Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change ACC 16 2018635 2018635 + Silent SNP C C A TCGA-OR-A5LJ-01A-11D-A29I-10 TCGA-OR-A5LJ-10A-01D-A29L-10 g.chr16:2018635C>A c.447C>A c.(445-447)acC>acA p.T149T CESC 16 2017754 2017754 + Missense_Mutation SNP G G C TCGA-C5-A1MK-01A-11D-A14W-08 TCGA-C5-A1MK-10A-01D-A14W-08 g.chr16:2017754G>C c.178G>C c.(178-180)Gag>Cag p.E60Q CESC 16 2018792 2018792 + Missense_Mutation SNP G G A TCGA-EK-A3GK-01A-11D-A20U-09 TCGA-EK-A3GK-10A-01D-A20U-09 g.chr16:2018792G>A c.604G>A c.(604-606)Gag>Aag p.E202K COAD 16 2018823 2018823 + Missense_Mutation SNP C C A TCGA-AA-3663-01A-01D-1719-10 TCGA-AA-3663-11A-01D-1719-10 g.chr16:2018823C>A c.635C>A c.(634-636)gCt>gAt p.A212D COAD 16 2018825 2018825 + Missense_Mutation SNP C C A TCGA-D5-6930-01A-11D-1924-10 TCGA-D5-6930-10A-01D-1924-10 g.chr16:2018825C>A c.637C>A c.(637-639)Ctg>Atg p.L213M COADREAD 16 2018823 2018823 + Missense_Mutation SNP C C A TCGA-AA-3663-01A-01D-1719-10 TCGA-AA-3663-11A-01D-1719-10 g.chr16:2018823C>A c.635C>A c.(634-636)gCt>gAt p.A212D COADREAD 16 2018825 2018825 + Missense_Mutation SNP C C A TCGA-D5-6930-01A-11D-1924-10 TCGA-D5-6930-10A-01D-1924-10 g.chr16:2018825C>A c.637C>A c.(637-639)Ctg>Atg p.L213M DLBC 16 2018580 2018580 + Missense_Mutation SNP G G A TCGA-G8-6324-01A-11D-2210-10 TCGA-G8-6324-10A-01D-2210-10 g.chr16:2018580G>A c.392G>A c.(391-393)cGg>cAg p.R131Q GBM 16 2018613 2018614 + Frame_Shift_Ins INS - - C TCGA-06-0195-01B-01D-1491-08 TCGA-06-0195-10A-01D-1491-08 g.chr16:2018613_2018614insC c.425_426insC c.(424-429)tgccccfs p.CP142fs GBMLGG 16 2018613 2018614 + Frame_Shift_Ins INS - - C TCGA-06-0195-01B-01D-1491-08 TCGA-06-0195-10A-01D-1491-08 g.chr16:2018613_2018614insC c.425_426insC c.(424-429)tgccccfs p.CP142fs GBMLGG 16 2018730 2018730 + Frame_Shift_Del DEL C C - TCGA-HW-7487-01A-11D-2024-08 TCGA-HW-7487-10A-01D-2024-08 g.chr16:2018730delC c.542delC c.(541-543)tccfs p.S181fs HNSC 16 2017315 2017315 + Missense_Mutation SNP A A G TCGA-CR-6484-01A-11D-1870-08 TCGA-CR-6484-10A-01D-1870-08 g.chr16:2017315A>G c.44A>G c.(43-45)gAc>gGc p.D15G LGG 16 2018730 2018730 + Frame_Shift_Del DEL C C - TCGA-HW-7487-01A-11D-2024-08 TCGA-HW-7487-10A-01D-2024-08 g.chr16:2018730delC c.542delC c.(541-543)tccfs p.S181fs LIHC 16 2018778 2018778 + Missense_Mutation SNP G G T TCGA-DD-AAEI-01A-11D-A40R-10 TCGA-DD-AAEI-10A-01D-A40U-10 g.chr16:2018778G>T c.590G>T c.(589-591)cGt>cTt p.R197L LUAD 16 2018677 2018677 + Missense_Mutation SNP G G T TCGA-44-2656-01A-02D-0969-08 TCGA-44-2656-10A-01D-0969-08 g.chr16:2018677G>T c.489G>T c.(487-489)gaG>gaT p.E163D LUAD 16 2018885 2018885 + Missense_Mutation SNP G G A TCGA-NJ-A4YP-01A-11D-A25L-08 TCGA-NJ-A4YP-10A-01D-A25L-08 g.chr16:2018885G>A c.697G>A c.(697-699)Gag>Aag p.E233K OV 16 2018849 2018850 + Frame_Shift_Ins INS - - C TCGA-30-1718-01A-01W-0633-09 TCGA-30-1718-10A-01W-0633-09 g.chr16:2018849_2018850insC c.661_662insC c.(661-663)gagfs p.E221fs SKCM 16 2017795 2017795 + Silent SNP G G A TCGA-FS-A1ZT-06A-11D-A197-08 TCGA-FS-A1ZT-10A-01D-A199-08 g.chr16:2017795G>A c.219G>A c.(217-219)cgG>cgA p.R73R

Mutation - ICGC Project Code Chromosome Chromosome Start Chromosome End Mutation Type Mutated from Allele Mutated to Allele Consequence Type AA Mutation CDS Mutation BLCA-CN 16 2012794 2012794 single base substitution G A upstream_gene_variant BLCA-US 16 2012571 2012571 single base substitution C T upstream_gene_variant BLCA-US 16 2012818 2012818 single base substitution G A upstream_gene_variant BRCA-EU 16 2012585 2012585 single base substitution G T upstream_gene_variant BRCA-EU 16 2013178 2013178 single base substitution G C upstream_gene_variant BRCA-EU 16 2013292 2013292 deletion of <=200bp A - upstream_gene_variant BRCA-EU 16 2014508 2014508 single base substitution C G upstream_gene_variant BRCA-EU 16 2014800 2014800 single base substitution G A upstream_gene_variant BRCA-EU 16 2015162 2015162 single base substitution C T upstream_gene_variant BRCA-EU 16 2015393 2015393 single base substitution T C upstream_gene_variant BRCA-EU 16 2016199 2016199 single base substitution C T upstream_gene_variant BRCA-EU 16 2016215 2016215 single base substitution C G upstream_gene_variant BRCA-EU 16 2016509 2016509 single base substitution G C upstream_gene_variant BRCA-EU 16 2016842 2016842 single base substitution G A 5_prime_UTR_variant BRCA-EU 16 2016842 2016842 single base substitution G A upstream_gene_variant BRCA-EU 16 2018413 2018413 single base substitution A G intron_variant BRCA-EU 16 2019354 2019354 single base substitution C T downstream_gene_variant BRCA-EU 16 2019796 2019796 single base substitution C T downstream_gene_variant BRCA-EU 16 2020672 2020672 single base substitution T A downstream_gene_variant BRCA-EU 16 2021662 2021662 single base substitution G C downstream_gene_variant BRCA-FR 16 2015162 2015162 single base substitution C T upstream_gene_variant BRCA-FR 16 2017469 2017469 single base substitution G T intron_variant BRCA-FR 16 2021662 2021662 single base substitution G C downstream_gene_variant BRCA-UK 16 2019796 2019796 single base substitution C T downstream_gene_variant BRCA-UK 16 2023227 2023227 single base substitution G C downstream_gene_variant BRCA-US 16 2014292 2014292 single base substitution G T upstream_gene_variant BTCA-JP 16 2013841 2013841 single base substitution C A upstream_gene_variant BTCA-JP 16 2015322 2015322 insertion of <=200bp - C upstream_gene_variant BTCA-JP 16 2017903 2017903 single base substitution G A intron_variant BTCA-JP 16 2017903 2017903 single base substitution G A missense_variant G60E 179G>A BTCA-JP 16 2018616 2018616 single base substitution C A 3_prime_UTR_variant BTCA-JP 16 2018616 2018616 single base substitution C A missense_variant P142H 425C>A BTCA-JP 16 2018616 2018616 single base substitution C A missense_variant P143H 428C>A CESC-US 16 2012214 2012214 single base substitution C T upstream_gene_variant CESC-US 16 2012342 2012342 single base substitution G A upstream_gene_variant CESC-US 16 2017754 2017754 single base substitution G C intron_variant CESC-US 16 2017754 2017754 single base substitution G C missense_variant E59Q 175G>C CESC-US 16 2017754 2017754 single base substitution G C missense_variant E60Q 178G>C CESC-US 16 2018792 2018792 single base substitution G A 3_prime_UTR_variant CESC-US 16 2018792 2018792 single base substitution G A missense_variant E201K 601G>A CESC-US 16 2018792 2018792 single base substitution G A missense_variant E202K 604G>A CLLE-ES 16 2013684 2013684 single base substitution T C upstream_gene_variant CLLE-ES 16 2019658 2019658 single base substitution G A downstream_gene_variant COAD-US 16 2011849 2011849 single base substitution G A upstream_gene_variant COAD-US 16 2012253 2012253 single base substitution G A upstream_gene_variant COAD-US 16 2012587 2012587 single base substitution G A upstream_gene_variant COAD-US 16 2014591 2014591 single base substitution C T upstream_gene_variant COAD-US 16 2018555 2018555 single base substitution C A 3_prime_UTR_variant COAD-US 16 2018555 2018555 single base substitution C A missense_variant P122T 364C>A COAD-US 16 2018555 2018555 single base substitution C A missense_variant P123T 367C>A COAD-US 16 2018580 2018580 single base substitution G A 3_prime_UTR_variant COAD-US 16 2018580 2018580 single base substitution G A missense_variant R130Q 389G>A COAD-US 16 2018580 2018580 single base substitution G A missense_variant R131Q 392G>A COAD-US 16 2018715 2018715 single base substitution G A 3_prime_UTR_variant COAD-US 16 2018715 2018715 single base substitution G A missense_variant R175Q 524G>A COAD-US 16 2018715 2018715 single base substitution G A missense_variant R176Q 527G>A COAD-US 16 2018823 2018823 single base substitution C A 3_prime_UTR_variant COAD-US 16 2018823 2018823 single base substitution C A missense_variant A211D 632C>A COAD-US 16 2018823 2018823 single base substitution C A missense_variant A212D 635C>A COAD-US 16 2018825 2018825 single base substitution C A 3_prime_UTR_variant COAD-US 16 2018825 2018825 single base substitution C A missense_variant L212M 634C>A COAD-US 16 2018825 2018825 single base substitution C A missense_variant L213M 637C>A COCA-CN 16 2012875 2012875 single base substitution G A upstream_gene_variant COCA-CN 16 2012910 2012910 single base substitution C T upstream_gene_variant COCA-CN 16 2013657 2013657 single base substitution G A upstream_gene_variant COCA-CN 16 2014332 2014332 single base substitution T C upstream_gene_variant COCA-CN 16 2014652 2014652 single base substitution A G upstream_gene_variant COCA-CN 16 2017783 2017783 single base substitution G T intron_variant COCA-CN 16 2017783 2017783 single base substitution G T missense_variant M68I 204G>T COCA-CN 16 2017783 2017783 single base substitution G T missense_variant M69I 207G>T COCA-CN 16 2018329 2018329 single base substitution C T intron_variant COCA-CN 16 2018748 2018748 single base substitution G T 3_prime_UTR_variant COCA-CN 16 2018748 2018748 single base substitution G T missense_variant R186L 557G>T COCA-CN 16 2018748 2018748 single base substitution G T missense_variant R187L 560G>T COCA-CN 16 2019427 2019427 single base substitution A G downstream_gene_variant EOPC-DE 16 2014792 2014792 single base substitution G A upstream_gene_variant EOPC-DE 16 2017142 2017142 single base substitution G A intron_variant EOPC-DE 16 2017142 2017142 single base substitution G A upstream_gene_variant ESAD-UK 16 2012931 2012931 single base substitution G A upstream_gene_variant ESAD-UK 16 2013699 2013702 deletion of <=200bp TGTA - upstream_gene_variant ESAD-UK 16 2014392 2014392 single base substitution C G upstream_gene_variant ESAD-UK 16 2015234 2015234 single base substitution G A upstream_gene_variant ESAD-UK 16 2020617 2020617 insertion of <=200bp - G downstream_gene_variant ESAD-UK 16 2023791 2023791 single base substitution G T downstream_gene_variant ESAD-UK 16 2023797 2023797 single base substitution C G downstream_gene_variant ESCA-CN 16 2018792 2018792 single base substitution G A 3_prime_UTR_variant ESCA-CN 16 2018792 2018792 single base substitution G A missense_variant E201K 601G>A ESCA-CN 16 2018792 2018792 single base substitution G A missense_variant E202K 604G>A GBM-US 16 2018613 2018613 insertion of <=200bp - C 3_prime_UTR_variant GBM-US 16 2018613 2018613 insertion of <=200bp - C frameshift_variant C141S? GBM-US 16 2018613 2018613 insertion of <=200bp - C frameshift_variant C142S? KIRC-US 16 2012906 2012906 single base substitution A T upstream_gene_variant KIRC-US 16 2018623 2018623 single base substitution C A 3_prime_UTR_variant KIRC-US 16 2018623 2018623 single base substitution C A synonymous_variant G144G 432C>A KIRC-US 16 2018623 2018623 single base substitution C A synonymous_variant G145G 435C>A KIRP-US 16 2014483 2014483 insertion of <=200bp - CGGCCT upstream_gene_variant LAML-KR 16 2019550 2019550 single base substitution T C downstream_gene_variant LAML-KR 16 2019666 2019666 single base substitution G T downstream_gene_variant LGG-US 16 2014319 2014319 single base substitution G C upstream_gene_variant LGG-US 16 2018730 2018730 deletion of <=200bp C - 3_prime_UTR_variant LGG-US 16 2018730 2018730 deletion of <=200bp C - frameshift_variant S180 LGG-US 16 2018730 2018730 deletion of <=200bp C - frameshift_variant S181 LICA-FR 16 2012823 2012823 single base substitution T A upstream_gene_variant LICA-FR 16 2018632 2018632 single base substitution C T 3_prime_UTR_variant LICA-FR 16 2018632 2018632 single base substitution C T synonymous_variant A147A 441C>T LICA-FR 16 2018632 2018632 single base substitution C T synonymous_variant A148A 444C>T LICA-FR 16 2021880 2021880 single base substitution T G downstream_gene_variant LICA-FR 16 2022049 2022049 single base substitution C T downstream_gene_variant LIHC-US 16 2013233 2013233 single base substitution G A upstream_gene_variant LINC-JP 16 2012411 2012411 single base substitution C G upstream_gene_variant LINC-JP 16 2012592 2012592 single base substitution G A upstream_gene_variant LINC-JP 16 2014861 2014861 single base substitution C T upstream_gene_variant LINC-JP 16 2015322 2015322 deletion of <=200bp C - upstream_gene_variant LINC-JP 16 2017142 2017142 single base substitution G A intron_variant LINC-JP 16 2017142 2017142 single base substitution G A upstream_gene_variant LINC-JP 16 2021228 2021228 single base substitution C T downstream_gene_variant LIRI-JP 16 2011872 2011872 single base substitution A C upstream_gene_variant LIRI-JP 16 2013392 2013392 single base substitution G A upstream_gene_variant LIRI-JP 16 2015793 2015793 single base substitution G A upstream_gene_variant LIRI-JP 16 2015954 2015954 deletion of <=200bp C - upstream_gene_variant LIRI-JP 16 2016331 2016331 single base substitution G A upstream_gene_variant LIRI-JP 16 2022091 2022091 single base substitution G C downstream_gene_variant LUSC-KR 16 2013279 2013279 single base substitution T C upstream_gene_variant LUSC-KR 16 2014424 2014424 single base substitution C G upstream_gene_variant LUSC-KR 16 2014979 2014979 single base substitution G T upstream_gene_variant LUSC-KR 16 2016767 2016767 single base substitution C T upstream_gene_variant LUSC-KR 16 2019569 2019569 single base substitution C T downstream_gene_variant LUSC-KR 16 2019795 2019795 single base substitution A G downstream_gene_variant LUSC-US 16 2012182 2012182 single base substitution G A upstream_gene_variant MALY-DE 16 2012936 2012936 single base substitution C T upstream_gene_variant MALY-DE 16 2013770 2013770 single base substitution A G upstream_gene_variant MALY-DE 16 2015007 2015007 single base substitution A G upstream_gene_variant MALY-DE 16 2020551 2020552 deletion of <=200bp TG - downstream_gene_variant MALY-DE 16 2022099 2022099 single base substitution C T downstream_gene_variant MALY-DE 16 2022252 2022252 single base substitution C G downstream_gene_variant MELA-AU 16 2012023 2012024 multiple base substitution (>=2bp and <=200bp) CC TT upstream_gene_variant MELA-AU 16 2012240 2012240 single base substitution G A upstream_gene_variant MELA-AU 16 2012683 2012684 multiple base substitution (>=2bp and <=200bp) GG AA upstream_gene_variant MELA-AU 16 2013379 2013379 single base substitution G A upstream_gene_variant MELA-AU 16 2014058 2014058 single base substitution A C upstream_gene_variant MELA-AU 16 2014729 2014729 single base substitution G A upstream_gene_variant MELA-AU 16 2014887 2014887 single base substitution C T upstream_gene_variant MELA-AU 16 2014917 2014917 single base substitution C T upstream_gene_variant MELA-AU 16 2014982 2014982 single base substitution C T upstream_gene_variant MELA-AU 16 2015648 2015648 single base substitution A G upstream_gene_variant MELA-AU 16 2016399 2016400 multiple base substitution (>=2bp and <=200bp) GT AG upstream_gene_variant MELA-AU 16 2017073 2017073 single base substitution C T intron_variant MELA-AU 16 2017073 2017073 single base substitution C T upstream_gene_variant MELA-AU 16 2017095 2017095 single base substitution C T intron_variant MELA-AU 16 2017095 2017095 single base substitution C T upstream_gene_variant MELA-AU 16 2017298 2017298 single base substitution C T synonymous_variant L8L 24C>T MELA-AU 16 2017298 2017298 single base substitution C T synonymous_variant L9L 27C>T MELA-AU 16 2018224 2018224 single base substitution C T intron_variant MELA-AU 16 2018381 2018381 single base substitution G A intron_variant MELA-AU 16 2018506 2018506 single base substitution C T 3_prime_UTR_variant MELA-AU 16 2018506 2018506 single base substitution C T synonymous_variant C105C 315C>T MELA-AU 16 2018506 2018506 single base substitution C T synonymous_variant C106C 318C>T MELA-AU 16 2018730 2018731 multiple base substitution (>=2bp and <=200bp) CC TT 3_prime_UTR_variant MELA-AU 16 2018730 2018731 multiple base substitution (>=2bp and <=200bp) CC TT missense_variant S180F 539CC>TT MELA-AU 16 2018730 2018731 multiple base substitution (>=2bp and <=200bp) CC TT missense_variant S181F 542CC>TT MELA-AU 16 2018778 2018778 single base substitution G C 3_prime_UTR_variant MELA-AU 16 2018778 2018778 single base substitution G C missense_variant R196P 587G>C MELA-AU 16 2018778 2018778 single base substitution G C missense_variant R197P 590G>C MELA-AU 16 2019718 2019718 single base substitution G A downstream_gene_variant MELA-AU 16 2019829 2019829 single base substitution G A downstream_gene_variant MELA-AU 16 2021132 2021132 single base substitution G A downstream_gene_variant MELA-AU 16 2021472 2021472 single base substitution G A downstream_gene_variant MELA-AU 16 2021984 2021984 single base substitution G A downstream_gene_variant MELA-AU 16 2021995 2021995 single base substitution G A downstream_gene_variant MELA-AU 16 2022020 2022020 single base substitution G A downstream_gene_variant MELA-AU 16 2022394 2022394 single base substitution G A downstream_gene_variant MELA-AU 16 2022587 2022587 single base substitution T C downstream_gene_variant MELA-AU 16 2023065 2023065 single base substitution T G downstream_gene_variant ORCA-IN 16 2018740 2018740 single base substitution G T 3_prime_UTR_variant ORCA-IN 16 2018740 2018740 single base substitution G T synonymous_variant R183R 549G>T ORCA-IN 16 2018740 2018740 single base substitution G T synonymous_variant R184R 552G>T ORCA-IN 16 2018766 2018766 single base substitution C G 3_prime_UTR_variant ORCA-IN 16 2018766 2018766 single base substitution C G missense_variant T192S 575C>G ORCA-IN 16 2018766 2018766 single base substitution C G missense_variant T193S 578C>G ORCA-IN 16 2022174 2022174 single base substitution G T downstream_gene_variant OV-AU 16 2018548 2018548 single base substitution G C 3_prime_UTR_variant OV-AU 16 2018548 2018548 single base substitution G C synonymous_variant S119S 357G>C OV-AU 16 2018548 2018548 single base substitution G C synonymous_variant S120S 360G>C OV-AU 16 2019107 2019107 single base substitution G A downstream_gene_variant PACA-AU 16 2012524 2012524 deletion of <=200bp C - upstream_gene_variant PACA-AU 16 2017141 2017141 single base substitution C T intron_variant PACA-AU 16 2017141 2017141 single base substitution C T upstream_gene_variant PACA-AU 16 2018699 2018699 single base substitution C T 3_prime_UTR_variant PACA-AU 16 2018699 2018699 single base substitution C T missense_variant R170C 508C>T PACA-AU 16 2018699 2018699 single base substitution C T missense_variant R171C 511C>T PACA-AU 16 2022149 2022151 deletion of <=200bp GCG - downstream_gene_variant PACA-CA 16 2012544 2012544 single base substitution G C upstream_gene_variant PACA-CA 16 2013234 2013234 single base substitution G T upstream_gene_variant PACA-CA 16 2013594 2013594 single base substitution G A upstream_gene_variant PACA-CA 16 2017542 2017545 deletion of <=200bp TGTG - intron_variant PAEN-AU 16 2013037 2013037 single base substitution C T upstream_gene_variant PAEN-IT 16 2019717 2019717 single base substitution C T downstream_gene_variant PBCA-DE 16 2014591 2014591 single base substitution C T upstream_gene_variant PBCA-DE 16 2021219 2021219 insertion of <=200bp - T downstream_gene_variant PRAD-CA 16 2021066 2021066 single base substitution C G downstream_gene_variant PRAD-UK 16 2020649 2020649 single base substitution G A downstream_gene_variant READ-US 16 2012627 2012627 single base substitution G A upstream_gene_variant READ-US 16 2014528 2014528 single base substitution G A upstream_gene_variant READ-US 16 2018650 2018650 single base substitution G A 3_prime_UTR_variant READ-US 16 2018650 2018650 single base substitution G A synonymous_variant E153E 459G>A READ-US 16 2018650 2018650 single base substitution G A synonymous_variant E154E 462G>A SKCA-BR 16 2014356 2014356 single base substitution A G upstream_gene_variant SKCA-BR 16 2018633 2018633 single base substitution A C 3_prime_UTR_variant SKCA-BR 16 2018633 2018633 single base substitution A C missense_variant T148P 442A>C SKCA-BR 16 2018633 2018633 single base substitution A C missense_variant T149P 445A>C SKCA-BR 16 2021965 2021965 single base substitution G A downstream_gene_variant SKCA-BR 16 2021984 2021984 single base substitution G A downstream_gene_variant SKCM-US 16 2012119 2012119 single base substitution G A upstream_gene_variant SKCM-US 16 2012137 2012137 single base substitution C T upstream_gene_variant SKCM-US 16 2012222 2012222 single base substitution G A upstream_gene_variant SKCM-US 16 2012881 2012881 single base substitution G A upstream_gene_variant SKCM-US 16 2017795 2017795 single base substitution G A intron_variant SKCM-US 16 2017795 2017795 single base substitution G A synonymous_variant R72R 216G>A SKCM-US 16 2017795 2017795 single base substitution G A synonymous_variant R73R 219G>A SKCM-US 16 2018561 2018561 single base substitution G A 3_prime_UTR_variant SKCM-US 16 2018561 2018561 single base substitution G A missense_variant G124R 370G>A SKCM-US 16 2018561 2018561 single base substitution G A missense_variant G125R 373G>A STAD-US 16 2012162 2012162 single base substitution G A upstream_gene_variant STAD-US 16 2018579 2018579 single base substitution C A 3_prime_UTR_variant STAD-US 16 2018579 2018579 single base substitution C A synonymous_variant R130R 388C>A STAD-US 16 2018579 2018579 single base substitution C A synonymous_variant R131R 391C>A UCEC-US 16 2012222 2012222 single base substitution G A upstream_gene_variant UCEC-US 16 2012499 2012499 single base substitution G A upstream_gene_variant UCEC-US 16 2017280 2017280 single base substitution C T synonymous_variant G2G 6C>T UCEC-US 16 2017280 2017280 single base substitution C T synonymous_variant G3G 9C>T UCEC-US 16 2017301 2017301 single base substitution C T synonymous_variant F10F 30C>T UCEC-US 16 2017301 2017301 single base substitution C T synonymous_variant F9F 27C>T UCEC-US 16 2017804 2017804 single base substitution T G intron_variant UCEC-US 16 2017804 2017804 single base substitution T G missense_variant I75M 225T>G UCEC-US 16 2017804 2017804 single base substitution T G missense_variant I76M 228T>G UCEC-US 16 2018738 2018738 single base substitution C T 3_prime_UTR_variant UCEC-US 16 2018738 2018738 single base substitution C T missense_variant R183W 547C>T UCEC-US 16 2018738 2018738 single base substitution C T missense_variant R184W 550C>T UCEC-US 16 2018741 2018741 single base substitution C T 3_prime_UTR_variant UCEC-US 16 2018741 2018741 single base substitution C T missense_variant R184C 550C>T UCEC-US 16 2018741 2018741 single base substitution C T missense_variant R185C 553C>T

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand TCGA-AG-4022-01 COSM3749346 c.459G>A p.E153E Substitution - coding silent 16:1968649-1968649 + CHC1591T COSM4800399 c.441C>T p.A147A Substitution - coding silent 16:1968631-1968631 + T2269 COSM4722018 c.112T>G p.F38V Substitution - Missense 16:1967385-1967385 + TCGA-AX-A0J1-01 COSM967979 c.6C>T p.G2G Substitution - coding silent 16:1967279-1967279 + 1517_PT COSM5754791 c.89C>T p.A30V Substitution - Missense 16:1967362-1967362 + LIM2405 COSM967982 c.547C>T p.R183W Substitution - Missense 16:1968737-1968737 + TCGA-D1-A167-01 COSM967982 c.547C>T p.R183W Substitution - Missense 16:1968737-1968737 + TCGA-D5-6930-01 COSM1376315 c.634C>A p.L212M Substitution - Missense 16:1968824-1968824 + TCGA-C5-A1MK-01 COSM4827123 c.175G>C p.E59Q Substitution - Missense 16:1967753-1967753 + SNUH_G76_S1 COSM967981 c.225T>G p.I75M Substitution - Missense 16:1967803-1967803 + S00825 COSM5659116 c.106C>T p.H36Y Substitution - Missense 16:1967379-1967379 + TCGA-B5-A0JY-01 COSM967980 c.27C>T p.F9F Substitution - coding silent 16:1967300-1967300 + Gp5D COSM2129436 c.504C>T p.S168S Substitution - coding silent 16:1968694-1968694 + TCGA-G4-6302-01 COSM3690809 c.364C>A p.P122T Substitution - Missense 16:1968554-1968554 + ESO-120 COSM1264351 c.231C>T p.R77R Substitution - coding silent 16:1967809-1967809 + 8016470 COSM3387263 c.508C>T p.R170C Substitution - Missense 16:1968698-1968698 + NB-1749 COSM1287652 c.262delG p.G88fs*3 Deletion - Frameshift 16:1968452-1968452 + CSCC-20-T COSM4499620 c.543C>T p.L181L Substitution - coding silent 16:1968733-1968733 + TCGA-FS-A1ZT-06 COSM3506853 c.216G>A p.R72R Substitution - coding silent 16:1967794-1967794 + CHC1591T COSM4800399 c.441C>T p.A147A Substitution - coding silent 16:1968631-1968631 + AOCS-122-1-4 COSM3948338 c.357G>C p.S119S Substitution - coding silent 16:1968547-1968547 + TCGA-EK-A3GK-01 COSM4853708 c.601G>A p.E201K Substitution - Missense 16:1968791-1968791 + CSCC-31-T COSM4456080 c.352_353AC>TT p.T118F Substitution - Missense 16:1968542-1968543 + CH-56-T2 COSM5651166 c.32G>A p.S11N Substitution - Missense 16:1967305-1967305 + TCGA-30-1718-01 COSM1323681 c.658_659insC p.E220fs*13 Insertion - Frameshift 16:1968848-1968849 + 1517_CLM COSM5754791 c.89C>T p.A30V Substitution - Missense 16:1967362-1967362 + TCGA-A5-A0GE-01 COSM967981 c.225T>G p.I75M Substitution - Missense 16:1967803-1967803 + BD130T COSM5516057 c.425C>A p.P142H Substitution - Missense 16:1968615-1968615 + TCGA-CG-5721-01 COSM4058933 c.388C>A p.R130R Substitution - coding silent 16:1968578-1968578 + ATL019 COSM5706032 c.451C>A p.P151T Substitution - Missense 16:1968641-1968641 + TCGA-D9-A3Z4-01 COSM3506854 c.370G>A p.G124R Substitution - Missense 16:1968560-1968560 + sysucc-2026T COSM5460996 c.204G>T p.M68I Substitution - Missense 16:1967782-1967782 + CSCC-47-T COSM4478717 c.222C>T p.T74T Substitution - coding silent 16:1967800-1967800 + S00501 COSM5658233 c.277T>C p.C93R Substitution - Missense 16:1968467-1968467 + TCGA-AA-3663-01 COSM3690810 c.524G>A p.R175Q Substitution - Missense 16:1968714-1968714 + TCGA-AM-5820-01 COSM3754757 c.389G>A p.R130Q Substitution - Missense 16:1968579-1968579 + OSCC-GB_00700111 COSM4890719 c.549G>T p.R183R Substitution - coding silent 16:1968739-1968739 + TCGA-AA-3663-01 COSM1376314 c.632C>A p.A211D Substitution - Missense 16:1968822-1968822 + OSCC-GB_01060111 COSM4883204 c.575C>G p.T192S Substitution - Missense 16:1968765-1968765 + ESCC_BICR_040T COSM4853708 c.601G>A p.E201K Substitution - Missense 16:1968791-1968791 + sysucc-863T COSM5765197 c.557G>T p.R186L Substitution - Missense 16:1968747-1968747 + Gp2D COSM2129436 c.504C>T p.S168S Substitution - coding silent 16:1968694-1968694 + TCGA-A3-3380-01 COSM471423 c.432C>A p.G144G Substitution - coding silent 16:1968622-1968622 + QC2-39-T2 COSM5655769 c.443C>T p.T148I Substitution - Missense 16:1968633-1968633 + TCGA-D1-A15Z-01 COSM967983 c.550C>T p.R184C Substitution - Missense 16:1968740-1968740 +

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.99354 16p13.3

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer A G Missense p.D15G c.44A>G 16 2017315 HNSC C A Synonymous p.G145G c.435C>A 16 2018623 RCCC - C Frameshift p.L144Pfs*55 c.430dupC 16 2018614 GBM C - Frameshift p.L182Sfs*66 c.544delC 16 2018730 LGG C T Missense p.R185C c.553C>T 16 2018741 UCEC C T Synonymous p.L27L c.81C>T 16 2017352 CM C T Synonymous p.R78R c.234C>T 16 2017810 ESCA G A Synonymous p.R73R c.219G>A 16 2017795 CM G T Missense p.E163D c.489G>T 16 2018677 LUAD