Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change BLCA 8 124663842 124663842 + Missense_Mutation SNP A A T TCGA-FD-A43P-01A-31D-A23U-08 TCGA-FD-A43P-10A-01D-A23U-08 g.chr8:124663842A>T c.1325T>A c.(1324-1326)aTg>aAg p.M442K BLCA 8 124664012 124664012 + Missense_Mutation SNP G G C TCGA-DK-A1AD-01A-11D-A13W-08 TCGA-DK-A1AD-10A-01D-A13W-08 g.chr8:124664012G>C c.1155C>G c.(1153-1155)atC>atG p.I385M BLCA 8 124664510 124664510 + Missense_Mutation SNP G G C TCGA-H4-A2HQ-01A-11D-A17V-08 TCGA-H4-A2HQ-10A-01D-A17V-08 g.chr8:124664510G>C c.657C>G c.(655-657)ttC>ttG p.F219L BRCA 8 124658251 124658251 + Missense_Mutation SNP G G C TCGA-B6-A0IK-01A-12W-A071-09 TCGA-B6-A0IK-10A-01W-A071-09 g.chr8:124658251G>C c.1474C>G c.(1474-1476)Ctt>Gtt p.L492V BRCA 8 124663967 124663967 + Silent SNP G G T TCGA-A7-A0DA-01A-31D-A10Y-09 TCGA-A7-A0DA-10A-01D-A110-09 g.chr8:124663967G>T c.1200C>A c.(1198-1200)tcC>tcA p.S400S BRCA 8 124664055 124664055 + Missense_Mutation SNP A A C TCGA-A2-A0T5-01A-21D-A099-09 TCGA-A2-A0T5-10A-01D-A099-09 g.chr8:124664055A>C c.1112T>G c.(1111-1113)gTg>gGg p.V371G BRCA 8 124664078 124664078 + Missense_Mutation SNP C C G TCGA-AN-A04D-01A-21W-A050-09 TCGA-AN-A04D-10A-01W-A055-09 g.chr8:124664078C>G c.1089G>C c.(1087-1089)tgG>tgC p.W363C BRCA 8 124664638 124664638 + Missense_Mutation SNP C C T TCGA-E2-A154-01A-11D-A10Y-09 TCGA-E2-A154-10A-01D-A110-09 g.chr8:124664638C>T c.529G>A c.(529-531)Gcc>Acc p.A177T BRCA 8 124664670 124664670 + Missense_Mutation SNP A A C TCGA-A8-A0A6-01A-12W-A071-09 TCGA-A8-A0A6-10A-01W-A071-09 g.chr8:124664670A>C c.497T>G c.(496-498)gTg>gGg p.V166G BRCA 8 124664946 124664946 + Missense_Mutation SNP T T A TCGA-BH-A0HF-01A-11W-A071-09 TCGA-BH-A0HF-10A-01W-A071-09 g.chr8:124664946T>A c.221A>T c.(220-222)aAa>aTa p.K74I CESC 8 124658171 124658171 + Silent SNP C C T TCGA-UC-A7PF-01A-11D-A351-09 TCGA-UC-A7PF-11A-31D-A351-09 g.chr8:124658171C>T c.1554G>A c.(1552-1554)gtG>gtA p.V518V CESC 8 124664078 124664078 + Missense_Mutation SNP C C G TCGA-JX-A3Q0-01A-11D-A21Q-09 TCGA-JX-A3Q0-10A-01D-A21Q-09 g.chr8:124664078C>G c.1089G>C c.(1087-1089)tgG>tgC p.W363C CESC 8 124664263 124664263 + Missense_Mutation SNP C C T TCGA-FU-A5XV-01A-11D-A28B-09 TCGA-FU-A5XV-10A-01D-A28E-09 g.chr8:124664263C>T c.904G>A c.(904-906)Gtc>Atc p.V302I CESC 8 124664926 124664926 + Missense_Mutation SNP C C T TCGA-MY-A5BD-01A-11D-A26G-09 TCGA-MY-A5BD-10A-01D-A26G-09 g.chr8:124664926C>T c.241G>A c.(241-243)Gac>Aac p.D81N COAD 8 124658144 124658144 + Silent SNP G G A TCGA-AA-3510-01A-01D-1408-10 TCGA-AA-3510-11A-01D-1408-10 g.chr8:124658144G>A c.1581C>T c.(1579-1581)ggC>ggT p.G527G COAD 8 124658144 124658144 + Silent SNP G G A TCGA-AA-3710-01A-01W-0995-10 TCGA-AA-3710-10A-01W-0995-10 g.chr8:124658144G>A c.1581C>T c.(1579-1581)ggC>ggT p.G527G COAD 8 124663888 124663888 + Missense_Mutation SNP C C T TCGA-AA-3975-01A-01W-0995-10 TCGA-AA-3975-10A-01W-0999-10 g.chr8:124663888C>T c.1279G>A c.(1279-1281)Gct>Act p.A427T COAD 8 124664009 124664009 + Missense_Mutation SNP G G T TCGA-AA-A00N-01A-02W-A00E-09 TCGA-AA-A00N-10A-01W-A00E-09 g.chr8:124664009G>T c.1158C>A c.(1156-1158)ttC>ttA p.F386L COAD 8 124664059 124664059 + Silent SNP G G A TCGA-AA-A010-01A-01W-A00E-09 TCGA-AA-A010-10A-01W-A00E-09 g.chr8:124664059G>A c.1108C>T c.(1108-1110)Ctg>Ttg p.L370L COAD 8 124664168 124664168 + Silent SNP G G A TCGA-CM-5344-01A-21D-1719-10 TCGA-CM-5344-10A-01D-1719-10 g.chr8:124664168G>A c.999C>T c.(997-999)agC>agT p.S333S COAD 8 124664172 124664172 + Missense_Mutation SNP C C T TCGA-AY-6197-01A-11D-1719-10 TCGA-AY-6197-10A-01D-1719-10 g.chr8:124664172C>T c.995G>A c.(994-996)cGc>cAc p.R332H COAD 8 124664205 124664205 + Missense_Mutation SNP C C T TCGA-AA-3821-01A-01W-0995-10 TCGA-AA-3821-10A-01W-0995-10 g.chr8:124664205C>T c.962G>A c.(961-963)cGg>cAg p.R321Q COAD 8 124664597 124664597 + Missense_Mutation SNP A A C TCGA-AZ-6600-01A-11D-1771-10 TCGA-AZ-6600-11A-01D-1771-10 g.chr8:124664597A>C c.570T>G c.(568-570)tgT>tgG p.C190W COAD 8 124665021 124665021 + Missense_Mutation SNP C C T TCGA-AA-3681-01A-01W-0900-09 TCGA-AA-3681-10A-01W-0900-09 g.chr8:124665021C>T c.146G>A c.(145-147)cGc>cAc p.R49H COAD 8 124665026 124665026 + Silent SNP G G A TCGA-AA-3710-01A-01W-0995-10 TCGA-AA-3710-10A-01W-0995-10 g.chr8:124665026G>A c.141C>T c.(139-141)tgC>tgT p.C47C COADREAD 8 124658144 124658144 + Silent SNP G G A TCGA-AA-3510-01A-01D-1408-10 TCGA-AA-3510-11A-01D-1408-10 g.chr8:124658144G>A c.1581C>T c.(1579-1581)ggC>ggT p.G527G COADREAD 8 124658144 124658144 + Silent SNP G G A TCGA-AA-3710-01A-01W-0995-10 TCGA-AA-3710-10A-01W-0995-10 g.chr8:124658144G>A c.1581C>T c.(1579-1581)ggC>ggT p.G527G COADREAD 8 124663888 124663888 + Missense_Mutation SNP C C T TCGA-AA-3975-01A-01W-0995-10 TCGA-AA-3975-10A-01W-0999-10 g.chr8:124663888C>T c.1279G>A c.(1279-1281)Gct>Act p.A427T COADREAD 8 124664009 124664009 + Missense_Mutation SNP G G T TCGA-AA-A00N-01A-02W-A00E-09 TCGA-AA-A00N-10A-01W-A00E-09 g.chr8:124664009G>T c.1158C>A c.(1156-1158)ttC>ttA p.F386L COADREAD 8 124664059 124664059 + Silent SNP G G A TCGA-AA-A010-01A-01W-A00E-09 TCGA-AA-A010-10A-01W-A00E-09 g.chr8:124664059G>A c.1108C>T c.(1108-1110)Ctg>Ttg p.L370L COADREAD 8 124664168 124664168 + Silent SNP G G A TCGA-CM-5344-01A-21D-1719-10 TCGA-CM-5344-10A-01D-1719-10 g.chr8:124664168G>A c.999C>T c.(997-999)agC>agT p.S333S COADREAD 8 124664172 124664172 + Missense_Mutation SNP C C T TCGA-AY-6197-01A-11D-1719-10 TCGA-AY-6197-10A-01D-1719-10 g.chr8:124664172C>T c.995G>A c.(994-996)cGc>cAc p.R332H COADREAD 8 124664205 124664205 + Missense_Mutation SNP C C T TCGA-AA-3821-01A-01W-0995-10 TCGA-AA-3821-10A-01W-0995-10 g.chr8:124664205C>T c.962G>A c.(961-963)cGg>cAg p.R321Q COADREAD 8 124664387 124664387 + Missense_Mutation SNP G G T TCGA-AG-A002-01A-01W-A00K-09 TCGA-AG-A002-10A-01W-A00K-09 g.chr8:124664387G>T c.780C>A c.(778-780)ttC>ttA p.F260L COADREAD 8 124664597 124664597 + Missense_Mutation SNP A A C TCGA-AZ-6600-01A-11D-1771-10 TCGA-AZ-6600-11A-01D-1771-10 g.chr8:124664597A>C c.570T>G c.(568-570)tgT>tgG p.C190W COADREAD 8 124664615 124664615 + Silent SNP G G A TCGA-AG-A002-01A-01W-A00K-09 TCGA-AG-A002-10A-01W-A00K-09 g.chr8:124664615G>A c.552C>T c.(550-552)ctC>ctT p.L184L COADREAD 8 124665021 124665021 + Missense_Mutation SNP C C T TCGA-AA-3681-01A-01W-0900-09 TCGA-AA-3681-10A-01W-0900-09 g.chr8:124665021C>T c.146G>A c.(145-147)cGc>cAc p.R49H COADREAD 8 124665026 124665026 + Silent SNP G G A TCGA-AA-3710-01A-01W-0995-10 TCGA-AA-3710-10A-01W-0995-10 g.chr8:124665026G>A c.141C>T c.(139-141)tgC>tgT p.C47C ESCA 8 124658211 124658211 + Missense_Mutation SNP G G A TCGA-VR-AA7I-01A-11D-A403-09 TCGA-VR-AA7I-10A-01D-A403-09 g.chr8:124658211G>A c.1514C>T c.(1513-1515)gCg>gTg p.A505V ESCA 8 124663967 124663967 + Silent SNP G G A TCGA-JY-A93D-01A-11D-A387-09 TCGA-JY-A93D-10A-01D-A38A-09 g.chr8:124663967G>A c.1200C>T c.(1198-1200)tcC>tcT p.S400S ESCA 8 124664405 124664405 + Silent SNP G G T TCGA-L5-A4OI-01A-11D-A27G-09 TCGA-L5-A4OI-11A-11D-A27G-09 g.chr8:124664405G>T c.762C>A c.(760-762)acC>acA p.T254T ESCA 8 124664819 124664819 + Silent SNP G G A TCGA-V5-A7RE-01A-11D-A351-09 TCGA-V5-A7RE-10A-01D-A351-09 g.chr8:124664819G>A c.348C>T c.(346-348)ttC>ttT p.F116F ESCA 8 124664837 124664837 + Silent SNP G G A TCGA-VR-A8EU-01A-11D-A36J-09 TCGA-VR-A8EU-10A-01D-A36M-09 g.chr8:124664837G>A c.330C>T c.(328-330)gcC>gcT p.A110A GBMLGG 8 124658070 124658070 + Missense_Mutation SNP G G T TCGA-DU-6392-01A-11D-1705-08 TCGA-DU-6392-10A-01D-1705-08 g.chr8:124658070G>T c.1655C>A c.(1654-1656)aCc>aAc p.T552N GBMLGG 8 124664240 124664240 + Silent SNP G G A TCGA-DU-7306-01A-11D-2086-08 TCGA-DU-7306-10A-01D-2086-08 g.chr8:124664240G>A c.927C>T c.(925-927)acC>acT p.T309T GBMLGG 8 124664296 124664296 + Missense_Mutation SNP C C T TCGA-S9-A6TX-01A-21D-A32B-08 TCGA-S9-A6TX-10A-01D-A329-08 g.chr8:124664296C>T c.871G>A c.(871-873)Gga>Aga p.G291R GBMLGG 8 124664297 124664297 + Silent SNP G G A TCGA-P5-A72W-01A-11D-A32B-08 TCGA-P5-A72W-10A-01D-A329-08 g.chr8:124664297G>A c.870C>T c.(868-870)ggC>ggT p.G290G GBMLGG 8 124664667 124664667 + Missense_Mutation SNP G G A TCGA-DU-6410-01A-11D-1893-08 TCGA-DU-6410-10A-01D-1893-08 g.chr8:124664667G>A c.500C>T c.(499-501)gCc>gTc p.A167V HNSC 8 124658219 124658219 + Silent SNP G G C TCGA-UF-A7JA-01A-12D-A34J-08 TCGA-UF-A7JA-10A-01D-A34M-08 g.chr8:124658219G>C c.1506C>G c.(1504-1506)gtC>gtG p.V502V HNSC 8 124664012 124664012 + Missense_Mutation SNP G G C TCGA-RS-A6TO-01A-32D-A34J-08 TCGA-RS-A6TO-10A-01D-A34M-08 g.chr8:124664012G>C c.1155C>G c.(1153-1155)atC>atG p.I385M HNSC 8 124664436 124664436 + Missense_Mutation SNP G G A TCGA-BA-5152-01A-02D-1870-08 TCGA-BA-5152-10A-01D-1870-08 g.chr8:124664436G>A c.731C>T c.(730-732)tCc>tTc p.S244F HNSC 8 124664536 124664536 + Missense_Mutation SNP G G A TCGA-BB-A6UM-01A-12D-A34J-08 TCGA-BB-A6UM-10A-01D-A34M-08 g.chr8:124664536G>A c.631C>T c.(631-633)Cgg>Tgg p.R211W HNSC 8 124664564 124664565 + Frame_Shift_Del DEL CA CA - TCGA-CV-A6JE-01A-11D-A31L-08 TCGA-CV-A6JE-10A-01D-A31J-08 g.chr8:124664564_124664565delCA c.602_603delTG c.(601-603)atgfs p.M201fs HNSC 8 124664957 124664957 + Silent SNP C C T TCGA-CV-A6JM-01A-11D-A31L-08 TCGA-CV-A6JM-10A-01D-A31J-08 g.chr8:124664957C>T c.210G>A c.(208-210)aaG>aaA p.K70K HNSC 8 124665031 124665031 + Missense_Mutation SNP G G A TCGA-CV-A468-01A-11D-A25Y-08 TCGA-CV-A468-10A-01D-A25Y-08 g.chr8:124665031G>A c.136C>T c.(136-138)Ccc>Tcc p.P46S KIPAN 8 124659249 124659249 + Silent SNP A A G TCGA-GL-A9DC-01A-11D-A36X-10 TCGA-GL-A9DC-10A-01D-A370-10 g.chr8:124659249A>G c.1356T>C c.(1354-1356)taT>taC p.Y452Y KIPAN 8 124664647 124664647 + Missense_Mutation SNP C C G TCGA-A3-3367-01A-02D-1421-08 TCGA-A3-3367-11A-01D-1421-08 g.chr8:124664647C>G c.520G>C c.(520-522)Gag>Cag p.E174Q KIRC 8 124664647 124664647 + Missense_Mutation SNP C C G TCGA-A3-3367-01A-02D-1421-08 TCGA-A3-3367-11A-01D-1421-08 g.chr8:124664647C>G c.520G>C c.(520-522)Gag>Cag p.E174Q KIRP 8 124659249 124659249 + Silent SNP A A G TCGA-GL-A9DC-01A-11D-A36X-10 TCGA-GL-A9DC-10A-01D-A370-10 g.chr8:124659249A>G c.1356T>C c.(1354-1356)taT>taC p.Y452Y LGG 8 124658070 124658070 + Missense_Mutation SNP G G T TCGA-DU-6392-01A-11D-1705-08 TCGA-DU-6392-10A-01D-1705-08 g.chr8:124658070G>T c.1655C>A c.(1654-1656)aCc>aAc p.T552N LGG 8 124664240 124664240 + Silent SNP G G A TCGA-DU-7306-01A-11D-2086-08 TCGA-DU-7306-10A-01D-2086-08 g.chr8:124664240G>A c.927C>T c.(925-927)acC>acT p.T309T LGG 8 124664296 124664296 + Missense_Mutation SNP C C T TCGA-S9-A6TX-01A-21D-A32B-08 TCGA-S9-A6TX-10A-01D-A329-08 g.chr8:124664296C>T c.871G>A c.(871-873)Gga>Aga p.G291R LGG 8 124664297 124664297 + Silent SNP G G A TCGA-P5-A72W-01A-11D-A32B-08 TCGA-P5-A72W-10A-01D-A329-08 g.chr8:124664297G>A c.870C>T c.(868-870)ggC>ggT p.G290G LGG 8 124664667 124664667 + Missense_Mutation SNP G G A TCGA-DU-6410-01A-11D-1893-08 TCGA-DU-6410-10A-01D-1893-08 g.chr8:124664667G>A c.500C>T c.(499-501)gCc>gTc p.A167V LIHC 8 124658143 124658143 + Missense_Mutation SNP C C T TCGA-DD-AADF-01A-11D-A40R-10 TCGA-DD-AADF-10A-01D-A40U-10 g.chr8:124658143C>T c.1582G>A c.(1582-1584)Ggg>Agg p.G528R LIHC 8 124659239 124659239 + Missense_Mutation SNP T T C TCGA-2Y-A9H5-01A-11D-A382-10 TCGA-2Y-A9H5-10A-01D-A385-10 g.chr8:124659239T>C c.1366A>G c.(1366-1368)Aga>Gga p.R456G LIHC 8 124664197 124664197 + Missense_Mutation SNP T T C TCGA-DD-AACX-01A-11D-A40R-10 TCGA-DD-AACX-10A-01D-A40U-10 g.chr8:124664197T>C c.970A>G c.(970-972)Aag>Gag p.K324E LIHC 8 124664210 124664210 + Silent SNP C C G TCGA-DD-AADC-01A-11D-A40R-10 TCGA-DD-AADC-10A-01D-A40U-10 g.chr8:124664210C>G c.957G>C c.(955-957)ccG>ccC p.P319P LIHC 8 124664565 124664565 + Missense_Mutation SNP A A G TCGA-UB-A7MB-01A-11D-A33Q-10 TCGA-UB-A7MB-10A-01D-A33Q-10 g.chr8:124664565A>G c.602T>C c.(601-603)aTg>aCg p.M201T LIHC 8 124664885 124664885 + Silent SNP C C T TCGA-DD-AAE7-01A-11D-A40R-10 TCGA-DD-AAE7-10A-01D-A40U-10 g.chr8:124664885C>T c.282G>A c.(280-282)acG>acA p.T94T LUAD 8 124657999 124657999 + Missense_Mutation SNP G G C TCGA-78-7155-01A-11D-2036-08 TCGA-78-7155-10A-01D-2036-08 g.chr8:124657999G>C c.1726C>G c.(1726-1728)Cgc>Ggc p.R576G LUAD 8 124658090 124658090 + Silent SNP G G A TCGA-49-6743-01A-11D-1855-08 TCGA-49-6743-11A-01D-1855-08 g.chr8:124658090G>A c.1635C>T c.(1633-1635)tgC>tgT p.C545C LUAD 8 124658139 124658139 + Missense_Mutation SNP C C T TCGA-73-7498-01A-12D-2184-08 TCGA-73-7498-10A-01D-2184-08 g.chr8:124658139C>T c.1586G>A c.(1585-1587)cGg>cAg p.R529Q LUAD 8 124658213 124658213 + Nonsense_Mutation SNP A A T TCGA-91-6831-01A-11D-1855-08 TCGA-91-6831-11A-02D-1855-08 g.chr8:124658213A>T c.1512T>A c.(1510-1512)tgT>tgA p.C504* LUAD 8 124659188 124659188 + Missense_Mutation SNP G G C TCGA-55-8089-01A-11D-2238-08 TCGA-55-8089-10A-01D-2238-08 g.chr8:124659188G>C c.1417C>G c.(1417-1419)Cct>Gct p.P473A LUAD 8 124659239 124659239 + Missense_Mutation SNP T T C TCGA-73-4675-01A-01D-1265-08 TCGA-73-4675-11A-01D-1265-08 g.chr8:124659239T>C c.1366A>G c.(1366-1368)Aga>Gga p.R456G LUAD 8 124663831 124663831 + Missense_Mutation SNP C C A TCGA-55-7727-01A-11D-2167-08 TCGA-55-7727-10A-01D-2167-08 g.chr8:124663831C>A c.1336G>T c.(1336-1338)Gtg>Ttg p.V446L LUAD 8 124663858 124663859 + Frame_Shift_Ins INS - - A TCGA-50-5930-01A-11D-1753-08 TCGA-50-5930-11A-01D-1753-08 g.chr8:124663858_124663859insA c.1308_1309insT c.(1306-1311)tttggafs p.G437fs LUAD 8 124663935 124663935 + Nonsense_Mutation SNP C C T TCGA-17-Z028-01A-01W-0746-08 TCGA-17-Z028-11A-01W-0746-08 g.chr8:124663935C>T c.1232G>A c.(1231-1233)tGg>tAg p.W411* LUAD 8 124664033 124664033 + Missense_Mutation SNP G G T TCGA-53-7626-01A-12D-2063-08 TCGA-53-7626-10A-01D-2063-08 g.chr8:124664033G>T c.1134C>A c.(1132-1134)agC>agA p.S378R LUAD 8 124664095 124664095 + Missense_Mutation SNP G G C TCGA-91-6829-01A-21D-1855-08 TCGA-91-6829-11A-01D-1855-08 g.chr8:124664095G>C c.1072C>G c.(1072-1074)Ctg>Gtg p.L358V LUAD 8 124664205 124664205 + Missense_Mutation SNP C C A TCGA-55-8507-01A-11D-2393-08 TCGA-55-8507-10A-01D-2393-08 g.chr8:124664205C>A c.962G>T c.(961-963)cGg>cTg p.R321L LUAD 8 124664210 124664210 + Silent SNP C C A TCGA-91-A4BC-01A-11D-A24D-08 TCGA-91-A4BC-10A-01D-A24F-08 g.chr8:124664210C>A c.957G>T c.(955-957)ccG>ccT p.P319P LUAD 8 124664241 124664241 + Missense_Mutation SNP G G T TCGA-91-6835-01A-11D-1855-08 TCGA-91-6835-11A-01D-1855-08 g.chr8:124664241G>T c.926C>A c.(925-927)aCc>aAc p.T309N LUAD 8 124664255 124664255 + Silent SNP C C G TCGA-75-7025-01A-12D-1945-08 TCGA-75-7025-10A-01D-1946-08 g.chr8:124664255C>G c.912G>C c.(910-912)ctG>ctC p.L304L LUAD 8 124664263 124664263 + Missense_Mutation SNP C C A TCGA-50-5933-01A-11D-1753-08 TCGA-50-5933-11A-01D-1753-08 g.chr8:124664263C>A c.904G>T c.(904-906)Gtc>Ttc p.V302F LUAD 8 124664403 124664403 + Missense_Mutation SNP G G A TCGA-05-4244-01A-01D-1105-08 TCGA-05-4244-10A-01D-1105-08 g.chr8:124664403G>A c.764C>T c.(763-765)gCc>gTc p.A255V LUAD 8 124664555 124664555 + Missense_Mutation SNP G G C TCGA-55-6968-01A-11D-1945-08 TCGA-55-6968-11A-01D-1945-08 g.chr8:124664555G>C c.612C>G c.(610-612)atC>atG p.I204M LUAD 8 124664765 124664765 + Missense_Mutation SNP G G T TCGA-05-4410-01A-21D-1855-08 TCGA-05-4410-10A-01D-1855-08 g.chr8:124664765G>T c.402C>A c.(400-402)agC>agA p.S134R LUAD 8 124664963 124664963 + Silent SNP C C A TCGA-MP-A4TD-01A-32D-A25L-08 TCGA-MP-A4TD-10A-01D-A25L-08 g.chr8:124664963C>A c.204G>T c.(202-204)cgG>cgT p.R68R LUAD 8 124664983 124664983 + Missense_Mutation SNP T T C TCGA-55-7994-01A-11D-2184-08 TCGA-55-7994-10A-01D-2184-08 g.chr8:124664983T>C c.184A>G c.(184-186)Atg>Gtg p.M62V LUAD 8 124665152 124665152 + Silent SNP T T C TCGA-64-1677-01A-01W-0928-08 TCGA-64-1677-10A-01W-0928-08 g.chr8:124665152T>C c.15A>G c.(13-15)tcA>tcG p.S5S LUSC 8 124658160 124658160 + Missense_Mutation SNP T T G TCGA-34-2600-01A-01D-1522-08 TCGA-34-2600-11A-01D-1522-08 g.chr8:124658160T>G c.1565A>C c.(1564-1566)aAa>aCa p.K522T LUSC 8 124658216 124658216 + Silent SNP T T C TCGA-66-2782-01A-01D-1522-08 TCGA-66-2782-11A-01D-1522-08 g.chr8:124658216T>C c.1509A>G c.(1507-1509)aaA>aaG p.K503K LUSC 8 124659171 124659171 + Silent SNP C C A TCGA-33-4566-01A-01D-1441-08 TCGA-33-4566-11A-01D-1441-08 g.chr8:124659171C>A c.1434G>T c.(1432-1434)ggG>ggT p.G478G LUSC 8 124663821 124663821 + Missense_Mutation SNP A A T TCGA-66-2792-01A-01D-0983-08 TCGA-66-2792-11A-01D-0983-08 g.chr8:124663821A>T c.1346T>A c.(1345-1347)aTc>aAc p.I449N LUSC 8 124664148 124664148 + Missense_Mutation SNP A A T TCGA-21-5784-01A-01D-1632-08 TCGA-21-5784-10A-01D-1632-08 g.chr8:124664148A>T c.1019T>A c.(1018-1020)aTg>aAg p.M340K LUSC 8 124664915 124664915 + Silent SNP G G A TCGA-39-5029-01A-01D-1441-08 TCGA-39-5029-11A-01D-1441-08 g.chr8:124664915G>A c.252C>T c.(250-252)acC>acT p.T84T PAAD 8 124664364 124664364 + Missense_Mutation SNP G G A TCGA-2L-AAQM-01A-11D-A397-08 TCGA-2L-AAQM-11A-11D-A39A-08 g.chr8:124664364G>A c.803C>T c.(802-804)cCa>cTa p.P268L PAAD 8 124664765 124664792 + Frame_Shift_Del DEL GCTGGGGGCCAACTGGCTCTGCAAGTAC GCTGGGGGCCAACTGGCTCTGCAAGTAC - TCGA-HZ-7918-01A-11D-2154-08 TCGA-HZ-7918-10A-01D-2154-08 g.chr8:124664765_124664792delGCTGGGGGCCAACTGGCTCTGCAAGTAC c.375_402delGTACTTGCAGAGCCAGTTGGCCCCCAGC c.(373-402)tcgtacttgcagagccagttggcccccagcfs p.SYLQSQLAPS125fs PAAD 8 124664939 124664939 + Silent SNP C C T TCGA-IB-7651-01A-11D-2154-08 TCGA-IB-7651-10A-01D-2154-08 g.chr8:124664939C>T c.228G>A c.(226-228)caG>caA p.Q76Q PAAD 8 124665022 124665022 + Missense_Mutation SNP G G A TCGA-IB-7651-01A-11D-2154-08 TCGA-IB-7651-10A-01D-2154-08 g.chr8:124665022G>A c.145C>T c.(145-147)Cgc>Tgc p.R49C PRAD 8 124664821 124664821 + Missense_Mutation SNP A A G TCGA-HC-A4ZV-01A-11D-A26M-08 TCGA-HC-A4ZV-10A-01D-A26K-08 g.chr8:124664821A>G c.346T>C c.(346-348)Ttc>Ctc p.F116L READ 8 124664387 124664387 + Missense_Mutation SNP G G T TCGA-AG-A002-01A-01W-A00K-09 TCGA-AG-A002-10A-01W-A00K-09 g.chr8:124664387G>T c.780C>A c.(778-780)ttC>ttA p.F260L READ 8 124664615 124664615 + Silent SNP G G A TCGA-AG-A002-01A-01W-A00K-09 TCGA-AG-A002-10A-01W-A00K-09 g.chr8:124664615G>A c.552C>T c.(550-552)ctC>ctT p.L184L SKCM 8 124658100 124658100 + Missense_Mutation SNP G G A TCGA-GN-A266-06A-11D-A197-08 TCGA-GN-A266-10A-01D-A199-08 g.chr8:124658100G>A c.1625C>T c.(1624-1626)tCc>tTc p.S542F SKCM 8 124658106 124658106 + Missense_Mutation SNP G G A TCGA-D3-A3C7-06A-11D-A196-08 TCGA-D3-A3C7-10A-01D-A198-08 g.chr8:124658106G>A c.1619C>T c.(1618-1620)tCc>tTc p.S540F SKCM 8 124658255 124658255 + Silent SNP C C T TCGA-EE-A2MT-06A-11D-A197-08 TCGA-EE-A2MT-10A-01D-A199-08 g.chr8:124658255C>T c.1470G>A c.(1468-1470)agG>agA p.R490R SKCM 8 124659189 124659189 + Silent SNP G G A TCGA-EE-A20F-06A-21D-A196-08 TCGA-EE-A20F-10A-01D-A198-08 g.chr8:124659189G>A c.1416C>T c.(1414-1416)gcC>gcT p.A472A SKCM 8 124659207 124659207 + Missense_Mutation SNP C C T TCGA-EE-A2GR-06A-11D-A197-08 TCGA-EE-A2GR-10A-01D-A199-08 g.chr8:124659207C>T c.1398G>A c.(1396-1398)atG>atA p.M466I SKCM 8 124659227 124659227 + Missense_Mutation SNP A A G TCGA-FS-A1ZK-06A-11D-A197-08 TCGA-FS-A1ZK-10A-01D-A199-08 g.chr8:124659227A>G c.1378T>C c.(1378-1380)Ttc>Ctc p.F460L SKCM 8 124659241 124659241 + Missense_Mutation SNP G G A TCGA-EE-A2GM-06B-11D-A196-08 TCGA-EE-A2GM-10A-01D-A198-08 g.chr8:124659241G>A c.1364C>T c.(1363-1365)tCc>tTc p.S455F SKCM 8 124663820 124663820 + Silent SNP G G A TCGA-EE-A2MQ-06A-11D-A197-08 TCGA-EE-A2MQ-10A-01D-A199-08 g.chr8:124663820G>A c.1347C>T c.(1345-1347)atC>atT p.I449I SKCM 8 124663868 124663868 + Silent SNP G G A TCGA-EE-A2MR-06A-11D-A196-08 TCGA-EE-A2MR-10A-01D-A198-08 g.chr8:124663868G>A c.1299C>T c.(1297-1299)ctC>ctT p.L433L SKCM 8 124663913 124663913 + Silent SNP G G C TCGA-EE-A2M5-06A-12D-A197-08 TCGA-EE-A2M5-10A-01D-A199-08 g.chr8:124663913G>C c.1254C>G c.(1252-1254)ccC>ccG p.P418P SKCM 8 124664134 124664134 + Missense_Mutation SNP C C T TCGA-FW-A3TV-06A-11D-A23B-08 TCGA-FW-A3TV-10A-01D-A23B-08 g.chr8:124664134C>T c.1033G>A c.(1033-1035)Ggg>Agg p.G345R SKCM 8 124664268 124664268 + Missense_Mutation SNP C C T TCGA-D3-A5GO-06A-12D-A27K-08 TCGA-D3-A5GO-10A-01D-A27N-08 g.chr8:124664268C>T c.899G>A c.(898-900)aGg>aAg p.R300K SKCM 8 124664269 124664269 + Missense_Mutation SNP T T C TCGA-D3-A5GO-06A-12D-A27K-08 TCGA-D3-A5GO-10A-01D-A27N-08 g.chr8:124664269T>C c.898A>G c.(898-900)Agg>Ggg p.R300G SKCM 8 124664570 124664570 + Silent SNP G G A TCGA-EE-A2MQ-06A-11D-A197-08 TCGA-EE-A2MQ-10A-01D-A199-08 g.chr8:124664570G>A c.597C>T c.(595-597)gcC>gcT p.A199A SKCM 8 124664648 124664648 + Silent SNP C C T TCGA-GN-A266-06A-11D-A197-08 TCGA-GN-A266-10A-01D-A199-08 g.chr8:124664648C>T c.519G>A c.(517-519)aaG>aaA p.K173K SKCM 8 124664732 124664732 + Silent SNP G G A TCGA-FW-A3R5-06A-11D-A23B-08 TCGA-FW-A3R5-10A-01D-A23B-08 g.chr8:124664732G>A c.435C>T c.(433-435)atC>atT p.I145I SKCM 8 124664923 124664923 + Missense_Mutation SNP G G A TCGA-EE-A2ML-06A-11D-A197-08 TCGA-EE-A2ML-10A-01D-A199-08 g.chr8:124664923G>A c.244C>T c.(244-246)Ccc>Tcc p.P82S

Mutation - ICGC Project Code Chromosome Chromosome Start Chromosome End Mutation Type Mutated from Allele Mutated to Allele Consequence Type AA Mutation CDS Mutation BLCA-CN 8 124664873 124664873 single base substitution A G synonymous_variant H98H 294T>C BLCA-CN 8 124664874 124664874 single base substitution T C missense_variant H98R 293A>G BLCA-US 8 124664012 124664012 single base substitution G C missense_variant I385M 1155C>G BLCA-US 8 124664510 124664510 single base substitution G C missense_variant F219L 657C>G BRCA-EU 8 124655140 124655140 single base substitution G A downstream_gene_variant BRCA-EU 8 124655519 124655520 deletion of <=200bp GT - downstream_gene_variant BRCA-EU 8 124656083 124656083 single base substitution G C downstream_gene_variant BRCA-EU 8 124658449 124658449 single base substitution C T intron_variant BRCA-EU 8 124658824 124658824 single base substitution T C intron_variant BRCA-EU 8 124660430 124660430 single base substitution C A intron_variant BRCA-EU 8 124660786 124660786 single base substitution T C intron_variant BRCA-EU 8 124660961 124660961 single base substitution T A intron_variant BRCA-EU 8 124662562 124662562 deletion of <=200bp A - intron_variant BRCA-EU 8 124662634 124662634 single base substitution T C intron_variant BRCA-EU 8 124662827 124662830 deletion of <=200bp TGTC - intron_variant BRCA-EU 8 124664720 124664720 single base substitution C T synonymous_variant E149E 447G>A BRCA-EU 8 124664786 124664786 single base substitution C A missense_variant L127F 381G>T BRCA-EU 8 124667106 124667106 deletion of <=200bp T - upstream_gene_variant BRCA-EU 8 124667106 124667106 insertion of <=200bp - T upstream_gene_variant BRCA-EU 8 124667752 124667752 single base substitution A G upstream_gene_variant BRCA-EU 8 124667920 124667920 single base substitution C T upstream_gene_variant BRCA-EU 8 124668931 124668931 single base substitution G T upstream_gene_variant BRCA-EU 8 124669268 124669268 single base substitution C A upstream_gene_variant BRCA-EU 8 124669363 124669363 single base substitution C T upstream_gene_variant BRCA-EU 8 124669574 124669574 single base substitution T G upstream_gene_variant BRCA-EU 8 124670112 124670112 single base substitution A T upstream_gene_variant BRCA-FR 8 124656083 124656083 single base substitution G C downstream_gene_variant BRCA-FR 8 124657426 124657426 single base substitution C G downstream_gene_variant BRCA-UK 8 124655140 124655140 single base substitution G A downstream_gene_variant BRCA-US 8 124658251 124658251 single base substitution G C missense_variant L492V 1474C>G BRCA-US 8 124663967 124663967 single base substitution G T synonymous_variant S400S 1200C>A BRCA-US 8 124664055 124664055 single base substitution A C missense_variant V371G 1112T>G BRCA-US 8 124664078 124664078 single base substitution C G missense_variant W363C 1089G>C BRCA-US 8 124664638 124664638 single base substitution C T missense_variant A177T 529G>A BRCA-US 8 124664670 124664670 single base substitution A C missense_variant V166G 497T>G BRCA-US 8 124664946 124664946 single base substitution T A missense_variant K74I 221A>T BTCA-JP 8 124664014 124664014 single base substitution T C missense_variant I385V 1153A>G CESC-US 8 124658171 124658171 single base substitution C T synonymous_variant V518V 1554G>A CESC-US 8 124664078 124664078 single base substitution C G missense_variant W363C 1089G>C CESC-US 8 124664263 124664263 single base substitution C T missense_variant V302I 904G>A CESC-US 8 124664926 124664926 single base substitution C T missense_variant D81N 241G>A CLLE-ES 8 124661521 124661521 single base substitution G A intron_variant COAD-US 8 124658144 124658144 single base substitution G A synonymous_variant G527G 1581C>T COAD-US 8 124664168 124664168 single base substitution G A synonymous_variant S333S 999C>T COAD-US 8 124664172 124664172 single base substitution C T missense_variant R332H 995G>A COAD-US 8 124664239 124664239 single base substitution C A missense_variant G310C 928G>T COAD-US 8 124664597 124664597 single base substitution A C missense_variant C190W 570T>G COAD-US 8 124664849 124664849 single base substitution G T synonymous_variant P106P 318C>A COAD-US 8 124665124 124665124 single base substitution C T missense_variant D15N 43G>A COCA-CN 8 124653657 124653657 single base substitution G T downstream_gene_variant COCA-CN 8 124657725 124657725 single base substitution C G downstream_gene_variant COCA-CN 8 124657998 124657998 single base substitution C T missense_variant R576H 1727G>A COCA-CN 8 124658105 124658105 single base substitution G A synonymous_variant S540S 1620C>T COCA-CN 8 124662306 124662306 single base substitution A C intron_variant COCA-CN 8 124664535 124664535 single base substitution C T missense_variant R211Q 632G>A COCA-CN 8 124666902 124666902 single base substitution C T upstream_gene_variant COCA-CN 8 124667894 124667894 single base substitution A G upstream_gene_variant EOPC-DE 8 124658450 124658450 single base substitution G A intron_variant EOPC-DE 8 124664206 124664206 single base substitution G A missense_variant R321W 961C>T ESAD-UK 8 124653307 124653307 single base substitution C A downstream_gene_variant ESAD-UK 8 124653863 124653863 single base substitution C T downstream_gene_variant ESAD-UK 8 124655053 124655053 single base substitution G T downstream_gene_variant ESAD-UK 8 124655922 124655922 single base substitution T G downstream_gene_variant ESAD-UK 8 124657538 124657538 single base substitution T C downstream_gene_variant ESAD-UK 8 124657980 124657980 single base substitution C G stop_lost *582S 1745G>C ESAD-UK 8 124658210 124658210 single base substitution C T synonymous_variant A505A 1515G>A ESAD-UK 8 124662046 124662046 single base substitution C T intron_variant ESAD-UK 8 124662549 124662549 insertion of <=200bp - A intron_variant ESAD-UK 8 124663101 124663101 single base substitution T G intron_variant ESAD-UK 8 124663353 124663353 single base substitution G A intron_variant ESAD-UK 8 124663931 124663931 single base substitution C A missense_variant E412D 1236G>T ESAD-UK 8 124664666 124664666 single base substitution G A synonymous_variant A167A 501C>T ESAD-UK 8 124666962 124666962 single base substitution C T upstream_gene_variant ESAD-UK 8 124667967 124667967 single base substitution T G upstream_gene_variant ESAD-UK 8 124668441 124668441 single base substitution G A upstream_gene_variant ESAD-UK 8 124668823 124668823 single base substitution G A upstream_gene_variant ESCA-CN 8 124659179 124659179 single base substitution C G missense_variant V476L 1426G>C ESCA-CN 8 124664902 124664902 single base substitution C T missense_variant V89I 265G>A KIRC-US 8 124664647 124664647 single base substitution C G missense_variant E174Q 520G>C LAML-KR 8 124664873 124664873 single base substitution A G synonymous_variant H98H 294T>C LAML-KR 8 124664874 124664874 single base substitution T C missense_variant H98R 293A>G LGG-US 8 124664240 124664240 single base substitution G A synonymous_variant T309T 927C>T LGG-US 8 124664667 124664667 single base substitution G A missense_variant A167V 500C>T LICA-CN 8 124663953 124663953 single base substitution T A missense_variant D405V 1214A>T LICA-CN 8 124664119 124664119 single base substitution T A missense_variant S350C 1048A>T LICA-CN 8 124664191 124664191 single base substitution A T missense_variant S326T 976T>A LICA-CN 8 124664530 124664530 single base substitution G T synonymous_variant R213R 637C>A LICA-FR 8 124653066 124653066 single base substitution T G downstream_gene_variant LIHC-US 8 124664565 124664565 single base substitution A G missense_variant M201T 602T>C LINC-JP 8 124658046 124658046 single base substitution G A missense_variant P560L 1679C>T LINC-JP 8 124663922 124663922 single base substitution G A synonymous_variant A415A 1245C>T LINC-JP 8 124664507 124664507 single base substitution C T synonymous_variant K220K 660G>A LIRI-JP 8 124655641 124655641 single base substitution T C downstream_gene_variant LIRI-JP 8 124656822 124656822 single base substitution A G downstream_gene_variant LIRI-JP 8 124657028 124657028 single base substitution G C downstream_gene_variant LIRI-JP 8 124661859 124661859 single base substitution G T intron_variant LIRI-JP 8 124663060 124663060 single base substitution A G intron_variant LIRI-JP 8 124664965 124664965 single base substitution G A missense_variant R68W 202C>T LIRI-JP 8 124666189 124666189 single base substitution A G upstream_gene_variant LUSC-KR 8 124657731 124657731 single base substitution T G downstream_gene_variant LUSC-US 8 124658160 124658160 single base substitution T G missense_variant K522T 1565A>C LUSC-US 8 124658216 124658216 single base substitution T C synonymous_variant K503K 1509A>G LUSC-US 8 124659171 124659171 single base substitution C A synonymous_variant G478G 1434G>T LUSC-US 8 124663821 124663821 single base substitution A T missense_variant I449N 1346T>A LUSC-US 8 124664148 124664148 single base substitution A T missense_variant M340K 1019T>A LUSC-US 8 124664915 124664915 single base substitution G A synonymous_variant T84T 252C>T MALY-DE 8 124653863 124653863 single base substitution C T downstream_gene_variant MALY-DE 8 124654085 124654085 single base substitution A C downstream_gene_variant MALY-DE 8 124656930 124656930 single base substitution T C downstream_gene_variant MALY-DE 8 124664050 124664050 single base substitution G A missense_variant R373C 1117C>T MALY-DE 8 124667607 124667607 single base substitution G A upstream_gene_variant MELA-AU 8 124652888 124652888 single base substitution A G downstream_gene_variant MELA-AU 8 124653003 124653003 single base substitution G A downstream_gene_variant MELA-AU 8 124653159 124653159 single base substitution T A downstream_gene_variant MELA-AU 8 124653315 124653315 single base substitution G A downstream_gene_variant MELA-AU 8 124653581 124653581 single base substitution C T downstream_gene_variant MELA-AU 8 124653762 124653762 single base substitution G A downstream_gene_variant MELA-AU 8 124653819 124653819 single base substitution G A downstream_gene_variant MELA-AU 8 124653883 124653883 single base substitution C T downstream_gene_variant MELA-AU 8 124654043 124654043 single base substitution G A downstream_gene_variant MELA-AU 8 124654123 124654123 single base substitution G A downstream_gene_variant MELA-AU 8 124654135 124654135 single base substitution C T downstream_gene_variant MELA-AU 8 124654194 124654194 single base substitution G A downstream_gene_variant MELA-AU 8 124654447 124654447 single base substitution G A downstream_gene_variant MELA-AU 8 124654482 124654482 single base substitution G A downstream_gene_variant MELA-AU 8 124655190 124655191 multiple base substitution (>=2bp and <=200bp) GG AT downstream_gene_variant MELA-AU 8 124655298 124655298 single base substitution T A downstream_gene_variant MELA-AU 8 124655528 124655528 single base substitution G A downstream_gene_variant MELA-AU 8 124655572 124655572 single base substitution C T downstream_gene_variant MELA-AU 8 124655785 124655785 single base substitution G A downstream_gene_variant MELA-AU 8 124655886 124655886 single base substitution T C downstream_gene_variant MELA-AU 8 124655895 124655895 single base substitution G A downstream_gene_variant MELA-AU 8 124656176 124656176 single base substitution G A downstream_gene_variant MELA-AU 8 124656855 124656855 single base substitution C T downstream_gene_variant MELA-AU 8 124657307 124657307 single base substitution A G downstream_gene_variant MELA-AU 8 124657660 124657660 single base substitution G T downstream_gene_variant MELA-AU 8 124657671 124657671 single base substitution C T downstream_gene_variant MELA-AU 8 124657713 124657713 single base substitution G C downstream_gene_variant MELA-AU 8 124658976 124658976 single base substitution G A intron_variant MELA-AU 8 124659787 124659787 single base substitution G A intron_variant MELA-AU 8 124659838 124659838 single base substitution G A intron_variant MELA-AU 8 124659941 124659941 single base substitution C T intron_variant MELA-AU 8 124660247 124660248 multiple base substitution (>=2bp and <=200bp) GG AA intron_variant MELA-AU 8 124660258 124660258 single base substitution T C intron_variant MELA-AU 8 124660308 124660308 single base substitution G A intron_variant MELA-AU 8 124660626 124660626 single base substitution G A intron_variant MELA-AU 8 124660785 124660786 multiple base substitution (>=2bp and <=200bp) CT TA intron_variant MELA-AU 8 124661156 124661156 single base substitution C T intron_variant MELA-AU 8 124661554 124661554 single base substitution G A intron_variant MELA-AU 8 124661668 124661668 single base substitution C T intron_variant MELA-AU 8 124662181 124662181 single base substitution C T intron_variant MELA-AU 8 124662666 124662666 single base substitution T A intron_variant MELA-AU 8 124663085 124663085 single base substitution G A intron_variant MELA-AU 8 124663283 124663283 single base substitution G A intron_variant MELA-AU 8 124663872 124663872 single base substitution C T missense_variant R432K 1295G>A MELA-AU 8 124663913 124663913 single base substitution G C synonymous_variant P418P 1254C>G MELA-AU 8 124664292 124664292 single base substitution C T missense_variant R292K 875G>A MELA-AU 8 124664624 124664624 single base substitution C T synonymous_variant R181R 543G>A MELA-AU 8 124664882 124664882 single base substitution C T synonymous_variant G95G 285G>A MELA-AU 8 124664923 124664923 single base substitution G A missense_variant P82S 244C>T MELA-AU 8 124665191 124665191 single base substitution C T upstream_gene_variant MELA-AU 8 124665762 124665762 single base substitution C T upstream_gene_variant MELA-AU 8 124666164 124666164 single base substitution C T upstream_gene_variant MELA-AU 8 124666246 124666246 single base substitution A G upstream_gene_variant MELA-AU 8 124667416 124667416 single base substitution G A upstream_gene_variant MELA-AU 8 124667597 124667597 single base substitution G A upstream_gene_variant MELA-AU 8 124667920 124667920 single base substitution C T upstream_gene_variant MELA-AU 8 124668447 124668447 single base substitution G A upstream_gene_variant MELA-AU 8 124668725 124668725 single base substitution G A upstream_gene_variant MELA-AU 8 124668827 124668827 single base substitution T C upstream_gene_variant MELA-AU 8 124668873 124668873 single base substitution G A upstream_gene_variant MELA-AU 8 124669232 124669233 multiple base substitution (>=2bp and <=200bp) CC TT upstream_gene_variant MELA-AU 8 124669786 124669786 single base substitution G A upstream_gene_variant MELA-AU 8 124669911 124669911 single base substitution C T upstream_gene_variant MELA-AU 8 124669943 124669943 single base substitution C T upstream_gene_variant MELA-AU 8 124669950 124669950 single base substitution G A upstream_gene_variant MELA-AU 8 124670168 124670168 single base substitution C T upstream_gene_variant OV-AU 8 124663077 124663077 single base substitution G A intron_variant OV-AU 8 124667589 124667589 single base substitution C T upstream_gene_variant OV-AU 8 124669627 124669627 single base substitution G C upstream_gene_variant PACA-CA 8 124656512 124656512 single base substitution G C downstream_gene_variant PACA-CA 8 124658148 124658148 single base substitution G A missense_variant T526M 1577C>T PACA-CA 8 124658248 124658248 single base substitution C A missense_variant A493S 1477G>T PACA-CA 8 124658818 124658818 single base substitution A G intron_variant PACA-CA 8 124659277 124659277 single base substitution G A intron_variant PACA-CA 8 124662548 124662548 insertion of <=200bp - A intron_variant PACA-CA 8 124664211 124664211 single base substitution G A missense_variant P319L 956C>T PACA-CA 8 124664458 124664458 single base substitution C T missense_variant A237T 709G>A PACA-CA 8 124667199 124667199 single base substitution G A upstream_gene_variant PACA-CA 8 124669083 124669083 single base substitution T C upstream_gene_variant PBCA-DE 8 124653637 124653637 single base substitution T G downstream_gene_variant PBCA-DE 8 124653654 124653654 single base substitution A G downstream_gene_variant PBCA-DE 8 124658211 124658211 single base substitution G A missense_variant A505V 1514C>T PBCA-DE 8 124663872 124663872 single base substitution C T missense_variant R432K 1295G>A PRAD-CA 8 124661736 124661736 single base substitution T C intron_variant PRAD-UK 8 124656512 124656512 single base substitution G C downstream_gene_variant PRAD-UK 8 124664211 124664211 single base substitution G A missense_variant P319L 956C>T PRAD-UK 8 124667796 124667796 single base substitution C G upstream_gene_variant PRAD-UK 8 124667811 124667811 single base substitution C T upstream_gene_variant PRAD-UK 8 124667850 124667850 single base substitution C G upstream_gene_variant PRAD-UK 8 124668199 124668199 single base substitution C G upstream_gene_variant PRAD-UK 8 124668208 124668208 single base substitution C G upstream_gene_variant PRAD-UK 8 124668323 124668323 single base substitution C G upstream_gene_variant PRAD-UK 8 124668429 124668429 single base substitution C G upstream_gene_variant PRAD-UK 8 124668538 124668538 single base substitution C T upstream_gene_variant PRAD-UK 8 124668770 124668770 single base substitution C G upstream_gene_variant PRAD-UK 8 124669194 124669194 single base substitution C T upstream_gene_variant PRAD-UK 8 124669247 124669247 single base substitution C T upstream_gene_variant PRAD-UK 8 124669640 124669640 single base substitution C A upstream_gene_variant PRAD-UK 8 124669842 124669842 single base substitution C G upstream_gene_variant PRAD-UK 8 124669873 124669977 deletion of <=200bp TAAGTCGAGCTCCCAGCAGGTGCCCTTGATGAGTTTGCCCTTGTAAGTCAATCCAGAAAGCCTTCATTTTCCCTCCTGGAGTTTTGGATTGCCATGGTGGGCACT - upstream_gene_variant PRAD-UK 8 124670109 124670109 single base substitution C G upstream_gene_variant PRAD-US 8 124664821 124664821 single base substitution A G missense_variant F116L 346T>C READ-US 8 124664494 124664494 single base substitution G A stop_gained Q225* 673C>T READ-US 8 124664710 124664710 single base substitution T C missense_variant K153E 457A>G RECA-EU 8 124666370 124666370 single base substitution G C upstream_gene_variant RECA-EU 8 124668397 124668397 single base substitution C T upstream_gene_variant RECA-EU 8 124668964 124668964 single base substitution T G upstream_gene_variant RECA-EU 8 124668965 124668965 single base substitution C T upstream_gene_variant SKCA-BR 8 124653512 124653512 single base substitution C T downstream_gene_variant SKCA-BR 8 124654454 124654454 single base substitution C T downstream_gene_variant SKCA-BR 8 124657121 124657121 single base substitution G A downstream_gene_variant SKCA-BR 8 124662133 124662133 single base substitution C A intron_variant SKCA-BR 8 124663015 124663015 single base substitution C T intron_variant SKCA-BR 8 124664099 124664099 single base substitution G A synonymous_variant F356F 1068C>T SKCA-BR 8 124668663 124668663 single base substitution G A upstream_gene_variant SKCA-BR 8 124669895 124669895 single base substitution C G upstream_gene_variant SKCA-BR 8 124669896 124669896 single base substitution C T upstream_gene_variant SKCM-US 8 124658100 124658100 single base substitution G A missense_variant S542F 1625C>T SKCM-US 8 124658106 124658106 single base substitution G A missense_variant S540F 1619C>T SKCM-US 8 124658255 124658255 single base substitution C T synonymous_variant R490R 1470G>A SKCM-US 8 124659189 124659189 single base substitution G A synonymous_variant A472A 1416C>T SKCM-US 8 124659207 124659207 single base substitution C T missense_variant M466I 1398G>A SKCM-US 8 124659227 124659227 single base substitution A G missense_variant F460L 1378T>C SKCM-US 8 124659241 124659241 single base substitution G A missense_variant S455F 1364C>T SKCM-US 8 124663820 124663820 single base substitution G A synonymous_variant I449I 1347C>T SKCM-US 8 124663868 124663868 single base substitution G A synonymous_variant L433L 1299C>T SKCM-US 8 124663913 124663913 single base substitution G C synonymous_variant P418P 1254C>G SKCM-US 8 124663999 124663999 single base substitution C T missense_variant G390R 1168G>A SKCM-US 8 124664134 124664134 single base substitution C T missense_variant G345R 1033G>A SKCM-US 8 124664570 124664570 single base substitution G A synonymous_variant A199A 597C>T SKCM-US 8 124664648 124664648 single base substitution C T synonymous_variant K173K 519G>A SKCM-US 8 124664732 124664732 single base substitution G A synonymous_variant I145I 435C>T SKCM-US 8 124664776 124664776 single base substitution A G synonymous_variant L131L 391T>C SKCM-US 8 124664832 124664832 single base substitution G A missense_variant S112F 335C>T SKCM-US 8 124664923 124664923 single base substitution G A missense_variant P82S 244C>T STAD-US 8 124663889 124663889 single base substitution G A synonymous_variant V426V 1278C>T STAD-US 8 124663913 124663913 single base substitution G A synonymous_variant P418P 1254C>T STAD-US 8 124663997 124663997 deletion of <=200bp C - frameshift_variant G390 STAD-US 8 124664441 124664441 single base substitution C A synonymous_variant L242L 726G>T STAD-US 8 124664458 124664458 single base substitution C T missense_variant A237T 709G>A STAD-US 8 124664667 124664667 single base substitution G A missense_variant A167V 500C>T STAD-US 8 124664818 124664818 single base substitution G A missense_variant P117S 349C>T STAD-US 8 124664881 124664881 deletion of <=200bp C - frameshift_variant E96 STAD-US 8 124664919 124664919 insertion of <=200bp - G frameshift_variant P83P? UCEC-US 8 124657995 124657995 deletion of <=200bp G - frameshift_variant T577 UCEC-US 8 124658060 124658060 single base substitution G T synonymous_variant S555S 1665C>A UCEC-US 8 124658211 124658211 single base substitution G A missense_variant A505V 1514C>T UCEC-US 8 124664311 124664311 single base substitution G T missense_variant L286I 856C>A UCEC-US 8 124664387 124664387 single base substitution G T missense_variant F260L 780C>A UCEC-US 8 124664453 124664453 single base substitution G A synonymous_variant N238N 714C>T UCEC-US 8 124664711 124664711 single base substitution C A missense_variant K152N 456G>T UCEC-US 8 124664722 124664722 single base substitution C T missense_variant E149K 445G>A UCEC-US 8 124664836 124664836 single base substitution C T missense_variant A111T 331G>A UCEC-US 8 124664965 124664965 single base substitution G A missense_variant R68W 202C>T UCEC-US 8 124665017 124665017 single base substitution G A synonymous_variant N50N 150C>T UCEC-US 8 124665026 124665026 single base substitution G A synonymous_variant C47C 141C>T UCEC-US 8 124665040 124665040 single base substitution G A missense_variant R43W 127C>T UCEC-US 8 124665125 124665125 single base substitution G A synonymous_variant H14H 42C>T

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand TCGA-DK-A1AD-01 COSM1313696 c.1155C>G p.I385M Substitution - Missense 8:123651772-123651772 - GHE0645 COSM376945 c.1630G>T p.D544Y Substitution - Missense 8:123645855-123645855 - RK186_C01 COSM1095799 c.202C>T p.R68W Substitution - Missense 8:123652725-123652725 - ESCC-100T COSM3942506 c.265G>A p.V89I Substitution - Missense 8:123652662-123652662 - TCGA-D3-A3C7-06 COSM3644839 c.1619C>T p.S540F Substitution - Missense 8:123645866-123645866 - TCGA-D1-A174-01 COSM1095792 c.1528C>T p.R510W Substitution - Missense 8:123645957-123645957 - TCGA-A2-A0T5-01 COSM3834000 c.1112T>G p.V371G Substitution - Missense 8:123651815-123651815 - PTC-7C COSM4162651 c.1037G>A p.R346K Substitution - Missense 8:123651890-123651890 - PCSI_0528_Pa_P_526 COSM3315940 c.956C>T p.P319L Substitution - Missense 8:123651971-123651971 - TCGA-FS-A1ZK-06 COSM3644843 c.1378T>C p.F460L Substitution - Missense 8:123646987-123646987 - CSCC-60-T COSM4530118 c.1669G>A p.G557R Substitution - Missense 8:123645816-123645816 - CSCC-60-T COSM1212662 c.1664C>T p.S555F Substitution - Missense 8:123645821-123645821 - T6 COSM5619390 c.450C>A p.T150T Substitution - coding silent 8:123652477-123652477 - B105-1-Tumor COSM4006837 c.293A>G p.H98R Substitution - Missense 8:123652634-123652634 - 0125_CRUK_PC_0125_T1_DNA COSM3315940 c.956C>T p.P319L Substitution - Missense 8:123651971-123651971 - TCGA-B0-5713-01 COSM486046 c.954C>G p.L318L Substitution - coding silent 8:123651973-123651973 - HCC39 COSM1623575 c.1245C>T p.A415A Substitution - coding silent 8:123651682-123651682 - TCGA-BR-7958-01 COSM3896577 c.349C>T p.P117S Substitution - Missense 8:123652578-123652578 - TCGA-66-2792-01 COSM749472 c.1346T>A p.I449N Substitution - Missense 8:123651581-123651581 - YUGATOR COSM5408778 c.1396A>G p.M466V Substitution - Missense 8:123646969-123646969 - T3724 COSM4696557 c.502G>A p.A168T Substitution - Missense 8:123652425-123652425 - TCGA-BR-6452-01 COSM3896576 c.500C>T p.A167V Substitution - Missense 8:123652427-123652427 - TCGA-EE-A2MT-06 COSM3644840 c.1470G>A p.R490R Substitution - coding silent 8:123646015-123646015 - TCGA-AX-A0J1-01 COSM1095800 c.150C>T p.N50N Substitution - coding silent 8:123652777-123652777 - T578 COSM4696555 c.1155C>A p.I385I Substitution - coding silent 8:123651772-123651772 - I-02 COSM1212661 c.961C>T p.R321W Substitution - Missense 8:123651966-123651966 - TCGA-AG-A002-01 COSM261699 c.552C>T p.L184L Substitution - coding silent 8:123652375-123652375 - PCSI_0467_Pa_P_526 COSM3315949 c.709G>A p.A237T Substitution - Missense 8:123652218-123652218 - TCGA-AA-3821-01 COSM294509 c.962G>A p.R321Q Substitution - Missense 8:123651965-123651965 - P03-2620 COSM245321 c.798C>T p.T266T Substitution - coding silent 8:123652129-123652129 - TCGA-AG-A002-01 COSM261698 c.780C>A p.F260L Substitution - Missense 8:123652147-123652147 - TCGA-EE-A2GR-06 COSM3644842 c.1398G>A p.M466I Substitution - Missense 8:123646967-123646967 - CN-AML-CR-63-Dx COSM4006836 c.294T>C p.H98H Substitution - coding silent 8:123652633-123652633 - TCGA-EE-A2ML-06 COSM3644853 c.244C>T p.P82S Substitution - Missense 8:123652683-123652683 - T3255 COSM4696558 c.444C>T p.C148C Substitution - coding silent 8:123652483-123652483 - OVCAR-4 COSM1674155 c.1215C>A p.D405E Substitution - Missense 8:123651712-123651712 - PCSI_0537_Pa_P_526 COSM5031260 c.1477G>T p.A493S Substitution - Missense 8:123646008-123646008 - PD24194a COSM5784698 c.447G>A p.E149E Substitution - coding silent 8:123652480-123652480 - 063T COSM1730226 c.471G>C p.E157D Substitution - Missense 8:123652456-123652456 - CSCC-31-T COSM4561237 c.876G>A p.R292R Substitution - coding silent 8:123652051-123652051 - TCGA-39-5029-01 COSM749470 c.252C>T p.T84T Substitution - coding silent 8:123652675-123652675 - ZZUFHECRKL-G035T COSM5440367 c.1426G>C p.V476L Substitution - Missense 8:123646939-123646939 - TCGA-21-5784-01 COSM749471 c.1019T>A p.M340K Substitution - Missense 8:123651908-123651908 - TCGA-GN-A266-06 COSM3644850 c.519G>A p.K173K Substitution - coding silent 8:123652408-123652408 - HCC144T COSM3663545 c.1679C>T p.P560L Substitution - Missense 8:123645806-123645806 - TCGA-FW-A3R5-06 COSM3924590 c.435C>T p.I145I Substitution - coding silent 8:123652492-123652492 - 408 COSM3315956 c.317C>A p.P106H Substitution - Missense 8:123652610-123652610 - C135 COSM3315947 c.735G>A p.S245S Substitution - coding silent 8:123652192-123652192 - CSCC-27-T COSM245321 c.798C>T p.T266T Substitution - coding silent 8:123652129-123652129 - TCGA-EB-A3XC-01 COSM3644852 c.335C>T p.S112F Substitution - Missense 8:123652592-123652592 - 587290 COSM1212664 c.1610T>C p.I537T Substitution - Missense 8:123645875-123645875 - TCGA-EJ-7123-01 COSM3675038 c.1312G>T p.G438* Substitution - Nonsense 8:123651615-123651615 - TCGA-FU-A5XV-01 COSM4844231 c.904G>A p.V302I Substitution - Missense 8:123652023-123652023 - TCGA-H4-A2HQ-01 COSM1313697 c.657C>G p.F219L Substitution - Missense 8:123652270-123652270 - PD9411a COSM3720472 c.1407C>T p.N469N Substitution - coding silent 8:123646958-123646958 - HCC174 COSM3663546 c.660G>A p.K220K Substitution - coding silent 8:123652267-123652267 - T1240 COSM4696556 c.708C>T p.I236I Substitution - coding silent 8:123652219-123652219 - TCGA-AA-A00N-01 COSM275763 c.1158C>A p.F386L Substitution - Missense 8:123651769-123651769 - S02285 COSM5685006 c.424C>A p.L142I Substitution - Missense 8:123652503-123652503 - BD114T COSM5503399 c.1153A>G p.I385V Substitution - Missense 8:123651774-123651774 - 2521259 COSM5890372 c.936G>A p.W312* Substitution - Nonsense 8:123651991-123651991 - TCGA-UC-A7PF-01 COSM4830202 c.1554G>A p.V518V Substitution - coding silent 8:123645931-123645931 - SNU-175 COSM3315963 c.51T>G p.S17S Substitution - coding silent 8:123652876-123652876 - T3080 COSM4696560 c.6C>T p.D2D Substitution - coding silent 8:123652921-123652921 - TCGA-DU-6410-01 COSM3896576 c.500C>T p.A167V Substitution - Missense 8:123652427-123652427 - TCGA-BR-4201-01 COSM3896573 c.1278C>T p.V426V Substitution - coding silent 8:123651649-123651649 - SNUH_G26_S1 COSM3982385 c.1180G>C p.G394R Substitution - Missense 8:123651747-123651747 - MO_1241 COSM214019 c.1339C>T p.R447C Substitution - Missense 8:123651588-123651588 - TCGA-D1-A101-01 COSM1095799 c.202C>T p.R68W Substitution - Missense 8:123652725-123652725 - 2521259 COSM5890371 c.1091G>A p.R364K Substitution - Missense 8:123651836-123651836 - 4095_T COSM3951266 c.1098G>A p.G366G Substitution - coding silent 8:123651829-123651829 - TCGA-EE-A2MQ-06 COSM3644845 c.1347C>T p.I449I Substitution - coding silent 8:123651580-123651580 - PT33 COSM5908853 c.1387G>A p.E463K Substitution - Missense 8:123646978-123646978 - sysucc-1067T COSM5479862 c.1620C>T p.S540S Substitution - coding silent 8:123645865-123645865 - TCGA-D1-A17U-01 COSM1095790 c.1730delC p.T577fs*>5 Deletion - Frameshift 8:123645755-123645755 - TCGA-AP-A0LM-01 COSM1095802 c.42C>T p.H14H Substitution - coding silent 8:123652885-123652885 - TCGA-CG-5728-01 COSM3896574 c.1254C>T p.P418P Substitution - coding silent 8:123651673-123651673 - 587376 COSM1212662 c.1664C>T p.S555F Substitution - Missense 8:123645821-123645821 - PT31 COSM5906826 c.1741C>T p.P581S Substitution - Missense 8:123645744-123645744 - 587338 COSM203129 c.1279G>A p.A427T Substitution - Missense 8:123651648-123651648 - TCGA-CG-5726-01 COSM3315949 c.709G>A p.A237T Substitution - Missense 8:123652218-123652218 - TCGA-EE-A2MQ-06 COSM3644849 c.597C>T p.A199A Substitution - coding silent 8:123652330-123652330 - HCC144 COSM3663545 c.1679C>T p.P560L Substitution - Missense 8:123645806-123645806 - PT40 COSM5923815 c.580G>A p.E194K Substitution - Missense 8:123652347-123652347 - TCGA-G4-6302-01 COSM3698819 c.928G>T p.G310C Substitution - Missense 8:123651999-123651999 - TCGA-A8-A0A6-01 COSM3834001 c.497T>G p.V166G Substitution - Missense 8:123652430-123652430 - HCC39T COSM1623575 c.1245C>T p.A415A Substitution - coding silent 8:123651682-123651682 - TCGA-D1-A103-01 COSM1095796 c.456G>T p.K152N Substitution - Missense 8:123652471-123652471 - CN-AML-CR-63-Dx COSM4006837 c.293A>G p.H98R Substitution - Missense 8:123652634-123652634 - HCA7 COSM4631256 c.732C>A p.S244S Substitution - coding silent 8:123652195-123652195 - HCC174T COSM3663546 c.660G>A p.K220K Substitution - coding silent 8:123652267-123652267 - TCGA-AN-A04D-01 COSM453967 c.1089G>C p.W363C Substitution - Missense 8:123651838-123651838 - TCGA-AA-3681-01 COSM268070 c.146G>A p.R49H Substitution - Missense 8:123652781-123652781 - Pat_32_A COSM5873866 c.482C>T p.T161M Substitution - Missense 8:123652445-123652445 - CSCC-31-T COSM4525130 c.1310G>A p.G437E Substitution - Missense 8:123651617-123651617 - TCGA-BM-6198-01 COSM3432093 c.673C>T p.Q225* Substitution - Nonsense 8:123652254-123652254 - HCC058T COSM5805101 c.1048A>T p.S350C Substitution - Missense 8:123651879-123651879 - TCGA-EE-A2MR-06 COSM3644846 c.1299C>T p.L433L Substitution - coding silent 8:123651628-123651628 - sysucc-935T COSM4760995 c.1727G>A p.R576H Substitution - Missense 8:123645758-123645758 - ESO-003 COSM1255989 c.762C>T p.T254T Substitution - coding silent 8:123652165-123652165 - pfg008T COSM1643499 c.286delG p.E96fs*12 Deletion - Frameshift 8:123652641-123652641 - pfg008T COSM1643499 c.286delG p.E96fs*12 Deletion - Frameshift 8:123652641-123652641 - TCGA-AX-A063-01 COSM1095791 c.1665C>A p.S555S Substitution - coding silent 8:123645820-123645820 - TCGA-CM-5344-01 COSM1454671 c.999C>T p.S333S Substitution - coding silent 8:123651928-123651928 - TCGA-GN-A266-06 COSM3644838 c.1625C>T p.S542F Substitution - Missense 8:123645860-123645860 - JVM-2 COSM1739459 c.307A>G p.N103D Substitution - Missense 8:123652620-123652620 - CSCC-20-T COSM4470534 c.1665C>T p.S555S Substitution - coding silent 8:123645820-123645820 - CSCC-49-T COSM4488712 c.336C>T p.S112S Substitution - coding silent 8:123652591-123652591 - TCGA-B6-A0IK-01 COSM453965 c.1474C>G p.L492V Substitution - Missense 8:123646011-123646011 - WA56 COSM237632 c.1629C>T p.F543F Substitution - coding silent 8:123645856-123645856 - PCSI0018 COSM216805 c.1577C>T p.T526M Substitution - Missense 8:123645908-123645908 - pfg127T COSM4760996 c.1165G>A p.G389R Substitution - Missense 8:123651762-123651762 - TCGA-AZ-4615-01 COSM3698820 c.318C>A p.P106P Substitution - coding silent 8:123652609-123652609 - TCGA-HC-A4ZV-01 COSM3675039 c.346T>C p.F116L Substitution - Missense 8:123652581-123652581 - T263 COSM4696553 c.1644delC p.E549fs*>33 Deletion - Frameshift 8:123645841-123645841 - EGC15 COSM5062866 c.1589G>A p.R530Q Substitution - Missense 8:123645896-123645896 - CSCC-44-T COSM4555296 c.649G>A p.E217K Substitution - Missense 8:123652278-123652278 - TCGA-A7-A0DA-01 COSM453966 c.1200C>A p.S400S Substitution - coding silent 8:123651727-123651727 - T578 COSM4696559 c.264C>T p.I88I Substitution - coding silent 8:123652663-123652663 - TCGA-D1-A161-01 COSM203130 c.141C>T p.C47C Substitution - coding silent 8:123652786-123652786 - HCC002T COSM5819364 c.976T>A p.S326T Substitution - Missense 8:123651951-123651951 - PCSI_0018_Pa_X COSM216805 c.1577C>T p.T526M Substitution - Missense 8:123645908-123645908 - TCGA-B5-A11Y-01 COSM1095801 c.127C>T p.R43W Substitution - Missense 8:123652800-123652800 - TCGA-AX-A0J0-01 COSM261698 c.780C>A p.F260L Substitution - Missense 8:123652147-123652147 - TCGA-AF-4110-01 COSM3432094 c.457A>G p.K153E Substitution - Missense 8:123652470-123652470 - Pat_02_B COSM5873865 c.682C>T p.H228Y Substitution - Missense 8:123652245-123652245 - TCGA-A3-3367-01 COSM486047 c.520G>C p.E174Q Substitution - Missense 8:123652407-123652407 - HCT8 COSM4635569 c.628G>A p.A210T Substitution - Missense 8:123652299-123652299 - TCGA-B0-5088-01 COSM486045 c.1598C>T p.T533M Substitution - Missense 8:123645887-123645887 - CSB24 COSM5026969 c.251C>T p.T84I Substitution - Missense 8:123652676-123652676 - TCGA-D5-6927-01 COSM3763037 c.43G>A p.D15N Substitution - Missense 8:123652884-123652884 - TCGA-AP-A056-01 COSM216090 c.1514C>T p.A505V Substitution - Missense 8:123645971-123645971 - CSCC-32-T COSM4540429 c.283G>A p.G95R Substitution - Missense 8:123652644-123652644 - ESCC_143 COSM1095798 c.331G>A p.A111T Substitution - Missense 8:123652596-123652596 - C10 COSM4616646 c.153G>T p.V51V Substitution - coding silent 8:123652774-123652774 - HCA7 COSM4631257 c.501C>T p.A167A Substitution - coding silent 8:123652426-123652426 - TCGA-AA-A010-01 COSM282283 c.1108C>T p.L370L Substitution - coding silent 8:123651819-123651819 - TCGA-AP-A0LM-01 COSM1095795 c.714C>T p.N238N Substitution - coding silent 8:123652213-123652213 - SNU-175 COSM3315958 c.282G>A p.T94T Substitution - coding silent 8:123652645-123652645 - C008 COSM5522976 c.453C>T p.L151L Substitution - coding silent 8:123652474-123652474 - MB_Exm575 COSM216090 c.1514C>T p.A505V Substitution - Missense 8:123645971-123645971 - GB07 COSM1743663 c.381G>A p.L127L Substitution - coding silent 8:123652546-123652546 - TCGA-BF-A3DL-01 COSM4904669 c.1168G>A p.G390R Substitution - Missense 8:123651759-123651759 - TCGA-DU-7306-01 COSM3929370 c.927C>T p.T309T Substitution - coding silent 8:123652000-123652000 - TCGA-JX-A3Q0-01 COSM453967 c.1089G>C p.W363C Substitution - Missense 8:123651838-123651838 - HCC048T COSM5820628 c.1214A>T p.D405V Substitution - Missense 8:123651713-123651713 - PR-03-870 COSM245320 c.374C>T p.S125L Substitution - Missense 8:123652553-123652553 - TCGA-AA-3510-01 COSM203128 c.1581C>T p.G527G Substitution - coding silent 8:123645904-123645904 - pfg068T COSM268070 c.146G>A p.R49H Substitution - Missense 8:123652781-123652781 - TCGA-AX-A0J1-01 COSM1095798 c.331G>A p.A111T Substitution - Missense 8:123652596-123652596 - 587342 COSM1212661 c.961C>T p.R321W Substitution - Missense 8:123651966-123651966 - T3091 COSM4696554 c.1170delG p.I391fs*38 Deletion - Frameshift 8:123651757-123651757 - LP6007523-DNA_A01 COSM5035867 c.1515G>A p.A505A Substitution - coding silent 8:123645970-123645970 - SJRHB012 COSM3737396 c.1639G>A p.D547N Substitution - Missense 8:123645846-123645846 - TCGA-B5-A0JY-01 COSM1095797 c.445G>A p.E149K Substitution - Missense 8:123652482-123652482 - TCGA-AY-6197-01 COSM1454672 c.995G>A p.R332H Substitution - Missense 8:123651932-123651932 - SS6003137 COSM3665310 c.1338G>A p.V446V Substitution - coding silent 8:123651589-123651589 - SA214 COSM214019 c.1339C>T p.R447C Substitution - Missense 8:123651588-123651588 - TCGA-AX-A0J0-01 COSM1095794 c.856C>A p.L286I Substitution - Missense 8:123652071-123652071 - 387 COSM4427346 c.592G>C p.E198Q Substitution - Missense 8:123652335-123652335 - LUAD-S01362 COSM346256 c.423A>T p.R141S Substitution - Missense 8:123652504-123652504 - SNU-C2B COSM203129 c.1279G>A p.A427T Substitution - Missense 8:123651648-123651648 - COLO678 COSM3315932 c.1133G>A p.S378N Substitution - Missense 8:123651794-123651794 - 2217540 COSM4421685 c.1445T>C p.V482A Substitution - Missense 8:123646920-123646920 - CSCC-27-T COSM1095797 c.445G>A p.E149K Substitution - Missense 8:123652482-123652482 - HCC061T COSM5805837 c.637C>A p.R213R Substitution - coding silent 8:123652290-123652290 - TCGA-66-2782-01 COSM749474 c.1509A>G p.K503K Substitution - coding silent 8:123645976-123645976 - 408 COSM3698820 c.318C>A p.P106P Substitution - coding silent 8:123652609-123652609 - CSCC-41-T COSM4483399 c.269C>T p.S90F Substitution - Missense 8:123652658-123652658 - SJRHB012_S COSM3737396 c.1639G>A p.D547N Substitution - Missense 8:123645846-123645846 - TCGA-EE-A2GM-06 COSM3644844 c.1364C>T p.S455F Substitution - Missense 8:123647001-123647001 - T13 COSM5345493 c.1599G>A p.T533T Substitution - coding silent 8:123645886-123645886 - TCGA-EE-A20F-06 COSM3644841 c.1416C>T p.A472A Substitution - coding silent 8:123646949-123646949 - TCGA-MY-A5BD-01 COSM4855800 c.241G>A p.D81N Substitution - Missense 8:123652686-123652686 - TCGA-BH-A0HF-01 COSM3834002 c.221A>T p.K74I Substitution - Missense 8:123652706-123652706 - TCGA-UB-A7MB-01 COSM4931227 c.602T>C p.M201T Substitution - Missense 8:123652325-123652325 - TCGA-EE-A2M5-06 COSM3644847 c.1254C>G p.P418P Substitution - coding silent 8:123651673-123651673 - TCGA-FW-A3TV-06 COSM3644848 c.1033G>A p.G345R Substitution - Missense 8:123651894-123651894 - TCGA-AZ-6600-01 COSM1454673 c.570T>G p.C190W Substitution - Missense 8:123652357-123652357 - sysucc-1163T COSM5459337 c.632G>A p.R211Q Substitution - Missense 8:123652295-123652295 - GC8_T COSM150536 c.1054A>T p.N352Y Substitution - Missense 8:123651873-123651873 - Au4 COSM5603916 c.543G>A p.R181R Substitution - coding silent 8:123652384-123652384 - TCGA-33-4566-01 COSM749473 c.1434G>T p.G478G Substitution - coding silent 8:123646931-123646931 - RKO COSM3315929 c.1261delG p.V421fs*8 Deletion - Frameshift 8:123651666-123651666 - TCGA-34-2600-01 COSM749475 c.1565A>C p.K522T Substitution - Missense 8:123645920-123645920 - TCGA-CD-5801-01 COSM3896575 c.726G>T p.L242L Substitution - coding silent 8:123652201-123652201 - pfg127T COSM4760995 c.1727G>A p.R576H Substitution - Missense 8:123645758-123645758 - LUAD-NYU847 COSM376945 c.1630G>T p.D544Y Substitution - Missense 8:123645855-123645855 - EOPC-041_tumor_01 COSM1212661 c.961C>T p.R321W Substitution - Missense 8:123651966-123651966 - TCGA-EB-A44O-01 COSM3644851 c.391T>C p.L131L Substitution - coding silent 8:123652536-123652536 - 6115233 COSM4696558 c.444C>T p.C148C Substitution - coding silent 8:123652483-123652483 - TCGA-E2-A154-01 COSM453969 c.529G>A p.A177T Substitution - Missense 8:123652398-123652398 - PCSI_0018_Pa_P COSM216805 c.1577C>T p.T526M Substitution - Missense 8:123645908-123645908 - PT42 COSM5925427 c.1583G>A p.G528E Substitution - Missense 8:123645902-123645902 - 1N57-VS-1T57 COSM4977464 c.190T>G p.C64G Substitution - Missense 8:123652737-123652737 - CSCC-56-T COSM4548778 c.456G>A p.K152K Substitution - coding silent 8:123652471-123652471 - B105-1-Tumor COSM4006836 c.294T>C p.H98H Substitution - coding silent 8:123652633-123652633 - HT115 COSM3315914 c.1730C>T p.T577M Substitution - Missense 8:123645755-123645755 - CN-AML-CR-6-Dx COSM4006837 c.293A>G p.H98R Substitution - Missense 8:123652634-123652634 - TCGA-DI-A0WH-01 COSM1095793 c.1322T>C p.I441T Substitution - Missense 8:123651605-123651605 - 587376 COSM1212663 c.1404G>T p.K468N Substitution - Missense 8:123646961-123646961 -

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.450252 8q24.13

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer - A Frameshift p.G437Wfs*59 c.1308dupT 8 124663859 LUAD A G Missense p.F116L c.346T>C 8 124664821 PRAD A G Missense p.F460L c.1378T>C 8 124659227 CM A G Missense p.L151P c.452T>C 8 124664715 STAD A T Missense p.I449N c.1346T>A 8 124663821 LUSC A T Missense p.M340K c.1019T>A 8 124664148 LUSC A T Nonsense p.C504* c.1512T>A 8 124658213 LUAD C A Missense p.R257I c.770G>T 8 124664397 MM C A Missense p.V302F c.904G>T 8 124664263 LUAD C A Synonymous p.L242L c.726G>T 8 124664441 STAD C - Frameshift p.E96Rfs*12 c.286delG 8 124664881 STAD C G Missense p.E174Q c.520G>C 8 124664647 RCCC C G Missense p.W363C c.1089G>C 8 124664078 BRCA C T Missense p.A177T c.529G>A 8 124664638 BRCA C T Missense p.A427T c.1279G>A 8 124663888 COREAD C T Missense p.E157K c.469G>A 8 124664698 CM C T Missense p.G390R c.1168G>A 8 124663999 CM C T Missense p.M466I c.1398G>A 8 124659207 CM C T Missense p.R489K c.1466G>A 8 124658259 CM C T Missense p.R49H c.146G>A 8 124665021 COREAD C T Nonsense p.W411* c.1232G>A 8 124663935 LUAD C T Synonymous p.R490R c.1470G>A 8 124658255 CM G A IntronicSNV . c.1351-2267C>T 8 124661521 CLL G A Missense p.A167V c.500C>T 8 124664667 LGG G A Missense p.A255V c.764C>T 8 124664403 LUAD G A Missense p.A505V c.1514C>T 8 124658211 MB G A Missense p.P418L c.1253C>T 8 124663914 CM G A Missense p.P82S c.244C>T 8 124664923 CM G A Missense p.R43W c.127C>T 8 124665040 UCEC G A Missense p.R447C c.1339C>T 8 124663828 BRCA G A Missense p.R68W c.202C>T 8 124664965 UCEC G A Missense p.S244F c.731C>T 8 124664436 HNSC G A Missense p.S455F c.1364C>T 8 124659241 CM G A Missense p.T526M c.1577C>T 8 124658148 PAAD G A Missense p.T84I c.251C>T 8 124664916 BRCA G A Synonymous p.A199A c.597C>T 8 124664570 CM G A Synonymous p.A472A c.1416C>T 8 124659189 CM G A Synonymous p.C47C c.141C>T 8 124665026 UCEC G A Synonymous p.C545C c.1635C>T 8 124658090 LUAD G A Synonymous p.I449I c.1347C>T 8 124663820 CM G A Synonymous p.P418P c.1254C>T 8 124663913 STAD G A Synonymous p.T309T c.927C>T 8 124664240 LGG G A Synonymous p.T84T c.252C>T 8 124664915 LUSC G A Synonymous p.V426V c.1278C>T 8 124663889 STAD G C Missense p.F219L c.657C>G 8 124664510 BLCA G C Missense p.I385M c.1155C>G 8 124664012 BLCA G C Missense p.L358V c.1072C>G 8 124664095 LUAD G C Missense p.L492V c.1474C>G 8 124658251 BRCA G C Synonymous p.P418P c.1254C>G 8 124663913 CM G - Frameshift p.T577Sfs*98 c.1730delC 8 124657995 UCEC GG TA Missense p.S540L c.1619_1620delinsTA 8 124658105 CM G T Missense p.S134R c.402C>A 8 124664765 LUAD G T Missense p.T309N c.926C>A 8 124664241 LUAD G T Synonymous p.S400S c.1200C>A 8 124663967 BRCA G T Synonymous p.S555S c.1665C>A 8 124658060 UCEC T C Missense p.R456G c.1366A>G 8 124659239 LUAD T C Synonymous p.K503K c.1509A>G 8 124658216 LUSC T C Synonymous p.S5S c.15A>G 8 124665152 LUAD T G Missense p.K522T c.1565A>C 8 124658160 LUSC