Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change BLCA 6 151686828 151686828 + Missense_Mutation SNP G G C TCGA-XF-AAN5-01A-11D-A42E-08 TCGA-XF-AAN5-10A-01D-A42H-08 g.chr6:151686828G>C c.1373C>G c.(1372-1374)tCc>tGc p.S458C BLCA 6 151687168 151687168 + Missense_Mutation SNP C C T TCGA-FD-A6TA-01A-12D-A339-08 TCGA-FD-A6TA-10A-21D-A339-08 g.chr6:151687168C>T c.1033G>A c.(1033-1035)Gac>Aac p.D345N BLCA 6 151687786 151687786 + Missense_Mutation SNP C C T TCGA-G2-A2EJ-01A-11D-A17V-08 TCGA-G2-A2EJ-10A-01D-A17V-08 g.chr6:151687786C>T c.415G>A c.(415-417)Gat>Aat p.D139N BLCA 6 151687920 151687920 + Missense_Mutation SNP C C T TCGA-E5-A2PC-01A-11D-A202-08 TCGA-E5-A2PC-10B-01D-A202-08 g.chr6:151687920C>T c.281G>A c.(280-282)cGa>cAa p.R94Q BRCA 6 151687437 151687437 + Missense_Mutation SNP G G A TCGA-A8-A06X-01A-21W-A019-09 TCGA-A8-A06X-10A-01W-A021-09 g.chr6:151687437G>A c.764C>T c.(763-765)gCc>gTc p.A255V BRCA 6 151687572 151687572 + Missense_Mutation SNP G G C TCGA-D8-A27G-01A-11D-A16D-09 TCGA-D8-A27G-10A-01D-A16D-09 g.chr6:151687572G>C c.629C>G c.(628-630)cCt>cGt p.P210R BRCA 6 151687962 151687962 + Missense_Mutation SNP A A T TCGA-D8-A1XZ-01A-11D-A14K-09 TCGA-D8-A1XZ-10A-01D-A14K-09 g.chr6:151687962A>T c.239T>A c.(238-240)aTg>aAg p.M80K BRCA 6 151694745 151694745 + Missense_Mutation SNP G G C TCGA-EW-A1J5-01A-11D-A13L-09 TCGA-EW-A1J5-10A-01D-A13O-09 g.chr6:151694745G>C c.28C>G c.(28-30)Cta>Gta p.L10V CESC 6 151687599 151687599 + Missense_Mutation SNP G G A TCGA-EA-A439-01A-11D-A243-09 TCGA-EA-A439-10A-01D-A243-09 g.chr6:151687599G>A c.602C>T c.(601-603)tCg>tTg p.S201L CESC 6 151687696 151687696 + Missense_Mutation SNP C C T TCGA-EK-A2RD-01A-12D-A20U-09 TCGA-EK-A2RD-10A-01D-A20U-09 g.chr6:151687696C>T c.505G>A c.(505-507)Gag>Aag p.E169K COAD 6 151686764 151686764 + Silent SNP G G A TCGA-AZ-6601-01A-11D-1771-10 TCGA-AZ-6601-11A-01D-1771-10 g.chr6:151686764G>A c.1437C>T c.(1435-1437)gaC>gaT p.D479D COAD 6 151686773 151686773 + Frame_Shift_Del DEL A A - TCGA-D5-6930-01A-11D-1924-10 TCGA-D5-6930-10A-01D-1924-10 g.chr6:151686773delA c.1428delT c.(1426-1428)tttfs p.F476fs COAD 6 151687566 151687566 + Missense_Mutation SNP G G A TCGA-DM-A1HB-01A-21D-A183-10 TCGA-DM-A1HB-10A-01D-A183-10 g.chr6:151687566G>A c.635C>T c.(634-636)cCt>cTt p.P212L COAD 6 151687639 151687639 + Missense_Mutation SNP T T A TCGA-F4-6460-01A-11D-1771-10 TCGA-F4-6460-10B-01D-1771-10 g.chr6:151687639T>A c.562A>T c.(562-564)Aat>Tat p.N188Y COAD 6 151687691 151687691 + Missense_Mutation SNP C C A TCGA-AZ-6598-01A-11D-1771-10 TCGA-AZ-6598-11A-01D-1771-10 g.chr6:151687691C>A c.510G>T c.(508-510)caG>caT p.Q170H COAD 6 151687861 151687861 + Missense_Mutation SNP C C T TCGA-DM-A28H-01A-11D-A16V-10 TCGA-DM-A28H-10A-01D-A16V-10 g.chr6:151687861C>T c.340G>A c.(340-342)Gcc>Acc p.A114T COAD 6 151687930 151687930 + Missense_Mutation SNP C C T TCGA-F4-6570-01A-11D-1771-10 TCGA-F4-6570-10A-01D-1771-10 g.chr6:151687930C>T c.271G>A c.(271-273)Gac>Aac p.D91N COAD 6 151694692 151694692 + Silent SNP C C T TCGA-AA-3864-01A-01W-0995-10 TCGA-AA-3864-10A-01W-0995-10 g.chr6:151694692C>T c.81G>A c.(79-81)acG>acA p.T27T COADREAD 6 151686764 151686764 + Silent SNP G G A TCGA-AZ-6601-01A-11D-1771-10 TCGA-AZ-6601-11A-01D-1771-10 g.chr6:151686764G>A c.1437C>T c.(1435-1437)gaC>gaT p.D479D COADREAD 6 151686773 151686773 + Frame_Shift_Del DEL A A - TCGA-D5-6930-01A-11D-1924-10 TCGA-D5-6930-10A-01D-1924-10 g.chr6:151686773delA c.1428delT c.(1426-1428)tttfs p.F476fs COADREAD 6 151687566 151687566 + Missense_Mutation SNP G G A TCGA-DM-A1HB-01A-21D-A183-10 TCGA-DM-A1HB-10A-01D-A183-10 g.chr6:151687566G>A c.635C>T c.(634-636)cCt>cTt p.P212L COADREAD 6 151687639 151687639 + Missense_Mutation SNP T T A TCGA-F4-6460-01A-11D-1771-10 TCGA-F4-6460-10B-01D-1771-10 g.chr6:151687639T>A c.562A>T c.(562-564)Aat>Tat p.N188Y COADREAD 6 151687691 151687691 + Missense_Mutation SNP C C A TCGA-AZ-6598-01A-11D-1771-10 TCGA-AZ-6598-11A-01D-1771-10 g.chr6:151687691C>A c.510G>T c.(508-510)caG>caT p.Q170H COADREAD 6 151687861 151687861 + Missense_Mutation SNP C C T TCGA-DM-A28H-01A-11D-A16V-10 TCGA-DM-A28H-10A-01D-A16V-10 g.chr6:151687861C>T c.340G>A c.(340-342)Gcc>Acc p.A114T COADREAD 6 151687930 151687930 + Missense_Mutation SNP C C T TCGA-F4-6570-01A-11D-1771-10 TCGA-F4-6570-10A-01D-1771-10 g.chr6:151687930C>T c.271G>A c.(271-273)Gac>Aac p.D91N COADREAD 6 151694683 151694683 + Silent SNP G G A TCGA-AG-A002-01A-01W-A00K-09 TCGA-AG-A002-10A-01W-A00K-09 g.chr6:151694683G>A c.90C>T c.(88-90)atC>atT p.I30I COADREAD 6 151694692 151694692 + Silent SNP C C T TCGA-AA-3864-01A-01W-0995-10 TCGA-AA-3864-10A-01W-0995-10 g.chr6:151694692C>T c.81G>A c.(79-81)acG>acA p.T27T DLBC 6 151687092 151687092 + Missense_Mutation SNP C C T TCGA-FF-8062-01A-11D-2210-10 TCGA-FF-8062-10A-01D-2210-10 g.chr6:151687092C>T c.1109G>A c.(1108-1110)cGc>cAc p.R370H ESCA 6 151687546 151687546 + Missense_Mutation SNP C C G TCGA-LN-A49V-01A-11D-A247-09 TCGA-LN-A49V-10A-01D-A247-09 g.chr6:151687546C>G c.655G>C c.(655-657)Gag>Cag p.E219Q GBM 6 151687420 151687420 + Missense_Mutation SNP G G A TCGA-14-1395-01B-11D-1845-08 TCGA-14-1395-10A-01D-1845-08 g.chr6:151687420G>A c.781C>T c.(781-783)Cgg>Tgg p.R261W GBM 6 151687542 151687542 + Missense_Mutation SNP G G T TCGA-06-6693-01A-11D-1845-08 TCGA-06-6693-10A-01D-1845-08 g.chr6:151687542G>T c.659C>A c.(658-660)aCc>aAc p.T220N GBMLGG 6 151686867 151686867 + Missense_Mutation SNP T T C TCGA-RY-A845-01A-11D-A36O-08 TCGA-RY-A845-10A-01D-A367-08 g.chr6:151686867T>C c.1334A>G c.(1333-1335)aAc>aGc p.N445S GBMLGG 6 151687324 151687324 + Silent SNP G G A TCGA-RY-A845-01A-11D-A36O-08 TCGA-RY-A845-10A-01D-A367-08 g.chr6:151687324G>A c.877C>T c.(877-879)Ctg>Ttg p.L293L GBMLGG 6 151687420 151687420 + Missense_Mutation SNP G G A TCGA-14-1395-01B-11D-1845-08 TCGA-14-1395-10A-01D-1845-08 g.chr6:151687420G>A c.781C>T c.(781-783)Cgg>Tgg p.R261W GBMLGG 6 151687542 151687542 + Missense_Mutation SNP G G T TCGA-06-6693-01A-11D-1845-08 TCGA-06-6693-10A-01D-1845-08 g.chr6:151687542G>T c.659C>A c.(658-660)aCc>aAc p.T220N GBMLGG 6 151694680 151694680 + Silent SNP G G A TCGA-DU-6392-01A-11D-1705-08 TCGA-DU-6392-10A-01D-1705-08 g.chr6:151694680G>A c.93C>T c.(91-93)ggC>ggT p.G31G HNSC 6 151686959 151686959 + Missense_Mutation SNP G G C TCGA-CV-7091-01A-11D-2012-08 TCGA-CV-7091-10A-01D-2013-08 g.chr6:151686959G>C c.1242C>G c.(1240-1242)agC>agG p.S414R HNSC 6 151686993 151686993 + Missense_Mutation SNP T T C TCGA-CR-5248-01A-01D-2012-08 TCGA-CR-5248-10A-01D-2013-08 g.chr6:151686993T>C c.1208A>G c.(1207-1209)aAc>aGc p.N403S HNSC 6 151687228 151687228 + Missense_Mutation SNP C C G TCGA-UF-A7J9-01A-12D-A34J-08 TCGA-UF-A7J9-10A-01D-A34M-08 g.chr6:151687228C>G c.973G>C c.(973-975)Gat>Cat p.D325H HNSC 6 151694704 151694704 + Silent SNP C C T TCGA-CV-7235-01A-11D-2012-08 TCGA-CV-7235-10A-01D-2013-08 g.chr6:151694704C>T c.69G>A c.(67-69)ctG>ctA p.L23L KIPAN 6 151686673 151686676 + Frame_Shift_Del DEL TTTC TTTC - TCGA-MH-A55W-01A-11D-A26P-10 TCGA-MH-A55W-10A-01D-A26P-10 g.chr6:151686673_151686676delTTTC c.1525_1528delGAAA c.(1525-1530)gaaaccfs p.ET509fs KIRP 6 151686673 151686676 + Frame_Shift_Del DEL TTTC TTTC - TCGA-MH-A55W-01A-11D-A26P-10 TCGA-MH-A55W-10A-01D-A26P-10 g.chr6:151686673_151686676delTTTC c.1525_1528delGAAA c.(1525-1530)gaaaccfs p.ET509fs LGG 6 151686867 151686867 + Missense_Mutation SNP T T C TCGA-RY-A845-01A-11D-A36O-08 TCGA-RY-A845-10A-01D-A367-08 g.chr6:151686867T>C c.1334A>G c.(1333-1335)aAc>aGc p.N445S LGG 6 151687324 151687324 + Silent SNP G G A TCGA-RY-A845-01A-11D-A36O-08 TCGA-RY-A845-10A-01D-A367-08 g.chr6:151687324G>A c.877C>T c.(877-879)Ctg>Ttg p.L293L LGG 6 151694680 151694680 + Silent SNP G G A TCGA-DU-6392-01A-11D-1705-08 TCGA-DU-6392-10A-01D-1705-08 g.chr6:151694680G>A c.93C>T c.(91-93)ggC>ggT p.G31G LIHC 6 151686763 151686763 + Missense_Mutation SNP C C T TCGA-DD-A39Z-01A-11D-A20W-10 TCGA-DD-A39Z-11A-21D-A20W-10 g.chr6:151686763C>T c.1438G>A c.(1438-1440)Gaa>Aaa p.E480K LIHC 6 151687080 151687080 + Missense_Mutation SNP T T G TCGA-UB-A7MB-01A-11D-A33Q-10 TCGA-UB-A7MB-10A-01D-A33Q-10 g.chr6:151687080T>G c.1121A>C c.(1120-1122)cAg>cCg p.Q374P LIHC 6 151687673 151687673 + Missense_Mutation SNP C C A TCGA-KR-A7K8-01A-11D-A33K-10 TCGA-KR-A7K8-10A-01D-A33K-10 g.chr6:151687673C>A c.528G>T c.(526-528)caG>caT p.Q176H LIHC 6 151687721 151687722 + Missense_Mutation DNP CC CC TA TCGA-G3-A6UC-01A-21D-A33K-10 TCGA-G3-A6UC-10A-01D-A33K-10 g.chr6:151687721_151687722CC>TA c.479_480GG>TA c.(478-480)cGG>cTA p.R160L LIHC 6 151687782 151687782 + Missense_Mutation SNP T T C TCGA-GJ-A9DB-01A-11D-A36X-10 TCGA-GJ-A9DB-10A-01D-A370-10 g.chr6:151687782T>C c.419A>G c.(418-420)cAt>cGt p.H140R LIHC 6 151694605 151694605 + Missense_Mutation SNP C C G TCGA-PD-A5DF-01A-11D-A27I-10 TCGA-PD-A5DF-10A-01D-A27I-10 g.chr6:151694605C>G c.168G>C c.(166-168)caG>caC p.Q56H LUAD 6 151687288 151687288 + Missense_Mutation SNP C C G TCGA-55-6969-01A-11D-1945-08 TCGA-55-6969-11A-01D-1945-08 g.chr6:151687288C>G c.913G>C c.(913-915)Gat>Cat p.D305H LUAD 6 151687533 151687533 + Missense_Mutation SNP T T C TCGA-44-6774-01A-21D-1855-08 TCGA-44-6774-10A-01D-1855-08 g.chr6:151687533T>C c.668A>G c.(667-669)gAa>gGa p.E223G LUAD 6 151694769 151694769 + Missense_Mutation SNP C C A TCGA-05-4382-01A-01D-1931-08 TCGA-05-4382-10A-01D-1265-08 g.chr6:151694769C>A c.4G>T c.(4-6)Gat>Tat p.D2Y LUSC 6 151686676 151686676 + Missense_Mutation SNP C C T TCGA-60-2698-01A-01D-1522-08 TCGA-60-2698-11A-01D-1522-08 g.chr6:151686676C>T c.1525G>A c.(1525-1527)Gaa>Aaa p.E509K LUSC 6 151687860 151687860 + Missense_Mutation SNP G G C TCGA-18-3421-01A-01D-0983-08 TCGA-18-3421-11A-01D-0983-08 g.chr6:151687860G>C c.341C>G c.(340-342)gCc>gGc p.A114G PAAD 6 151687214 151687214 + Silent SNP G G A TCGA-IB-7651-01A-11D-2154-08 TCGA-IB-7651-10A-01D-2154-08 g.chr6:151687214G>A c.987C>T c.(985-987)atC>atT p.I329I PAAD 6 151687588 151687588 + Nonsense_Mutation SNP C C A TCGA-IB-7651-01A-11D-2154-08 TCGA-IB-7651-10A-01D-2154-08 g.chr6:151687588C>A c.613G>T c.(613-615)Gaa>Taa p.E205* PRAD 6 151686671 151686671 + Silent SNP G G A TCGA-EJ-7782-01A-11D-2114-08 TCGA-EJ-7782-10A-01D-2114-08 g.chr6:151686671G>A c.1530C>T c.(1528-1530)acC>acT p.T510T PRAD 6 151686671 151686671 + Silent SNP G G A TCGA-XK-AAIW-01A-11D-A41K-08 TCGA-XK-AAIW-10A-01D-A41N-08 g.chr6:151686671G>A c.1530C>T c.(1528-1530)acC>acT p.T510T PRAD 6 151687732 151687732 + Nonsense_Mutation SNP G G A TCGA-KK-A6E0-01A-11D-A30X-08 TCGA-KK-A6E0-11A-11D-A30X-08 g.chr6:151687732G>A c.469C>T c.(469-471)Cga>Tga p.R157* READ 6 151694683 151694683 + Silent SNP G G A TCGA-AG-A002-01A-01W-A00K-09 TCGA-AG-A002-10A-01W-A00K-09 g.chr6:151694683G>A c.90C>T c.(88-90)atC>atT p.I30I SKCM 6 151686700 151686700 + Silent SNP A A G TCGA-EE-A2GC-06A-11D-A197-08 TCGA-EE-A2GC-10A-01D-A199-08 g.chr6:151686700A>G c.1501T>C c.(1501-1503)Tta>Cta p.L501L SKCM 6 151686991 151686991 + Nonsense_Mutation SNP G G A TCGA-EE-A2GC-06A-11D-A197-08 TCGA-EE-A2GC-10A-01D-A199-08 g.chr6:151686991G>A c.1210C>T c.(1210-1212)Cag>Tag p.Q404* SKCM 6 151686992 151686992 + Silent SNP G G A TCGA-EE-A2GC-06A-11D-A197-08 TCGA-EE-A2GC-10A-01D-A199-08 g.chr6:151686992G>A c.1209C>T c.(1207-1209)aaC>aaT p.N403N SKCM 6 151687318 151687318 + Missense_Mutation SNP G G A TCGA-EE-A29M-06A-11D-A196-08 TCGA-EE-A29M-10A-01D-A198-08 g.chr6:151687318G>A c.883C>T c.(883-885)Ctc>Ttc p.L295F SKCM 6 151687339 151687339 + Nonsense_Mutation SNP C C A TCGA-D3-A5GU-06A-11D-A27K-08 TCGA-D3-A5GU-10A-01D-A27N-08 g.chr6:151687339C>A c.862G>T c.(862-864)Gaa>Taa p.E288* SKCM 6 151687577 151687577 + Silent SNP G G A TCGA-EE-A2GO-06A-11D-A196-08 TCGA-EE-A2GO-10A-01D-A198-08 g.chr6:151687577G>A c.624C>T c.(622-624)tcC>tcT p.S208S SKCM 6 151687610 151687610 + Silent SNP G G A TCGA-EE-A3JE-06A-11D-A20D-08 TCGA-EE-A3JE-10A-01D-A20D-08 g.chr6:151687610G>A c.591C>T c.(589-591)ccC>ccT p.P197P SKCM 6 151687921 151687921 + Nonsense_Mutation SNP G G A TCGA-EE-A2MR-06A-11D-A196-08 TCGA-EE-A2MR-10A-01D-A198-08 g.chr6:151687921G>A c.280C>T c.(280-282)Cga>Tga p.R94*

Mutation - ICGC Project Code Chromosome Chromosome Start Chromosome End Mutation Type Mutated from Allele Mutated to Allele Consequence Type AA Mutation CDS Mutation BLCA-US 6 151687786 151687786 single base substitution C T missense_variant D139N 415G>A BLCA-US 6 151687920 151687920 single base substitution C T missense_variant R94Q 281G>A BRCA-EU 6 151680699 151680699 single base substitution C G downstream_gene_variant BRCA-EU 6 151681468 151681468 single base substitution C G downstream_gene_variant BRCA-EU 6 151681773 151681773 single base substitution G A downstream_gene_variant BRCA-EU 6 151683530 151683530 single base substitution G A downstream_gene_variant BRCA-EU 6 151683741 151683741 single base substitution C T downstream_gene_variant BRCA-EU 6 151683936 151683936 single base substitution G A downstream_gene_variant BRCA-EU 6 151684190 151684190 single base substitution G T downstream_gene_variant BRCA-EU 6 151684201 151684201 single base substitution G C downstream_gene_variant BRCA-EU 6 151685848 151685848 single base substitution G C 3_prime_UTR_variant BRCA-EU 6 151685988 151685988 single base substitution C A 3_prime_UTR_variant BRCA-EU 6 151686049 151686049 single base substitution A C 3_prime_UTR_variant BRCA-EU 6 151686166 151686166 single base substitution G C 3_prime_UTR_variant BRCA-EU 6 151686236 151686236 single base substitution G A 3_prime_UTR_variant BRCA-EU 6 151686263 151686263 single base substitution G A 3_prime_UTR_variant BRCA-EU 6 151687303 151687303 single base substitution C A missense_variant A300S 898G>T BRCA-EU 6 151690781 151690781 single base substitution A T intron_variant BRCA-EU 6 151692552 151692552 single base substitution C T intron_variant BRCA-EU 6 151693838 151693838 single base substitution G C intron_variant BRCA-EU 6 151694941 151694941 single base substitution C A intron_variant BRCA-EU 6 151695405 151695405 single base substitution C G intron_variant BRCA-EU 6 151696329 151696329 deletion of <=200bp A - intron_variant BRCA-EU 6 151696329 151696329 insertion of <=200bp - A intron_variant BRCA-EU 6 151697011 151697011 single base substitution A T intron_variant BRCA-EU 6 151697086 151697086 single base substitution C G intron_variant BRCA-EU 6 151697639 151697639 deletion of <=200bp A - intron_variant BRCA-EU 6 151697785 151697785 single base substitution C G intron_variant BRCA-EU 6 151698393 151698393 single base substitution C T intron_variant BRCA-EU 6 151699083 151699083 deletion of <=200bp A - intron_variant BRCA-EU 6 151699114 151699114 single base substitution A T intron_variant BRCA-EU 6 151699945 151699945 single base substitution G T intron_variant BRCA-EU 6 151700028 151700028 single base substitution G C intron_variant BRCA-EU 6 151703401 151703401 deletion of <=200bp T - intron_variant BRCA-EU 6 151703703 151703703 single base substitution G A intron_variant BRCA-EU 6 151703879 151703879 single base substitution C T intron_variant BRCA-EU 6 151706503 151706503 single base substitution C T intron_variant BRCA-EU 6 151706767 151706767 single base substitution A G intron_variant BRCA-EU 6 151707548 151707548 single base substitution T C intron_variant BRCA-EU 6 151708414 151708414 single base substitution C T intron_variant BRCA-EU 6 151709201 151709201 single base substitution T A intron_variant BRCA-EU 6 151711992 151711992 single base substitution G A intron_variant BRCA-EU 6 151712405 151712405 single base substitution G C intron_variant BRCA-EU 6 151712793 151712793 single base substitution C T upstream_gene_variant BRCA-EU 6 151714505 151714505 insertion of <=200bp - A upstream_gene_variant BRCA-EU 6 151714713 151714713 single base substitution T G upstream_gene_variant BRCA-EU 6 151715238 151715238 single base substitution C A upstream_gene_variant BRCA-EU 6 151715418 151715418 single base substitution G C upstream_gene_variant BRCA-EU 6 151715577 151715577 single base substitution T A upstream_gene_variant BRCA-EU 6 151716181 151716181 single base substitution A C upstream_gene_variant BRCA-EU 6 151716474 151716474 single base substitution G A upstream_gene_variant BRCA-FR 6 151680699 151680699 single base substitution C G downstream_gene_variant BRCA-FR 6 151697785 151697785 single base substitution C G intron_variant BRCA-FR 6 151699114 151699114 single base substitution A T intron_variant BRCA-FR 6 151706866 151706866 single base substitution T C intron_variant BRCA-FR 6 151714713 151714713 single base substitution T G upstream_gene_variant BRCA-FR 6 151715418 151715418 single base substitution G C upstream_gene_variant BRCA-UK 6 151696559 151696559 single base substitution G T intron_variant BRCA-UK 6 151715586 151715586 single base substitution G C upstream_gene_variant BRCA-UK 6 151716474 151716474 single base substitution G A upstream_gene_variant BRCA-US 6 151687437 151687437 single base substitution G A missense_variant A255V 764C>T BRCA-US 6 151687572 151687572 single base substitution G C missense_variant P210R 629C>G BRCA-US 6 151687962 151687962 single base substitution A T missense_variant M80K 239T>A BRCA-US 6 151694745 151694745 single base substitution G C missense_variant L10V 28C>G BTCA-JP 6 151686711 151686711 single base substitution T A missense_variant D497V 1490A>T CESC-US 6 151687599 151687599 single base substitution G A missense_variant S201L 602C>T CESC-US 6 151687696 151687696 single base substitution C T missense_variant E169K 505G>A COAD-US 6 151686764 151686764 single base substitution G A synonymous_variant D479D 1437C>T COAD-US 6 151686773 151686773 deletion of <=200bp A - frameshift_variant F476 COAD-US 6 151687639 151687639 single base substitution T A missense_variant N188Y 562A>T COAD-US 6 151687691 151687691 single base substitution C A missense_variant Q170H 510G>T COAD-US 6 151687861 151687861 single base substitution C T missense_variant A114T 340G>A COAD-US 6 151687930 151687930 single base substitution C T missense_variant D91N 271G>A COCA-CN 6 151686858 151686858 single base substitution T C missense_variant Y448C 1343A>G COCA-CN 6 151688888 151688888 single base substitution G T intron_variant COCA-CN 6 151694712 151694712 single base substitution C T missense_variant G21S 61G>A COCA-CN 6 151694721 151694721 single base substitution G A stop_gained R18* 52C>T COCA-CN 6 151695005 151695005 single base substitution A C intron_variant COCA-CN 6 151698748 151698748 single base substitution A T intron_variant COCA-CN 6 151703927 151703927 single base substitution G A intron_variant COCA-CN 6 151714576 151714576 single base substitution A C upstream_gene_variant ESAD-UK 6 151680668 151680668 single base substitution C G downstream_gene_variant ESAD-UK 6 151680911 151680912 deletion of <=200bp TC - downstream_gene_variant ESAD-UK 6 151683315 151683315 single base substitution A G downstream_gene_variant ESAD-UK 6 151683976 151683976 single base substitution C T downstream_gene_variant ESAD-UK 6 151684798 151684798 single base substitution C G downstream_gene_variant ESAD-UK 6 151688043 151688043 deletion of <=200bp A - intron_variant ESAD-UK 6 151688444 151688444 single base substitution C T intron_variant ESAD-UK 6 151691171 151691171 single base substitution C A intron_variant ESAD-UK 6 151693618 151693618 single base substitution T A intron_variant ESAD-UK 6 151694949 151694949 single base substitution C T intron_variant ESAD-UK 6 151698290 151698290 insertion of <=200bp - G intron_variant ESAD-UK 6 151701227 151701227 single base substitution A T intron_variant ESAD-UK 6 151701258 151701258 single base substitution C T intron_variant ESAD-UK 6 151701698 151701698 single base substitution G C intron_variant ESAD-UK 6 151705954 151705954 single base substitution C A intron_variant ESAD-UK 6 151707040 151707040 single base substitution G A intron_variant ESAD-UK 6 151710821 151710821 single base substitution T C intron_variant ESAD-UK 6 151712444 151712444 single base substitution G C intron_variant ESAD-UK 6 151713181 151713181 single base substitution G C upstream_gene_variant ESAD-UK 6 151714091 151714091 single base substitution C T upstream_gene_variant ESAD-UK 6 151715571 151715571 deletion of <=200bp A - upstream_gene_variant GBM-US 6 151687420 151687420 single base substitution G A missense_variant R261W 781C>T GBM-US 6 151687542 151687542 single base substitution G T missense_variant T220N 659C>A KIRP-US 6 151686673 151686676 deletion of <=200bp TTTC - frameshift_variant ET509 LICA-CN 6 151687879 151687879 single base substitution T A missense_variant I108F 322A>T LICA-FR 6 151687600 151687600 single base substitution A C missense_variant S201A 601T>G LICA-FR 6 151687601 151687601 single base substitution G A synonymous_variant T200T 600C>T LICA-FR 6 151698505 151698505 deletion of <=200bp T - intron_variant LIHC-US 6 151687080 151687080 single base substitution T G missense_variant Q374P 1121A>C LIHC-US 6 151687673 151687673 single base substitution C A missense_variant Q176H 528G>T LIHC-US 6 151694605 151694605 single base substitution C G missense_variant Q56H 168G>C LINC-JP 6 151684856 151684856 single base substitution C T downstream_gene_variant LINC-JP 6 151686711 151686711 single base substitution T A missense_variant D497V 1490A>T LINC-JP 6 151687931 151687931 single base substitution G A synonymous_variant I90I 270C>T LINC-JP 6 151688855 151688855 single base substitution T C intron_variant LINC-JP 6 151704854 151704854 single base substitution T C intron_variant LINC-JP 6 151707839 151707839 single base substitution C A intron_variant LIRI-JP 6 151681911 151681911 single base substitution T A downstream_gene_variant LIRI-JP 6 151684043 151684043 single base substitution T A downstream_gene_variant LIRI-JP 6 151684258 151684258 single base substitution T C downstream_gene_variant LIRI-JP 6 151684713 151684713 single base substitution T C downstream_gene_variant LIRI-JP 6 151685634 151685634 single base substitution T G 3_prime_UTR_variant LIRI-JP 6 151686757 151686757 single base substitution G A stop_gained R482* 1444C>T LIRI-JP 6 151695836 151695836 single base substitution A T intron_variant LIRI-JP 6 151696944 151696944 single base substitution T C intron_variant LIRI-JP 6 151699276 151699276 single base substitution T C intron_variant LIRI-JP 6 151701098 151701098 single base substitution C T intron_variant LIRI-JP 6 151701702 151701702 single base substitution C T intron_variant LIRI-JP 6 151702524 151702524 single base substitution C T intron_variant LIRI-JP 6 151709410 151709422 deletion of <=200bp CCAGCTTTTCCAA - intron_variant LIRI-JP 6 151710380 151710380 single base substitution G T intron_variant LIRI-JP 6 151714178 151714178 single base substitution T G upstream_gene_variant LIRI-JP 6 151715355 151715355 single base substitution T A upstream_gene_variant LIRI-JP 6 151715933 151715933 single base substitution A G upstream_gene_variant LIRI-JP 6 151716840 151716840 single base substitution T G upstream_gene_variant LUSC-KR 6 151684433 151684433 single base substitution C A downstream_gene_variant LUSC-KR 6 151685594 151685594 single base substitution A T 3_prime_UTR_variant LUSC-KR 6 151686905 151686905 single base substitution C T synonymous_variant E432E 1296G>A LUSC-KR 6 151688265 151688265 single base substitution T C intron_variant LUSC-KR 6 151689855 151689855 single base substitution A C intron_variant LUSC-KR 6 151693313 151693313 single base substitution C A intron_variant LUSC-KR 6 151693478 151693478 single base substitution C A intron_variant LUSC-KR 6 151694504 151694504 single base substitution A G intron_variant LUSC-KR 6 151695005 151695005 single base substitution A C intron_variant LUSC-KR 6 151700073 151700073 single base substitution G C intron_variant LUSC-KR 6 151711376 151711376 single base substitution C G intron_variant LUSC-KR 6 151712134 151712134 single base substitution C T intron_variant LUSC-KR 6 151713476 151713476 single base substitution T G upstream_gene_variant LUSC-US 6 151686676 151686676 single base substitution C T missense_variant E509K 1525G>A LUSC-US 6 151687860 151687860 single base substitution G C missense_variant A114G 341C>G MALY-DE 6 151687024 151687024 single base substitution T A missense_variant S393C 1177A>T MALY-DE 6 151690761 151690761 deletion of <=200bp A - intron_variant MALY-DE 6 151695131 151695131 single base substitution G A intron_variant MALY-DE 6 151697458 151697458 single base substitution G A intron_variant MALY-DE 6 151704362 151704362 single base substitution A C intron_variant MALY-DE 6 151704902 151704903 deletion of <=200bp AC - intron_variant MALY-DE 6 151705360 151705360 single base substitution G A intron_variant MALY-DE 6 151713037 151713037 single base substitution T G upstream_gene_variant MALY-DE 6 151715490 151715490 single base substitution C T upstream_gene_variant MALY-DE 6 151715738 151715738 single base substitution T C upstream_gene_variant MALY-DE 6 151715901 151715902 deletion of <=200bp GT - upstream_gene_variant MELA-AU 6 151682425 151682425 single base substitution C T downstream_gene_variant MELA-AU 6 151682856 151682856 single base substitution C T downstream_gene_variant MELA-AU 6 151683896 151683896 single base substitution G A downstream_gene_variant MELA-AU 6 151683933 151683933 single base substitution G A downstream_gene_variant MELA-AU 6 151685041 151685041 single base substitution G A downstream_gene_variant MELA-AU 6 151686668 151686668 single base substitution G A synonymous_variant V511V 1533C>T MELA-AU 6 151688553 151688553 single base substitution G A intron_variant MELA-AU 6 151688764 151688764 single base substitution G A intron_variant MELA-AU 6 151688968 151688968 single base substitution A G intron_variant MELA-AU 6 151689306 151689306 single base substitution G A intron_variant MELA-AU 6 151689409 151689409 single base substitution G A intron_variant MELA-AU 6 151689497 151689497 single base substitution G A intron_variant MELA-AU 6 151690167 151690167 single base substitution G A intron_variant MELA-AU 6 151691374 151691374 single base substitution A T intron_variant MELA-AU 6 151691633 151691633 single base substitution G A intron_variant MELA-AU 6 151692288 151692288 single base substitution G A intron_variant MELA-AU 6 151692344 151692344 single base substitution A C intron_variant MELA-AU 6 151692720 151692720 single base substitution C T intron_variant MELA-AU 6 151693887 151693887 single base substitution G A intron_variant MELA-AU 6 151694758 151694758 insertion of <=200bp - GTT inframe_insertion N5NN MELA-AU 6 151694831 151694831 single base substitution G A intron_variant MELA-AU 6 151695286 151695286 single base substitution G A intron_variant MELA-AU 6 151695410 151695410 single base substitution G A intron_variant MELA-AU 6 151695760 151695760 single base substitution G A intron_variant MELA-AU 6 151696924 151696924 single base substitution G A intron_variant MELA-AU 6 151697017 151697017 single base substitution A T intron_variant MELA-AU 6 151697383 151697383 single base substitution A T intron_variant MELA-AU 6 151697516 151697516 single base substitution C T intron_variant MELA-AU 6 151698644 151698644 single base substitution C A intron_variant MELA-AU 6 151698655 151698655 single base substitution G A intron_variant MELA-AU 6 151698716 151698716 single base substitution C T intron_variant MELA-AU 6 151698939 151698939 single base substitution G A intron_variant MELA-AU 6 151699718 151699718 single base substitution G A intron_variant MELA-AU 6 151700127 151700127 single base substitution A G intron_variant MELA-AU 6 151700473 151700473 single base substitution C T intron_variant MELA-AU 6 151701383 151701383 deletion of <=200bp A - intron_variant MELA-AU 6 151704324 151704324 single base substitution G A intron_variant MELA-AU 6 151704798 151704798 single base substitution G A intron_variant MELA-AU 6 151705065 151705065 single base substitution G T intron_variant MELA-AU 6 151705330 151705330 single base substitution A G intron_variant MELA-AU 6 151706653 151706653 single base substitution G A intron_variant MELA-AU 6 151706861 151706861 single base substitution T C intron_variant MELA-AU 6 151708225 151708225 single base substitution G A intron_variant MELA-AU 6 151708581 151708582 multiple base substitution (>=2bp and <=200bp) GG AA intron_variant MELA-AU 6 151709697 151709697 single base substitution G T intron_variant MELA-AU 6 151709842 151709843 multiple base substitution (>=2bp and <=200bp) GT TA intron_variant MELA-AU 6 151711516 151711516 single base substitution G A intron_variant MELA-AU 6 151712722 151712722 single base substitution C T upstream_gene_variant MELA-AU 6 151713676 151713676 single base substitution C T upstream_gene_variant MELA-AU 6 151717192 151717192 single base substitution T G upstream_gene_variant ORCA-IN 6 151713807 151713807 single base substitution C G upstream_gene_variant OV-AU 6 151684795 151684795 single base substitution G A downstream_gene_variant OV-AU 6 151689709 151689709 single base substitution C T intron_variant OV-AU 6 151693788 151693788 single base substitution A C intron_variant OV-AU 6 151696522 151696522 single base substitution T C intron_variant OV-AU 6 151700828 151700828 single base substitution T C intron_variant OV-AU 6 151703892 151703892 single base substitution T C intron_variant OV-AU 6 151707061 151707061 single base substitution A G intron_variant OV-AU 6 151707158 151707158 single base substitution C A intron_variant OV-AU 6 151713656 151713656 single base substitution C A upstream_gene_variant OV-AU 6 151717353 151717353 single base substitution G A upstream_gene_variant PACA-AU 6 151682466 151682466 single base substitution G A downstream_gene_variant PACA-AU 6 151684005 151684008 deletion of <=200bp AAAC - downstream_gene_variant PACA-AU 6 151687486 151687486 single base substitution C T missense_variant V239I 715G>A PACA-AU 6 151688547 151688547 single base substitution C T intron_variant PACA-AU 6 151689225 151689225 single base substitution A T intron_variant PACA-AU 6 151694674 151694674 single base substitution T C synonymous_variant V33V 99A>G PACA-AU 6 151694737 151694737 single base substitution T C synonymous_variant Q12Q 36A>G PACA-AU 6 151703641 151703641 single base substitution C T intron_variant PACA-AU 6 151705370 151705370 single base substitution A T intron_variant PACA-AU 6 151712725 151712725 single base substitution G T upstream_gene_variant PACA-AU 6 151717390 151717390 single base substitution G T upstream_gene_variant PACA-CA 6 151690494 151690494 insertion of <=200bp - T intron_variant PACA-CA 6 151690830 151690830 single base substitution G A intron_variant PACA-CA 6 151691700 151691700 single base substitution T C intron_variant PACA-CA 6 151692093 151692093 single base substitution C A intron_variant PACA-CA 6 151692094 151692094 single base substitution C A intron_variant PACA-CA 6 151700790 151700790 single base substitution A G intron_variant PACA-CA 6 151705646 151705646 insertion of <=200bp - A intron_variant PACA-CA 6 151706295 151706295 single base substitution T G intron_variant PACA-CA 6 151707182 151707182 single base substitution A G intron_variant PACA-CA 6 151708716 151708716 single base substitution C T intron_variant PAEN-AU 6 151699696 151699696 single base substitution T C intron_variant PBCA-DE 6 151715901 151715902 deletion of <=200bp GT - upstream_gene_variant PRAD-CA 6 151702209 151702209 single base substitution A G intron_variant PRAD-UK 6 151694290 151694308 deletion of <=200bp AAAAAAAAAAAAAAAAAAA - intron_variant PRAD-UK 6 151715931 151715931 insertion of <=200bp - GC upstream_gene_variant PRAD-US 6 151686671 151686671 single base substitution G A synonymous_variant T510T 1530C>T PRAD-US 6 151687732 151687732 single base substitution G A stop_gained R157* 469C>T RECA-EU 6 151680787 151680787 single base substitution C G downstream_gene_variant RECA-EU 6 151683632 151683632 single base substitution T G downstream_gene_variant RECA-EU 6 151688682 151688682 single base substitution C A intron_variant RECA-EU 6 151695005 151695005 single base substitution A C intron_variant SKCA-BR 6 151681073 151681073 single base substitution A T downstream_gene_variant SKCA-BR 6 151684004 151684016 deletion of <=200bp AAAACAAACAAAC - downstream_gene_variant SKCA-BR 6 151693971 151693971 single base substitution T C intron_variant SKCA-BR 6 151694611 151694611 single base substitution G A synonymous_variant V54V 162C>T SKCA-BR 6 151695000 151695000 insertion of <=200bp - AAAAC intron_variant SKCA-BR 6 151695490 151695490 single base substitution C T intron_variant SKCA-BR 6 151696168 151696168 single base substitution T A intron_variant SKCA-BR 6 151698670 151698671 deletion of <=200bp AT - intron_variant SKCA-BR 6 151700813 151700813 single base substitution A T intron_variant SKCA-BR 6 151703635 151703635 single base substitution C T intron_variant SKCA-BR 6 151704507 151704507 single base substitution G A intron_variant SKCA-BR 6 151704918 151704918 single base substitution A C intron_variant SKCA-BR 6 151708451 151708451 single base substitution T C intron_variant SKCA-BR 6 151708483 151708505 deletion of <=200bp GTGTCAACACTGAGAAGACATTT - intron_variant SKCA-BR 6 151711405 151711405 single base substitution C T intron_variant SKCA-BR 6 151711462 151711462 single base substitution T C intron_variant SKCA-BR 6 151715069 151715069 single base substitution G C upstream_gene_variant SKCA-BR 6 151715900 151715900 insertion of <=200bp - CGT upstream_gene_variant SKCM-US 6 151686700 151686700 single base substitution A G synonymous_variant L501L 1501T>C SKCM-US 6 151687318 151687318 single base substitution G A missense_variant L295F 883C>T SKCM-US 6 151687339 151687339 single base substitution C A stop_gained E288* 862G>T SKCM-US 6 151687577 151687577 single base substitution G A synonymous_variant S208S 624C>T SKCM-US 6 151687921 151687921 single base substitution G A stop_gained R94* 280C>T STAD-US 6 151686764 151686764 single base substitution G A synonymous_variant D479D 1437C>T STAD-US 6 151687158 151687158 single base substitution T C missense_variant N348S 1043A>G STAD-US 6 151687265 151687265 single base substitution G A synonymous_variant A312A 936C>T STAD-US 6 151687417 151687417 single base substitution G A missense_variant R262C 784C>T STAD-US 6 151687420 151687420 single base substitution G A missense_variant R261W 781C>T STAD-US 6 151687601 151687601 single base substitution G A synonymous_variant T200T 600C>T STAD-US 6 151687648 151687648 single base substitution C T missense_variant A185T 553G>A STAD-US 6 151687735 151687735 single base substitution C T missense_variant G156R 466G>A STAD-US 6 151687891 151687891 single base substitution C T missense_variant A104T 310G>A STAD-US 6 151694619 151694619 single base substitution A G synonymous_variant L52L 154T>C THCA-SA 6 151687988 151687988 single base substitution G T missense_variant D71E 213C>A UCEC-US 6 151687930 151687930 single base substitution C T missense_variant D91N 271G>A

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand TCGA-HU-A4GX-01 COSM3859141 c.466G>A p.G156R Substitution - Missense 6:151366600-151366600 - TCGA-HU-8602-01 COSM3859140 c.553G>A p.A185T Substitution - Missense 6:151366513-151366513 - SK-MEL-2 COSM1672839 c.137C>T p.S46F Substitution - Missense 6:151373501-151373501 - CHC205T COSM4003737 c.1296G>A p.E432E Substitution - coding silent 6:151365770-151365770 - TCGA-G2-A2EJ-01 COSM1311669 c.415G>A p.D139N Substitution - Missense 6:151366651-151366651 - PS-155-6D COSM4423688 c.819C>T p.L273L Substitution - coding silent 6:151366247-151366247 - Pat_40_A COSM5869516 c.517G>A p.E173K Substitution - Missense 6:151366549-151366549 - DLD1 COSM4625693 c.1123A>G p.K375E Substitution - Missense 6:151365943-151365943 - TCGA-EA-A439-01 COSM4843766 c.602C>T p.S201L Substitution - Missense 6:151366464-151366464 - PS-155-1D COSM4423688 c.819C>T p.L273L Substitution - coding silent 6:151366247-151366247 - 587238 COSM1233128 c.1444C>T p.R482* Substitution - Nonsense 6:151365622-151365622 - PD5964a COSM5778601 c.898G>T p.A300S Substitution - Missense 6:151366168-151366168 - TCGA-D1-A176-01 COSM1074588 c.226C>A p.L76I Substitution - Missense 6:151366840-151366840 - 6T COSM3734254 c.232C>G p.H78D Substitution - Missense 6:151366834-151366834 - T1743 COSM4742093 c.681C>T p.S227S Substitution - coding silent 6:151366385-151366385 - BN44T COSM1621065 c.270C>T p.I90I Substitution - coding silent 6:151366796-151366796 - sysucc-274T COSM5476636 c.52C>T p.R18* Substitution - Nonsense 6:151373586-151373586 - PT46 COSM5928879 c.163C>T p.H55Y Substitution - Missense 6:151373475-151373475 - 585276 COSM326901 c.1382A>G p.N461S Substitution - Missense 6:151365684-151365684 - PDA_059 COSM5001075 c.694G>T p.A232S Substitution - Missense 6:151366372-151366372 - T3658 COSM4742092 c.699C>T p.S233S Substitution - coding silent 6:151366367-151366367 - CHC433T COSM4003737 c.1296G>A p.E432E Substitution - coding silent 6:151365770-151365770 - T2944 COSM326901 c.1382A>G p.N461S Substitution - Missense 6:151365684-151365684 - SC_9047 COSM5558005 c.107A>T p.K36M Substitution - Missense 6:151373531-151373531 - TCGA-AZ-6601-01 COSM1441211 c.1437C>T p.D479D Substitution - coding silent 6:151365629-151365629 - TCGA-D5-6930-01 COSM1441212 c.1428delT p.F476fs*3 Deletion - Frameshift 6:151365638-151365638 - TCGA-14-1395-01 COSM3019323 c.781C>T p.R261W Substitution - Missense 6:151366285-151366285 - TCGA-CD-A4MG-01 COSM3859137 c.936C>T p.A312A Substitution - coding silent 6:151366130-151366130 - TCGA-06-6693-01 COSM3410664 c.659C>A p.T220N Substitution - Missense 6:151366407-151366407 - C608 COSM4443036 c.848C>T p.S283F Substitution - Missense 6:151366218-151366218 - NCI-H23 COSM1196341 c.510G>T p.Q170H Substitution - Missense 6:151366556-151366556 - tumor_4145056 COSM5950125 c.1177A>T p.S393C Substitution - Missense 6:151365889-151365889 - RK308_C01 COSM1233128 c.1444C>T p.R482* Substitution - Nonsense 6:151365622-151365622 - TCGA-CG-5733-01 COSM3019323 c.781C>T p.R261W Substitution - Missense 6:151366285-151366285 - DLD1 COSM4625692 c.1272G>A p.Q424Q Substitution - coding silent 6:151365794-151365794 - BN44 COSM1621065 c.270C>T p.I90I Substitution - coding silent 6:151366796-151366796 - TCGA-F4-6570-01 COSM1074587 c.271G>A p.D91N Substitution - Missense 6:151366795-151366795 - CCC2 COSM3662203 c.1490A>T p.D497V Substitution - Missense 6:151365576-151365576 - HT55 COSM3019331 c.596A>T p.Q199L Substitution - Missense 6:151366470-151366470 - DLD1 COSM3019321 c.876C>T p.P292P Substitution - coding silent 6:151366190-151366190 - TCGA-HU-8602-01 COSM3859136 c.1043A>G p.N348S Substitution - Missense 6:151366023-151366023 - T2769 COSM4742095 c.184C>T p.R62C Substitution - Missense 6:151366882-151366882 - TCGA-EJ-7782-01 COSM3783945 c.1530C>T p.T510T Substitution - coding silent 6:151365536-151365536 - Pat_59_A COSM5869517 c.479G>A p.R160Q Substitution - Missense 6:151366587-151366587 - 402 COSM3829313 c.629C>G p.P210R Substitution - Missense 6:151366437-151366437 - TCGA-A8-A06X-01 COSM450689 c.764C>T p.A255V Substitution - Missense 6:151366302-151366302 - TCGA-BR-8361-01 COSM3859143 c.154T>C p.L52L Substitution - coding silent 6:151373484-151373484 - HCT15 COSM3019321 c.876C>T p.P292P Substitution - coding silent 6:151366190-151366190 - Pat_40_B COSM5869516 c.517G>A p.E173K Substitution - Missense 6:151366549-151366549 - HCC058T COSM5804095 c.322A>T p.I108F Substitution - Missense 6:151366744-151366744 - T263 COSM4742096 c.106A>G p.K36E Substitution - Missense 6:151373532-151373532 - TCGA-BR-6452-01 COSM3859142 c.310G>A p.A104T Substitution - Missense 6:151366756-151366756 - TCGA-DM-A28H-01 COSM1441214 c.340G>A p.A114T Substitution - Missense 6:151366726-151366726 - TCGA-KR-A7K8-01 COSM4918201 c.528G>T p.Q176H Substitution - Missense 6:151366538-151366538 - 24T COSM108551 c.1525G>A p.E509K Substitution - Missense 6:151365541-151365541 - T3064 COSM4742095 c.184C>T p.R62C Substitution - Missense 6:151366882-151366882 - TCGA-EE-A2GO-06 COSM3621478 c.624C>T p.S208S Substitution - coding silent 6:151366442-151366442 - SA106 COSM214272 c.839C>T p.P280L Substitution - Missense 6:151366227-151366227 - BICR_22 COSM3019326 c.655G>A p.E219K Substitution - Missense 6:151366411-151366411 - T2284 COSM4742089 c.1259T>A p.M420K Substitution - Missense 6:151365807-151365807 - 8066067 COSM3019344 c.36A>G p.Q12Q Substitution - coding silent 6:151373602-151373602 - 6P2-1 COSM3734254 c.232C>G p.H78D Substitution - Missense 6:151366834-151366834 - Pat_59_B COSM5869518 c.286G>A p.E96K Substitution - Missense 6:151366780-151366780 - PS-155-5D COSM4423688 c.819C>T p.L273L Substitution - coding silent 6:151366247-151366247 - sysucc-1240T COSM5766147 c.1343A>G p.Y448C Substitution - Missense 6:151365723-151365723 - T2944 COSM4742091 c.808C>T p.R270C Substitution - Missense 6:151366258-151366258 - TCGA-AZ-6598-01 COSM1196341 c.510G>T p.Q170H Substitution - Missense 6:151366556-151366556 - CRC-10T COSM5457718 c.61G>A p.G21S Substitution - Missense 6:151373577-151373577 - LUAD-E00897 COSM364711 c.666G>A p.L222L Substitution - coding silent 6:151366400-151366400 - T3724 COSM4742090 c.870C>T p.R290R Substitution - coding silent 6:151366196-151366196 - 6P2-2 COSM3734254 c.232C>G p.H78D Substitution - Missense 6:151366834-151366834 - TCGA-PD-A5DF-01 COSM4909794 c.168G>C p.Q56H Substitution - Missense 6:151373470-151373470 - TCGA-F4-6460-01 COSM1441213 c.562A>T p.N188Y Substitution - Missense 6:151366504-151366504 - CSCC-56-T COSM4501149 c.581C>T p.P194L Substitution - Missense 6:151366485-151366485 - SNUH_G73_S1 COSM4003737 c.1296G>A p.E432E Substitution - coding silent 6:151365770-151365770 - TCGA-BG-A0M0-01 COSM1074586 c.1274C>A p.T425N Substitution - Missense 6:151365792-151365792 - TCGA-E5-A2PC-01 COSM1311670 c.281G>A p.R94Q Substitution - Missense 6:151366785-151366785 - SC_9094 COSM5569669 c.80C>T p.T27M Substitution - Missense 6:151373558-151373558 - TCGA-D3-A5GU-06 COSM3621477 c.862G>T p.E288* Substitution - Nonsense 6:151366204-151366204 - CSCC-29-T COSM4451046 c.1034A>T p.D345V Substitution - Missense 6:151366032-151366032 - TCGA-BR-8487-01 COSM3859138 c.784C>T p.R262C Substitution - Missense 6:151366282-151366282 - STC252 COSM5061499 c.696G>A p.A232A Substitution - coding silent 6:151366370-151366370 - TCGA-D8-A1XZ-01 COSM1487323 c.239T>A p.M80K Substitution - Missense 6:151366827-151366827 - TCGA-EE-A29M-06 COSM3621476 c.883C>T p.L295F Substitution - Missense 6:151366183-151366183 - 2151 COSM5014655 c.931G>A p.E311K Substitution - Missense 6:151366135-151366135 - PS-155-3D COSM4423688 c.819C>T p.L273L Substitution - coding silent 6:151366247-151366247 - T3021 COSM4742094 c.641delC p.P214fs*23 Deletion - Frameshift 6:151366425-151366425 - TCGA-18-3421-01 COSM740600 c.341C>G p.A114G Substitution - Missense 6:151366725-151366725 - ESCC_5 COSM5623284 c.129T>G p.A43A Substitution - coding silent 6:151373509-151373509 - H23 COSM1196341 c.510G>T p.Q170H Substitution - Missense 6:151366556-151366556 - 468 COSM4437494 c.350G>A p.G117E Substitution - Missense 6:151366716-151366716 - TCGA-UB-A7MB-01 COSM4931810 c.1121A>C p.Q374P Substitution - Missense 6:151365945-151365945 - TCGA-BR-4184-01 COSM3859139 c.600C>T p.T200T Substitution - coding silent 6:151366466-151366466 - PTC_118 COSM5957626 c.213C>A p.D71E Substitution - Missense 6:151366853-151366853 - TCGA-F1-6874-01 COSM1441211 c.1437C>T p.D479D Substitution - coding silent 6:151365629-151365629 - TCGA-AP-A0LM-01 COSM1074587 c.271G>A p.D91N Substitution - Missense 6:151366795-151366795 - HCT8 COSM3019321 c.876C>T p.P292P Substitution - coding silent 6:151366190-151366190 - 8066067 COSM3019343 c.99A>G p.V33V Substitution - coding silent 6:151373539-151373539 - TCGA-EK-A2RD-01 COSM4820324 c.505G>A p.E169K Substitution - Missense 6:151366561-151366561 - TCGA-60-2698-01 COSM108551 c.1525G>A p.E509K Substitution - Missense 6:151365541-151365541 - pfg181T COSM4762619 c.1004C>T p.S335L Substitution - Missense 6:151366062-151366062 - STC232 COSM4742094 c.641delC p.P214fs*23 Deletion - Frameshift 6:151366425-151366425 - SNUH_G26_S1 COSM4003737 c.1296G>A p.E432E Substitution - coding silent 6:151365770-151365770 - 8015299 COSM3781581 c.715G>A p.V239I Substitution - Missense 6:151366351-151366351 - 587256 COSM1233129 c.695C>T p.A232V Substitution - Missense 6:151366371-151366371 - TCGA-EE-A2MR-06 COSM3621479 c.280C>T p.R94* Substitution - Nonsense 6:151366786-151366786 - TCGA-D8-A27G-01 COSM3829313 c.629C>G p.P210R Substitution - Missense 6:151366437-151366437 - TCGA-EW-A1J5-01 COSM1487324 c.28C>G p.L10V Substitution - Missense 6:151373610-151373610 - CCC2T COSM3662203 c.1490A>T p.D497V Substitution - Missense 6:151365576-151365576 - 01-P459 COSM4586322 c.185G>A p.R62H Substitution - Missense 6:151366881-151366881 - SC_9047 COSM5571274 c.99A>T p.V33V Substitution - coding silent 6:151373539-151373539 - PDA_031 COSM4999526 c.344G>T p.S115I Substitution - Missense 6:151366722-151366722 - TCGA-KK-A6E0-01 COSM4876819 c.469C>T p.R157* Substitution - Nonsense 6:151366597-151366597 - 18195 COSM1311670 c.281G>A p.R94Q Substitution - Missense 6:151366785-151366785 - YULOCUS COSM3621479 c.280C>T p.R94* Substitution - Nonsense 6:151366786-151366786 - TCGA-EE-A2GC-06 COSM3621475 c.1501T>C p.L501L Substitution - coding silent 6:151365565-151365565 -

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.520072;Hs.520073 6q25.1 2433493|CGAP|BC020172|A/T|non-coding||2183|Candidate

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer A G Synonymous p.L501L c.1501T>C 6 151686700 CM A T Missense p.M80K c.239T>A 6 151687962 BRCA C A Missense p.D2Y c.4G>T 6 151694769 LUAD C T Missense p.D139N c.415G>A 6 151687786 BLCA C T Missense p.R94Q c.281G>A 6 151687920 BLCA C T Synonymous p.L222L c.666G>A 6 151687535 BRCA C T Synonymous p.L23L c.69G>A 6 151694704 HNSC G A Missense p.L295F c.883C>T 6 151687318 CM G A Missense p.P280L c.839C>T 6 151687362 BRCA G A Missense p.R261W c.781C>T 6 151687420 GBM G A Missense p.R261W c.781C>T 6 151687420 STAD G A Missense p.S195L c.584C>T 6 151687617 BRCA G A Nonsense p.R157* c.469C>T 6 151687732 PRAD G A Synonymous p.D479D c.1437C>T 6 151686764 STAD G A Synonymous p.S208S c.624C>T 6 151687577 CM G A Synonymous p.T200T c.600C>T 6 151687601 CM G C Missense p.A114G c.341C>G 6 151687860 LUSC G C Missense p.S414R c.1242C>G 6 151686959 HNSC GG AA Missense p.Q404* c.1209_1210delinsTT 6 151686991 CM G T Missense p.T220N c.659C>A 6 151687542 GBM T C Missense p.E223G c.668A>G 6 151687533 LUAD T C Missense p.N403S c.1208A>G 6 151686993 HNSC T C Missense p.N461S c.1382A>G 6 151686819 SCLC T C Missense p.N461S c.1382A>G 6 151686819 THCA