PTM - CPLM Gene Name UniProt ID Type Position Code TOM1L2 Q6ZVM7 Ubiquitination 101 K TOM1L2 Q6ZVM7 Ubiquitination 106 K TOM1L2 Q6ZVM7 Ubiquitination 145 K TOM1L2 Q6ZVM7 Ubiquitination 147 K TOM1L2 Q6ZVM7 Ubiquitination 400 K TOM1L2 Q6ZVM7 Ubiquitination 462 K TOM1L2 Q6ZVM7 Ubiquitination 236 K TOM1L2 Q6ZVM7 Ubiquitination 421 K TOM1L2 Q6ZVM7 Ubiquitination 447 K TOM1L2 Q6ZVM7 Ubiquitination 469 K

PTM - dbPAF Gene Name UniProt ID Position Type Species TOM1L2 Q6ZVM7 160 S Homo sapiens(Human) TOM1L2 Q6ZVM7 164 T Homo sapiens(Human) TOM1L2 Q6ZVM7 177 T Homo sapiens(Human) TOM1L2 Q6ZVM7 187 T Homo sapiens(Human) TOM1L2 Q6ZVM7 191 S Homo sapiens(Human) TOM1L2 Q6ZVM7 192 Y Homo sapiens(Human) TOM1L2 Q6ZVM7 193 S Homo sapiens(Human) TOM1L2 Q6ZVM7 194 S Homo sapiens(Human) TOM1L2 Q6ZVM7 200 Y Homo sapiens(Human) TOM1L2 Q6ZVM7 373 S Homo sapiens(Human) TOM1L2 Q6ZVM7 394 S Homo sapiens(Human) TOM1L2 Q6ZVM7 401 T Homo sapiens(Human) TOM1L2 Q6ZVM7 403 T Homo sapiens(Human) TOM1L2 Q6ZVM7 404 Y Homo sapiens(Human) TOM1L2 Q6ZVM7 415 S Homo sapiens(Human) TOM1L2 Q6ZVM7 423 S Homo sapiens(Human) TOM1L2 Q6ZVM7 424 S Homo sapiens(Human) TOM1L2 Q6ZVM7 456 T Homo sapiens(Human) TOM1L2 Q6ZVM7 457 S Homo sapiens(Human) TOM1L2 Q6ZVM7 479 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q6ZVM7 S160-p Phosphorylation MADLdALsPIHtPQR Q6ZVM7 T164-p Phosphorylation dALsPIHtPQRsVPE Q6ZVM7 S168-p Phosphorylation PIHtPQRsVPEVDPA Q6ZVM7 T177-p Phosphorylation PEVDPAAtMPRSQSQ Q6ZVM7 T187-p Phosphorylation RSQSQQRtSAGSysS Q6ZVM7 Y192-p Phosphorylation QRtSAGSysSPPPAP Q6ZVM7 S193-p Phosphorylation RtSAGSysSPPPAPy Q6ZVM7 Y200-p Phosphorylation sSPPPAPySAPQAPA Q6ZVM7 S226-p Phosphorylation EQIARLRsELDVVRG Q6ZVM7 S394-p Phosphorylation FAQTRGNsLAEQRkt Q6ZVM7 T401-p Phosphorylation sLAEQRktVtyEDPQ Q6ZVM7 T403-p Phosphorylation AEQRktVtyEDPQAV Q6ZVM7 Y404-p Phosphorylation EQRktVtyEDPQAVG Q6ZVM7 S415-p Phosphorylation QAVGGLAsALDNRkQ Q6ZVM7 S423-p Phosphorylation ALDNRkQssEGIPVA Q6ZVM7 S424-p Phosphorylation LDNRkQssEGIPVAQ Q6ZVM7 T456-p Phosphorylation DDLEEGVtSEEFDkF Q6ZVM7 S479-p Phosphorylation EMVPDLPsPPMEAPA Q6ZVM7 K48-ub Ubiquitination NETEEGPkDAIRALK Q6ZVM7 K101-ub Ubiquitination FIDSVLVkIISPkNN Q6ZVM7 K106-ub Ubiquitination LVkIISPkNNPPTIV Q6ZVM7 K145-ub Ubiquitination VHIYEELkRkGVEFP Q6ZVM7 K147-ub Ubiquitination IYEELkRkGVEFPMA Q6ZVM7 K236-ub Ubiquitination DVVRGNTkVMSEMLT Q6ZVM7 K400-ub Ubiquitination NsLAEQRktVtyEDP Q6ZVM7 K421-ub Ubiquitination AsALDNRkQssEGIP Q6ZVM7 K447-ub Ubiquitination VWLRTDLkGDDLEEG Q6ZVM7 K462-ub Ubiquitination VtSEEFDkFLEERAk Q6ZVM7 K469-ub Ubiquitination kFLEERAkAAEMVPD

PTM - dbPTM UniProt ID Position Code Type Resources References Q6ZVM7 160 S Phosphorylation Swiss-Prot 1010711 18669648 Q6ZVM7 164 T Phosphorylation Swiss-Prot 1010711 18669648 Q6ZVM7 192 Y Phosphorylation Swiss-Prot 1010711 15951569;19534553 Q6ZVM7 200 Y Phosphorylation Swiss-Prot 1010711 15951569;19534553 Q6ZVM7 404 Y Phosphorylation Swiss-Prot 1010711 17389395;19534553 Q6ZVM7 160 S Phosphorylation PhosphoELM.10011 18669648 Q6ZVM7 164 T Phosphorylation PhosphoELM.10011 18669648 Q6ZVM7 192 Y Phosphorylation PhosphoELM.10011 15951569 Q6ZVM7 157 D Caspase Phosphositeplus.1010730 18722006 Q6ZVM7 101 K Ubiquitylation Phosphositeplus.1010730 21890473 Q6ZVM7 106 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q6ZVM7 145 K Ubiquitylation Phosphositeplus.1010730 21890473 Q6ZVM7 147 K Ubiquitylation Phosphositeplus.1010730 21890473 Q6ZVM7 236 K Ubiquitylation Phosphositeplus.1010730 21906983 Q6ZVM7 400 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q6ZVM7 421 K Ubiquitylation Phosphositeplus.1010730 21906983 Q6ZVM7 447 K Ubiquitylation Phosphositeplus.1010730 21906983 Q6ZVM7 462 K Ubiquitylation Phosphositeplus.1010730 21890473 Q6ZVM7 469 K Ubiquitylation Phosphositeplus.1010730 21906983 Q6ZVM7 160 S Phosphorylation Phosphositeplus.1010730 18669648;20068231;20363803 Q6ZVM7 164 T Phosphorylation Phosphositeplus.1010730 18669648;20068231;20363803 Q6ZVM7 187 T Phosphorylation Phosphositeplus.1010730 19534553 Q6ZVM7 192 Y Phosphorylation Phosphositeplus.1010730 15951569;17016520;18083107;18180459;19534553 Q6ZVM7 200 Y Phosphorylation Phosphositeplus.1010730 15951569;17016520;18083107;19534553 Q6ZVM7 404 Y Phosphorylation Phosphositeplus.1010730 17389395;18083107;18180459;18707149;19534553;19901323;20007894;20736484 Q6ZVM7 160 S Phosphorylation HPRD 9.0 18669648,19651622,20068231 Q6ZVM7 373 S Phosphorylation HPRD 9.0 20068231 Q6ZVM7 423 S Phosphorylation HPRD 9.0 20068231 Q6ZVM7 164 T Phosphorylation HPRD 9.0 18669648,19651622,20068231 Q6ZVM7 177 T Phosphorylation HPRD 9.0 18212344 Q6ZVM7 200 Y Phosphorylation HPRD 9.0 15951569 Q6ZVM7 404 Y Phosphorylation HPRD 9.0 17389395,19901323 Q6ZVM7 160 S Phosphorylation SysPTM 1.1 18669648 Q6ZVM7 164 T Phosphorylation SysPTM 1.1 18669648 Q6ZVM7 177 T Phosphorylation SysPTM 1.1 18212344

PTM - HPRD Symbol Position Code Type References TOM1L2 110 S Phosphorylation 18669648,19651622,20068231 TOM1L2 114 T Phosphorylation 18669648,19651622,20068231 TOM1L2 127 T Phosphorylation 18212344 TOM1L2 132 T Phosphorylation 18212344 TOM1L2 150 Y Phosphorylation 15951569 TOM1L2 155 Y Phosphorylation 15951569 TOM1L2 160 S Phosphorylation 18669648,19651622,20068231 TOM1L2 164 T Phosphorylation 18669648,19651622,20068231 TOM1L2 177 T Phosphorylation 18212344 TOM1L2 200 Y Phosphorylation 15951569 TOM1L2 354 Y Phosphorylation 17389395,19901323 TOM1L2 359 Y Phosphorylation 17389395,19901323 TOM1L2 373 S Phosphorylation 20068231 TOM1L2 378 S Phosphorylation 20068231 TOM1L2 404 Y Phosphorylation 17389395,19901323 TOM1L2 423 S Phosphorylation 20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q6ZVM7 160 S 18669648 HTP Phosphorylation Q6ZVM7 164 T 18669648 HTP Phosphorylation Q6ZVM7 192 Y 15951569 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q6ZVM7 160 Phosphoserine 20068231 Q6ZVM7 164 Phosphothreonine 20068231

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type TOM1L2 IPI00446294 S 160 ADLDALpSPIHTPQ phosphorylation TOM1L2 IPI00446294 T 164 ALSPIHpTPQRSVP phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 146691 127001 - K Ubiquitination 21987572 146691 127001 - K Ubiquitination 21139048 146691 127001 - K Ubiquitination 21890473 146691 127001 - K Ubiquitination 21906983 146691 127001 - K Ubiquitination 22053931 146691 127001 - K Ubiquitination 22505724 146691 127001 - K Ubiquitination 21963094 146691 127001 - K Ubiquitination 23000965 146691 127001 - K Ubiquitination 24654937 146691 127001 - K Ubiquitination 25147182

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID TOM1L2 Homo sapiens (Human) 97; 95 "97,YEELKRKGVEFPM; 95,HIYEELKRKGVEF" 97:21890473; 95:21890473 TOM1L2 Homo sapiens (Human) 138; 101; 106; 302; 344 "138,VVRGNTKVMSEML; 101,IDSVLVKIISPKN; 106,VKIISPKNNPPTI; 302,SLAEQRKTVTYED; 344,TSEEFDKFLEERA" 138:21906983; 101:21890473; 106:21890473; 302:21890473; 344:21890473 TOM1L2 Homo sapiens (Human) 186; 371; 397; 412; 350; 95; 419 "186,VVRGNTKVMSEML; 371,SALDNRKQSSEGI; 397,WLRTDLKGDDLEE; 412,TSEEFDKFLEERA; 350,SLAEQRKTVTYED; 95,HIYEELKRKGVEF; 419,FLEERAKAAEMVP" "186:21906983; 371:21906983; 397:21906983; 412:21890473; 350:21890473,21906983; 95:21890473; 419:21906983" TOM1L2 Homo sapiens (Human) 424; 101; 191; 355; 402; 417; 106; 376 "424,FLEERAKAAEMVP; 101,IDSVLVKIISPKN; 191,VVRGNTKVMSEML; 355,SLAEQRKTVTYED; 402,WLRTDLKGDDLEE; 417,TSEEFDKFLEERA; 106,VKIISPKNNPPTI; 376,SALDNRKQSSEGI" "424:21906983; 101:21890473; 191:21906983; 355:21890473,21906983; 402:21906983; 417:21890473; 106:21890473,21906983; 376:21906983" TOM1L2 Homo sapiens (Human) 154; 202; 133; 180; 195 "154,SALDNRKQSSEGI; 202,FLEERAKAAEMVP; 133,SLAEQRKTVTYED; 180,WLRTDLKGDDLEE; 195,TSEEFDKFLEERA" "154:21906983; 202:21906983; 133:21890473,21906983; 180:21906983; 195:21890473" TOM1L2 Homo sapiens (Human) 462; 101; 236; 447; 145; 400; 147; 469; 106; 421 "462,TSEEFDKFLEERA; 101,IDSVLVKIISPKN; 236,VVRGNTKVMSEML; 447,WLRTDLKGDDLEE; 145,HIYEELKRKGVEF; 400,SLAEQRKTVTYED; 147,YEELKRKGVEFPM; 469,FLEERAKAAEMVP; 106,VKIISPKNNPPTI; 421,SALDNRKQSSEGI" "462:21890473; 101:21890473; 236:21906983; 447:21906983; 145:21890473; 400:21890473,21906983; 147:21890473; 469:21906983; 106:21890473,21906983; 421:21906983" TOM1L2 Homo sapiens (Human) 400 "400,SLAEQRKTVTYED" 400:22053931