PTM - dbPAF Gene Name UniProt ID Position Type Species ZNRF2; RNF202 Q8NHG8 106 S Homo sapiens(Human) ZNRF2; RNF202 Q8NHG8 107 S Homo sapiens(Human) ZNRF2; RNF202 Q8NHG8 108 S Homo sapiens(Human) ZNRF2; RNF202 Q8NHG8 111 Y Homo sapiens(Human) ZNRF2; RNF202 Q8NHG8 113 S Homo sapiens(Human) ZNRF2; RNF202 Q8NHG8 116 S Homo sapiens(Human) ZNRF2; RNF202 Q8NHG8 119 S Homo sapiens(Human) ZNRF2; RNF202 Q8NHG8 120 S Homo sapiens(Human) ZNRF2; RNF202 Q8NHG8 135 S Homo sapiens(Human) ZNRF2; RNF202 Q8NHG8 145 S Homo sapiens(Human) ZNRF2; RNF202 Q8NHG8 15 T Homo sapiens(Human) ZNRF2; RNF202 Q8NHG8 151 S Homo sapiens(Human) ZNRF2; RNF202 Q8NHG8 18 Y Homo sapiens(Human) ZNRF2; RNF202 Q8NHG8 19 S Homo sapiens(Human) ZNRF2; RNF202 Q8NHG8 193 S Homo sapiens(Human) ZNRF2; RNF202 Q8NHG8 21 S Homo sapiens(Human) ZNRF2; RNF202 Q8NHG8 25 S Homo sapiens(Human) ZNRF2; RNF202 Q8NHG8 34 T Homo sapiens(Human) ZNRF2; RNF202 Q8NHG8 6 S Homo sapiens(Human) ZNRF2; RNF202 Q8NHG8 80 S Homo sapiens(Human) ZNRF2; RNF202 Q8NHG8 82 S Homo sapiens(Human) ZNRF2; RNF202 Q8NHG8 89 S Homo sapiens(Human) ZNRF2; RNF202 Q8NHG8 92 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q8NHG8 S6-p Phosphorylation __MGAKQsGPAAANG Q8NHG8 Y18-p Phosphorylation ANGRTRAysGsDLPS Q8NHG8 S19-p Phosphorylation NGRTRAysGsDLPSS Q8NHG8 S21-p Phosphorylation RTRAysGsDLPSSSS Q8NHG8 T34-p Phosphorylation SSGGANGtAGGGGGA Q8NHG8 S60-p Phosphorylation VPSAHQPsASGGAAA Q8NHG8 S80-p Phosphorylation AAPAAPRsRsLGGAV Q8NHG8 S82-p Phosphorylation PAAPRsRsLGGAVGs Q8NHG8 S89-p Phosphorylation sLGGAVGsVAsGARA Q8NHG8 S92-p Phosphorylation GAVGsVAsGARAAQS Q8NHG8 S108-p Phosphorylation FSIPNSSsGPyGsQD Q8NHG8 Y111-p Phosphorylation PNSSsGPyGsQDsVH Q8NHG8 S113-p Phosphorylation SSsGPyGsQDsVHss Q8NHG8 S116-p Phosphorylation GPyGsQDsVHssPED Q8NHG8 S119-p Phosphorylation GsQDsVHssPEDGGG Q8NHG8 S120-p Phosphorylation sQDsVHssPEDGGGG Q8NHG8 S135-p Phosphorylation RDRPVGGsPGGPRLV Q8NHG8 S145-p Phosphorylation GPRLVIGsLPAHLsP Q8NHG8 S151-p Phosphorylation GsLPAHLsPHMFGGF Q8NHG8 S193-p Phosphorylation TYNEDVLsKDAGECA Q8NHG8 K165-ub Ubiquitination FKCPVCSkFVSSDEM

PTM - dbPTM UniProt ID Position Code Type Resources References Q8NHG8 18 Y Phosphorylation Swiss-Prot 1010711 18220336 Q8NHG8 19 S Phosphorylation Swiss-Prot 1010711 19413330 Q8NHG8 82 S Phosphorylation Swiss-Prot 1010711 18220336;18669648;19690332 Q8NHG8 113 S Phosphorylation Swiss-Prot 1010711 17525332;19690332 Q8NHG8 116 S Phosphorylation Swiss-Prot 1010711 17525332;19690332 Q8NHG8 119 S Phosphorylation Swiss-Prot 1010711 17525332 Q8NHG8 135 S Phosphorylation Swiss-Prot 1010711 17081983 Q8NHG8 151 S Phosphorylation Swiss-Prot 1010711 18669648 Q8NHG8 19 S Phosphorylation PhosphoELM.10011 18669648;18220336 Q8NHG8 21 S Phosphorylation PhosphoELM.10011 18669648 Q8NHG8 82 S Phosphorylation PhosphoELM.10011 18669648;18220336 Q8NHG8 106 S Phosphorylation PhosphoELM.10011 18669648 Q8NHG8 107 S Phosphorylation PhosphoELM.10011 18669648 Q8NHG8 108 S Phosphorylation PhosphoELM.10011 18669648 Q8NHG8 113 S Phosphorylation PhosphoELM.10011 18669648;17525332 Q8NHG8 116 S Phosphorylation PhosphoELM.10011 18669648;17525332 Q8NHG8 119 S Phosphorylation PhosphoELM.10011 18669648;17525332 Q8NHG8 120 S Phosphorylation PhosphoELM.10011 18669648 Q8NHG8 135 S Phosphorylation PhosphoELM.10011 17081983 Q8NHG8 151 S Phosphorylation PhosphoELM.10011 18669648 Q8NHG8 18 Y Phosphorylation PhosphoELM.10011 18220336 Q8NHG8 111 Y Phosphorylation PhosphoELM.10011 18669648 Q8NHG8 108 S Phosphorylation Phosphositeplus.1010730 19690332 Q8NHG8 113 S Phosphorylation Phosphositeplus.1010730 17525332;18669648;19690332 Q8NHG8 116 S Phosphorylation Phosphositeplus.1010730 17525332;18669648;19690332 Q8NHG8 119 S Phosphorylation Phosphositeplus.1010730 17525332;19690332 Q8NHG8 120 S Phosphorylation Phosphositeplus.1010730 19690332 Q8NHG8 135 S Phosphorylation Phosphositeplus.1010730 17081983;19664995;20068231;20363803;21406692;22115753 Q8NHG8 145 S Phosphorylation Phosphositeplus.1010730 20068231;21406692 Q8NHG8 151 S Phosphorylation Phosphositeplus.1010730 18669648;20068231;21406692;22115753 Q8NHG8 19 S Phosphorylation Phosphositeplus.1010730 18220336;19664994;19690332;20166139 Q8NHG8 21 S Phosphorylation Phosphositeplus.1010730 19276368;19690332;20736484 Q8NHG8 80 S Phosphorylation Phosphositeplus.1010730 19276368 Q8NHG8 82 S Phosphorylation Phosphositeplus.1010730 18220336;18669648;19276368;19690332;20068231;20166139;20363803;20393185;21406692;21659604 Q8NHG8 18 Y Phosphorylation Phosphositeplus.1010730 18220336 Q8NHG8 19 S Phosphorylation HPRD 9.0 18669648,19413330,19664994,20166139 Q8NHG8 21 S Phosphorylation HPRD 9.0 18669648 Q8NHG8 82 S Phosphorylation HPRD 9.0 18669648,18212344,19651622,20166139,20068231 Q8NHG8 106 S Phosphorylation HPRD 9.0 18669648 Q8NHG8 107 S Phosphorylation HPRD 9.0 18669648 Q8NHG8 108 S Phosphorylation HPRD 9.0 18669648 Q8NHG8 113 S Phosphorylation HPRD 9.0 17525332,18669648 Q8NHG8 116 S Phosphorylation HPRD 9.0 17525332,18669648 Q8NHG8 119 S Phosphorylation HPRD 9.0 17525332,18669648 Q8NHG8 120 S Phosphorylation HPRD 9.0 18669648 Q8NHG8 135 S Phosphorylation HPRD 9.0 19664995,19651622,20068231 Q8NHG8 145 S Phosphorylation HPRD 9.0 19651622,20068231 Q8NHG8 151 S Phosphorylation HPRD 9.0 18669648,19651622,20068231 Q8NHG8 111 Y Phosphorylation HPRD 9.0 18669648 Q8NHG8 82 S Phosphorylation SysPTM 1.1 18669648;18212344 Q8NHG8 113 S Phosphorylation SysPTM 1.1 17081983 Q8NHG8 116 S Phosphorylation SysPTM 1.1 17081983 Q8NHG8 119 S Phosphorylation SysPTM 1.1 17081983 Q8NHG8 120 S Phosphorylation SysPTM 1.1 17081983 Q8NHG8 135 S Phosphorylation SysPTM 1.1 17081983 Q8NHG8 151 S Phosphorylation SysPTM 1.1 18669648

PTM - HPRD Symbol Position Code Type References ZNRF2 106 S Phosphorylation 18669648 ZNRF2 107 S Phosphorylation 18669648 ZNRF2 108 S Phosphorylation 18669648 ZNRF2 111 Y Phosphorylation 18669648 ZNRF2 113 S Phosphorylation 17525332,18669648 ZNRF2 116 S Phosphorylation 17525332,18669648 ZNRF2 119 S Phosphorylation 17525332,18669648 ZNRF2 120 S Phosphorylation 18669648 ZNRF2 135 S Phosphorylation 19664995,19651622,20068231 ZNRF2 145 S Phosphorylation 19651622,20068231 ZNRF2 151 S Phosphorylation 18669648,19651622,20068231 ZNRF2 19 S Phosphorylation 18669648,19413330,19664994,20166139 ZNRF2 21 S Phosphorylation 18669648 ZNRF2 82 S Phosphorylation 18669648,18212344,19651622,20166139,20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q8NHG8 111 Y 18669648 HTP Phosphorylation Q8NHG8 82 S 18669648 HTP Phosphorylation Q8NHG8 82 S 18220336 HTP Phosphorylation Q8NHG8 135 S 17081983 HTP Phosphorylation Q8NHG8 108 S 18669648 HTP Phosphorylation Q8NHG8 107 S 18669648 HTP Phosphorylation Q8NHG8 106 S 18669648 HTP Phosphorylation Q8NHG8 18 Y 18220336 HTP Phosphorylation Q8NHG8 120 S 18669648 HTP Phosphorylation Q8NHG8 113 S 18669648 HTP Phosphorylation Q8NHG8 113 S 17525332 HTP Phosphorylation Q8NHG8 151 S 18669648 HTP Phosphorylation Q8NHG8 19 S 18669648 HTP Phosphorylation Q8NHG8 19 S 18220336 HTP Phosphorylation Q8NHG8 21 S 18669648 HTP Phosphorylation Q8NHG8 116 S 18669648 HTP Phosphorylation Q8NHG8 116 S 17525332 HTP Phosphorylation Q8NHG8 119 S 18669648 HTP Phosphorylation Q8NHG8 119 S 17525332 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q8NHG8 82 Phosphoserine 18669648;19690332;20068231;21406692;23186163;24275569 Q8NHG8 89 Phosphoserine 24275569 Q8NHG8 113 Phosphoserine 19690332 Q8NHG8 116 Phosphoserine 19690332 Q8NHG8 135 Phosphoserine 17081983;20068231;21406692;23186163;24275569 Q8NHG8 151 Phosphoserine 18669648 Q8NHG8 193 Phosphoserine 23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type ZNRF2 IPI00293427 S 135 DRPVGGpSPGGPRL phosphorylation ZNRF2 IPI00293427 S 145 PRLVIGpSLPAHLS phosphorylation ZNRF2 IPI00293427 S 151 SLPAHLpSPHMFGG phosphorylation ZNRF2 IPI00293427 S 82 AAPRSRpSLGGAVG phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 223082 128825 - K Ubiquitination 21139048