PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus HIC1 HIC2 11554746 biogrid,intact exp G GP P G G GP GP GP G G GP P G P G P G P GP GP G GP G PIAS1 HIC1 17283066 biogrid exp G GP P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP G PIAS2 HIC1 23704280,17283066 biogrid exp G G G G G G G G G G G G G G G G G G UBE2I HIC1 17283066,23417673 biogrid exp G GP P G G GP GP GP GP G GP P GP P G P G P G GP GP GP G HIC1 SUZ12 22315224 biogrid exp G G G G GP GP G GP G GP G G P G G GP G GP G MTA1 HIC1 20547755,23417673 biogrid exp G GP P G G GP GP P GP GP G GP P GP P G P G P G GP G GP G RBBP4 HIC1 20547755 biogrid exp G GP P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP G HIC1 SENP3 17283066 biogrid exp G GP P G G GP GP P G G G GP P G P G P G P GP GP G GP G HDAC4 HIC1 17283066 biogrid exp G G P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP G EED HIC1 22315224 biogrid exp G GP P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP G HIC1 HIC1 12052894,10611298,16724116 hprd,biogrid,intact exp G GP P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP G HIC1 EZH2 22315224 biogrid exp G P GP P GP G GP G P P P GP GP GP SP1 HIC1 23704280 biogrid exp G GP P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP G ARID1A HIC1 19486893 biogrid,intact exp G GP P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP G HIC1 PIAS4 23704280 biogrid exp G G G G G G G G G G G G MBD3 HIC1 20547755 biogrid exp G GP P G G GP GP GP GP G GP P GP G P G GP GP GP GP G STAT3 HIC1 24067369 biogrid exp G GP P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP G CHD3 HIC1 20547755 biogrid exp G GP P G G GP GP GP GP G GP P GP P G P G P GP GP G GP G HIC1 PHF19 22315224 biogrid exp G GP P G G GP GP GP G G GP P GP P G P G P G GP GP GP G PHF1 HIC1 22315224 biogrid exp G GP P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP G HIC1 PIAS3 23704280 biogrid exp G G G G G G G G G G G G G G G G G G HIC1 SIRT1 22510409,16269335,17283066,23417673 hprd,biogrid,intact exp, ortho G GP P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP G HIC1 TCF7L2 16724116, 25402006 biogrid,mint,intact exp, ortho, pred G GP P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP G CTBP1 HIC1 19486893,16762039,17213307,12052894, 25402006, 21836163 hprd,biogrid,intact exp, pred G GP P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP G CTBP2 HIC1 19486893,16762039,20547755, 25402006, 21836163, 16082366 biogrid,intact exp, pred G G P G G GP GP GP GP G GP P G P G P G P GP GP G GP G HDAC1 HIC1 12052894, 25402006 hprd exp, pred G GP P G G GP GP P GP GP G GP P GP P G P G P G GP GP GP G CTNNB1 HIC1 16724116, 25402006 mint,intact exp, pred G GP P G G GP GP P GP G G GP P GP P G P G P G GP G GP G YWHAE HIC1 ortho G GP P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP G XRCC5 HIC1 25402006 pred G GP P G G GP GP GP GP G GP P GP P G P G P GP GP GP GP G HIC1 SMARCC2 25402006 pred G GP P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP G KLF8 HIC1 25402006 pred G G G G G G G G G G G HIC1 ZFPM2 25402006 pred G GP P G G GP P P GP GP G GP P GP P G P G P GP GP GP GP G JUP HIC1 25402006 pred G G G G GP GP P G G G GP G P G P G P G GP G GP G SATB1 HIC1 25402006 pred G GP P G G G GP P G GP G G P G G G GP G G G G KLF4 HIC1 25402006 pred G G G G GP GP GP G G GP GP G P G G GP G GP G APC HIC1 25402006 pred G GP P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP SMARCB1 HIC1 25402006 pred G GP P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP G ZEB1 HIC1 25402006 pred P P P P P P P P P HSD17B4 HIC1 21836163 pred G GP P G G GP GP P GP GP G GP P G P G P G P GP GP GP GP G KLF3 HIC1 25402006 pred G GP P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP G TP53 HIC1 21836163 pred G G G G G G G G G GP G G P G G GP G G G XRCC6 HIC1 25402006 pred G GP P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP G RUNX3 HIC1 25402006 pred G G G G G G GP G G G G G G G MECOM HIC1 25402006 pred G P P G G GP GP P GP P G GP P GP P G P G P GP GP GP GP G ZNF217 HIC1 25402006 pred G GP P G G GP GP P GP GP G GP P GP P G P G P GP GP G GP G PSEN1 HIC1 25402006 pred G GP P G G GP GP P GP GP G GP P G P G P G P GP GP GP GP G KMT2D HIC1 25402006 pred G GP P G G GP GP GP G G G P G P G P G G G G G G SMARCA2 HIC1 25402006 pred G GP P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP G HIC1 SMARCE1 25402006 pred G GP P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP G HIC1 TCF7L1 25402006 pred G G G G G G G G G G G G G G G G G G ACTL6B HIC1 25402006 pred P P P P P P G P HNF1A HIC1 25402006 pred G G G G GP GP P GP G P G G GP G GP HIC1 CAGE1 21836163 pred P P P P P P P P P P P P P P P FHL3 HIC1 25402006 pred G G P G G GP P G G G P GP P P G GP G G GP G HNF4A HIC1 25402006 pred GP G G GP GP P G GP G P G GP GP P G HIC1 TGIF1 25402006 pred G G P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP G NRIP1 HIC1 25402006 pred G GP P G G GP GP P G GP G GP P GP P G P G P GP GP GP GP G HIC1 DPH1 21836163 pred HIC1 KAT2B 25402006 pred G G G G G G G G G G G G G G G G G G SMARCA4 HIC1 25402006 pred G GP P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP G TCF3 HIC1 25402006 pred G GP P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP G EP300 HIC1 25402006 pred G GP P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP G HIC1 MTA3 21836163 pred G GP P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP G CBX4 HIC1 25402006 pred G GP P G G GP GP P GP GP G GP P GP P G P G P G GP GP GP G HIC1 LEF1 25402006 pred G G P G GP GP GP GP G G P G G G GP G G HIC1 CREBBP 25402006 pred G GP P G G GP GP P GP GP G GP P GP P G P G P GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q14526 O88712 two hybrid 12052894 physical association X 2 Q14526 O88712 fluorescence microscopy 12052894 colocalization X 2 Q14526 O88712 two hybrid 12052894 physical association X 2 Q14526 O88712 pull down 12052894 physical association X 2 Q14526 O88712 anti tag coimmunoprecipitation 12052894 physical association X 2 Q14526 Q53Z05 anti bait coimmunoprecipitation 16269335 physical association X 2 Q14526 A0A024QZQ1 anti bait coimmunoprecipitation 16269335 physical association X 2 Q14526 A0A024R2Q3 anti tag coimmunoprecipitation 16724116 physical association X 2 Q14526 A0A024R2Q3 imaging technique 16724116 colocalization X 2 Q14526 O88712 imaging technique 16724116 colocalization X 2 Q14526 O88712 imaging technique 16724116 colocalization X 2 Q14526 O88712 anti tag coimmunoprecipitation 16762039 physical association X 2 Q14526 O88712 two hybrid 16762039 physical association X 2 Q14526 P56546 anti tag coimmunoprecipitation 16762039 physical association X 2 Q14526 O88712 anti bait coimmunoprecipitation 16762039 physical association X 2 Q14526 P56546 two hybrid 16762039 physical association X 2 Q14526 P56545 anti bait coimmunoprecipitation 19486893 physical association X 2 Q14526 P56545 two hybrid 19486893 physical association X 2 Q14526 O14497 two hybrid 19486893 physical association X 2 Q14526 O14497 anti bait coimmunoprecipitation 19486893 physical association X 2 Q14526 Q96JB3 two hybrid 11554746 physical association X 2 Q14526 Q96JB3-2 imaging technique 11554746 colocalization X 2 Q14526 Q96JB3 imaging technique 11554746 colocalization X 2 Q14526 G3HK86 anti bait coimmunoprecipitation 12052894 physical association X 2 Q14526 Q14526 two hybrid 12052894 physical association X 2 Q14526 Q9NQB0 anti bait coimmunoprecipitation 16724116 physical association X 2 Q14526 Q9NQB0 pull down 16724116 physical association X 2 Q14526 Q9NQB0 anti bait coimmunoprecipitation 16724116 physical association X 2 Q14526 Q9NQB0 imaging technique 16724116 colocalization X 2 Q14526 Q9NQB0 anti tag coimmunoprecipitation 16724116 physical association X 2 Q14526 Q9NQB0 pull down 16724116 physical association X 2 Q14526 Q13363 anti bait coimmunoprecipitation 16762039 physical association X 2 Q14526 Q13363 anti bait coimmunoprecipitation 17213307 physical association X 2 Q14526 Q13363 anti tag coimmunoprecipitation 17213307 physical association X 2 Q14526 Q13363 two hybrid 19486893 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B HIC1 SIRT1 MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0428(imaging technique)|MI:0004(affinity chromatography technology) 16269335,17283066,22510409,23417673,23704280 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(biogrid) UniProt_81667|BIOGRID_282384|BIOGRID_216487|HPRD_31946|BIOGRID_209031|BIOGRID_138132|BIOGRID_289625|BIOGRID_209030 bait|bait|bait|-|prey|bait|bait|bait prey|prey|prey|-|bait|prey|prey|prey HIC1 HIC2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 11554746 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(biogrid)|(intact)|(intact)|(intact) BIOGRID_257766|BIOGRID_257765|UniProt_67760|UniProt_67758|UniProt_67759 bait|bait|neutral component|bait|neutral component prey|prey|null|prey|null HIC1 SUZ12 MI:0018(two hybrid) 22315224 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_192092 bait prey HIC1 TCF7L2 MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique) 16724116 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_86787|MINT_49439|MINT_49436|MINT_81574|MINT_49435|MINT_81575|MINT_49438|MINT_49437|MINT_81570|MINT_81571|MINT_81572|MINT_49434|MINT_81573|UniProt_86780|UniProt_86782|UniProt_86781|UniProt_86786|UniProt_86785 prey|bait|bait|prey|prey|bait|prey|bait|neutral component|prey|bait|neutral component|bait|neutral component|prey|bait|bait|bait bait|prey|prey|bait|bait|prey|bait|prey|neutral component|bait|prey|neutral component|prey|neutral component|bait|prey|prey|prey CHD3 HIC1 MI:0004(affinity chromatography technology) 20547755 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_140082 prey bait PHF1 HIC1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 22315224 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_192086|BIOGRID_192089|BIOGRID_192090 prey|bait|prey bait|prey|bait PIAS2 HIC1 MI:0415(enzymatic study) 17283066 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_138131 bait prey UBE2I HIC1 MI:0415(enzymatic study)|MI:0004(affinity chromatography technology) 17283066,23417673 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_138128|BIOGRID_282385 bait|prey prey|bait HIC1 EZH2 MI:0018(two hybrid) 22315224 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_192091 bait prey CTBP2 HIC1 MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid) 16762039,19486893,20547755 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact) BIOGRID_129632|BIOGRID_212179|BIOGRID_212180|BIOGRID_129629|BIOGRID_140083|UniProt_100510|UniProt_100513 prey|prey|prey|prey|prey|prey|prey bait|bait|bait|bait|bait|bait|bait SUMO2 HIC1 MI:0004(affinity chromatography technology) 23417673 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_282381 prey bait ARID1A HIC1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 19486893 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact)|(intact) BIOGRID_129630|BIOGRID_129631|UniProt_100511|UniProt_100512 prey|prey|prey|prey bait|bait|bait|bait EED HIC1 MI:0018(two hybrid) 22315224 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_192093 prey bait CTNNB1 HIC1 MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0493(in vivo) 16724116 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0915(physical association)|- MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0468(hprd) MINT_49440|MINT_49441|UniProt_86789|MINT_81576|UniProt_86790|MINT_81577|HPRD_39883 neutral component|bait|bait|neutral component|neutral component|bait|- neutral component|prey|prey|neutral component|neutral component|prey|- TCF4 HIC1 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0493(in vivo) 16724116 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|- (biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_214364|BIOGRID_214363|BIOGRID_214362|BIOGRID_214361|HPRD_39883 prey|prey|bait|bait|- bait|bait|prey|prey|- HDAC1 HIC1 MI:0493(in vivo) 12052894 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_8688 - - MTA1 HIC1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20547755,23417673 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_140080|BIOGRID_282382|BIOGRID_282383 prey|prey|bait bait|bait|prey CTBP1 HIC1 MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0018(two hybrid)|MI:0006(anti bait coimmunoprecipitation)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation) 12052894,16762039,17213307,19486893 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0468(hprd)|(intact)|(intact)|(biogrid)|(biogrid)|(intact)|(biogrid)|(intact) BIOGRID_212178|HPRD_11173|UniProt_100509|UniProt_85402|BIOGRID_129628|BIOGRID_126401|UniProt_87318|BIOGRID_126402|UniProt_87319 prey|-|prey|prey|prey|prey|bait|bait|prey bait|-|bait|bait|bait|bait|prey|prey|bait RBBP4 HIC1 MI:0004(affinity chromatography technology) 20547755 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_140084 prey bait UBC HIC1 MI:0004(affinity chromatography technology) 19850743 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_149110 bait prey HDAC4 HIC1 MI:0415(enzymatic study) 17283066 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_138133 prey bait HIC1 SENP3 MI:0415(enzymatic study) 17283066 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_138129 prey bait HIC1 PHF19 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 22315224 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_192087|BIOGRID_192088|BIOGRID_192085 prey|bait|bait bait|prey|prey PIAS1 HIC1 MI:0415(enzymatic study) 17283066 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_138130 bait prey

PPI - HINT Gene A Gene B PMID Method Quality CTBP2 HIC1 16762039,20547755,19486893,19486893,19486893,16762039 0004,0004,0006,0018,0004,0018 LC CTBP1 HIC1 17213307,16762039,17213307,16762039,17213307 0007,0006,0006,0004,0004 LC HIC1 SIRT1 16269335,22510409,23417673,17283066,16269335 0006,0004,0004,0004,0004 LC HIC1 Q9BRL8 20547755,23417673 0004,0004 LC CTBP2 HIC1 16762039,20547755,19486893,19486893,19486893,16762039 0004,0004,0006,0018,0004,0018 LC CTBP1 HIC1 17213307,16762039,17213307,16762039,17213307 0007,0006,0006,0004,0004 LC HIC1 SIRT1 16269335,22510409,23417673,17283066,16269335 0006,0004,0004,0004,0004 LC HIC1 Q9BRL8 20547755,23417673 0004,0004 LC ARID1A HIC1 19486893,19486893,19486893 0018,0004,0006 LC PHF1 HIC1 22315224,22315224 0004,0018 LC PIAS1 HIC1 17283066 0415 LC PIAS2 HIC1 17283066 0415 LC CTBP2 HIC1 16762039,19486893,19486893,19486893,16762039 0004,0006,0018,0004,0018 LC UBE2I HIC1 17283066 0415 LC MECOM HIC1 24907396,24907396 0004,0055 LC CTBP1 HIC1 19486893 0018 LC HIC1 HIC1 12052894,10611298,16724116 0018,0018,0018 LC HIC1 PHF19 22315224,22315224 0004,0018 LC HIC1 HIC2 11554746,11554746 0428,0018 LC HIC1 SENP3 17283066 0415 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5T6S3 Q14526 PHF19 HIC1 0.569 22315224 Q14526 O43189 HIC1 PHF1 0.569 22315224 Q8N2W9 Q14526 PIAS4 HIC1 0.126 23704280 Q9H4L4 Q14526 SENP3 HIC1 0.309 17283066 Q9Y6X2 Q14526 PIAS3 HIC1 0.126 23704280 Q14526 P08047 HIC1 SP1 0.126 23704280 Q14526 O75925 HIC1 PIAS1 0.309 17283066 Q14526 O14497 HIC1 ARID1A 0.702 19486893 Q96JB3 Q14526 HIC2 HIC1 0.396 11554746 Q14526 O75928 HIC1 PIAS2 0.396 17283066,23704280 Q14526 O88712 HIC1 CTBP1 0.748 12052894,16724116 Q9NQB0 Q14526 TCF7L2 HIC1 0.872 16724116 Q14526 P35222 HIC1 CTNNB1 0.309 16724116 Q96EB6 Q14526 SIRT1 HIC1 0.692 16269335,17283066,22510409,23417673 Q14526 O75530 HIC1 EED 0.21 22315224 Q14526 O95983 HIC1 MBD3 0.21 20547755 Q14526 P40763 HIC1 STAT3 0.569 24067369 Q14526 P56524 HIC1 HDAC4 0.21 17283066 Q14526 P63279 HIC1 UBE2I 0.454 23417673,17283066 Q14526 Q09028 HIC1 RBBP4 0.21 20547755 Q14526 Q12873 HIC1 CHD3 0.21 20547755 Q14526 Q14526 HIC1 HIC1 0.332 10611298 Q15022 Q14526 SUZ12 HIC1 0.21 22315224 Q15910 Q14526 EZH2 HIC1 0.21 22315224 Q14526 Q13330 HIC1 MTA1 0.507 23417673,20547755 Q14526 Q13363 HIC1 CTBP1 0.623 19486893,16762039 Q14526 Q13465 HIC1 MECOM 0.569 24907396 Q14526 Q03112 HIC1 MECOM 0.569 24907396 Q14526 P56545 HIC1 CTBP2 0.872 19486893,16762039,20547755

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 ARID1A HIC1 MI:0045 experimental interaction detection MI:0461 interaction database PHF1 HIC1 MI:0045 experimental interaction detection MI:0461 interaction database EED HIC1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS1 HIC1 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 HIC1 MI:0045 experimental interaction detection MI:0461 interaction database MBD3 HIC1 MI:0045 experimental interaction detection MI:0461 interaction database UBC HIC1 MI:0045 experimental interaction detection MI:0461 interaction database TCF4 HIC1 MI:0045 experimental interaction detection MI:0461 interaction database CTNNB1 HIC1 MI:0045 experimental interaction detection MI:0461 interaction database STAT3 HIC1 MI:0045 experimental interaction detection MI:0461 interaction database HDAC4 HIC1 MI:0045 experimental interaction detection MI:0461 interaction database CTBP2 HIC1 MI:0045 experimental interaction detection MI:0461 interaction database SUMO2 HIC1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2I HIC1 MI:0045 experimental interaction detection MI:0461 interaction database MECOM HIC1 MI:0045 experimental interaction detection MI:0461 interaction database RBBP4 HIC1 MI:0045 experimental interaction detection MI:0461 interaction database CHD3 HIC1 MI:0045 experimental interaction detection MI:0461 interaction database MTA1 HIC1 MI:0045 experimental interaction detection MI:0461 interaction database CTBP1 HIC1 MI:0045 experimental interaction detection MI:0461 interaction database MECOM HIC1 MI:0045 experimental interaction detection MI:0461 interaction database HIC1 SUZ12 MI:0045 experimental interaction detection MI:0461 interaction database HIC1 EZH2 MI:0045 experimental interaction detection MI:0461 interaction database HIC1 PHF19 MI:0045 experimental interaction detection MI:0461 interaction database HIC1 SIRT1 MI:0045 experimental interaction detection MI:0461 interaction database HIC1 HIC2 MI:0045 experimental interaction detection MI:0461 interaction database HIC1 SENP3 MI:0045 experimental interaction detection MI:0461 interaction database HIC1 TCF7L2 MI:0045 experimental interaction detection MI:0461 interaction database