PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ZNRF1 ZNRF2 22797923 biogrid exp G G G G G G G G G G G G G G G G G G ATP1A2 ZNRF2 22797923 biogrid exp G G G G G G G G G G G G YWHAQ ZNRF2 23444366,22797923 biogrid exp G G G G G G G G G G G G G G G G G G ATP1A1 ZNRF2 22797923 biogrid exp G G G G G G G G G G G G G G G G G G UBC ZNRF2 22797923 biogrid exp G G G G G G G G G G G G G G G G G G ELAVL1 ZNRF2 19322201 biogrid exp G G G G G G G G G G G G G G G G G G ZNRF2 CCDC8 24711643 biogrid exp G G G G G G G G G G G G G G G G G G XPO1 ZNRF2 26673895 biogrid exp G G G G G G G G G G G G G G G G G G UBE2D1 ZNRF2 19690564, 23023127 biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G UBE2D3 ZNRF2 19690564, 23023127 biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G UBE2E1 ZNRF2 18615712, 23023127 biogrid exp, pred G G G G G G G G G G G G G G G G G G UBE2N ZNRF2 16215985,18615712,19690564,22797923, 23023127, 21836163 biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G ZNRF2 UBE2D4 19690564, 23023127 biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G UBE2D2 ZNRF2 19690564, 23023127 biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G ZNRF2 UBE2T 23023127 pred G G G G G G G G UBE2G2 ZNRF2 23023127 pred G G G G G G G G G G G G G G G G G G ZNRF2 UBE2F 23023127 pred G G G G G G G G G G G G G G G G G G ZNRF2 UBE2E3 23023127 pred G G G G G G G G G G G G G G G G G G UBE2NL ZNRF2 23023127 pred G G G G G G G G G G G G G G G G G G CAND1 ZNRF2 23023127 pred G G G G G G G G G G G G G G G G G G ZNRF2 UBE2E2 23023127 pred G G G G G G G G G G G G G G G G G G UBE2C ZNRF2 23023127 pred G G G G G G G G G G G G G G G G G G UBE2K ZNRF2 23023127 pred G G G G G G G G G G G G G G G G G G UBE2B ZNRF2 23023127 pred G G G G G G G G G G G G G G G G G G UBE2R2 ZNRF2 23023127 pred G G G G G G G G G G G G G G G G G G UBE2M ZNRF2 23023127 pred G G G G G G G G G G G G G G G G G G UBE2L6 ZNRF2 23023127 pred G G G G G G G G G G G G G G G G G G UBE2A ZNRF2 23023127 pred G G G G G G G G G G G G G G G G G G UBE2I ZNRF2 23023127 pred G G G G G G G G G G G G G G G G G G UBE2S ZNRF2 23023127 pred G G G G G G G G G G G G G G G ZNRF2 STUB1 23023127 pred G G G G G G G G G G G G G G G G G G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B ATP1A2 ZNRF2 MI:0047(far western blotting)|MI:0047(far western blotting)|MI:0047(far western blotting) 22797923 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(biogrid)|(biogrid) BIOGRID_200711|BIOGRID_200700|BIOGRID_200714 prey|prey|prey bait|bait|bait UBE2N ZNRF2 MI:0018(two hybrid)|MI:0047(far western blotting)|MI:0047(far western blotting)|MI:0018(two hybrid)|MI:0018(two hybrid) 16215985,18615712,19690564,22797923 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_201351|BIOGRID_200712|BIOGRID_200701|BIOGRID_123630|BIOGRID_194172 prey|prey|prey|bait|bait bait|bait|bait|prey|prey ELAVL1 ZNRF2 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187902 bait prey UBE2D3 ZNRF2 MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_123503 bait prey ZNRF1 ZNRF2 MI:0047(far western blotting)|MI:0047(far western blotting)|MI:0047(far western blotting)|MI:0047(far western blotting) 22797923 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_200710|BIOGRID_200702|BIOGRID_200713|BIOGRID_200706 bait|prey|prey|bait prey|bait|bait|prey UBE2D2 ZNRF2 MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_123471 bait prey UBC ZNRF2 MI:0004(affinity chromatography technology)|MI:0047(far western blotting) 21139048,22797923 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_170056|BIOGRID_200715 bait|prey prey|bait UBE2E1 ZNRF2 MI:0018(two hybrid) 18615712 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_201352 prey bait ZNRF2 UBE2D4 MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_123535 prey bait UBE2D1 ZNRF2 MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_123437 bait prey YWHAQ ZNRF2 MI:0004(affinity chromatography technology)|MI:0047(far western blotting)|MI:0047(far western blotting)|MI:0047(far western blotting) 22797923,23444366 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_258095|BIOGRID_200699|BIOGRID_200698|BIOGRID_200697 bait|prey|prey|prey prey|bait|bait|bait

PPI - HINT Gene A Gene B PMID Method Quality YWHAQ ZNRF2 23444366,22797923,22797923 0004,0004,0047 LC UBE2N ZNRF2 27173435 0676 HT UBE2N ZNRF2 27173435 0676 HT YWHAQ ZNRF2 23444366,22797923,22797923 0004,0004,0047 LC ATP1A1 ZNRF2 22797923 0415 LC UBC ZNRF2 22797923 0415 LC YWHAQ ZNRF2 22797923,22797923 0004,0047 LC ATP1A2 ZNRF2 22797923,22797923 0401,0004 LC UBE2D1 ZNRF2 19690564 0018 HT UBE2E1 ZNRF2 18615712 0018 LC UBE2D3 ZNRF2 19690564 0018 HT UBE2N ZNRF2 16215985,19690564 0018,0018 LC,HT UBE2D2 ZNRF2 19690564 0018 HT ZNRF2 UBE2D4 19690564 0018 HT ZNRF2 HEL-S-71 16215985,18615712,19690564 0018,0018,0018 LC,HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8NHG8 P61077 ZNRF2 UBE2D3 0.183 19690564 Q8NHG8 Q8ND25 ZNRF2 ZNRF1 0.376 22797923 Q8NHG8 P05023 ZNRF2 ATP1A1 0.309 22797923 Q8NHG8 P51965 ZNRF2 UBE2E1 0.309 18615712 Q9H0W5 Q8NHG8 CCDC8 ZNRF2 0.126 24711643 Q9Y2X8 Q8NHG8 UBE2D4 ZNRF2 0.183 19690564 Q8NHG8 Q6P5F9 ZNRF2 XPO1 0.126 26673895 Q8NHG8 P50993 ZNRF2 ATP1A2 0.309 22797923 Q8NHG8 P61088 ZNRF2 UBE2N 0.837 19690564,27173435,16215985,22797923,18615712,unassigned1312 Q8NHG8 P29311 ZNRF2 BMH1 0.21 19648646 Q8ZI64 Q8NHG8 CCA ZNRF2 0.126 20711500 Q8NHG8 P27348 ZNRF2 YWHAQ 0.569 23444366,22797923 Q8NHG8 P62837 ZNRF2 UBE2D2 0.183 19690564 Q8NHG8 P51668 ZNRF2 UBE2D1 0.183 19690564 Q8NHG8 Q15717 ZNRF2 ELAVL1 0.126 19322201

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 XPO1 ZNRF2 MI:0045 experimental interaction detection MI:0461 interaction database SIAH2 ZNRF2 MI:0362 inference MI:1106 pathways database FBXO21 ZNRF2 MI:0362 inference MI:1106 pathways database TUBB4A ZNRF2 MI:0362 inference MI:0461 interaction database ATP1A1 ZNRF2 MI:0045 experimental interaction detection MI:0461 interaction database UBB ZNRF2 MI:0362 inference MI:1106 pathways database UBC ZNRF2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIM21 ZNRF2 MI:0362 inference MI:1106 pathways database YWHAQ ZNRF2 MI:0045 experimental interaction detection MI:0461 interaction database CCNF ZNRF2 MI:0362 inference MI:1106 pathways database UBE2A ZNRF2 MI:0362 inference MI:1106 pathways database ATP1A2 ZNRF2 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D1 ZNRF2 MI:0045 experimental interaction detection MI:0461 interaction database UBE2E1 ZNRF2 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 ZNRF2 MI:0362 inference MI:1106 pathways database UBE2D3 ZNRF2 MI:0045 experimental interaction detection MI:0461 interaction database UBE2N ZNRF2 MI:0045 experimental interaction detection MI:0461 interaction database YWHAE ZNRF2 MI:0362 inference MI:0461 interaction database UBE2D2 ZNRF2 MI:0045 experimental interaction detection MI:0461 interaction database RBX1 ZNRF2 MI:0362 inference MI:1106 pathways database RPS27A ZNRF2 MI:0362 inference MI:1106 pathways database UBA52 ZNRF2 MI:0362 inference MI:1106 pathways database SKP1 ZNRF2 MI:0362 inference MI:1106 pathways database TUBB4B ZNRF2 MI:0362 inference MI:0461 interaction database SKP2 ZNRF2 MI:0362 inference MI:1106 pathways database CUL1 ZNRF2 MI:0362 inference MI:1106 pathways database PTCH1 ZNRF2 MI:0362 inference MI:0461 interaction database TUBB2A ZNRF2 MI:0362 inference MI:0461 interaction database TRIP12 ZNRF2 MI:0362 inference MI:1106 pathways database ELAVL1 ZNRF2 MI:0045 experimental interaction detection MI:0461 interaction database LONRF1 ZNRF2 MI:0362 inference MI:1106 pathways database UBE2NL ZNRF2 MI:0362 inference MI:0461 interaction database HECTD2 ZNRF2 MI:0362 inference MI:1106 pathways database FBXO31 ZNRF2 MI:0362 inference MI:1106 pathways database FBXW9 ZNRF2 MI:0362 inference MI:1106 pathways database FBXW10 ZNRF2 MI:0362 inference MI:1106 pathways database RNF213 ZNRF2 MI:0362 inference MI:1106 pathways database FBXL22 ZNRF2 MI:0362 inference MI:1106 pathways database FBXL19 ZNRF2 MI:0362 inference MI:1106 pathways database FBXW12 ZNRF2 MI:0362 inference MI:1106 pathways database RNF19B ZNRF2 MI:0362 inference MI:1106 pathways database RNF144B ZNRF2 MI:0362 inference MI:1106 pathways database RBBP6 ZNRF2 MI:0362 inference MI:1106 pathways database HUWE1 ZNRF2 MI:0362 inference MI:1106 pathways database TRIM69 ZNRF2 MI:0362 inference MI:1106 pathways database SIAH1 ZNRF2 MI:0362 inference MI:1106 pathways database HERC6 ZNRF2 MI:0362 inference MI:1106 pathways database UBR2 ZNRF2 MI:0362 inference MI:1106 pathways database FBXL14 ZNRF2 MI:0362 inference MI:1106 pathways database FBXW8 ZNRF2 MI:0362 inference MI:1106 pathways database FBXL16 ZNRF2 MI:0362 inference MI:1106 pathways database FBXO15 ZNRF2 MI:0362 inference MI:1106 pathways database ZNRF1 ZNRF2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FBXL13 ZNRF2 MI:0362 inference MI:1106 pathways database FBXO22 ZNRF2 MI:0362 inference MI:1106 pathways database ZNRF2 FBXO27 MI:0362 inference MI:1106 pathways database ZNRF2 FBXO30 MI:0362 inference MI:1106 pathways database ZNRF2 RNF217 MI:0362 inference MI:1106 pathways database ZNRF2 DTX3L MI:0362 inference MI:1106 pathways database ZNRF2 FBXO41 MI:0362 inference MI:1106 pathways database ZNRF2 LMO7 MI:0362 inference MI:1106 pathways database ZNRF2 MYLIP MI:0362 inference MI:1106 pathways database ZNRF2 FBXW7 MI:0362 inference MI:1106 pathways database ZNRF2 FBXO32 MI:0362 inference MI:1106 pathways database ZNRF2 FBXW5 MI:0362 inference MI:1106 pathways database ZNRF2 MIB2 MI:0362 inference MI:1106 pathways database ZNRF2 SPSB1 MI:0362 inference MI:1106 pathways database ZNRF2 FBXL8 MI:0362 inference MI:1106 pathways database ZNRF2 FBXO17 MI:0362 inference MI:1106 pathways database ZNRF2 FBXL20 MI:0362 inference MI:1106 pathways database ZNRF2 FBXL18 MI:0362 inference MI:1106 pathways database ZNRF2 NEDD4L MI:0362 inference MI:1106 pathways database ZNRF2 TUBB2B MI:0362 inference MI:0461 interaction database ZNRF2 RBCK1 MI:0362 inference MI:1106 pathways database ZNRF2 CCDC8 MI:0045 experimental interaction detection MI:0461 interaction database ZNRF2 FBXL15 MI:0362 inference MI:1106 pathways database ZNRF2 FBXO44 MI:0362 inference MI:1106 pathways database ZNRF2 UNKL MI:0362 inference MI:1106 pathways database ZNRF2 SMURF2 MI:0362 inference MI:1106 pathways database ZNRF2 TRIM36 MI:0362 inference MI:1106 pathways database ZNRF2 FBXO6 MI:0362 inference MI:1106 pathways database ZNRF2 RNF19A MI:0362 inference MI:1106 pathways database ZNRF2 RLIM MI:0362 inference MI:1106 pathways database ZNRF2 FBXL12 MI:0362 inference MI:1106 pathways database ZNRF2 FBXO40 MI:0362 inference MI:1106 pathways database ZNRF2 HERC5 MI:0362 inference MI:1106 pathways database ZNRF2 FBXL7 MI:0362 inference MI:1106 pathways database ZNRF2 FBXO2 MI:0362 inference MI:1106 pathways database ZNRF2 FBXO10 MI:0362 inference MI:1106 pathways database ZNRF2 FBXO9 MI:0362 inference MI:1106 pathways database ZNRF2 FBXL5 MI:0362 inference MI:1106 pathways database ZNRF2 FBXL4 MI:0362 inference MI:1106 pathways database ZNRF2 FBXW11 MI:0362 inference MI:1106 pathways database ZNRF2 FBXO4 MI:0362 inference MI:1106 pathways database ZNRF2 FBXL21 MI:0362 inference MI:1106 pathways database ZNRF2 FBXL3 MI:0362 inference MI:1106 pathways database ZNRF2 FBXW2 MI:0362 inference MI:1106 pathways database ZNRF2 BTRC MI:0362 inference MI:1106 pathways database ZNRF2 UBE2D4 MI:0045 experimental interaction detection MI:0461 interaction database ZNRF2 FBXO7 MI:0362 inference MI:1106 pathways database ZNRF2 RNF115 MI:0362 inference MI:1106 pathways database ZNRF2 RNF114 MI:0362 inference MI:1106 pathways database ZNRF2 PTCH2 MI:0362 inference MI:0461 interaction database ZNRF2 WSB1 MI:0362 inference MI:1106 pathways database