two hybrid 19549727 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBE2U RNF26 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102658|BIOGRID_123669 bait|bait prey|prey UBE2D3 RNF26 MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0018(two hybrid) 19549727,19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact) BIOGRID_123495|UniProt_102485|UniProt_100825 bait|bait|bait prey|prey|prey UBE2W RNF26 MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0018(two hybrid) 19549727,19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact) BIOGRID_123706|UniProt_102695|UniProt_100922 bait|bait|bait prey|prey|prey RNF26 UBE2D4 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100910 prey bait UBE2G2 RNF26 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102570|BIOGRID_123581 bait|bait prey|prey UBE2Q1 RNF26 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102623|BIOGRID_123634 bait|bait prey|prey UBE2D1 RNF26 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100800 bait prey UBE2E1 RNF26 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100833 bait prey UBE2D2 RNF26 MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0018(two hybrid) 19549727,19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(biogrid) UniProt_100816|UniProt_102452|BIOGRID_123462 bait|bait|bait prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality ZMPSTE24 RNF26 26186194 0004 HT CYB5R3 RNF26 26186194 0004 HT EIF2S2 RNF26 26186194 0004 HT STOM RNF26 26186194 0004 HT ZNF143 RNF26 26186194 0004 HT RAB2A RNF26 26186194 0004 HT ETF1 RNF26 26186194 0004 HT ARF5 RNF26 26186194 0004 HT EEF1A2 RNF26 26186194 0004 HT Q53ET8 RNF26 26186194 0004 HT RBM26 RNF26 26186194 0004 HT Q86SZ9 RNF26 26186194 0004 HT RNF26 RAB1B 26186194 0004 HT RNF26 CUEDC2 26186194 0004 HT ZMPSTE24 RNF26 26186194 0004 HT CYB5R3 RNF26 26186194 0004 HT EIF2S2 RNF26 26186194 0004 HT STOM RNF26 26186194 0004 HT ZNF143 RNF26 26186194 0004 HT RAB2A RNF26 26186194 0004 HT ETF1 RNF26 26186194 0004 HT ARF5 RNF26 26186194 0004 HT EEF1A2 RNF26 26186194 0004 HT Q53ET8 RNF26 26186194 0004 HT RBM26 RNF26 26186194 0004 HT Q86SZ9 RNF26 26186194 0004 HT RNF26 RAB1B 26186194 0004 HT RNF26 CUEDC2 26186194 0004 HT UBE2D1 RNF26 19549727 0018 HT UBE2E1 RNF26 19549727 0018 HT UBE2G2 RNF26 19690564,19690564 0397,0018 HT UBE2D3 RNF26 19690564,19549727,19690564 0397,0018,0018 HT UBE2D2 RNF26 19690564,19549727,19690564 0397,0018,0018 HT UBE2U RNF26 19690564,19690564 0397,0018 HT UBE2Q1 RNF26 19690564,19690564 0397,0018 HT UBE2W RNF26 19690564,19549727,19690564 0397,0018,0018 HT RNF26 UBE2D4 19549727 0018 HT RNF26 MITA 25254379,25254379 0415,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9BY78 P62837 RNF26 UBE2D2 0.583 19690564,19549727 Q9BY78 Q86WV6 RNF26 TMEM173 0.454 25254379 Q9BY78 P51668 RNF26 UBE2D1 0.332 19549727 Q9BY78 O75844 RNF26 ZMPSTE24 0.126 26186194 Q9BY78 P00387 RNF26 CYB5R3 0.126 26186194 Q9BY78 P20042 RNF26 EIF2S2 0.126 26186194 Q9BY78 P20340 RNF26 RAB6A 0.126 26186194 Q9BY78 P27105 RNF26 STOM 0.126 26186194 Q9BY78 P51965 RNF26 UBE2E1 0.332 19549727 Q9BY78 P52747 RNF26 ZNF143 0.126 26186194 Q9BY78 P60604 RNF26 UBE2G2 0.376 19690564 Q9BY78 P61019 RNF26 RAB2A 0.126 26186194 Q9BY78 P61077 RNF26 UBE2D3 0.61 19690564,19549727 Q9BY78 P62495 RNF26 ETF1 0.126 26186194 Q9BY78 P84085 RNF26 ARF5 0.126 26186194 Q9BY78 Q05639 RNF26 EEF1A2 0.126 26186194 Q9BY78 Q06323 RNF26 PSME1 0.126 26186194 Q9BY78 Q5T8P6 RNF26 RBM26 0.126 26186194 Q9BY78 Q5VVX9 RNF26 UBE2U 0.286 19690564 Q9BY78 Q7Z7E8 RNF26 UBE2Q1 0.286 19690564 Q9BY78 Q96B02 RNF26 UBE2W 0.61 19690564,19549727 Q9H0U4 Q9BY78 RAB1B RNF26 0.126 26186194 Q9H467 Q9BY78 CUEDC2 RNF26 0.126 26186194 Q9Y2X8 Q9BY78 UBE2D4 RNF26 0.454 19549727

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 ZMPSTE24 RNF26 MI:0045 experimental interaction detection MI:0461 interaction database CYB5R3 RNF26 MI:0045 experimental interaction detection MI:0461 interaction database EIF2S2 RNF26 MI:0045 experimental interaction detection MI:0461 interaction database RAB6A RNF26 MI:0045 experimental interaction detection MI:0461 interaction database STOM RNF26 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D1 RNF26 MI:0045 experimental interaction detection MI:0461 interaction database UBE2E1 RNF26 MI:0045 experimental interaction detection MI:0461 interaction database ZNF143 RNF26 MI:0045 experimental interaction detection MI:0461 interaction database UBE2G2 RNF26 MI:0045 experimental interaction detection MI:0461 interaction database RAB2A RNF26 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 RNF26 MI:0045 experimental interaction detection MI:0461 interaction database ETF1 RNF26 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 RNF26 MI:0045 experimental interaction detection MI:0461 interaction database ARF5 RNF26 MI:0045 experimental interaction detection MI:0461 interaction database EEF1A2 RNF26 MI:0045 experimental interaction detection MI:0461 interaction database PSME1 RNF26 MI:0045 experimental interaction detection MI:0461 interaction database RBL2 RNF26 MI:0045 experimental interaction detection MI:0461 interaction database E2F4 RNF26 MI:0045 experimental interaction detection MI:0461 interaction database RBM26 RNF26 MI:0045 experimental interaction detection MI:0461 interaction database UBE2U RNF26 MI:0045 experimental interaction detection MI:0461 interaction database UBE2Q1 RNF26 MI:0045 experimental interaction detection MI:0461 interaction database TMEM173 RNF26 MI:0045 experimental interaction detection MI:0461 interaction database UBE2W RNF26 MI:0045 experimental interaction detection MI:0461 interaction database RNF26 RAB1B MI:0045 experimental interaction detection MI:0461 interaction database RNF26 CUEDC2 MI:0045 experimental interaction detection MI:0461 interaction database RNF26 UBE2D4 MI:0045 experimental interaction detection MI:0461 interaction database