PTM - dbPAF Gene Name UniProt ID Position Type Species BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 15 Y Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 174 T Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 178 S Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 260 T Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 294 S Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 367 S Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 382 S Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 389 T Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 393 S Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 410 S Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 412 S Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 414 S Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 421 S Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 422 T Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 423 S Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 426 S Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 427 S Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 431 T Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 435 S Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 439 S Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 443 T Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 463 T Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 466 S Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 469 S Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 481 S Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 489 S Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 506 S Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 509 T Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 512 S Homo sapiens(Human) BRSK2; C11orf7; PEN11B; SADA; STK29; HUSSY-12 Q8IWQ3 513 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q8IWQ3 R409-m1 Methylation EMAQHGQrsrsISGA Q8IWQ3 R411-m1 Methylation AQHGQrsrsISGASS Q8IWQ3 R437-m1 Methylation VtPHPsPrGsPLPtP Q8IWQ3 Y15-p Phosphorylation GGAQHAQyVGPYRLE Q8IWQ3 T174-p Phosphorylation VGDSLLEtSCGSPHY Q8IWQ3 T260-p Phosphorylation VDAARRLtLEHIQKH Q8IWQ3 S294-p Phosphorylation VQIRSLPsLEDIDPD Q8IWQ3 S367-p Phosphorylation PPRKRVDsPMLNRHG Q8IWQ3 S382-p Phosphorylation KRRPERKsMEVLSVT Q8IWQ3 S393-p Phosphorylation LSVTDGGsPVPARRA Q8IWQ3 S410-p Phosphorylation MAQHGQrsrsISGAS Q8IWQ3 S412-p Phosphorylation QHGQrsrsISGASSG Q8IWQ3 S423-p Phosphorylation ASSGLSTsPLssPRV Q8IWQ3 S426-p Phosphorylation GLSTsPLssPRVtPH Q8IWQ3 S427-p Phosphorylation LSTsPLssPRVtPHP Q8IWQ3 T431-p Phosphorylation PLssPRVtPHPsPrG Q8IWQ3 S435-p Phosphorylation PRVtPHPsPrGsPLP Q8IWQ3 S439-p Phosphorylation PHPsPrGsPLPtPKG Q8IWQ3 T443-p Phosphorylation PrGsPLPtPKGTPVH Q8IWQ3 T463-p Phosphorylation PAGTPNPtPPsSPSV Q8IWQ3 S466-p Phosphorylation TPNPtPPsSPSVGGV Q8IWQ3 S481-p Phosphorylation PWRARLNsIKNSFLG Q8IWQ3 S489-p Phosphorylation IKNSFLGsPRFHRRK Q8IWQ3 S506-p Phosphorylation VPTPEEMsNLtPEss Q8IWQ3 T509-p Phosphorylation PEEMsNLtPEssPEL Q8IWQ3 S512-p Phosphorylation MsNLtPEssPELAKK Q8IWQ3 S513-p Phosphorylation sNLtPEssPELAKKs Q8IWQ3 S520-p Phosphorylation sPELAKKsWFGNFIS Q8IWQ3 K48-ub Ubiquitination TCQKVAIkIVNREKL

PTM - dbPTM UniProt ID Position Code Type Resources References Q8IWQ3 174 T Phosphorylation Swiss-Prot 1010711 14976552;18339622 Q8IWQ3 294 S Phosphorylation Swiss-Prot 1010711 19369195 Q8IWQ3 367 S Phosphorylation Swiss-Prot 1010711 19369195 Q8IWQ3 382 S Phosphorylation Swiss-Prot 1010711 19369195;19413330;19690332 Q8IWQ3 389 T Phosphorylation Swiss-Prot 1010711 19369195 Q8IWQ3 393 S Phosphorylation Swiss-Prot 1010711 19369195;19413330;19690332 Q8IWQ3 412 S Phosphorylation Swiss-Prot 1010711 19690332 Q8IWQ3 422 T Phosphorylation Swiss-Prot 1010711 19369195 Q8IWQ3 423 S Phosphorylation Swiss-Prot 1010711 19369195;19413330 Q8IWQ3 427 S Phosphorylation Swiss-Prot 1010711 19369195 Q8IWQ3 435 S Phosphorylation Swiss-Prot 1010711 19369195 Q8IWQ3 466 S Phosphorylation Swiss-Prot 1010711 19369195 Q8IWQ3 489 S Phosphorylation Swiss-Prot 1010711 18669648 Q8IWQ3 509 T Phosphorylation Swiss-Prot 1010711 19690332 Q8IWQ3 489 S Phosphorylation PhosphoELM.10011 18669648 Q8IWQ3 174 T Phosphorylation PhosphoELM.10011 14976552 Q8IWQ3 294 S Phosphorylation Phosphositeplus.1010730 19369195 Q8IWQ3 367 S Phosphorylation Phosphositeplus.1010730 19369195 Q8IWQ3 382 S Phosphorylation Phosphositeplus.1010730 19369195;19690332;20363803 Q8IWQ3 393 S Phosphorylation Phosphositeplus.1010730 19369195;19690332;20363803 Q8IWQ3 412 S Phosphorylation Phosphositeplus.1010730 19690332 Q8IWQ3 423 S Phosphorylation Phosphositeplus.1010730 19369195;19690332;20363803;21659604 Q8IWQ3 427 S Phosphorylation Phosphositeplus.1010730 19369195;20363803 Q8IWQ3 435 S Phosphorylation Phosphositeplus.1010730 19369195;20363803 Q8IWQ3 489 S Phosphorylation Phosphositeplus.1010730 18669648;20363803;20393185;21406692;21659604 Q8IWQ3 174 T Phosphorylation Phosphositeplus.1010730 14976552 Q8IWQ3 260 T Phosphorylation Phosphositeplus.1010730 16870137 Q8IWQ3 431 T Phosphorylation Phosphositeplus.1010730 20363803 Q8IWQ3 509 T Phosphorylation Phosphositeplus.1010730 19690332;20363803 Q8IWQ3 382 S Phosphorylation HPRD 9.0 19413330 Q8IWQ3 393 S Phosphorylation HPRD 9.0 19413330 Q8IWQ3 423 S Phosphorylation HPRD 9.0 19413330 Q8IWQ3 439 S Phosphorylation HPRD 9.0 19413330 Q8IWQ3 469 S Phosphorylation HPRD 9.0 19413330 Q8IWQ3 489 S Phosphorylation HPRD 9.0 18669648 Q8IWQ3 489 S Phosphorylation SysPTM 1.1 18669648

PTM - HPRD Symbol Position Code Type References BRSK2 382 S Phosphorylation 19413330 BRSK2 393 S Phosphorylation 19413330 BRSK2 423 S Phosphorylation 19413330 BRSK2 428 S Phosphorylation 19413330 BRSK2 439 S Phosphorylation 19413330 BRSK2 469 S Phosphorylation 19413330 BRSK2 489 S Phosphorylation 18669648 BRSK2 535 S Phosphorylation 18669648

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q8IWQ3 174 T 14976552 LKB1 LTP Phosphorylation Q8IWQ3 489 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q8IWQ3 174 Phosphothreonine; by LKB1 14976552;18339622 Q8IWQ3 260 Phosphothreonine; by PKA 16870137 Q8IWQ3 367 Phosphoserine 19369195 Q8IWQ3 382 Phosphoserine 19369195;19690332 Q8IWQ3 393 Phosphoserine 19369195;19690332 Q8IWQ3 412 Phosphoserine 19690332 Q8IWQ3 422 Phosphothreonine 19958286 Q8IWQ3 509 Phosphothreonine 19690332

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type BRSK2 IPI00604667 S 294 QIRSLPpSLEDIDP phosphorylation BRSK2 IPI00604667 S 367 PRKRVDpSPMLNRH phosphorylation BRSK2 IPI00604667 S 382 RRPERKpSMEVLSV phosphorylation BRSK2 IPI00604667 S 393 SVTDGGpSPVPARR phosphorylation BRSK2 IPI00604667 S 416 KAMFSKpSLDIAEA phosphorylation BRSK2 IPI00604667 S 445 SSGLSTpSPLSSPR phosphorylation BRSK2 IPI00604667 S 449 STSPLSpSPRVTPH phosphorylation BRSK2 IPI00604667 S 457 RVTPHPpSPRGSPL phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 9024 114491 - K Ubiquitination 22609399 9024 114491 - K Ubiquitination 23029325