PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CDC25C BRSK2 15150265 hprd,biogrid exp G WEE1 BRSK2 15150265 hprd,biogrid exp G CDC25B BRSK2 15150265 hprd,biogrid exp G G G G G BRSK2 COPS5 22609399 biogrid exp G G G G G BRSK2 KBTBD7 20562859 biogrid,intact exp G G G G G VCP BRSK2 23907667 biogrid exp G G G G G BRSK2 FZR1 23029325, 25402006, 16082366 biogrid exp, ortho, pred G G G G G PRKAA1 BRSK2 16306228, 23023127 biogrid exp, pred G G G G YWHAE BRSK2 ortho G G G G G TTBK2 BRSK2 23023127 pred G G G G G BRSK2 TTN 23023127 pred G G G G G MAPK3 BRSK2 23023127 pred G G G G G ANK1 BRSK2 23023127 pred G G G G PXK BRSK2 23023127 pred G G G G G CAP2 BRSK2 23023127 pred G G G G G TEK BRSK2 23023127 pred G G G G G CDK8 BRSK2 23023127 pred G G G G G BRSK2 TAOK3 23023127 pred G G G G G BRSK2 CDK19 23023127 pred G G G G G ILK BRSK2 23023127 pred G G G G G MAP2K4 BRSK2 23023127 pred G G G G G GRK6 BRSK2 23023127 pred G G G G G BRSK2 SNRK 23023127 pred G G G G G TSSK4 BRSK2 23023127 pred G G BRSK2 MAST1 23023127 pred G G G G BRSK2 CDK20 23023127 pred G G G G CDKL1 BRSK2 23023127 pred MAPK8 BRSK2 23023127 pred G G G G G BRSK2 CAMK1G 23023127 pred G G G G MAST4 BRSK2 23023127 pred G G G G G PRKCB BRSK2 23023127 pred G G G G G BRSK2 CAMKV 23023127 pred G G G G G BRSK2 RPS6KC1 23023127 pred G G G G G ULK1 BRSK2 23023127 pred G G G G G MAP2K6 BRSK2 23023127 pred G G G G G BRSK2 CDKL2 23023127 pred G G G G G BRSK2 NUAK2 23023127 pred PRICKLE2 BRSK2 23023127 pred G G G G G SIK1 BRSK2 23023127 pred G G G G G PAK2 BRSK2 23023127 pred G G G G G PHKG2 BRSK2 23023127 pred G G G G G MARK3 BRSK2 23023127 pred G G G G G PRKAR2B BRSK2 23023127 pred G G G G G STK11 BRSK2 23023127 pred G G G G G CAMK1 BRSK2 23023127 pred G G G G G EPHA5 BRSK2 23023127 pred G G G G BRSK2 CDK15 23023127 pred G G G G PRKCG BRSK2 23023127 pred G G G G G BRSK2 SIK2 23023127 pred G G G G G BRSK2 STK24 23023127 pred G G G G G IGF1R BRSK2 23023127 pred G G G G G MAPK6 BRSK2 23023127 pred G G G G G EPHA7 BRSK2 23023127 pred G G G G G BRSK2 AKT3 23023127 pred G G G G G BRSK2 MARK1 23023127 pred G G G G G BRSK2 PASK 23023127 pred G G G G G BRSK2 PAK7 23023127 pred G G G G CAMK1D BRSK2 23023127 pred G G G G G BRSK2 PAK6 23023127 pred G G G G G MAP2K7 BRSK2 23023127 pred G G G G G KALRN BRSK2 23023127 pred G G G G VRK3 BRSK2 23023127 pred G G G G G DCLK1 BRSK2 23023127 pred G G G G G BRSK2 CAB39 21836163 pred G G G G G PRKCQ BRSK2 23023127 pred G G G G G PRKG2 BRSK2 23023127 pred G G G G G BRSK2 AURKC 23023127 pred G G G G MAP3K6 BRSK2 23023127 pred G CAMK4 BRSK2 23023127 pred G G G G G ACVR1B BRSK2 23023127 pred G G G G G NUAK1 BRSK2 23023127, 21836163 pred G G G G G RPS6KA2 BRSK2 23023127 pred G G G G G BRSK2 STK26 23023127 pred G DLG1 BRSK2 23023127 pred G G G G G STK25 BRSK2 23023127 pred G G G G G PAK3 BRSK2 23023127 pred G G G G G BRSK2 SIK3 23023127 pred G G G G G MAPK14 BRSK2 23023127 pred G G G G G BRSK2 TSSK1B 23023127 pred ULK3 BRSK2 23023127 pred G G G G G PAK1 BRSK2 23023127 pred G G G G G BRSK2 CAMK2A 25402006, 23023127 pred G G G G G AAK1 BRSK2 23023127 pred G G G G G CAMK2G BRSK2 23023127 pred G G G G G GRK5 BRSK2 23023127 pred G G G G G AURKA BRSK2 23023127 pred G PRMT5 BRSK2 16082366 pred G G G G G MAP4K2 BRSK2 23023127 pred BRSK2 MAP3K5 23023127 pred G G G G G BRSK2 PLK3 23023127 pred G BRSK2 PLK2 23023127 pred G G G G G BRSK2 BRSK1 23023127 pred G G G G BRSK2 WNK2 23023127 pred G G G G G MAP3K9 BRSK2 23023127 pred G G G G G TYRO3 BRSK2 23023127 pred G G G G G GSK3A BRSK2 23023127 pred G G G G G CAMK2B BRSK2 23023127 pred G G G G RAB3A BRSK2 23023127 pred G G G G G ACVR2A BRSK2 23023127 pred G G G G G BRSK2 PSKH2 23023127 pred G G G G G BRSK2 SGK2 23023127 pred G G G G G BRSK2 NIM1K 23023127 pred G G G G G MAPK9 BRSK2 23023127 pred G G G G G MAPK11 BRSK2 23023127 pred G G G G G MLK4 BRSK2 23023127 pred G G G G G GSK3B BRSK2 23023127 pred G G G G G SNAP91 BRSK2 23023127 pred G G G G DAPK3 BRSK2 23023127 pred MARK2 BRSK2 23023127 pred G G G G G BRSK2 TAOK2 23023127 pred G G G G G CDC42 BRSK2 23023127 pred G G G G G PRKCZ BRSK2 23023127 pred G G G G G BRSK2 DCLK3 23023127 pred STK4 BRSK2 23023127 pred G G G G G PDPK1 BRSK2 23023127 pred G G G G G BRSK2 MKNK1 23023127 pred G G G G G CDK17 BRSK2 23023127 pred G G G G G PRKCI BRSK2 23023127 pred G G G G G PDPK2P BRSK2 23023127 pred BRSK2 TESK2 23023127 pred G G G G G BRSK2 TSSK6 23023127 pred BRSK2 DAPK2 23023127 pred G G G G G MAPK12 BRSK2 23023127 pred G G G G G ADRBK2 BRSK2 23023127 pred G G G G G ADCK1 BRSK2 23023127 pred G G G G G MAST3 BRSK2 23023127 pred G G G G G BRSK2 MAP3K4 23023127 pred G G G G G SBK1 BRSK2 23023127 pred G G G G BRSK2 ACVR1C 23023127 pred G G G G G BRSK2 SGK3 23023127 pred BRSK2 MARK4 23023127 pred G G G G G MAP2K1 BRSK2 23023127 pred G G G G G ROCK2 BRSK2 23023127 pred G G G G G PRKACB BRSK2 23023127 pred G G G G G BRSK2 STK39 23023127 pred G G G G G TESK1 BRSK2 23023127 pred G G G G G BRSK2 RPS6KA6 23023127 pred G G G G G BRSK2 CAMKK1 23023127 pred G G G G G PRKACG BRSK2 23023127 pred CDK5 BRSK2 23023127 pred G G G G MAPK10 BRSK2 23023127 pred G G G G G MATK BRSK2 23023127 pred G G G RPS6KA5 BRSK2 23023127 pred G G G G G BRSK2 CDC42BPB 23023127 pred G G G G G NEK5 BRSK2 23023127 pred BRSK2 MINK1 23023127 pred G G G G G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B AMPKa1 BRSK2 MI:0004(affinity chromatography technology) 16306228 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_145586 bait prey WEE1 BRSK2 MI:0415(enzymatic study)|MI:0492(in vitro) 15150265 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_217819|HPRD_15737 prey|- bait|- UBC BRSK2 MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology) 18254724,22609399,23029325 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_187968|BIOGRID_117485|BIOGRID_216725 prey|prey|prey bait|bait|bait BRSK2 FZR1 MI:0004(affinity chromatography technology) 23029325 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_216726 prey bait VCP BRSK2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23907667 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_310046|BIOGRID_310048|BIOGRID_310047 bait|bait|prey prey|prey|bait BRSK2 KBTBD7 MI:0004(affinity chromatography technology) 20562859 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_125354 prey bait CDC25B BRSK2 MI:0415(enzymatic study)|MI:0492(in vitro) 15150265 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_217820|HPRD_17001 prey|- bait|- BRSK2 COPS5 MI:0004(affinity chromatography technology) 22609399 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187967 prey bait CDC25C BRSK2 MI:0492(in vitro)|MI:0415(enzymatic study) 15150265 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_37577|BIOGRID_217821 -|prey -|bait

PPI - HINT Gene A Gene B PMID Method Quality UBC BRSK2 18254724,22609399 0096,0004 LC BRSK2 KBTBD7 20562859,20562859 0007,0004 HT BRSK2 KBTBD7 20562859,20562859 0007,0004 HT UBC BRSK2 18254724,22609399 0096,0004 LC WEE1 BRSK2 15150265 0415 LC CDC25C BRSK2 15150265 0415 LC DKFZP686G14213 BRSK2 15150265 0415 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8IWQ3 P30291 BRSK2 WEE1 0.309 15150265 Q8IWQ3 P55072 BRSK2 VCP 0.569 23907667 Q8IWQ3 P30305 BRSK2 CDC25B 0.309 15150265 Q8IWQ3 P30307 BRSK2 CDC25C 0.309 15150265 Q9Y4K3 Q8IWQ3 TRAF6 BRSK2 0.236 unassigned1304 Q8WVZ9 Q8IWQ3 KBTBD7 BRSK2 0.236 20562859 Q99PL5 Q8IWQ3 RRBP1 BRSK2 0.236 26496610 Q92905 Q8IWQ3 COPS5 BRSK2 0.454 22609399 Q9UM11 Q8IWQ3 FZR1 BRSK2 0.21 23029325 Q8IWQ3 Q13131 BRSK2 PRKAA1 0.126 16306228

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 UBC BRSK2 MI:0045 experimental interaction detection MI:0461 interaction database WEE1 BRSK2 MI:0045 experimental interaction detection MI:0461 interaction database CDC25B BRSK2 MI:0045 experimental interaction detection MI:0461 interaction database CDC25C BRSK2 MI:0045 experimental interaction detection MI:0461 interaction database MTNR1B BRSK2 MI:0362 inference MI:0461 interaction database VCP BRSK2 MI:0045 experimental interaction detection MI:0461 interaction database YWHAE BRSK2 MI:0362 inference MI:0461 interaction database PRKAA1 BRSK2 MI:0045 experimental interaction detection MI:0461 interaction database BRSK2 KBTBD7 MI:0045 experimental interaction detection MI:0461 interaction database BRSK2 COPS5 MI:0045 experimental interaction detection MI:0461 interaction database BRSK2 RRBP1 MI:0362 inference MI:0461 interaction database BRSK2 FZR1 MI:0045 experimental interaction detection MI:0461 interaction database