PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SULT1A1 TOM1L2 22939629 biogrid exp G GP G G G GP G GP GP G GP GP G G G GP GP G GP G GP G GP G GP G GP GP G TOM1L2 UBA2 22939629 biogrid exp G GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G G GP GP G GP G GP GP G RCN1 TOM1L2 22939629 biogrid exp G GP G G G GP G G GP G GP G G G G GP GP G GP G GP GP GP G GP G G GP G TOM1L2 SRXN1 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EGFR TOM1L2 12577067 i2d exp G GP G GP G G GP G GP GP G G G GP GP G G G GP GP G G GP G GP GP G AGL TOM1L2 26344197 biogrid exp G GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G TOM1L2 MYO6 23023224 biogrid exp G GP G GP G G GP G GP GP G G G GP GP G GP G GP GP GP GP G GP GP TOM1L2 TOLLIP 20936779,16412388 biogrid,i2d,intact exp G GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G LAPTM5 TOM1L2 15231748 hprd,biogrid,i2d,mint,intact exp G GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G G GP GP G GP G GP GP G UBC TOM1L2 23314748 biogrid exp G GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G SERPINH1 TOM1L2 22939629 biogrid exp G GP P G GP GP GP G G G GP P G GP G P GP G GP GP G IGBP1 TOM1L2 22939629 biogrid exp G GP G G GP GP G G GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G TOM1L2 RNF11 15231748 hprd,biogrid,i2d,mint,intact exp G GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G TOM1L2 SIN3A 22939629 biogrid exp G GP G G GP GP G GP GP G GP G G GP G GP GP G GP G GP GP GP G GP G GP GP G DSTN TOM1L2 22939629 biogrid exp G GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G XPO1 TOM1L2 26673895 biogrid exp G GP G G GP GP G GP GP G GP G G GP G GP GP G GP G GP GP GP G GP G GP GP G S100A6 TOM1L2 22939629 biogrid exp G GP G G GP GP G G GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G NEDD4 TOM1L2 19953087 biogrid exp G GP G GP P G GP GP GP G G GP G GP GP G GP G GP GP GP G GP G GP P G DFFA TOM1L2 22939629 biogrid exp G GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G MAP3K1 TOM1L2 25260751 biogrid exp G GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G LAGE3 TOM1L2 22939629 biogrid exp G GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G BAG3 TOM1L2 23824909 biogrid exp G GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G CLTC TOM1L2 16412388 biogrid exp G GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G S100A4 TOM1L2 22939629 biogrid exp G G G G GP G G G G G G G G GP G G G G G G GP G G G G G G G G APP TOM1L2 21832049 innatedb,biogrid exp G GP G G GP GP G G GP G G G G G G GP GP G GP G GP GP G G GP G G GP G AHCYL1 TOM1L2 22939629 biogrid exp G GP G G G GP G G GP G GP G G G G G GP G GP G G G GP G G G GP G G TOM1L2 CUEDC1 ortho G GP G G GP GP G GP GP G GP GP G GP G GP GP G P G GP GP GP G GP G GP P G YWHAE TOM1L2 ortho G GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G TOM1L2 MED8 ortho G GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G TOM1L2 CROT ortho G GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G STX7 TOM1L2 ortho G G G G G G G G GP G GP G G GP G G G G G G G G G G G G GP GP G TRIO TOM1L2 16082366 ortho, pred G GP G G G GP G G GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G TOM1L2 GGA2 23023127 pred G GP G G G GP G G GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G ALS2CL TOM1L2 21836163 pred G GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G STX1A TOM1L2 23023127 pred G G G GP G G P G G G G GP GP GP G G G G G GP GP G G CLINT1 TOM1L2 23023127 pred G GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G TOM1 TOM1L2 23023127 pred G GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G TOM1L2 ZFYVE16 21836163 pred G GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G TOM1L2 BTBD2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G HGS TOM1L2 25402006 pred G GP G G GP GP G GP GP G GP G G G G GP GP G GP G GP GP GP G GP G GP GP G STAM2 TOM1L2 23023127 pred G GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G ADD1 TOM1L2 25402006 pred G GP G G GP GP G G GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G TOM1L2 STAM 23023127 pred G GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G TOM1L2 GGA1 23023127 pred G GP G G GP GP G GP GP G GP G G GP G GP GP G GP G GP GP GP G GP G GP GP G TOM1L2 GGA3 23023127 pred G GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP G GP G GP G GP GP G TOM1L2 TSG101 21836163 pred G GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP G GP G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q6ZVM7 Q9Y3C5 two hybrid 15231748 physical association X 2 Q6FIE9 Q6ZVM7 two hybrid pooling approach 20936779 physical association X 2 Q6ZVM7 ubiquitinase assay 25260751 ubiquitination reaction C 5 Q6ZVM7 Q13571 two hybrid 15231748 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B TOM1L2 TOLLIP MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid) 16412388,20936779 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid)|(biogrid) UniProt_110778|BIOGRID_194907|BIOGRID_127216 prey|bait|prey bait|prey|bait TOM1L2 SIN3A MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241027 prey bait LAPTM5 TOM1L2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0407(direct interaction) (intact)|MI:0468(hprd)|(biogrid) UniProt_79190|HPRD_2823|BIOGRID_259136 bait|-|bait prey|-|prey SULT1A1 TOM1L2 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_239275 bait prey TOM1L2 UBA2 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_242775 prey bait SERPINH1 TOM1L2 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_243196 bait prey APP TOM1L2 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_227895 prey bait CLTC TOM1L2 MI:0004(affinity chromatography technology) 16412388 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_194910 prey bait TOM1L2 MYO6 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23023224 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_260138|BIOGRID_260136 prey|prey bait|bait LAGE3 TOM1L2 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_237658 bait prey TOM1L2 SRXN1 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_243044 prey bait AHCYL1 TOM1L2 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_236511 bait prey S100A6 TOM1L2 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_242907 bait prey RCN1 TOM1L2 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_240085 bait prey UBC TOM1L2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473,21906983,21963094,21987572,22053931,22505724,23000965,23314748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_179159|BIOGRID_222211|BIOGRID_223510|BIOGRID_265590|BIOGRID_269420|BIOGRID_247921|BIOGRID_163175|BIOGRID_169870|BIOGRID_175709 bait|bait|bait|bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey|prey|prey|prey DFFA TOM1L2 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_242455 bait prey BAG3 TOM1L2 MI:0004(affinity chromatography technology) 23824909 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_283134 bait prey DSTN TOM1L2 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_242077 bait prey S100A4 TOM1L2 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241440 bait prey IGBP1 TOM1L2 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_238672 bait prey NEDD4 TOM1L2 MI:0415(enzymatic study) 19953087 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_148282 bait prey TOM1L2 RNF11 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|- (biogrid)|(intact)|MI:0468(hprd) BIOGRID_259433|UniProt_78514|HPRD_37398 prey|prey|- bait|bait|-

PPI - HINT Gene A Gene B PMID Method Quality DFFA TOM1L2 22939629 0401 HT AHCYL1 TOM1L2 22939629 0401 HT S100A6 TOM1L2 22939629 0401 HT S100A4 TOM1L2 22939629 0401 HT AGL TOM1L2 26344197 0401 HT SULT1A1 TOM1L2 22939629 0401 HT SERPINH1 TOM1L2 22939629 0401 HT IGBP1 TOM1L2 22939629 0401 HT LAGE3 TOM1L2 22939629 0401 HT TOM1L2 SIN3A 22939629 0401 HT TOM1L2 SRXN1 22939629 0401 HT TOM1L2 UBA2 22939629 0401 HT TOM1L2 HEL-S-84 22939629 0401 HT TOM1L2 HEL32 22939629 0401 HT DFFA TOM1L2 22939629 0401 HT AHCYL1 TOM1L2 22939629 0401 HT S100A6 TOM1L2 22939629 0401 HT S100A4 TOM1L2 22939629 0401 HT AGL TOM1L2 26344197 0401 HT SULT1A1 TOM1L2 22939629 0401 HT SERPINH1 TOM1L2 22939629 0401 HT IGBP1 TOM1L2 22939629 0401 HT LAGE3 TOM1L2 22939629 0401 HT TOM1L2 SIN3A 22939629 0401 HT TOM1L2 SRXN1 22939629 0401 HT TOM1L2 UBA2 22939629 0401 HT TOM1L2 HEL-S-84 22939629 0401 HT TOM1L2 HEL32 22939629 0401 HT DFFA TOM1L2 22939629 0401 LC AHCYL1 TOM1L2 22939629 0401 LC S100A6 TOM1L2 22939629 0401 LC S100A4 TOM1L2 22939629 0401 LC AGL TOM1L2 26344197 0401 LC NEDD4 TOM1L2 19953087 0415 HT SULT1A1 TOM1L2 22939629 0401 LC SERPINH1 TOM1L2 22939629 0401 LC IGBP1 TOM1L2 22939629 0401 LC MAP3K1 TOM1L2 25260751 0415 LC LAPTM5 TOM1L2 15231748 0018 HT LAGE3 TOM1L2 22939629 0401 LC TOM1L2 SIN3A 22939629 0401 LC TOM1L2 SRXN1 22939629 0401 LC TOM1L2 TOLLIP 20936779,20936779 0398,0018 HT TOM1L2 SMURF1 20804422 0415 LC TOM1L2 UBA2 22939629 0401 LC TOM1L2 MYO6 23023224,23023224 0004,0018 LC TOM1L2 RNF11 15231748 0018 HT TOM1L2 HEL-S-84 22939629 0401 LC TOM1L2 HEL32 22939629 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q6ZVM7 O14980 TOM1L2 XPO1 0.126 26673895 Q6ZVM7 P60981 TOM1L2 DSTN 0.081 22939629 Q6ZVM7 O43865 TOM1L2 AHCYL1 0.081 22939629 Q9HCE7 Q6ZVM7 SMURF1 TOM1L2 0.183 20804422 Q6ZVM7 Q62925 TOM1L2 MAP3K1 0.033 25260751 Q6ZVM7 P05067 TOM1L2 APP 0.183 21832049 Q6ZVM7 P35573 TOM1L2 AGL 0.081 26344197 Q6ZVM7 Q00610 TOM1L2 CLTC 0.21 16412388 Q6ZVM7 Q6P5F9 TOM1L2 XPO1 0.126 26673895 Q6ZVM7 P0CG48 TOM1L2 UBC 0.183 23314748 Q6ZVM7 O95817 TOM1L2 BAG3 0.126 23824909 Q6ZVM7 P06703 TOM1L2 S100A6 0.081 22939629 Q8IZU0 Q6ZVM7 FAM9B TOM1L2 0.236 unassigned1304 Q9UM54 Q6ZVM7 MYO6 TOM1L2 0.454 23023224 Q9Y3C5 Q6ZVM7 RNF11 TOM1L2 0.332 15231748 Q9H0E2 Q6ZVM7 TOLLIP TOM1L2 0.569 20936779,16412388,unassigned1304 Q6ZVM7 P26447 TOM1L2 S100A4 0.081 22939629 Q96ST3 Q6ZVM7 SIN3A TOM1L2 0.081 22939629 Q9BYN0 Q6ZVM7 SRXN1 TOM1L2 0.081 22939629 Q9UBT2 Q6ZVM7 UBA2 TOM1L2 0.081 22939629 Q6ZVM7 P46934 TOM1L2 NEDD4 0.183 19953087 Q6ZVM7 Q13571 TOM1L2 LAPTM5 0.332 15231748 Q6ZVM7 P78318 TOM1L2 IGBP1 0.081 22939629 Q6ZVM7 Q14657 TOM1L2 LAGE3 0.081 22939629 Q6ZVM7 P50225 TOM1L2 SULT1A1 0.081 22939629 Q6ZVM7 P50454 TOM1L2 SERPINH1 0.081 22939629 Q6ZVM7 Q15293 TOM1L2 RCN1 0.081 22939629 Q6ZVM7 O00273 TOM1L2 DFFA 0.081 22939629 Q6ZVM7 Q13233 TOM1L2 MAP3K1 0.183 25260751

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 XPO1 TOM1L2 MI:0045 experimental interaction detection MI:0461 interaction database STX7 TOM1L2 MI:0362 inference MI:0461 interaction database TOM1 TOM1L2 MI:0362 inference MI:0461 interaction database TRIO TOM1L2 MI:0362 inference MI:0461 interaction database BAG3 TOM1L2 MI:0045 experimental interaction detection MI:0461 interaction database APP TOM1L2 MI:0045 experimental interaction detection MI:0461 interaction database UBC TOM1L2 MI:0045 experimental interaction detection MI:0461 interaction database NEDD4 TOM1L2 MI:0045 experimental interaction detection MI:0461 interaction database CLTC TOM1L2 MI:0045 experimental interaction detection MI:0461 interaction database MAP3K1 TOM1L2 MI:0045 experimental interaction detection MI:0461 interaction database LAPTM5 TOM1L2 MI:0045 experimental interaction detection MI:0461 interaction database TOM1L2 STX12 MI:0362 inference MI:0461 interaction database TOM1L2 MED8 MI:0362 inference MI:0461 interaction database TOM1L2 TOLLIP MI:0045 experimental interaction detection MI:0461 interaction database TOM1L2 CUEDC1 MI:0362 inference MI:0461 interaction database TOM1L2 CROT MI:0362 inference MI:0461 interaction database TOM1L2 MYO6 MI:0045 experimental interaction detection MI:0461 interaction database TOM1L2 RNF11 MI:0045 experimental interaction detection MI:0461 interaction database