PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus DVL2 KLHL15 20007894 i2d exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G KLHL15 LIMCH1 26186194 biogrid exp G GP G GP G GP GP G GP G GP GP G G GP GP GP G GP GP GP G G G GP GP COPS6 KLHL15 19615732,21145461 biogrid,intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G DCUN1D1 KLHL15 21145461 biogrid exp P G G G GP G P P G P P P P GP G GP G GP GP P GP GP P P GP G CUL3 KLHL15 23135275,21145461 innatedb,biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G KLHL15 KPTN 26186194 biogrid exp P GP G P GP G GP GP G GP GP GP GP GP GP P P G P GP GP GP GP GP GP GP G ZNF511 KLHL15 26186194 biogrid exp G G G G G GP G G GP G GP G G G G GP GP G GP G GP G GP G GP G G GP G PPP2CA KLHL15 23135275 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ACP5 KLHL15 26186194 biogrid exp G G G G G GP G GP G G G G G G G G G G G GP G G PPP2R1A KLHL15 23135275 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G KLHL15 CDC42EP4 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G HSP90AB1 KLHL15 22939624 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G KLHL15 WRAP73 26186194 biogrid exp GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G P GP GP GP GP G GP GP G NUDCD3 KLHL15 25036637 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PPP2R2B KLHL15 23135275 biogrid exp GP P G G G GP G GP GP G GP G GP G G GP GP G GP G GP G GP GP GP G GP GP G CER1 KLHL15 26186194 biogrid exp G G G G G G G G G G G G G GP G G G G G G G G G G G G G G PRRC2B KLHL15 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G IDS KLHL15 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KLHL15 COPS3 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G C2orf68 KLHL15 26186194 biogrid exp G GP G G GP GP G GP GP G GP G G GP G GP GP G GP G GP GP G GP GP GP GP G G CUL5 KLHL15 21145461 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G FAM122A KLHL15 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G KLHL15 KLHL15 23135275 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SAMD7 KLHL15 26186194 biogrid exp P P P P P P P P P P P P P P P P P P P P ZNF444 KLHL15 26186194 biogrid exp GP GP G G GP GP G G GP G GP G G GP G GP GP G G G GP G G G GP GP GP GP G HSP90AA1 KLHL15 22939624 biogrid exp GP GP G G G GP G G GP G G G G G G G GP G G G GP G G G G G G GP G COPS5 KLHL15 19615732,21145461 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NEDD8 KLHL15 21145461 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G KBTBD11 KLHL15 23023127 pred GP GP G G GP GP G P GP G GP GP GP GP G GP GP P P G P GP P GP GP GP P P G KLHL26 KLHL15 23023127 pred GP P G P GP G P GP G GP P P GP G GP GP P GP G P GP GP GP GP GP GP G KLHL38 KLHL15 23023127 pred P P P P P P P P P P P P P P P P P P P P P BTBD6 KLHL15 23023127 pred G G G G GP G G G GP G G G G GP G GP G G G G G G G GP GP G G G G KLHL15 BTBD9 23023127 pred P G G G GP GP G G GP G G G GP GP G G GP GP G G GP G G GP GP GP G BCL6 KLHL15 23023127 pred G G G G GP G G G G G G G G GP G G G G G G GP G G G G GP G G G KLHL12 KLHL15 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PRPF31 KLHL15 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SOCS3 KLHL15 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP GP GP G GP GP G ZBTB7B KLHL15 23023127 pred GP GP G GP P G GP G G G G GP G GP P G GP GP GP G GP G GP P ZBTB44 KLHL15 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q96M94 Q7L5N1 affinity chromatography technology 21145461 physical association X 2 Q96M94 Q96M94 affinity chromatography technology 23135275 physical association X 2 Q96M94 B3KUN1 affinity chromatography technology 23135275 physical association X 2 Q96M94 Q7L5N1 affinity chromatography technology 19615732 physical association X 2 Q96GG9 Q96M94 affinity chromatography technology 21145461 physical association X 2 A8K7B7 Q96M94 affinity chromatography technology 23135275 physical association X 2 A0A024R7W9 Q96M94 affinity chromatography technology 21145461 physical association X 2 A0A024R7W9 Q96M94 affinity chromatography technology 19615732 physical association X 2 P0CG48 Q96M94 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q96M94 affinity chromatography technology 21906983 physical association X 2 Q96M94 A0A024R475 affinity chromatography technology 21145461 physical association X 2 Q96M94 Q93034 affinity chromatography technology 21145461 physical association X 2 Q96M94 Q15843 affinity chromatography technology 21145461 physical association X 2 Q96M94 Q00005 affinity chromatography technology 23135275 physical association X 2 Q96M94 Q00005 affinity chromatography technology 23135275 physical association X 2 Q96M94 Q00005 affinity chromatography technology 23135275 physical association X 2 Q96M94 A0A024R475 affinity chromatography technology 23135275 physical association X 2 Q96M94 Q00005 pull down 23135275 direct interaction X 2 Q96M94 P07900-2 affinity chromatography technology 22939624 physical association X 2 Q8IVD9 Q96M94 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q96M94 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2 Q96M94 anti tag coimmunoprecipitation 19615732 physical association C 35 Q96M94 anti tag coimmunoprecipitation 19615732 physical association C 55

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q96M94 P22304 KLHL15 IDS 0.126 26186194 Q96M94 Q5JSZ5 KLHL15 PRRC2B 0.126 26186194 Q96M94 Q8N0Y2 KLHL15 ZNF444 0.126 26186194 Q96M94 Q8NB15 KLHL15 ZNF511 0.126 26186194 Q9H3Q1 Q96M94 CDC42EP4 KLHL15 0.126 26186194 Q96M94 P07900 KLHL15 HSP90AA1 0.126 22939624 Q9Y664 Q96M94 KPTN KLHL15 0.126 26186194 Q96M94 Q7Z3H4 KLHL15 SAMD7 0.126 26186194 Q96M94 P13686 KLHL15 ACP5 0.126 26186194 Q96M94 O95813 KLHL15 CER1 0.126 26186194 Q96M94 Q13618 KLHL15 CUL3 0.309 23135275,21145461 Q96M94 Q7L5N1 KLHL15 COPS6 0.332 19615732,21145461 Q96M94 Q92905 KLHL15 COPS5 0.332 19615732,21145461 Q96M94 Q93034 KLHL15 CUL5 0.126 21145461 Q96M94 Q96E09 KLHL15 FAM122A 0.126 26186194 Q96M94 Q96GG9 KLHL15 DCUN1D1 0.126 21145461 Q96M94 P08238 KLHL15 HSP90AB1 0.126 22939624 Q96M94 P30153 KLHL15 PPP2R1A 0.21 23135275 Q96M94 Q8IVD9 KLHL15 NUDCD3 0.126 25036637 Q96M94 Q00005 KLHL15 PPP2R2B 0.569 23135275 Q96M94 P67775 KLHL15 PPP2CA 0.21 23135275 Q96M94 Q96M94 KLHL15 KLHL15 0.236 23135275 Q9P2S5 Q96M94 WRAP73 KLHL15 0.126 26186194 Q9UNS2 Q96M94 COPS3 KLHL15 0.126 26186194 Q9UPQ0 Q96M94 LIMCH1 KLHL15 0.126 26186194 Q96M94 A6NHQ4 KLHL15 C17ORF96 0.126 27705803 Q96M94 Q15843 KLHL15 NEDD8 0.126 21145461 Q96M94 Q2NKX9 KLHL15 C2ORF68 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 CER1 KLHL15 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AA1 KLHL15 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 KLHL15 MI:0045 experimental interaction detection MI:0461 interaction database UBC KLHL15 MI:0045 experimental interaction detection MI:0461 interaction database ACP5 KLHL15 MI:0045 experimental interaction detection MI:0461 interaction database IDS KLHL15 MI:0045 experimental interaction detection MI:0461 interaction database PPP2R1A KLHL15 MI:0045 experimental interaction detection MI:0461 interaction database PPP2CA KLHL15 MI:0045 experimental interaction detection MI:0461 interaction database PPP2R2B KLHL15 MI:0045 experimental interaction detection MI:0461 interaction database CUL3 KLHL15 MI:0045 experimental interaction detection MI:0461 interaction database NEDD8 KLHL15 MI:0045 experimental interaction detection MI:0461 interaction database C2orf68 KLHL15 MI:0045 experimental interaction detection MI:0461 interaction database PRRC2B KLHL15 MI:0045 experimental interaction detection MI:0461 interaction database COPS6 KLHL15 MI:0045 experimental interaction detection MI:0461 interaction database SAMD7 KLHL15 MI:0045 experimental interaction detection MI:0461 interaction database NUDCD3 KLHL15 MI:0045 experimental interaction detection MI:0461 interaction database ZNF444 KLHL15 MI:0045 experimental interaction detection MI:0461 interaction database ZNF511 KLHL15 MI:0045 experimental interaction detection MI:0461 interaction database COPS5 KLHL15 MI:0045 experimental interaction detection MI:0461 interaction database CUL5 KLHL15 MI:0045 experimental interaction detection MI:0461 interaction database FAM122A KLHL15 MI:0045 experimental interaction detection MI:0461 interaction database DCUN1D1 KLHL15 MI:0045 experimental interaction detection MI:0461 interaction database KLHL15 CDC42EP4 MI:0045 experimental interaction detection MI:0461 interaction database KLHL15 WRAP73 MI:0045 experimental interaction detection MI:0461 interaction database KLHL15 COPS3 MI:0045 experimental interaction detection MI:0461 interaction database KLHL15 LIMCH1 MI:0045 experimental interaction detection MI:0461 interaction database KLHL15 KPTN MI:0045 experimental interaction detection MI:0461 interaction database