PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TRAF1 UBE2O 23381138 biogrid exp G G G G GP GP G G G GP G G G G GP G G G G G G G G G CPNE4 UBE2O 12522145 hprd exp G G GP G G G P GP G G P RPS20 UBE2O 19549727 intact exp P P P P P P P ZNF687 UBE2O 22939629 biogrid exp GP G GP GP G GP G P G G GP G G G G G G GP CPNE2 UBE2O 12522145 hprd exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G UBE2O ECT2 22990118 biogrid exp G G G G G G G UBE2O LUC7L2 26186194 biogrid exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G LCA5 UBE2O 26638075 biogrid,intact exp G G G G G GP G GP G GP G G G G GP G G G G G G G G G SMARCA4 UBE2O 19549727 intact exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G UBE2V1 UBE2O 25260751 intact exp NAP1L1 UBE2O 26186194 biogrid exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G FTSJ3 UBE2O 24778252 biogrid exp G GP G G G GP G GP G GP G G G G GP G G G G G G G GP G UBE2O UBE2O 19549727,23455153,24703950 biogrid,intact exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G PAFAH1B3 UBE2O 19549727 intact exp G G G GP G G G G GP G G G G G G G G G G G CBX6 UBE2O 21282530 intact exp G GP G G G GP G GP G GP G G G G GP G G G G G G G GP G CHD1L UBE2O 19549727 intact exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G ZNF707 UBE2O 26186194 biogrid exp G GP G G GP GP GP G GP G G GP G G G G P G WBSCR22 UBE2O 26186194 biogrid exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G RAD21 UBE2O 22145905 biogrid exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G RNF10 UBE2O 19549727 biogrid,intact exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G ANKRD1 UBE2O 26186194 biogrid exp P GP G P SLX4 UBE2O 19596235 intact exp P G G GP GP P G P G G GP G G GP RPS7 UBE2O 19549727 intact exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G RPL12 UBE2O 19549727 intact exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G UBE2O APPL1 25416956 biogrid,intact exp G GP G G GP GP G G G GP G G G G GP G G G G G G G GP G SMAD7 UBE2O 23455153 biogrid exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G P G TRAF2 UBE2O 23381138 biogrid exp P P P P P P G G P UBE2O XAGE1A, XAGE1B, XAGE1C, XAGE1D, XAGE1E 19549727 intact exp P P P P P P UBE2O NOL12 26186194 biogrid exp G G G G G G G G G G G G G G G UBE2O SAP30L 19549727 intact exp G G G G G G G G G G G G G G G G G G G G G G G G UBE2O NXF1 22658674 biogrid exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G UBE2O SIRT7 22586326 biogrid exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G SYT11 UBE2O 26186194 biogrid exp G GP G G G GP G G G GP G G G G GP G G G G G G G G G YBX1 UBE2O 19549727 intact exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G UBE2O MED4 25281560 biogrid exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G MCAM UBE2O 19549727 intact exp G G G G G GP G GP G GP G G G G GP G G G G G G G G G ITGB3BP UBE2O 26496610 biogrid,intact exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G SHBG UBE2O 15862967 hprd,biogrid,i2d exp POP7 UBE2O 22863883 biogrid exp G GP G G G GP G G G GP G G G G GP G G G G G G G GP G UBA52 UBE2O 19549727 intact exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G UBC UBE2O 17550899 biogrid exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G TRAF4 UBE2O 23381138 biogrid exp G GP G GP G P G GP G G G G GP G G G G G G GP G RPL29 UBE2O 19549727 intact exp G G G G G G G G G G G G G G G G G G G G G G G G TRAF5 UBE2O 23381138 biogrid exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G HIST1H2BC, HIST1H2BE, HIST1H2BF, HIST1H2BG, HIST1H2BI UBE2O 25281560 biogrid exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G GRK5 UBE2O 22952844 biogrid exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G FRG1 UBE2O 26186194 biogrid exp UBE2O RNF11 23751493 biogrid exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G PNKP UBE2O 15385968 biogrid exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G JUN UBE2O 20936779,25609649 i2d,intact exp G GP G G G GP G G G GP G G G G GP G G G G G G G G G UBE2O LUC7L 26186194 biogrid exp G GP G G G GP G GP G G G G G G GP G G G G G G G GP G GABARAPL2 UBE2O 19549727 intact exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G HIST1H2BA UBE2O 26186194 biogrid exp GP UBE2O RLIM 23455153 intact exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G UBE2O WDR26 22939629 biogrid exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G ZFP41 UBE2O 26186194 biogrid exp GP G GP P G GP G G GP G G G G G GP G SFRP4 UBE2O 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G GP G TRAF3 UBE2O 23381138 biogrid exp G GP G G GP GP G G G GP G G G G GP G G G G G G G GP G KIAA0753 UBE2O 24613305 biogrid exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G POLA2 UBE2O 22863883 biogrid exp P G GP P P P G G P G G G G G G GP BAP1 UBE2O 19615732,24703950 biogrid,intact exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G HEXIM1 UBE2O 26186194 biogrid exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G HNRNPAB UBE2O 19549727 intact exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G GSTP1 UBE2O 26496610 biogrid,intact exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G UBE2O TRAF6 23381138 biogrid exp G GP G G GP G G GP G GP G G G G G G G G G G G G GP G OSM UBE2O 26186194 biogrid exp P G GP P P G P P SMAD6 UBE2O 23455153 biogrid,intact exp G G G G G G G G G G G G G G G G G G CPNE1 UBE2O 12522145 hprd exp G G G G G G G G G G G G G G G G G G G G G G G G NTRK1 UBE2O 25921289 biogrid exp P P G P P P P TRIM27 UBE2O 19549727 biogrid,intact exp G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G NBR1 UBE2O ortho G GP G G G GP G GP G GP G G G G GP G G G G G G G GP G MUS81 UBE2O 25402006 pred G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G KPNA1 UBE2O 25402006 pred G GP G G G GP G GP G GP G G G G GP G G G G G G G GP G UBE2O TERF2IP 25402006 pred G GP G G GP GP G G G GP G G G G GP G G G G G G G GP G AHCYL2 UBE2O 25402006 pred G G G G G GP G G G GP G G G G GP G G G G G G G G G SLX4IP UBE2O 25402006 pred GP P P P G GP G G P G G G G P PGAM5 UBE2O 25402006 pred P G P P P P P G G GP PLK1 UBE2O 25402006 pred P G G GP P G GP P G GP G G G G GP LRRC1 UBE2O 25402006 pred G P GP G G G GP G G GP G G G G G P G EME1 UBE2O 25402006 pred G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G ERCC1 UBE2O 25402006 pred G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G ERCC4 UBE2O 25402006 pred G GP G G G GP G GP G GP G G G G GP G G G G G G G GP G UBE2O SLC25A13 25402006 pred G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G RANGAP1 UBE2O 25402006 pred G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G UBE2O NUP50 25402006 pred G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G UBR5 UBE2O 25402006 pred G G G G G GP G G G GP G G G G GP G G G G G G G GP G NUP188 UBE2O 25402006 pred G GP G G GP GP G GP G GP G G G G GP G G G G G G G GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O75817 Q9C0C9 biochemical 22863883 colocalization X 2 Q9C0C9 P04278-3 two hybrid 15862967 direct interaction X 2 Q9C0C9 P34947 affinity chromatography technology 22952844 physical association X 2 Q9C0C9 Q8N1G0 biochemical 22939629 colocalization X 2 Q9C0C9 Q9H8V3-4 affinity chromatography technology 22990118 physical association X 2 Q9C0C9 O00463 affinity chromatography technology 23381138 physical association X 2 Q9C0C9 Q9Y4K3 affinity chromatography technology 23381138 physical association X 2 Q9C0C9 Q9Y4K3 affinity chromatography technology 23381138 physical association X 2 Q9C0C9 O43541-2 affinity chromatography technology 23455153 physical association X 2 Q9C0C9 O43541-2 affinity chromatography technology 23455153 physical association X 2 Q9C0C9 Q14181 biochemical 22863883 colocalization X 2 Q9C0C9 Q9C0C9 enzymatic study 24703950 direct interaction X 2 Q9C0C9 Q8IY81 affinity chromatography technology 24778252 physical association X 2 A0A024R9J0 Q9C0C9 affinity chromatography technology 22145905 physical association X 2 P0CG48 Q9C0C9 affinity chromatography technology 22053931 physical association X 2 P0CG48 Q9C0C9 affinity chromatography technology 22505724 physical association X 2 P0CG48 Q9C0C9 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q9C0C9 affinity chromatography technology 23000965 physical association X 2 P0CG48 Q9C0C9 affinity chromatography technology 24703950 physical association X 2 P0CG48 Q9C0C9 affinity chromatography technology 24816145 physical association X 2 P0CG48 Q9C0C9 affinity chromatography technology 17550899 physical association X 2 P0CG48 Q9C0C9 affinity chromatography technology 25015289 physical association X 2 P0CG48 Q9C0C9 pull down 12938929 direct interaction X 2 P0CG48 Q9C0C9 affinity chromatography technology 20639865 physical association X 2 P0CG48 Q9C0C9 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q9C0C9 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q9C0C9 affinity chromatography technology 21906983 physical association X 2 A0A024RBP0 Q9C0C9 two hybrid 19549727 direct interaction X 2 Q9C0C9 Q9NRC8 affinity chromatography technology 22586326 physical association X 2 Q9C0C9 Q9H7D7-4 biochemical 22939629 colocalization X 2 Q9C0C9 Q13077-2 affinity chromatography technology 23381138 physical association X 2 Q9C0C9 A0A024R8H5 affinity chromatography technology 23381138 physical association X 2 Q9C0C9 Q13114-2 affinity chromatography technology 23381138 physical association X 2 Q9C0C9 Q96T60 affinity chromatography technology 15385968 physical association X 2 Q9C0C9 O15105-2 affinity chromatography technology 23455153 physical association X 2 Q9C0C9 O15105-2 affinity chromatography technology 23455153 physical association X 2 Q9C0C9 affinity chromatography technology 22190034 physical association X 2 Q9C0C9 Q9Y3C5 affinity chromatography technology 23751493 physical association X 2 Q9C0C9 A0A024R305 affinity chromatography technology 24703950 physical association X 2 Q9C0C9 A0A024R305 enzymatic study 24703950 direct interaction X 2 Q9C0C9 A0A024R305 pull down 24703950 direct interaction X 2 Q9C0C9 Q9UKG1 two hybrid 25416956 direct interaction X 2 Q9C0C9 A0A024R305 biochemical 24703950 colocalization X 2 Q9C0C9 A0A024R305 affinity chromatography technology 19615732 physical association X 2 Q9C0C9 P14373 two hybrid 19549727 direct interaction X 2 A0A024QZ59 Q9C0C9 affinity chromatography technology 23381138 physical association X 2 Q96A23 Q9C0C9 two hybrid 12522145 - X 2 Q96A23 Q9C0C9 in vitro 12522145 - X 2 Q96A23 Q9C0C9 in vitro 12522145 - X 2 Q96A23 Q9C0C9 two hybrid 12522145 - X 2 Q9C0C9 P04278 two hybrid 15862967 - X 2 Q9C0C9 Q99829 in vitro 12522145 - X 2 Q9C0C9 Q99829 two hybrid 12522145 - X 2 Q9C0C9 Q96FN4 two hybrid 12522145 - X 2 Q9C0C9 Q99829 in vitro 12522145 - X 2 Q9C0C9 Q99829 two hybrid 12522145 - X 2 Q9C0C9 Q96FN4 two hybrid 12522145 - X 2 Q9C0C9 P04278 two hybrid 15862967 - X 2 Q9C0C9 anti tag coimmunoprecipitation 22190034 association C 19 Q9C0C9 anti tag coimmunoprecipitation 19596235 association C 57 Q9C0C9 tandem affinity purification 21282530 association C 54 Q9C0C9 anti tag coimmunoprecipitation 19596235 association C 77 Q9C0C9 pull down 22190034 association C 15 Q9C0C9 tandem affinity purification 23455153 association C 185 Q9C0C9 Q99729 two hybrid 19549727 physical association X 2 Q9C0C9 A0A024R0L6 two hybrid 19549727 physical association X 2 Q9C0C9 P30050 two hybrid 19549727 physical association X 2 Q9C0C9 P62081 two hybrid 19549727 physical association X 2 Q9C0C9 P62987 two hybrid 19549727 physical association X 2 Q9C0C9 Q86WJ1 two hybrid 19549727 physical association X 2 Q9C0C9 O35182 anti tag coimmunoprecipitation 23455153 physical association X 2 Q9C0C9 Q9C0C9 anti tag coimmunoprecipitation 23455153 physical association X 2 Q9C0C9 Q9NVW2 anti tag coimmunoprecipitation 23455153 physical association X 2 Q9C0C9 O35182 anti tag coimmunoprecipitation 23455153 physical association X 2 Q9C0C9 O35182 anti tag coimmunoprecipitation 23455153 physical association X 2 O35253 Q9C0C9 anti tag coimmunoprecipitation 23455153 physical association X 2 O35253 Q9C0C9 anti tag coimmunoprecipitation 23455153 physical association X 2 Q9C0C9 anti tag coimmunoprecipitation 19615732 physical association C 21 Q9C0C9 ubiquitinase assay 25260751 ubiquitination reaction C 4 A0A024RBP0 Q9C0C9 two hybrid array 19549727 physical association X 2 Q9C0C9 P14373 two hybrid array 19549727 physical association X 2 Q9C0C9 A0A024R3I5 two hybrid 19549727 physical association X 2 Q9C0C9 P47914 two hybrid 19549727 physical association X 2 Q9C0C9 A7E2E1 two hybrid 19549727 physical association X 2 Q9C0C9 Q9HD64 two hybrid 19549727 physical association X 2 Q9C0C9 P60520 two hybrid 19549727 physical association X 2 Q9C0C9 Q9HAJ7 two hybrid 19549727 physical association X 2 Q9C0C9 O43541 anti tag coimmunoprecipitation 23455153 physical association X 2 Q9C0C9 Q9UKG1 two hybrid prey pooling approach 25416956 physical association X 2 Q9C0C9 Q9UKG1 two hybrid array 25416956 physical association X 2 Q9C0C9 Q9UKG1 validated two hybrid 25416956 physical association X 2 P60866 Q9C0C9 two hybrid 19549727 physical association X 2 P67809 Q9C0C9 two hybrid 19549727 physical association X 2 Q99ML9 Q9C0C9 anti tag coimmunoprecipitation 23455153 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBE2O TRAF4 MI:0004(affinity chromatography technology) 23381138 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_249999 prey bait HNRNPAB UBE2O MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100926 prey bait SHBG UBE2O MI:0018(two hybrid)|MI:0018(two hybrid) 15862967 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_211106|HPRD_35283 bait|- prey|- ZNF687 UBE2O MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_240661 prey bait RPL12 UBE2O MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100929 prey bait MCAM UBE2O MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100927 prey bait POP7 UBE2O MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_302069 prey bait TRIM27 UBE2O MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124462|UniProt_101497 prey|prey bait|bait TRAF3 UBE2O MI:0004(affinity chromatography technology) 23381138 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_249998 bait prey UBC UBE2O MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 12938929,20639865,21139048,21890473,21906983,21963094,22053931,22505724,23000965,24703950,8634298 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_167532|BIOGRID_264171|BIOGRID_222015|BIOGRID_224851|BIOGRID_310245|BIOGRID_166986|BIOGRID_310244|BIOGRID_174305|BIOGRID_160121|BIOGRID_197246|BIOGRID_176978|BIOGRID_267842 bait|bait|bait|bait|prey|bait|prey|bait|bait|prey|bait|bait prey|prey|prey|prey|bait|prey|bait|prey|prey|bait|prey|prey GRK5 UBE2O MI:0004(affinity chromatography technology) 22952844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_218477 bait prey RPS20 UBE2O MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100933 prey bait SMAD7 UBE2O MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23455153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_258155|BIOGRID_258156 bait|prey prey|bait TRAF1 UBE2O MI:0004(affinity chromatography technology) 23381138 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_249996 bait prey CHD1L UBE2O MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100937 prey bait SMAD6 UBE2O MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 23455153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(intact)|(biogrid) UniProt_177608|BIOGRID_258158|UniProt_128011|BIOGRID_258157 prey|bait|prey|prey bait|prey|bait|bait RPS7 UBE2O MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100931 prey bait SMARCA4 UBE2O MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100934 prey bait CPNE1 UBE2O MI:0492(in vitro) 12522145 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_12935 - - TRAF5 UBE2O MI:0004(affinity chromatography technology) 23381138 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_250000 bait prey PNKP UBE2O MI:0096(pull down) 15385968 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_251212 bait prey UBE2O SAP30L MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100940 bait prey UBE2O XAGE1A MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100936 bait prey UBE2O TRAF6 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23381138 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_250001|BIOGRID_250002 prey|bait bait|prey UBE2O RNF11 MI:0004(affinity chromatography technology) 23751493 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_282488 prey bait PAFAH1B3 UBE2O MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100930 prey bait UBE2O ECT2 MI:0004(affinity chromatography technology) 22990118 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_245946 prey bait GABARAPL2 UBE2O MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100938 prey bait BAP1 UBE2O MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19615732,24703950 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid) UniProt_100630|BIOGRID_310237|BIOGRID_120627|BIOGRID_310238|BIOGRID_310234 bait|prey|bait|bait|bait prey|bait|prey|prey|prey UBE2O WDR26 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_239105 bait prey UBA52 UBE2O MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100935 prey bait POLA2 UBE2O MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_302042 prey bait UBE2O RLIM MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 23455153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_128013|UniProt_177610 prey|prey bait|bait YBX1 UBE2O MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100928 prey bait UBE2O SIRT7 MI:0004(affinity chromatography technology) 22586326 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_189705 prey bait TRAF2 UBE2O MI:0004(affinity chromatography technology) 23381138 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_249997 bait prey RNF10 UBE2O MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124175|UniProt_101180 prey|prey bait|bait RPL29 UBE2O MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100932 prey bait RAD21 UBE2O MI:0018(two hybrid) 22145905 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_181905 bait prey CPNE4 UBE2O MI:0492(in vitro) 12522145 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_12949 - - CPNE2 UBE2O MI:0492(in vitro) 12522145 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_12941 - -

PPI - HINT Gene A Gene B PMID Method Quality WBSCR22 UBE2O 26186194 0004 HT POP7 UBE2O 22863883 0401 HT HEXIM1 UBE2O 26186194 0004 HT JUN UBE2O 25609649 0006 HT GSTP1 UBE2O 26496610 0007 HT UBC UBE2O 12938929,17550899,8634298,20639865 0096,0004,0096,0004 LC OSM UBE2O 26186194 0004 HT ITGB3BP UBE2O 26496610,26496610 0007,0004 HT POLA2 UBE2O 22863883 0401 HT FRG1 UBE2O 26186194 0004 HT ANKRD1 UBE2O 26186194 0004 HT SFRP4 UBE2O 26186194 0004 HT LCA5 UBE2O 26638075,26638075,26638075,26638075 1314,1313,0004,0007 HT ZNF687 UBE2O 22939629 0401 HT ZFP41 UBE2O 26186194 0004 HT BAP1 UBE2O 24703950,24703950,19615732,19615732,24703950,24703950 0096,0415,0004,0007,0401,0004 LC,HT HIST1H2BA UBE2O 26186194 0004 HT ZNF707 UBE2O 26186194 0004 HT SYT11 UBE2O 26186194 0004 HT UBE2O Q9H2B0 26186194 0004 HT UBE2O WDR26 22939629 0401 HT UBE2O LUC7L 26186194 0004 HT UBE2O NOL12 26186194 0004 HT UBE2O LUC7L2 26186194 0004 HT UBE2O HEL-S-22 26496610 0004 HT WBSCR22 UBE2O 26186194 0004 HT POP7 UBE2O 22863883 0401 HT HEXIM1 UBE2O 26186194 0004 HT JUN UBE2O 25609649 0006 HT GSTP1 UBE2O 26496610 0007 HT OSM UBE2O 26186194 0004 HT ITGB3BP UBE2O 26496610,26496610 0007,0004 HT POLA2 UBE2O 22863883 0401 HT FRG1 UBE2O 26186194 0004 HT ANKRD1 UBE2O 26186194 0004 HT SFRP4 UBE2O 26186194 0004 HT LCA5 UBE2O 26638075,26638075,26638075,26638075 1314,1313,0004,0007 HT ZNF687 UBE2O 22939629 0401 HT ZFP41 UBE2O 26186194 0004 HT BAP1 UBE2O 19615732,19615732 0004,0007 HT HIST1H2BA UBE2O 26186194 0004 HT ZNF707 UBE2O 26186194 0004 HT SYT11 UBE2O 26186194 0004 HT UBE2O Q9H2B0 26186194 0004 HT UBE2O WDR26 22939629 0401 HT UBE2O LUC7L 26186194 0004 HT UBE2O NOL12 26186194 0004 HT UBE2O LUC7L2 26186194 0004 HT UBE2O HEL-S-22 26496610 0004 HT UBC UBE2O 12938929,17550899,8634298,20639865 0096,0004,0096,0004 LC BAP1 UBE2O 24703950,24703950,24703950,24703950 0096,0415,0401,0004 LC POP7 UBE2O 22863883 0401 LC SHBG UBE2O 15862967 0018 LC TRIM27 UBE2O 19549727,19549727 0397,0018 HT RPL12 UBE2O 19549727 0018 HT MCAM UBE2O 19549727 0018 HT RPL29 UBE2O 19549727 0018 HT SMARCA4 UBE2O 19549727 0018 HT GABARAPL2 UBE2O 19549727 0018 HT RPS20 UBE2O 19549727 0018 HT RPS7 UBE2O 19549727 0018 HT UBA52 UBE2O 19549727 0018 HT YBX1 UBE2O 19549727 0018 HT UBE2V1 UBE2O 25260751 0997 LC POLA2 UBE2O 22863883 0401 LC PAFAH1B3 UBE2O 19549727 0018 HT CHD1L UBE2O 19549727 0018 HT ZNF687 UBE2O 22939629 0401 LC RNF10 UBE2O 19549727,19549727 0397,0018 HT BAP1 UBE2O 24703950,24703950,24703950,24703950 0096,0415,0401,0004 LC CPNE4 UBE2O 12522145 0018 LC CPNE2 UBE2O 12522145 0018 LC HNRNPAB UBE2O 19549727 0018 HT CPNE1 UBE2O 12522145 0018 LC UBE2O UBE2O 24703950 0415 LC UBE2O WDR26 22939629 0401 LC UBE2O SAP30L 19549727 0018 HT UBE2O XAGE1A|XAGE1B|XAGE1C|XAGE1D|XAGE1E 19549727 0018 HT UBE2O APPL1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9C0C9 P60866 UBE2O RPS20 0.183 19549727 Q9C0C9 O43541 UBE2O SMAD6 0.332 23455153 Q9C0C9 O43709 UBE2O WBSCR22 0.126 26186194 Q9C0C9 Q8N5U6 UBE2O RNF10 0.376 19549727 Q9H8V3 Q9C0C9 ECT2 UBE2O 0.126 22990118 Q9C0C9 Q8N8Y5 UBE2O ZFP41 0.126 26186194 Q9C0C9 O60216 UBE2O RAD21 0.126 22145905 Q9NPJ6 Q9C0C9 MED4 UBE2O 0.126 25281560 Q9NQ29 Q9C0C9 LUC7L UBE2O 0.126 26186194 Q9NRC8 Q9C0C9 SIRT7 UBE2O 0.126 22586326 Q9NVW2 Q9C0C9 RLIM UBE2O 0.126 23455153 Q9C0C9 O35253 UBE2O SMAD7 0.126 23455153 Q9C0C9 Q8IY81 UBE2O FTSJ3 0.126 24778252 Q9Y3C5 Q9C0C9 RNF11 UBE2O 0.21 23751493 Q9Y383 Q9C0C9 LUC7L2 UBE2O 0.126 26186194 Q9C0C9 P0CG48 UBE2O UBC 0.126 17550899 Q9C0C9 Q6FHJ7 UBE2O SFRP4 0.126 26186194 Q9C0C9 O94992 UBE2O HEXIM1 0.126 26186194 Q9C0C9 P13725 UBE2O OSM 0.126 26186194 Q9C0C9 P04278 UBE2O SHBG 0.183 15862967 Q9C0C9 P14373 UBE2O TRIM27 0.376 19549727 Q9C0C9 P04608 UBE2O TAT 0.286 22190034 Q9C0C9 P04629 UBE2O NTRK1 0.126 25921289 Q9C0C9 P05412 UBE2O JUN 0.126 25609649 Q9C0C9 O96017 UBE2O CHEK2 0.126 23178491 Q9C0C9 P15208 UBE2O INSR 0.236 26496610 Q9C0C9 P09211 UBE2O GSTP1 0.236 26496610 Q9C0C9 Q13352 UBE2O ITGB3BP 0.236 26496610 Q9C0C9 Q5VUG0 UBE2O SFMBT2 0.236 unassigned1304 Q9UKG1 Q9C0C9 APPL1 UBE2O 0.583 25416956,unassigned1304 Q9C0C9 Q9C0C9 UBE2O UBE2O 0.436 24703950,23455153 Q9C0C9 Q8CJ40 UBE2O CROCC 0.236 26496610 Q9C0C9 Q86VQ0 UBE2O LCA5 0.416 26638075 Q9C0C9 P30050 UBE2O RPL12 0.332 19549727 Q9C0C9 Q96A08 UBE2O HIST1H2BA 0.126 26186194 Q9C0C9 Q96C28 UBE2O ZNF707 0.126 26186194 Q9C0C9 Q9BT88 UBE2O SYT11 0.126 26186194 Q9C0C9 Q9BUZ4 UBE2O TRAF4 0.21 23381138 Q9C0C9 Q96T60 UBE2O PNKP 0.21 15385968 Q9C0C9 O15105 UBE2O SMAD7 0.236 23455153 Q9C0C9 O35182 UBE2O SMAD6 0.332 23455153 Q9C0C9 O75817 UBE2O POP7 0.081 22863883 Q9C0C9 P51532 UBE2O SMARCA4 0.332 19549727 Q9C0C9 P60520 UBE2O GABARAPL2 0.332 19549727 Q9C0C9 P62081 UBE2O RPS7 0.332 19549727 Q9C0C9 P62987 UBE2O UBA52 0.183 19549727 Q9C0C9 P67809 UBE2O YBX1 0.183 19549727 Q9C0C9 Q14181 UBE2O POLA2 0.081 22863883 Q9C0C9 Q15102 UBE2O PAFAH1B3 0.332 19549727 Q9C0C9 Q86WJ1 UBE2O CHD1L 0.332 19549727 Q9C0C9 Q8IY92 UBE2O SLX4 0.236 19596235 Q9C0C9 Q8N1G0 UBE2O ZNF687 0.081 22939629 Q9C0C9 Q92560 UBE2O BAP1 0.78 24703950,27705803,19615732 Q9C0C9 Q99729 UBE2O HNRNPAB 0.183 19549727 Q9C0C9 Q99ML9 UBE2O RNF111 0.126 23455153 Q9H7D7 Q9C0C9 WDR26 UBE2O 0.081 22939629 Q9HAJ7 Q9C0C9 SAP30L UBE2O 0.332 19549727 Q9HD64 Q9C0C9 XAGE1E UBE2O 0.183 19549727 Q9Y4K3 Q9C0C9 TRAF6 UBE2O 0.376 23381138 Q9UBU9 Q9C0C9 NXF1 UBE2O 0.126 22658674 Q9UGY1 Q9C0C9 NOL12 UBE2O 0.126 26186194 Q9C0C9 P34947 UBE2O GRK5 0.126 22952844 Q9C0C9 P43121 UBE2O MCAM 0.183 19549727 Q9C0C9 P47914 UBE2O RPL29 0.183 19549727 Q9C0C9 P62807 UBE2O HIST1H2BI 0.126 25281560 Q9C0C9 Q14331 UBE2O FRG1 0.126 26186194 Q9C0C9 Q12933 UBE2O TRAF2 0.21 23381138 Q9C0C9 Q13077 UBE2O TRAF1 0.21 23381138 Q9C0C9 Q15327 UBE2O ANKRD1 0.126 26186194 Q9C0C9 Q13114 UBE2O TRAF3 0.21 23381138 Q9C0C9 Q13404 UBE2O UBE2V1 0.033 25260751 Q9C0C9 O00463 UBE2O TRAF5 0.21 23381138 Q9C0C9 P55209 UBE2O NAP1L1 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 TRAF5 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database SMAD7 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database SMAD6 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database WBSCR22 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database RAD21 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database HEXIM1 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database CBX6 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database RAB36 UBE2O MI:0362 inference MI:0461 interaction database CHEK2 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database SHBG UBE2O MI:0045 experimental interaction detection MI:0461 interaction database NTRK1 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database JUN UBE2O MI:0045 experimental interaction detection MI:0461 interaction database INSR UBE2O MI:0362 inference MI:0461 interaction database GSTP1 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database UBC UBE2O MI:0045 experimental interaction detection MI:0461 interaction database OSM UBE2O MI:0045 experimental interaction detection MI:0461 interaction database TRIM27 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database RPL12 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database GRK5 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database MCAM UBE2O MI:0045 experimental interaction detection MI:0461 interaction database RPL29 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database SMARCA4 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database NAP1L1 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database GABARAPL2 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database RPS20 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database RPS7 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database HIST1H2BC UBE2O MI:0045 experimental interaction detection MI:0461 interaction database UBA52 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database YBX1 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database TRAF2 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database TRAF1 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database TRAF3 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database ITGB3BP UBE2O MI:0045 experimental interaction detection MI:0461 interaction database UBE2V1 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database FRG1 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database NBR1 UBE2O MI:0362 inference MI:0461 interaction database PAFAH1B3 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database ANKRD1 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database KIAA0753 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database CROCC UBE2O MI:0362 inference MI:0461 interaction database SFRP4 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database RNF111 UBE2O MI:0362 inference MI:0461 interaction database LCA5 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database CHD1L UBE2O MI:0045 experimental interaction detection MI:0461 interaction database FTSJ3 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database SLX4 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database RNF10 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database ZFP41 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database BAP1 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database HIST1H2BA UBE2O MI:0045 experimental interaction detection MI:0461 interaction database CPNE4 UBE2O MI:0362 inference MI:0461 interaction database ZNF707 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database CPNE2 UBE2O MI:0362 inference MI:0461 interaction database RAB40C UBE2O MI:0362 inference MI:0461 interaction database PNKP UBE2O MI:0045 experimental interaction detection MI:0461 interaction database HNRNPAB UBE2O MI:0045 experimental interaction detection MI:0461 interaction database CPNE1 UBE2O MI:0362 inference MI:0461 interaction database SYT11 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database TRAF4 UBE2O MI:0045 experimental interaction detection MI:0461 interaction database UBE2O ECT2 MI:0045 experimental interaction detection MI:0461 interaction database UBE2O SAP30L MI:0045 experimental interaction detection MI:0461 interaction database UBE2O XAGE1A MI:0045 experimental interaction detection MI:0461 interaction database UBE2O MED4 MI:0045 experimental interaction detection MI:0461 interaction database UBE2O LUC7L MI:0045 experimental interaction detection MI:0461 interaction database UBE2O SIRT7 MI:0045 experimental interaction detection MI:0461 interaction database UBE2O RLIM MI:0045 experimental interaction detection MI:0461 interaction database UBE2O NXF1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2O NOL12 MI:0045 experimental interaction detection MI:0461 interaction database UBE2O APPL1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2O LUC7L2 MI:0045 experimental interaction detection MI:0461 interaction database UBE2O RNF11 MI:0045 experimental interaction detection MI:0461 interaction database UBE2O TRAF6 MI:0045 experimental interaction detection MI:0461 interaction database